Circulation January 2024 PMID 37634130

Safety of Switching From a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial.

Linda P T Joosten, Sander van Doorn, Peter M van de Ven, Bart T G Köhlen, Melchior C Nierman, Huiberdina L Koek, Martin E W Hemels, Menno V Huisman, Marieke Kruip, Laura M Faber, Nynke M Wiersma, Wim F Buding, Rob Fijnheer, Henk J Adriaansen, Kit C Roes

Mentions

242
Peak: 73 in Feb 2024
across 4 sources since Aug 2023

Extended reach

914,089
potential audience

Total likes

636

Video views

5,447

Mentions per month

Aug 2023 – Sep 2025

Where it's discussed

  • X / Twitter220 posts
  • News18 articles
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions emphasize the potential risks linked to switching anticoagulants in frail older patients, with phrases like 'more bleeding complications' and questions about safety, tone, and methodology indicating cautious skepticism. Some examples highlight the importance of careful patient evaluation and whether the findings should influence clinical decisions, reflecting a focus on clinical relevance and debate.

AgreementLow agreement

Most discussions highlight concerns or skepticism about switching, especially due to increased bleeding risks, reflecting a cautious stance rather than full agreement.

InterestModerate interest

The topic generated moderate interest, with comments on the safety, methodology, and clinical implications, but not overwhelming enthusiasm.

EngagementModerate engagement

Participants referenced detailed results, discussed implications, and questioned methodology, showing active but not deeply complex engagement.

ImpactNeutral impact

Overall, the discussions seem to reinforce clinical caution but don’t appear to drive immediate change in practice or policies significantly.

Abstract in brief

  • This study investigated whether switching frail older patients with atrial fibrillation from vitamin K antagonists (VKAs) to non-vitamin K oral anticoagulants (NOACs) is safe and effective.
  • The trial included patients around 83 years old with high frailty scores and followed them over 12 months to compare bleeding complications and thromboembolic events between those who switched to NOACs and those who continued VKAs.
  • The results showed no significant benefit in switching, with a similar or slightly higher risk of bleeding in the NOAC group, leading to the trial being stopped early for futility.]

Top posts

Most liked on X and Bluesky
エビデンスおばさん(健康情報)
@EvidenceObasan · X

適切に管理されたワーファリン、やはり

Mar 5, 2024 · 132 likes · 19 shares · 5,564 followers View post →
Circulation
@CircAHA · X

The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to non-vitamin K oral anticoagulant #NOAC in frail older patients with AF was associated with more bleeding complications https://t.co/S1Q1nIcxoM https://t.co/x6RYs1YHf7

Feb 1, 2024 · 109 likes · 50 shares · 77,325 followers View post →
Michael Makris
@ProfMakris · X

Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch RCT published in @circulation. https://t.co/iEoDlVgr7V https://t.co/NRVLp4BTdS

Oct 28, 2023 · 72 likes · 26 shares · 13,930 followers View post →
L Corral-Gudino (tutorCyLlo)
@Luis_Corral_Gud · X

¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de los antivitamina K ha considerar como prioritaria (Frail-AF) https://t.co/qSKTt0EzC4 y edoxaban se suma a la reducción de dosis por edad https://t.co/8F0iRkw2LZ https://t.co/M703XwnVLM

Jul 11, 2024 · 19 likes · 11 shares · 7,336 followers View post →
まめたろう,MD, PhD
@mameeps · X

【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続 に割付 1⃣は2⃣と比べ ✅出血性合併症の増加 ✅血栓塞栓症は減少させない 【FRAIL-AF】https://t.co/pjyqSASvtG https://t.co/GWB5sGmypZ

Feb 16, 2024 · 18 likes · 5 shares · 4,927 followers View post →
ときヲ
@toki_wo_koe · X

JCでのまとめをつらつら。 これまでの、各DOACのlandmark study結果から、出血の観点から「DOAC>VKA」という流れは間違いない。 しかし、実臨床やっていると、フレイリティの高い高齢A-fib患者の抗凝固って困る。過去のRCTでは除外されているポピュレーション #循薬ネット https://t.co/ox4ew2zVjl https://t.co/ZF5NFOv0Em

