PubHawk
Sci Adv August 2023 PMID 37585529

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.

Jacob R Mann, Elizabeth D McKenna, Darilang Mawrie, Vasileios Papakis, Francesco Alessandrini, Eric N Anderson, Ryan Mayers, Hannah E Ball, Evan Kaspi, Katherine Lubinski, Desiree M Baron, Liana Tellez, John E Landers, Udai B Pandey, Evangelos Kiskinis

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Mentions

56
Peak: 22 in Nov 2023
across 6 sources since Aug 2023

Extended reach

400,069
potential audience

Total likes

14,044

Video views

340,563

Mentions per month

Aug 2023 – Aug 2024

Where it's discussed

  • X / Twitter38 posts
  • News11 articles
  • Blogs3 articles
  • Reddit2 posts
  • Bluesky1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Posts show enthusiasm about the research, with phrases like 'genuinely cool' and 'breakthrough with ALS,' reflecting high interest and positive reception. The tone suggests that the discovery about NEK1's role in microtubule stability and nuclear import is perceived as a significant step forward, with some sharing personal pride or hope for new therapies, indicating meaningful engagement and perceived impact.

AgreementModerate agreement

Most posts express positive support or acknowledgment of the research findings, indicating general agreement about the significance of the study.

InterestHigh interest

Discussions show high interest, with comments highlighting breakthroughs and linking to potential implications for ALS research.

EngagementModerate engagement

Several comments reference detailed aspects of the study or personal experiences, indicating a moderate level of thoughtful engagement.

ImpactHigh impact

Many posts describe the research as groundbreaking or life-changing, emphasizing the study's potential to influence ALS treatment and understanding.

Abstract in brief

  • NEK1 mutations are a major genetic factor in ALS, and these mutations impair motor neuron function by disrupting microtubule stability and the process of nuclear import.
  • The study shows that NEK1 directly phosphorylates key proteins like tubulin and importin1, which are crucial for maintaining the microtubule cytoskeleton and nucleocytoplasmic transport, and that loss of NEK1 function causes defects in these processes.
  • Importantly, drugs that stabilize microtubules can reverse the deficits caused by NEK1 dysfunction in cell and animal models, highlighting NEK1 as a promising target for developing ALS therapies.]
Read the full abstract

Top posts

Most liked on X and Bluesky
ShorterLab
@ShorterLab · X

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/GPq2YZRgCf

Aug 17, 2023 · 12 likes · 5 shares · 12,044 followers View post →
Ryan Mayers
@RPM_in_STEM · X

Excited to see the work I did during my master's finally made it into a publication in Science Advances! Beth, Evangelos, and the other members of this team are outstanding mentors, and I'm so glad I got to be a part of this project. https://t.co/oqkphYQ2zW

Aug 17, 2023 · 4 likes · 1 share · 45 followers View post →
Cell Biology J-Club
@cell_club · X

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/CJ1pG1dZjJ

Aug 17, 2023 · 2 likes · 6,112 followers View post →
Debbie J.R. Jones
@DebbieJRJones2 · X

@SirPatStew #IceBucketChallange ***ALS RESEARCH UPDATE*** https://t.co/nKAacdOmUL

Nov 10, 2023 · 2 likes · 26 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Mann JR, McKenna ED, Mawrie D, et al. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci. Adv. 2023. doi: 10.1126/sciadv.adi5548 https://t.co/lGtDGV7Apy

Aug 17, 2023 · 1 like · 15,703 followers View post →
ExpendableMudge (He/him)
@expendablemudge · X

Whenever I feel truly despondent, some news comes along to lift my spirits enough to make it worthwhile waking up tomorrow. https://t.co/YSneyUztPK

Nov 9, 2023 · 1 like · 2,733 followers View post →

All mentions

Travis Stanford
@travishb · X

@MariaMorkaa @ABC https://t.co/Wfsf6MNuQ9 It worked!

