Nat Commun July 2023 PMID 37468485

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.

Matthieu Dos Santos, Akansha M Shah, Yichi Zhang, Svetlana Bezprozvannaya, Kenian Chen, Lin Xu, Weichun Lin, John R McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N Olson

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Peak: 9 in Jul 2023

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The overall tone suggests recognition of the study's importance, with users posting about its findings and significance, such as referencing gene programs and muscle development mechanisms. The brief nature of responses and sharing of the publication's title reflect moderate curiosity and acknowledgment of its impact.

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Most discussions acknowledge the significance of the study, showing agreement with its findings.

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Comments display moderate interest, mainly sharing links and titles without deep analysis.

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The responses are brief, indicating limited in-depth engagement with the research details.

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There is a recognition that the research could influence future studies, but explicit statements are minimal.

Abstract in brief

The study used single nucleus RNAseq and ATACseq to create a detailed map of gene activity during different stages of mouse skeletal muscle development, highlighting how gene programs change from embryonic to postnatal stages.
It identified key transcription factors like Myogenin, Klf5, and Tead4 working together to promote muscle gene expression during fiber formation, with Maf acting as a switch to turn on mature muscle genes during fiber maturation.
The research also showed that mice lacking specific voltage-gated calcium channels (Cav1.1) have disrupted Maf expression and impaired muscle maturation, linking gene regulation to muscle function and development.

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Gene Regulatory Programs in Muscle Development and Maturation

This study uses single nucleus RNAseq and ATACseq to map gene activity during mouse skeletal muscle development, identifying key transcription factors like Myogenin, Klf5, and Maf that regulate myofiber formation and…

STEM RTCL TV · Oct 16, 2023 29 views

Stem Development

@StemDevelopment · X

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution https://t.co/11bcTqR29T

Jul 23, 2023 · 72 followers View post →

Professor Adam Sharples

@DrAdamPSharples · X