Nov 2, 2023 · 18 likes · 2 shares · 2,584 followers View post →

All mentions

Weekly Review of Cardiology Developments and Studies

This week in cardiology, we discuss listener feedback on SURPASS CVOT ablation limits and recent FDA alerts regarding the Watchman device. Join Dr. John Mandola as he covers oral anticoagulation options for elderly…

Medscape · Aug 8, 2025 588 views
Mar家庭医
@gene_fam_aura · X

心房細動に対してビタミンK拮抗薬(VKA)で管理されている虚弱高齢者で、DOAC(NOAC)への切替えが安全に可能かを確かめた研究 ・対象は75歳以上、かつGroningen frailty indicatorスコア≧3の虚弱高齢者 ・eGFR<30の患者や弁膜症性心房細動の患者は除外 https://t.co/ff8ekxQ1fG

Sep 20, 2025 · 74 followers View post →
Niklas Schenker
@nschenk24.bsky.social · Bluesky

Umstellen, gerade im höheren Alter, scheint nicht ganz trivial zu sein (pubmed.ncbi.nlm.nih.gov/37634130/). Allerdings sind im Vergleich DOAKs schon überzeugender, siehe zB. ARISTOTLE (www.nejm.org/doi/pdf/10.1...).

Mar 22, 2025 · 1 like · 1 share View post →
Ko Harada
@Ko__Harada · X

1. https://t.co/cPgNPcAHw4 2. https://t.co/zyZSTJLixN 3. https://t.co/mouYm7Rz3E 4. https://t.co/6QvXhBvEPp 5. https://t.co/DjmSDlzazE 6. https://t.co/AwbRdVjVYy 7. https://t.co/D1gzJbxE5u

Feb 15, 2025 · 5 likes · 10,512 followers View post →
Santiago Patiño Giraldo
@drsapg · X

Muy interesante! Pero parece que no debería ser tan automático el cambio: https://t.co/phGf022Oiq https://t.co/fyeuHZiIhE

Oct 2, 2024 · 720 followers View post →
Santiago Patiño Giraldo
@drsapg · X

De acuerdo con un estudio pragmático abierto; esta conducta se asocia a un mayor riesgo de sangrado. Para mi un resultado inesperado pues uno piensa que al simplificar régimen menos sangrado. ¿Ustedes qué piensan? Estudio: https://t.co/phGf022Oiq

Oct 1, 2024 · 720 followers View post →
Y Kano
@ykano21 · X

Circulation。フレイル高齢者の心房細動に対する抗凝固療法変更の効果を検討するRCT https://t.co/l6gYrH4gtt

Sep 28, 2024 · 1,396 followers View post →
Cardiology Papers
@Cardiology_P · X

Letter by Millis et al Regarding Article, “Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial” https://t.co/hzuVYCNrLv

Jul 15, 2024 · 1 like · 59 followers View post →
Cardiology Papers
@Cardiology_P · X

Letter by Kohsaka et al Regarding Article, “Safety of Switching From a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial” https://t.co/rtxCAgjIRE

Jul 14, 2024 · 1 like · 59 followers View post →
Conchi Guindel
@CGuindel · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 12, 2024 · 11 shares · 358 followers View post →
Clara Arenós
@aremoncl · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 12, 2024 · 11 shares · 202 followers View post →
Jose Daniel Mosquera Lozano
@jdmosqueral · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 12, 2024 · 11 shares · 232 followers View post →
Ignacio Reyes A.
@Reyes_paliativo · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 12, 2024 · 11 shares · 65 followers View post →
Cardiology Papers
@Cardiology_P · X

Letter by Ko et al Regarding Article, “Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial” https://t.co/VpS3PqOar6