Aug 10, 2024 · 1 like · 1,149 followers View post →
Travis Stanford
@travishb · X

@ABC @MarcJSpears https://t.co/Wfsf6MNuQ9

Aug 10, 2024 · 1 like · 1,149 followers View post →
Petros Basakis
@petros__b · X

Another recent discovery by the Kiskinis Lab: ALS-linked, loss-of-function NEK1, a diverse serine/threonine kinase, can no longer regulate microtubule homeostasis and nuclear import in ALS iPSC-derived motor neurons. #PSY303DC https://t.co/c5mTnvFSaC

Dec 10, 2023 View post →
Faith
@Fainora · X

@dfchispas the ice bucket challenge actually raised enough money to make a significant breakthrough in als research https://t.co/Q3Ib0IiaND

Nov 22, 2023 · 266 followers View post →
Drosophilosopher
@HammedBadmos · X

RT @interactivefly: Mann, J. R., McKenna, E. D., Mawrie, D., ..., Landers, J. E., Pandey, U. B. and Kiskinis, E. (2023). Loss of function…

Nov 21, 2023 · 1 share · 1,365 followers View post →
The Interactive Fly
@interactivefly.bsky.social · Bluesky

Mann, J. R., McKenna, E. D., Mawrie, D., ..., Landers, J. E., Pandey, U. B. and Kiskinis, E. (2023). Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci Adv 9(33): eadi5548 www.science.org/doi/10.1126/...

Nov 20, 2023 View post →
Thomas Brody
@interactivefly · X

Mann, J. R., McKenna, E. D., Mawrie, D., ..., Landers, J. E., Pandey, U. B. and Kiskinis, E. (2023). Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci Adv 9(33): eadi5548 https://t.co/SQcSNjsSQj

Nov 20, 2023 · 1 like · 1 share · 2,024 followers View post →
Miya
@miyamin_e · X

love positive news!! https://t.co/let9MRUxdf

Nov 14, 2023 · 38 followers View post →
Highfinancier 2: The Quickbooking
@donsheldon · X

Feel good story of the day. https://t.co/bdHNZlXnbB

Nov 10, 2023 · 229 followers View post →
Marcelus G. Z.
@MaGioZal · X

The #IceBucketChallenge Actually Worked - @YouTube/⁦@SciShow⁩ #ALS #DNA #NEK1 https://t.co/qv3q3S4myB

Nov 10, 2023 · 751 followers View post →
Corine
@FloatingIsland · X

The Ice Bucket Challenge Actually Worked https://t.co/phUzMN3XTh via @YouTube

Nov 10, 2023 · 1 like · 417 followers View post →
Debbie J.R. Jones
@DebbieJRJones2 · X

@SirPatStew #IceBucketChallange ***ALS RESEARCH UPDATE*** https://t.co/nKAacdOmUL

Nov 10, 2023 · 2 likes · 26 followers View post →
Romance
@RomanticRevival · X

RT @OtherMomo: Genuinely cool https://t.co/dgxWdbvMah

Nov 10, 2023 · 1 share · 183 followers View post →
Baba Yaga
@Baba_171717 · X

Αυτό ήρθε από το ice bucket challenge.

Nov 10, 2023 · 366 followers View post →
Shuyin //_^
@Shuyin_b · X

https://t.co/jWSwdlhwrM breakthrough with ALS

Nov 10, 2023 · 670 followers View post →
James
@JTDH · X

The Ice Bucket Challenge Actually Worked https://t.co/0RFLlpgvju via @YouTube

Nov 10, 2023 · 1,229 followers View post →
JasonDoolin
@JasonDoolin · X

The Ice Bucket Challenge Actually Worked https://t.co/0HXVTujf6X via @YouTube

Nov 10, 2023 · 448 followers View post →
BravoKitty411
@BravoKitty411 · X

The Ice Bucket Challenge Actually Worked https://t.co/7cffrU0cmf via @YouTube

Nov 9, 2023 · 34 followers View post →
Serdar Kalsin
@SRDKLSN · X

The Ice Bucket Challenge Actually Worked https://t.co/3zTTFS1RTg

Nov 9, 2023 · 1 like · 251 followers View post →
https://bsky.app/profile/dreamous.bsky.social
@Dreamous · X

