What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study's patient-level data with fidelity to the original research protocol.
Several discussions criticize the original STAR*D study, highlighting that only 35% remission was found with the new analysis compared to the previously claimed higher rates, using phrases like 'stinks' and 'did not follow its protocols' to express dissatisfaction. Others show moderation with mentions of reanalysis and methodological critiques, indicating a mix of skepticism and engagement that could influence how future depression treatments are interpreted and applied.
AgreementLow agreement
Most discussions express skepticism or criticism about the original study’s findings and protocols, indicating disagreement.
InterestModerate interest
Participants show curiosity about the reanalysis and its implications, reflecting moderate interest.
EngagementModerate engagement
Posts delve into methodological issues and implications of the new analysis, showing some thoughtful engagement.
ImpactModerate impact
The conversations challenge prior beliefs about treatment success rates, suggesting a moderate potential impact on clinical perspectives.
Abstract in brief
The reanalysis of the STARD study focuses on how effective and how much improvement depressed patients experienced after up to four rounds of antidepressant treatments, highlighting real-world clinical settings with diverse patient groups.
The study involved patients seeking care (not just research participants), many with other medical or psychiatric conditions, and tested multiple antidepressants when initial treatment with citalopram failed, aiming to reflect typical clinical practice.
The original STARD study defined remission and response based on standardized scales but was criticized for possibly overstating success rates because it used nonblinded assessments instead of the protocol-approved blinded measures, potentially inflating outcomes.]
Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, they estimated only 35% remitted after at <=4 treatment attempts, much less than the original 67%
https://t.co/FyTcLNWJRH
#psychiatry #clinicaltrials https://t.co/dR0aiBKUTv
Aug 11, 2023 · 73 likes · 16 shares · 8,481 followersView post →
Lバ
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study's patient-level data with fidelity to the original research https://t.co/obJ7R6ur13
Aug 11, 2023 · 46 likes · 9 shares · 2,279 followersView post →
CP
Carlat Psychiatry
@CarlatPsych · X
Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, they estimated 35% remitted after at <=4 treatment attempts, much less than the original 67% -@ChrisAikenMD
https://t.co/sV4wrOmx6J
#psychiatry #clinicaltrials https://t.co/oISGGxq5hZ
Aug 11, 2023 · 35 likes · 9 shares · 8,078 followersView post →
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Melissa Raven
@psychepi · X
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study ... with fidelity to the original research … @BMJ_Open https://t.co/VULGhSJBio
• 1977 Psychiatry: Pretest. Nelson, J.
• Original STAR*D (Rush et al. 2006): https://t.co/rUWEFaf5ir…
• Re-analysis (Pigott et al. 2023): https://t.co/g6X1VP29mR… https://t.co/rqhHBLg0N8
Jun 4, 2025 · 9 likes · 1 share · 2,667 followersView post →
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Nicolas Badre
@BadreNicolas · X
List of pharma companies mentioned in the disclosure of STAR*D (picture below).
• Original STAR*D (Rush et al. 2006): https://t.co/rUWEFaf5ir
• Re-analysis (Pigott et al. 2023): https://t.co/g6X1VP29mR
• Recent textbook mention of STAR*D Tasman (2024, p1844)
• 2006 STAR*D https://t.co/iktyMGHyUl
This episode discusses international alerts regarding ADHD medications, scrutiny of Dr. Fraga's ADHD segments, and the STARD study reanalysis on antidepressant efficacy and patient improvement in real-world settings.
This reanalysis of the STARD study examines how effective antidepressant treatments are and the extent of patient improvement after up to four trials, focusing on real-world clinical settings involving diverse patient…
List of pharma companies mentioned in the disclosure of STAR*D (picture below).