Jul 11, 2024 · 1 like · 59 followers View post →
Gabriela Picco
@GabpiccoPicco · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 1,131 followers View post →
Silvia Suárez
@SilviaPorto88 · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 269 followers View post →
Samuel García Rubio
@SonoSamMD · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 1,274 followers View post →
María Moral
@twittmariamoral · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 855 followers View post →
viztorpg
@viztorpg · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 156 followers View post →
Berk
@BerkBmf · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 500 followers View post →
Dani Ramos
@PaliativosTeam · X

RT @Luis_Corral_Gud: ¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de l…

Jul 11, 2024 · 11 shares · 4,146 followers View post →
L Corral-Gudino (tutorCyLlo)
@Luis_Corral_Gud · X

¿Son los > 80 años "especiales" a la hora de ANTICOAGULAR en #fibrilaciónauricular? Pues sí lo parece. La opción de los antivitamina K ha considerar como prioritaria (Frail-AF) https://t.co/qSKTt0EzC4 y edoxaban se suma a la reducción de dosis por edad https://t.co/8F0iRkw2LZ https://t.co/M703XwnVLM

Jul 11, 2024 · 19 likes · 11 shares · 7,336 followers View post →
Shiori Nishimura
@ShioNishimura · X

Letter by Kohsaka et al Regarding Article “Safety of Switching From a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial”| Circulation https://t.co/FaLEmpHaf8

Jul 9, 2024 · 2 likes · 250 followers View post →
Miquel Mas
@DrMqAgMas · X

Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/0pmWMqeY1E

May 12, 2024 · 2,465 followers View post →
MedicalUpdateOnline
@MedUpdateOn1ine · X

Safety of switching from a Vitamin K antagonist to a non–Vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation https://t.co/BQ98CV3j87 https://t.co/P9XHn2VkXe

May 7, 2024 · 2 likes · 6,201 followers View post →
Juan E Correa-Morales
@veladconmigo · X

Daily recommendation #hpm FRAIL-AF RCT: Nonvalvular AF frail patients >75 years HR 1.69 for switching to an NOAC relative to continuing INR-guided VKA treatment 95% CI, 1.23–2.32; P=0.00112 https://t.co/oRbUkcCqHn https://t.co/UzR0x1nDyT

May 6, 2024 · 1 like · 873 followers View post →
Antonio Manteca
@amango30 · X

RT @RevistaMFSamfyc: Seguridad de pasar de un anticoagulante oral antagonista de vitamina K a uno no antagonista de vitamina K en pacientes…

Apr 27, 2024 · 1 share · 139 followers View post →
Antonio Manteca
@amango30 · X

RT @RevistaMFSamfyc: Seguridad de pasar de un anticoagulante oral antagonista de vit K a uno no antagonista de vit K en ancianos frágiles c…

Apr 23, 2024 · 1 share · 139 followers View post →
ISAYoung
@ISA_AII_Young · X

Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial https://t.co/tmYNw1bOIu https://t.co/Ti4UzQnFMU

Apr 22, 2024 · 2 likes · 459 followers View post →
bujaj49
@bujaj49 · X

RT @DrDavidWarriner: Free full text link here to the paper: @CircAHA https://t.co/zC7uqLYKq7

Apr 21, 2024 · 1 share · 1,040 followers View post →
David Warriner
@DrDavidWarriner · X

Free full text link here to the paper: @CircAHA https://t.co/zC7uqLYKq7

Apr 19, 2024 · 3 likes · 1 share · 7,268 followers View post →
@RalfK@troet.cafe
@_RalfK · X

@fbalex19071 @vmuecke_k Sicher? Fast alle diese Studien liefen mit schlecht eingestelltem Warfarin (TTR<60%). Es gibt nur sehr wenige #doak vs Phenprocoumon Studien. FRAIL-AF ist eine (rwd) Studie, die VKA im Vorteil zeigt https://t.co/LProNiQFsE https://t.co/IlkFFWGCpU https://t.co/BzeVWcO1Dx

Apr 9, 2024 · 7 likes · 359 followers View post →
Revista MFAndalucia
@RevistaMFSamfyc · X