https://t.co/fd8MilHG7R <3 so happy

Nov 9, 2023 · 1 like · 1,912 followers View post →
Astreanightfang
@Astreanightfang · X

https://t.co/bmSWvfZ0Oe

Nov 9, 2023 · 60 followers View post →
█▀█▀█ ████ █▀█▀█ ████
@OtherMomo · X

Genuinely cool https://t.co/dgxWdbvMah

Nov 9, 2023 · 1 like · 1 share · 754 followers View post →
ExpendableMudge (He/him)
@expendablemudge · X

Whenever I feel truly despondent, some news comes along to lift my spirits enough to make it worthwhile waking up tomorrow. https://t.co/YSneyUztPK

Nov 9, 2023 · 1 like · 2,733 followers View post →
kodiakbear
@kodiakbear1969 · X

SciShow https://t.co/ALMhMvcN4p

Nov 9, 2023 · 97 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

'New' ALS gene destabilizes neuron's structure and chokes off its nucleus https://t.co/4QLR73fR8S https://t.co/qmZqZ3UG5K https://t.co/gyTuzq2P62

Sep 13, 2023 · 93 followers View post →
MND Research Australia
@MND_RIA · X

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/wlblTT4lLw "highlights NEK1 as a pleiotropic kinase with regulatory roles in two critical pathways for MN function involved in ALS pathogenesis"

Aug 20, 2023 · 1,626 followers View post →
Rothstein Lab
@Rothstein_Lab · X

RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…

Aug 19, 2023 · 5 shares · 1,288 followers View post →
Jacob Blum
@lumberjacob91 · X

RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…

Aug 18, 2023 · 5 shares · 143 followers View post →
Eunus S. Ali, Ph.D.
@Eunus_Sheemul · X

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/y0rPr5m87a

Aug 18, 2023 · 1,572 followers View post →
TJ Krzystek
@LakeErieNeuro · X

https://t.co/Po38J5O2Jt

Aug 18, 2023 · 1 like · 383 followers View post →
Sandeep Kumar Rai
@Sandeep61011718 · X

RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…

Aug 18, 2023 · 5 shares · 579 followers View post →
Calì_Lab
@lab_cali · X

RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…

Aug 18, 2023 · 5 shares · 2,111 followers View post →
Perlson lab
@LabPerlson · X

RT @ShorterLab: Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances h…

Aug 18, 2023 · 5 shares · 577 followers View post →
ShorterLab
@ShorterLab · X

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/GPq2YZRgCf

Aug 17, 2023 · 12 likes · 5 shares · 12,044 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Mann JR, McKenna ED, Mawrie D, et al. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Sci. Adv. 2023. doi: 10.1126/sciadv.adi5548 https://t.co/lGtDGV7Apy

Aug 17, 2023 · 1 like · 15,703 followers View post →
Charles Jourdan Reyes, Ph.D.
@reyes_jourdan · X

RT @RPM_in_STEM: Excited to see the work I did during my master's finally made it into a publication in Science Advances! Beth, Evangelos…

Aug 17, 2023 · 1 share · 624 followers View post →
Cell Biology J-Club
@cell_club · X

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import | Science Advances https://t.co/CJ1pG1dZjJ

Aug 17, 2023 · 2 likes · 6,112 followers View post →
Ryan Mayers
@RPM_in_STEM · X

Excited to see the work I did during my master's finally made it into a publication in Science Advances! Beth, Evangelos, and the other members of this team are outstanding mentors, and I'm so glad I got to be a part of this project. https://t.co/oqkphYQ2zW

Aug 17, 2023 · 4 likes · 1 share · 45 followers View post →
TJ Krzystek
@LakeErieNeuro · X

https://t.co/Po38J5O2Jt

Aug 16, 2023 · 1 like · 383 followers View post →