• Original STAR*D (Rush et al. 2006): https://t.co/rUWEFaf5ir
• Re-analysis (Pigott et al. 2023): https://t.co/g6X1VP29mR
• Recent textbook mention of STAR*D Tasman (2024, p1844)
• 2006 STAR*D https://t.co/iktyMGHyUl
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? e063095.full.pdf https://t.co/haFfWNemn2
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? Reanalysis of the STAR*D study's patient-level data with fidelity to the original research
https://t.co/zN2Vie4Qyu
Mar 27, 2024 · 1 like · 1 share · 184 followersView post →
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Lasse Mattila
@Lasse_Mattila · X
#8 Månadens nyheter: Internationella varningar för ADHD-läkemedel; granskningshärvan kring Fråga doktorn-inslag; STAR*D-skandalen och antidepressiva läkemedel: https://t.co/B6jIKsC3ks
#MånadensNyheter #ADHD #FrågaDoktorn #SVT #Granskningsnämnden #STARD #Antidepressiva
RT @Luke_629: What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapie…
Aug 12, 2023 · 9 shares · 667 followersView post →
FD
Felipe Guillen, M.D
@pipeguillenMD · X
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study's patient-level data to the original research protocol https://t.co/SSeTxSTSV6
RT @Luke_629: What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapie…
Aug 12, 2023 · 9 shares · 1,651 followersView post →
T精
TT /精神科備忘録
@EgBopt37gajSY4H · X
RT @Luke_629: What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapie…
Aug 12, 2023 · 9 shares · 202 followersView post →
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llontyanne
@iron_tyanne · X
RT @Luke_629: What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapie…
Aug 12, 2023 · 9 shares · 117 followersView post →
あ
あるく
@ayumu_tomaru · X
RT @Luke_629: What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapie…
Aug 11, 2023 · 9 shares · 297 followersView post →
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yoshiyuki nishio
@nishiokov · X
RT @Luke_629: What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapie…
Aug 11, 2023 · 9 shares · 519 followersView post →
Lバ
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study's patient-level data with fidelity to the original research https://t.co/obJ7R6ur13
Aug 11, 2023 · 46 likes · 9 shares · 2,279 followersView post →
MA
Max Andrade
@psycheparaiba · X
RT @CarlatPsych: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, th…
Aug 11, 2023 · 9 shares · 203 followersView post →
AF
A Punk Rock Future
@APunkRockFuture · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 1,332 followersView post →
CP
Carlat Psychiatry
@CarlatPsych · X
Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, they estimated 35% remitted after at <=4 treatment attempts, much less than the original 67% -@ChrisAikenMD
https://t.co/sV4wrOmx6J
#psychiatry #clinicaltrials https://t.co/oISGGxq5hZ
Aug 11, 2023 · 35 likes · 9 shares · 8,078 followersView post →
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gabafeitina
@gabrielbasto_ · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 101 followersView post →
MP
Marko Paşa
@markopaassa · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 152 followersView post →
AA
Agnes Ayton
@AgnesAyton · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 7,429 followersView post →
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Austin Lam
@austinaldenlam · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 1,084 followersView post →
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Dr. Tahoora Ali
@drtahooraali · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 365 followersView post →
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Mario Perales
@Dr_MarioPerales · X
RT @chrisaikenmd: Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, t…
Aug 11, 2023 · 16 shares · 67 followersView post →
CM
Chris Aiken, MD
@chrisaikenmd · X
Was STAR*D wrong? New analysis finds #depression trial did not follow its protocols. With a more conservative approach, they estimated only 35% remitted after at <=4 treatment attempts, much less than the original 67%
https://t.co/FyTcLNWJRH
#psychiatry #clinicaltrials https://t.co/dR0aiBKUTv
Aug 11, 2023 · 73 likes · 16 shares · 8,481 followersView post →
SS
Scientology Switzerland
@Scientology_CH · X
RT @Altostrata: Gold standard STAR*D study supposedly showing remission from antidepressant treatment continues to stink. 35% remitted.
Wh…
Gold standard STAR*D study supposedly showing remission from antidepressant treatment continues to stink. 35% remitted.
What are the treatment remission, response and extent of improvement rates...A reanalysis of the STAR*D study’s patient-level data.... https://t.co/dxKxBKc1ST
Aug 1, 2023 · 4 likes · 3 shares · 6,608 followersView post →
WC
Wren Cage
@_eleven13_ · X
RT @MedicatingNorm1: Article from the BMJ: "What are the treatment remission, response and extent of improvement rates after up to four tri…
Article from the BMJ: "What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients?"
Article Link: https://t.co/ABoWFCzxN3
#antidepressants
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study ... with fidelity to the original research … @BMJ_Open https://t.co/VULGhSJBio
STAR D Reanalysis | PDF | Major Depressive Disorder ...
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Open access Original research. BMJ Open: first published as 10.1136/bmjopen-2022-063095 on 25 July 2023. Downloaded from http://bmjopen.bmj.com/ on ...
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BMJ Open, 13(7), e063095. https://doi.org/10.1136/bmjopen-2022-063095. • Schwarzbold, M., Diaz, A., Martins, E. T., Rufino, A., Amante, L. N., Thais, M. E. ...