Seguridad de pasar de un anticoagulante oral antagonista de vitamina K a uno no antagonista de vitamina K en pacientes ancianos frágiles con fibrilación auricular: resultados del ensayo controlado aleatorizado FRAIL-AF https://t.co/inHhtvz1jB PMID 37634130

Apr 3, 2024 · 1 share · 723 followers View post →
☫кептагоп™Я☫
@kentaron1971 · X

@CKD_pharmacist これなんですけど- https://t.co/ThJNq0MCQf

Mar 15, 2024 · 2 likes · 12,446 followers View post →
☫кептагоп™Я☫
@kentaron1971 · X

そして明日はこれ‼️ #MEBIUS https://t.co/TYYSf5Xh9W

Mar 13, 2024 · 1 like · 12,446 followers View post →
General Practice University of Otago Christchurch
@GP_ChCh_UOC · X

And again: newer is not better when it comes to medicines. Switching INR –guided warfarin to NOAC in frail older patients with A Fib = more bleeding complications without additional benefit in thromboembolism protection. https://t.co/nhnZyeWZSB

Mar 7, 2024 · 1 like · 10 followers View post →
おさんぽOL
@1999_adme · X

RT @Fizz_DI: ワルファリンで治療中の虚弱高齢者(平均83歳、n=1,330)、DOACへの切替で塞栓症は減らずに出血が増えた、という報告。 ・切替 vs 継続 主要な出血:HR=1.69 [95%CI: 1.23-2.32] 血栓塞栓症:HR=1.26 [95%C…

Mar 6, 2024 · 1 share · 510 followers View post →
Fizz-DI@比較と使い分け-KOJIMA Yushi
@Fizz_DI · X

ワルファリンで治療中の虚弱高齢者(平均83歳、n=1,330)、DOACへの切替で塞栓症は減らずに出血が増えた、という報告。 ・切替 vs 継続 主要な出血:HR=1.69 [95%CI: 1.23-2.32] 血栓塞栓症:HR=1.26 [95%CI: 0.60-2.61] Circulation.149(4):279-289,(2024) PMID:37634130 https://t.co/ptoQB0ZPJg

Mar 5, 2024 · 11 likes · 1 share · 34,322 followers View post →
みや
@1ch1go1ch1e · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 3,542 followers View post →
たけだこうが@貴志ひまわり薬局
@ugatti · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 316 followers View post →
komteck
@yPHBXIl72vEV82S · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 787 followers View post →
結月拓実@「揺れる光」を撮る人
@Takumi_0331 · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 1,852 followers View post →
白石達也 | 医師×AIベンチャー
@dr_white1103 · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 1,528 followers View post →
Phゴリラ
@Essensal2501 · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 1,211 followers View post →
まこと
@ma_co10 · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 88 followers View post →
むぎゅむぎゅ
@AcIqc6WDVlQg63v · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 930 followers View post →
よっちゃん@BPACC薬剤師
@yochn_how2_Suc · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 762 followers View post →
@ishiemonn 腎臓内科
@ishiemonn · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 244 followers View post →
果ての大学免疫学者
@meitianyaxiao11 · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 136 followers View post →
gacktapple
@gackt_apple · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 249 followers View post →
aaa
@9CrWfj7cIf5g6Ag · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 148 followers View post →
Gabu
@lX1IithG4dsRYVi · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 746 followers View post →
HAL@アンパンマンGO
@standalonhal · X

RT @EvidenceObasan: 適切に管理されたワーファリン、やはり

Mar 5, 2024 · 19 shares · 264 followers View post →
エビデンスおばさん(健康情報)
@EvidenceObasan · X

適切に管理されたワーファリン、やはり

Mar 5, 2024 · 132 likes · 19 shares · 5,564 followers View post →
Jesús Palacio
@je_pala · X

RT @air_garcia: El cambio de tratamiento con AVK guiado por el INR a un NACO en ptes ancianos frágiles con FA se asoció con + complicacione…

