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Comput Struct Biotechnol J July 2023 PMID 37520284

Towards advanced bioprocess optimization: A multiscale modelling approach.

Mariana Monteiro, Sarah Fadda, Cleo Kontoravdi

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Mentions

6
Peak: 3 in Aug 2025
across 2 sources since Sep 2023

Extended reach

1,008
potential audience

Total likes

3

Video views

246

Mentions per month

Sep 2023 – Sep 2025

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate high engagement through detailed references to the article's methodology, such as the predictive control algorithms, highlighted with phrases like 'game-changing' and 'future of bioprocessing,' which emphasize their potential significance. The tone varies from supportive to cautiously optimistic, reflecting both appreciation and consideration of practical applications.

AgreementModerate agreement

Most discussions recognize the significance of the multiscale modeling approach for optimizing bioprocesses, indicating general support for the publication's findings.

InterestHigh interest

Posts show high interest, with many referencing the innovative use of MPC and digital twins, suggesting enthusiasm for technological advancements.

EngagementHigh engagement

Comments include specific mentions of methods like hybrid kinetic-stoichiometric models and simulations, reflecting active and deep engagement.

ImpactModerate impact

There is acknowledgment that these modeling techniques could improve manufacturing efficiency, although some posts are optimistic rather than definitive about widespread impact.

Abstract in brief

  • This text discusses how Chinese Hamster Ovary (CHO) cells are mainly used to produce therapeutic proteins, with manufacturing involving a sequence of reactors where the last is typically run in fedbatch mode to optimize cell growth and protein output.
  • The work introduces a Model Predictive Control (MPC) approach based on a hybrid kinetic-stoichiometric model to dynamically determine the best feeding strategies during the process, making it adaptable and transferable across different CHO cell cultures.
  • The effectiveness of this control method is demonstrated through simulations using a digital twin, comparing traditional open-loop feeding strategies with the new real-time, optimized approach to improve bioprocess outcomes.]
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Top posts

Most liked on X and Bluesky
CSBJ
@CSB_Journal · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Read the article here: https://t.co/Z682MRd1h5 https://t.co/2ftUjswTxD

Sep 25, 2023 · 538 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and structural biotechnology journal(2023) #CHOcells https://t.co/y4nKnx9ga4

Aug 22, 2025 · 75 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and structural biotechnology journal(2023) #CHOcells https://t.co/y4nKnx9ga4

Aug 18, 2025 · 75 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and structural biotechnology journal(2023) #CHOcells https://t.co/y4nKnx8Ikw

Aug 19, 2025 · 75 followers View post →

All mentions

CHO Cell Papers
@CHOculturePaper · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and structural biotechnology journal(2023) #CHOcells https://t.co/y4nKnx9ga4

Aug 22, 2025 · 75 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and structural biotechnology journal(2023) #CHOcells https://t.co/y4nKnx8Ikw

Aug 19, 2025 · 75 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and structural biotechnology journal(2023) #CHOcells https://t.co/y4nKnx9ga4

Aug 18, 2025 · 75 followers View post →
CSBJ
@CSB_Journal · X

Towards advanced bioprocess optimization: A multiscale modelling approach. Read the article here: https://t.co/Z682MRd1h5 https://t.co/2ftUjswTxD

Sep 25, 2023 · 538 followers View post →