Targeting the loss of cGAS/STING signaling in cancer.

Abstract in brief

• The cGAS-STING pathway is crucial for immune defense because it detects abnormal cytoplasmic DNA, which can come from pathogens or internal cell issues like faulty DNA repair, helping the immune system target cancer cells.
• Cancer cells often suppress the cGAS-STING pathway to avoid immune detection, which helps them survive and can lead to resistance against immune-based therapies like immune checkpoint blockade (ICB).
• The article explores how understanding and reversing this suppression could enhance anti-tumor immunity by reactivating the cGAS-STING pathway, potentially overcoming resistance to current cancer immunotherapies.]