Mar 3, 2024 · 1 share · 6,043 followers View post →
Tom Andersen
@twitevit · X

RT @Medicinmanden: Supervigtigt klinisk forsøg! I dag skiftes den blodfortyndende behandling til skrøbelige ældre ofte fra ældre præparater…

Mar 1, 2024 · 1 share · 1,831 followers View post →
Mats Jacob H:son Lin
@Medicinmanden · X

Supervigtigt klinisk forsøg! I dag skiftes den blodfortyndende behandling til skrøbelige ældre ofte fra ældre præparater (VKA) til nyere (fXa-hæmmere). Dette store kliniske viser, at det skal vi stoppe med! #geriatri #dklæger #cardiology https://t.co/owcLcDf9jE

Mar 1, 2024 · 13 likes · 1 share · 1,304 followers View post →
(仮称)hanzou1121
@hanzou1121 · X

・高齢フレイル患者に対するVKA→NOACへの変更の安全性 https://t.co/sYg48h8Be7

Feb 26, 2024 · 1 like · 733 followers View post →
Abdulla A. Damluji, MD, PhD
@DrDamluji · X

Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: the FRAIL-AF Trial @CircAHA

Feb 24, 2024 · 4 likes · 15,802 followers View post →
Antonio Nicolas
@Anniba65Nicolas · X

RT @pedreiramicina: En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear A…

Feb 24, 2024 · 6 shares · 607 followers View post →
Juan Gérvas
@JuanGrvas · X

RT @pedreiramicina: En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear A…

Feb 24, 2024 · 6 shares · 22,361 followers View post →
Jesús F Sierra
@quequesierra · X

RT @pedreiramicina: En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear A…

Feb 24, 2024 · 6 shares · 526 followers View post →
A.R. García
@air_garcia · X

El cambio de tratamiento con AVK guiado por el INR a un NACO en ptes ancianos frágiles con FA se asoció con + complicaciones hemorrágicas vs la continuación del tratamiento con AVK, sin reducción asociada de las complicaciones tromboembólicas. #segpac https://t.co/pGNZJwZ4ps

Feb 19, 2024 · 1 share · 802 followers View post →
BIT Navarra
@BITNavarra · X

RT @rincondesisifo: (Circulation) ¿Es seguro el cambio de una cumarina a un ACOD en pacientes ancianos frágiles con FA? https://t.co/X8AQij…

Feb 19, 2024 · 3 shares · 6,003 followers View post →
CEでDealerのカワバタン
@Me09407435Me · X

RT @mameeps: 【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続…

Feb 18, 2024 · 5 shares · 1,002 followers View post →
まめたろう,MD, PhD
@mameeps · X

RT @mameeps: 【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続…

Feb 18, 2024 · 5 shares · 4,927 followers View post →
Rosa Madridejos
@RosaMadridejos · X

RT @annabonet: Seguridad del cambio de un antagonista de la vitamina K a un anticoagulante oral no antagonista de la vitamina K en paciente…

Feb 18, 2024 · 3 shares · 495 followers View post →
AcinetobacterC
@AcinetobacterC · X

RT @annabonet: Seguridad del cambio de un antagonista de la vitamina K a un anticoagulante oral no antagonista de la vitamina K en paciente…

Feb 17, 2024 · 3 shares · 308 followers View post →
hoeman
@_hoeman · X

RT @annabonet: Seguridad del cambio de un antagonista de la vitamina K a un anticoagulante oral no antagonista de la vitamina K en paciente…

Feb 17, 2024 · 3 shares · 1,221 followers View post →
Rosa Madridejos
@RosaMadridejos · X

RT @rincondesisifo: (Circulation) ¿Es seguro el cambio de una cumarina a un ACOD en pacientes ancianos frágiles con FA? https://t.co/X8AQij…

Feb 17, 2024 · 3 shares · 495 followers View post →
Yunox
@ysakamo27214609 · X

RT @mameeps: 【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続…

Feb 17, 2024 · 5 shares · 66 followers View post →
Anna Bonet Esteve
@annabonet · X

