Nat Commun July 2023 PMID 37433798

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors.

Cheng-Kai Shiau, Lina Lu, Rachel Kieser, Kazutaka Fukumura, Timothy Pan, Hsiao-Yun Lin, Jie Yang, Eric L Tong, GaHyun Lee, Yuanqing Yan, Jason T Huse, Ruli Gao

Mentions

14
Peak: 8 in Jul 2023
across 4 sources since Jul 2023

Extended reach

21,360
potential audience

Total likes

16

Video views

57

Mentions per month

Jul 2023 – Oct 2023

Where it's discussed

  • X / Twitter8 posts
  • News3 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions demonstrate genuine interest and recognition of the article's importance, exemplified by references to novel techniques like scNanoGPS and mentions of tumor heterogeneity; words like 'innovative' and 'significant' reflect a positive and engaged tone, emphasizing the potential for transformative impact in cancer research.

AgreementModerate agreement

Most discussions acknowledge the significance of the new long-read sequencing method, highlighting its innovative analysis of genotypes and phenotypes in tumors.

InterestHigh interest

Participants show strong interest, with mentions of new tools like scNanoGPS and its potential to advance cancer research.

EngagementModerate engagement

Posts often include specific references to methods and potential implications, indicating active engagement.

ImpactModerate impact

There's a shared perception that this research could substantially influence future studies in tumor genomics and single-cell analysis.

Abstract in brief

  • Single-cell nanopore sequencing can enhance multi-omics studies but faces issues like high sequencing errors and reliance on short reads or barcode whitelists.
  • The new tool, scNanoGPS, allows for the analysis of both genotypes and phenotypes in single cells by processing long-read transcriptomes without needing short-read guidance.
  • By using scNanoGPS on thousands of samples, researchers unveiled unique gene expression patterns and mutations in tumor and immune cells, underscoring the diverse roles of various cell types in tumors.

Top posts

Most liked on X and Bluesky
BioDecoded
@BioDecoded · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors | Nature Communications https://t.co/h6s3k4N598 #Bioinformatics https://t.co/0fIrwUmjTp

Jul 17, 2023 · 12 likes · 1 share · 8,899 followers View post →
RNA-Seq Blog
@RNASeqBlog · X

Researchers at @NUFeinbergMed have developed scNanoGPS to calculate same-cell #genotypes (#mutations) and #phenotypes (#gene/isoform expressions) without short-read nor whitelist guidance. https://t.co/tIrfCwYi1B

Jul 13, 2023 · 3 likes · 1 share · 8,592 followers View post →
Taco Jesse
@TJesse62 · X

RT @RNASeqBlog: Researchers at @NUFeinbergMed have developed scNanoGPS to calculate same-cell #genotypes (#mutations) and #phenotypes (#gen…

Jul 13, 2023 · 1 share · 1,730 followers View post →
Ikemen
@HandsomeKinoko · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors @HandsomeKinoko #note https://t.co/3Rp3YHUYDW

Jul 20, 2023 · 1,272 followers View post →
Long-read metagenomics-Papers
@LR_metagenomics · X

nanopore: High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors https://t.co/3YjP8bAETW

Jul 12, 2023 · 368 followers View post →
Gang Wu
@wufgang · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors https://t.co/77KfSihUF2

Jul 11, 2023 · 264 followers View post →

All mentions

Ikemen
@HandsomeKinoko · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors @HandsomeKinoko #note https://t.co/3Rp3YHUYDW

Jul 20, 2023 · 1,272 followers View post →
Carlos Mora
@CarlosM49544824 · X

RT @BioDecoded: High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors | Nature Co…

Jul 18, 2023 · 1 share · 70 followers View post →
BioDecoded
@BioDecoded · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors | Nature Communications https://t.co/h6s3k4N598 #Bioinformatics https://t.co/0fIrwUmjTp

Jul 17, 2023 · 12 likes · 1 share · 8,899 followers View post →
Taco Jesse
@TJesse62 · X

RT @RNASeqBlog: Researchers at @NUFeinbergMed have developed scNanoGPS to calculate same-cell #genotypes (#mutations) and #phenotypes (#gen…

Jul 13, 2023 · 1 share · 1,730 followers View post →
RNA-Seq Blog
@RNASeqBlog · X

Researchers at @NUFeinbergMed have developed scNanoGPS to calculate same-cell #genotypes (#mutations) and #phenotypes (#gene/isoform expressions) without short-read nor whitelist guidance. https://t.co/tIrfCwYi1B

Jul 13, 2023 · 3 likes · 1 share · 8,592 followers View post →
Nanopore_research
@Nanoporepapers_ · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors Follow us :) https://t.co/Lx2TfpJ2ci

Jul 12, 2023 · 100 followers View post →
Long-read metagenomics-Papers
@LR_metagenomics · X

nanopore: High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors https://t.co/3YjP8bAETW

Jul 12, 2023 · 368 followers View post →
Gang Wu
@wufgang · X

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors https://t.co/77KfSihUF2

Jul 11, 2023 · 264 followers View post →