Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.

Jacob R Mann, Elizabeth D McKenna, Darilang Mawrie, Vasileios Papakis, Francesco Alessandrini, Eric N Anderson, Ryan Mayers, Hannah E Ball, Evan Kaspi, Katherine Lubinski, Desiree M Baron, Liana Tellez, John E Landers, Udai B Pandey, Evangelos Kiskinis

August 2023 Sci Adv

Synopsis of Social media discussions

Posts show enthusiasm about the research, with phrases like 'genuinely cool' and 'breakthrough with ALS,' reflecting high interest and positive reception. The tone suggests that the discovery about NEK1's role in microtubule stability and nuclear import is perceived as a significant step forward, with some sharing personal pride or hope for new therapies, indicating meaningful engagement and perceived impact.

A
Agreement
 Moderate agreement

Most posts express positive support or acknowledgment of the research findings, indicating general agreement about the significance of the study.

I
Interest
 High level of interest

Discussions show high interest, with comments highlighting breakthroughs and linking to potential implications for ALS research.

E
Engagement
 Moderate level of engagement

Several comments reference detailed aspects of the study or personal experiences, indicating a moderate level of thoughtful engagement.

I
Impact
 High level of impact

Many posts describe the research as groundbreaking or life-changing, emphasizing the study's potential to influence ALS treatment and understanding.

Social Mentions

YouTube

1 Videos

Bluesky

1 Posts

Twitter

38 Posts

Blogs

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News

11 Articles

Reddit

2 Posts

Metrics

Video Views

340,563

Total Likes

14,044

Extended Reach

400,069

Social Features

56

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

The Impact of NEK1 Mutations on ALS and Microtubule Stability

The Impact of NEK1 Mutations on ALS and Microtubule Stability

The Ice Bucket Challenge raised millions for ALS research. This video explores how NEK1 mutations impair motor neuron function by disrupting microtubule stability and nuclear import, and how microtubule-stabilizing drugs may offer therapeutic potential.

SciShow

November 9, 2023

340,563 views

  • Travis Stanford
    @travishb (Twitter)

    @MariaMorkaa @ABC https://t.co/Wfsf6MNuQ9 It worked!
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    August 10, 2024

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  • Travis Stanford
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    @ABC @MarcJSpears https://t.co/Wfsf6MNuQ9
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    August 10, 2024

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  • Petros Basakis
    @petros__b (Twitter)

    Another recent discovery by the Kiskinis Lab: ALS-linked, loss-of-function NEK1, a diverse serine/threonine kinase, can no longer regulate microtubule homeostasis and nuclear import in ALS iPSC-derived motor neurons. #PSY303DC https://t.co/c5mTnvFSaC
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    December 10, 2023

  • Faith
    @Fainora (Twitter)

    @dfchispas the ice bucket challenge actually raised enough money to make a significant breakthrough in als research https://t.co/Q3Ib0IiaND
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    November 22, 2023

  • Drosophilosopher
    @HammedBadmos (Twitter)

    RT @interactivefly: Mann, J. R., McKenna, E. D., Mawrie, D., ..., Landers, J. E., Pandey, U. B. and Kiskinis, E. (2023). Loss of function…
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    November 21, 2023

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  • The Interactive Fly
    @interactivefly.bsky.social (Bluesky)

    Mann, J. R., McKenna, E. D., Mawrie, D., ..., Landers, J. E., Pandey, U. B. and Kiskinis, E. (2023). Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci Adv 9(33): eadi5548 www.science.org/doi/10.1126/...
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    November 20, 2023

  • Thomas Brody
    @interactivefly (Twitter)

    Mann, J. R., McKenna, E. D., Mawrie, D., ..., Landers, J. E., Pandey, U. B. and Kiskinis, E. (2023). Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci Adv 9(33): eadi5548 https://t.co/SQcSNjsSQj
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    November 20, 2023

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  • Miya
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    love positive news!! https://t.co/let9MRUxdf
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    November 14, 2023

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    Feel good story of the day. https://t.co/bdHNZlXnbB
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    November 10, 2023

  • Marcelus G. Z.
    @MaGioZal (Twitter)

    The #IceBucketChallenge Actually Worked - @YouTube/⁦@SciShow⁩ #ALS #DNA #NEK1 https://t.co/qv3q3S4myB
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    November 10, 2023

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    @FloatingIsland (Twitter)

    The Ice Bucket Challenge Actually Worked https://t.co/phUzMN3XTh via @YouTube
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    November 10, 2023

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  • Debbie J.R. Jones
    @DebbieJRJones2 (Twitter)