Seguridad del cambio de un antagonista de la vitamina K a un anticoagulante oral no antagonista de la vitamina K en pacientes de edad avanzada y frágiles con fibrilación auricular: Resultados del ensayo controlado aleatorizado FRAIL-AF | Circulación https://t.co/M2dc2hJITL

Feb 17, 2024 · 6 likes · 3 shares · 912 followers View post →
Hiroyuki Sato 佐藤宏行
@foreverhero0819 · X

RT @mameeps: 【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続…

Feb 16, 2024 · 5 shares · 3,771 followers View post →
Abel Novoa
@AbelNovoa · X

RT @rincondesisifo: (Circulation) ¿Es seguro el cambio de una cumarina a un ACOD en pacientes ancianos frágiles con FA? https://t.co/X8AQij…

Feb 16, 2024 · 3 shares · 6,671 followers View post →
色々自粛中(ガラス細工の様な繊細なハートを持つ貴公子
@ECGEPSCADEVICE · X

RT @mameeps: 【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続…

Feb 16, 2024 · 5 shares · 9,374 followers View post →
まめたろう,MD, PhD
@mameeps · X

【フレイル高齢者の抗凝固:VKA→NOAC切替え】 フレイル高齢AF 1330患者を、 (平均83歳、Groningen Frailty Indicator score中央値4/除外:cCr<30,弁膜症性AF) 1⃣VKA→NOAC切替2⃣VKA継続 に割付 1⃣は2⃣と比べ ✅出血性合併症の増加 ✅血栓塞栓症は減少させない 【FRAIL-AF】https://t.co/pjyqSASvtG https://t.co/GWB5sGmypZ

Feb 16, 2024 · 18 likes · 5 shares · 4,927 followers View post →
rincondesisifo
@rincondesisifo · X

(Circulation) ¿Es seguro el cambio de una cumarina a un ACOD en pacientes ancianos frágiles con FA? https://t.co/X8AQijGBEP ECA OJO!! https://t.co/urMyhM2pU5

Feb 16, 2024 · 11 likes · 3 shares · 8,441 followers View post →
Dr. Luis Villela
@hematologo · X

RT @AlejandroLazo2: CLOT+ | Safety of Switching From a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older…

Feb 11, 2024 · 1 share · 1,834 followers View post →
Benjamin Vipler, MD, MEd
@VipsMDMEd · X

Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/v41WBZbs7k

Feb 11, 2024 · 3 likes · 6,315 followers View post →
Alejandro Lazo
@AlejandroLazo2 · X

CLOT+ | Safety of Switching From a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial. https://t.co/WMvsOMCfTe

Feb 11, 2024 · 2 likes · 1 share · 154 followers View post →
Shiori Nishimura
@ShioNishimura · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 7, 2024 · 50 shares · 250 followers View post →
Revista MFAndalucia
@RevistaMFSamfyc · X

Seguridad de pasar de un anticoagulante oral antagonista de vit K a uno no antagonista de vit K en ancianos frágiles con fibrilación auricular: resultados del ensayo controlado aleatorizado FRAIL-AF https://t.co/qEiNNju3d3 PMID 37634130

Feb 6, 2024 · 1 share · 723 followers View post →
CK Teoh
@HeartFailureDoc · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 5, 2024 · 50 shares · 131 followers View post →
Geriatría Hospital U. La Paz
@GeriatriaLaPaz · X

Por lo que hace énfasis en la necesidad de realizar una minuciosa evaluación del paciente al elegir entre continuar con AVK o cambiar a un ACOD en esta población. https://t.co/EGBDOQbN1D

