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Nat Commun July 2023 PMID 37491476

Compilation of reported protein changes in the brain in Alzheimer's disease.

Manor Askenazi, Tomas Kavanagh, Geoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski, Eleanor Drummond

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Mentions

7
Peak: 4 in Jul 2023
across 3 sources since Jul 2023

Extended reach

79,791
potential audience

Total likes

10

Video views

21

Mentions per month

Jul 2023 – Oct 2023

Where it's discussed

  • X / Twitter4 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect support and interest in the article's findings, emphasizing the identification of 848 consistent protein changes and their implications for Alzheimer's research, as seen in phrases like 'proteomics found 848 proteins' and 'associated with synapse, vesicle, and lysosomal pathways.' The tone conveys appreciation for the study's contribution to understanding disease mechanisms and potential therapies.

AgreementStrong agreement

The discussions strongly align with the publication's findings, emphasizing the consistency of protein changes in Alzheimer's research.

InterestModerate interest

Posts show moderate interest by highlighting specific proteins and their roles, indicating a relevant but not highly elaborate engagement.

EngagementModerate engagement

The posts reference key terms like 'synapse,' 'lysosome,' and 'mitochondria,' suggesting some depth in understanding but not extensive analysis.

ImpactHigh impact

The focus on the potential for future research and drug targets reflects a belief in the significant implications of the study.

Abstract in brief

  • This study reviews 38 proteomic research papers to identify proteins that change in the brains of people with Alzheimer’s disease, focusing on different brain regions and disease stages.
  • It found 848 proteins that consistently change across multiple studies, with some proteins involved in early disease processes like synapse and lysosome functions, and others related to mitochondria changing mainly in advanced stages.
  • The results, compiled into a database called NeuroPro, offer valuable insights into how protein levels vary in Alzheimer's and suggest potential targets for future research or drug development.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Francis Villatoro
@emulenews · X

#NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC proteomics found 848 proteins were consistently altered in 5 or more studies, associated with synapse, vesicle, and lysosomal pathways, and in mitochondria. https://t.co/wZjqA6OcA0

Jul 29, 2023 · 10 likes · 3 shares · 45,128 followers View post →
Jorge Ligero
@ligero999 · X

RT @emulenews: #NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC pr…

Jul 31, 2023 · 3 shares · 17,309 followers View post →
Guillermo Peris
@waltzing_piglet · X

RT @emulenews: #NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC pr…

Jul 29, 2023 · 3 shares · 12,457 followers View post →
emilio lindosa lucas
@411emilio · X

RT @emulenews: #NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC pr…

Jul 29, 2023 · 3 shares · 4,852 followers View post →

All mentions

Jorge Ligero
@ligero999 · X

RT @emulenews: #NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC pr…

Jul 31, 2023 · 3 shares · 17,309 followers View post →
emilio lindosa lucas
@411emilio · X

RT @emulenews: #NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC pr…

Jul 29, 2023 · 3 shares · 4,852 followers View post →
Guillermo Peris
@waltzing_piglet · X

RT @emulenews: #NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC pr…

Jul 29, 2023 · 3 shares · 12,457 followers View post →
Francis Villatoro
@emulenews · X

#NatureCommunications Compilation of reported protein changes in the brain in Alzheimer’s disease https://t.co/XYjKn1vYFC proteomics found 848 proteins were consistently altered in 5 or more studies, associated with synapse, vesicle, and lysosomal pathways, and in mitochondria. https://t.co/wZjqA6OcA0

Jul 29, 2023 · 10 likes · 3 shares · 45,128 followers View post →