    @SirPatStew #IceBucketChallange ***ALS RESEARCH UPDATE*** https://t.co/nKAacdOmUL
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    November 10, 2023

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  • Romance
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    RT @OtherMomo: Genuinely cool https://t.co/dgxWdbvMah
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    November 10, 2023

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  • Baba Yaga
    @Baba_171717 (Twitter)

    Αυτό ήρθε από το ice bucket challenge.
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    November 10, 2023

  • Shuyin //_^
    @Shuyin_b (Twitter)

    https://t.co/jWSwdlhwrM breakthrough with ALS
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    November 10, 2023

  • James
    @JTDH (Twitter)

    The Ice Bucket Challenge Actually Worked https://t.co/0RFLlpgvju via @YouTube
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    November 10, 2023

  • JasonDoolin
    @JasonDoolin (Twitter)

    The Ice Bucket Challenge Actually Worked https://t.co/0HXVTujf6X via @YouTube
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    November 10, 2023

  • BravoKitty411
    @BravoKitty411 (Twitter)

    The Ice Bucket Challenge Actually Worked https://t.co/7cffrU0cmf via @YouTube
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    November 9, 2023

  • Serdar Kalsin
    @SRDKLSN (Twitter)

    The Ice Bucket Challenge Actually Worked https://t.co/3zTTFS1RTg
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    November 9, 2023

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    @Dreamous (Twitter)

    https://t.co/fd8MilHG7R <3 so happy
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    November 9, 2023

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    https://t.co/bmSWvfZ0Oe
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    November 9, 2023

  • █▀█▀█ ████ █▀█▀█ ████
    @OtherMomo (Twitter)

    Genuinely cool https://t.co/dgxWdbvMah
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    November 9, 2023

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    Whenever I feel truly despondent, some news comes along to lift my spirits enough to make it worthwhile waking up tomorrow. https://t.co/YSneyUztPK
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    November 9, 2023

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    SciShow https://t.co/ALMhMvcN4p
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    November 9, 2023

  • Altamiro Bottino
    @BottinoAltamiro (Twitter)

    'New' ALS gene destabilizes neuron's structure and chokes off its nucleus https://t.co/4QLR73fR8S https://t.co/qmZqZ3UG5K https://t.co/gyTuzq2P62
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    September 13, 2023

  • MND Research Australia
    @MND_RIA (Twitter)

    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/wlblTT4lLw "highlights NEK1 as a pleiotropic kinase with regulatory roles in two critical pathways for MN function involved in ALS pathogenesis"
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    August 20, 2023

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    RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…
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    August 19, 2023

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    RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…
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  • Eunus S. Ali, Ph.D.
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    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/y0rPr5m87a
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    August 18, 2023

  • TJ Krzystek
    @LakeErieNeuro (Twitter)

    https://t.co/Po38J5O2Jt
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    August 18, 2023

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  • Sandeep Kumar Rai
    @Sandeep61011718 (Twitter)

    RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…
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    August 18, 2023

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    RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…
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    August 18, 2023

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    RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…
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    August 18, 2023

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    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/GPq2YZRgCf
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    August 17, 2023

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  • Norio Nakatsuji
    @norionakatsuji (Twitter)

    元論文→ Reference: Mann JR, McKenna ED, Mawrie D, et al. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci. Adv. 2023. doi: 10.1126/sciadv.adi5548 https://t.co/lGtDGV7Apy
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    August 17, 2023

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  • Charles Jourdan Reyes, Ph.D.
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    RT @RPM_in_STEM: Excited to see the work I did during my master's finally made it into a publication in Science Advances! Beth, Evangelos…
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    August 17, 2023

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    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/CJ1pG1dZjJ
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    August 17, 2023

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  • Ryan Mayers
    @RPM_in_STEM (Twitter)

    Excited to see the work I did during my master's finally made it into a publication in Science Advances! Beth, Evangelos, and the other members of this team are outstanding mentors, and I'm so glad I got to be a part of this project. https://t.co/oqkphYQ2zW
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    August 17, 2023

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  • TJ Krzystek
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    https://t.co/Po38J5O2Jt
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    August 16, 2023

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Abstract Synopsis

  • NEK1 mutations are a major genetic factor in ALS, and these mutations impair motor neuron function by disrupting microtubule stability and the process of nuclear import.
  • The study shows that NEK1 directly phosphorylates key proteins like tubulin and importin1, which are crucial for maintaining the microtubule cytoskeleton and nucleocytoplasmic transport, and that loss of NEK1 function causes defects in these processes.
  • Importantly, drugs that stabilize microtubules can reverse the deficits caused by NEK1 dysfunction in cell and animal models, highlighting NEK1 as a promising target for developing ALS therapies.]