Feb 5, 2024 · 2 likes · 1,976 followers View post →
Giulio Francesco Romiti
@GiulioFRomiti · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 187 followers View post →
CSANZ
@thecsanz · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 3,792 followers View post →
BHR
@6uenos · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 63 followers View post →
Haseeb Raza FACC, FHRS, FESC, CEPS-A, FCPS EP
@HaseebEPHF · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 1,846 followers View post →
Panteleimon Papakonstantinou
@PanteleimonPap2 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 278 followers View post →
Daniel Steven
@danielsteven_ep · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 989 followers View post →
ong beng hooi
@ongbenghooi1 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 3, 2024 · 50 shares · 534 followers View post →
Caleb Ferguson
@calebferg · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 7,429 followers View post →
Dr Alo, DO, FACC
@MohammedAlo · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 12,657 followers View post →
Turja Chakraborty
@TurjaChk · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 154 followers View post →
Hussein A.Taqi
@husseintaqi86 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 220 followers View post →
Maggie Simpson
@m4ggiesimpson · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 4,387 followers View post →
HFA_Young of Romania
@hfayoungro · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 43 followers View post →
curzen
@ncurzen · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 4,962 followers View post →
Pilar Garcia-Iglesias
@Amleto3333 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 197 followers View post →
Jose J Carvajal
@cardioactual16 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 390 followers View post →
Konstantinos Vlachos
@vlachoskonstan1 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 682 followers View post →
Dr Anastasia Mihailidou FAHA FCSANZ FESC
@AnastasiaSMihai · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 19,281 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 32,517 followers View post →
Lê Văn Lắm
@levanlam95 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 41 followers View post →
Carlos González
@carloseduardogm · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 231 followers View post →
Josh Wilcox
@jdrwilcox · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 1,139 followers View post →
Hany Ragy
@Hragy · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 80,352 followers View post →
Seigo Izumo
@SeigoIzumo · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 3,968 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 2,460 followers View post →
Shazia Afzal, MD, FESC
@DrShazAfzal · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 314 followers View post →
GEHEG
@hematogeriatria · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 2, 2024 · 50 shares · 2,089 followers View post →
Ahmad Masri
@MasriAhmadMD · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 8,900 followers View post →
Kripa Rajak, M.D.
@KripaRajak3 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 884 followers View post →
Raj Khandwalla, MD, MA, FACC
@rajkmd · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 1,060 followers View post →
EOLO MORANDI JR.
@eolojr · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 538 followers View post →
Sittinun Thangjui, MD
@sthangjui · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 196 followers View post →
Georgios Diakidis
@SpartanEmDoc · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 140 followers View post →
Salima Qamruddin MD
@SalimaqMD · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 1,031 followers View post →
Fabricio Vassallo, MD, PhD
@fvassallomd · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 1,179 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 2,416 followers View post →
Ritu Thamman MD
@iamritu · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 31,656 followers View post →
Syed Ali Naqvi
@SyedYNaqvi1 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 2,572 followers View post →
Domenico Galante
@domdoct · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 919 followers View post →
HS
@HaythamSharar · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 122 followers View post →
Andrew Behrmann
@Andy_Behr25 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 520 followers View post →
Barbara
@Barbara42467151 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 26 followers View post →
Antonio de Marvao
@AdeMarvao · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 2,631 followers View post →
灰土
@CIED_Rehab · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 91 followers View post →
Hiroyuki Sato 佐藤宏行
@foreverhero0819 · X

RT @CircAHA: The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to…

Feb 1, 2024 · 50 shares · 3,771 followers View post →
Circulation
@CircAHA · X

The randomized controlled trial Frail Atrial Fibrillation (#FRAIL-AF) showed that switching from vitamin K antagonists #VKA to non-vitamin K oral anticoagulant #NOAC in frail older patients with AF was associated with more bleeding complications https://t.co/S1Q1nIcxoM https://t.co/x6RYs1YHf7

Feb 1, 2024 · 109 likes · 50 shares · 77,325 followers View post →
Rob DiDomenico
@robdeedo · X

Should FRAIL AF, despite its limitations, give us pause about use of DOACs in frail older adults with AF?

Jan 25, 2024 · 2 likes · 999 followers View post →
Bishesh Poudyal
@Poudyalbishesh · X

RT @richardbuka: 1/ FRAIL-AF RCT of switch to DOAC or cont VKA in frail elderly with AF. VKA = better bleeding profile and no diff in strok…

Dec 27, 2023 · 3 shares · 3,431 followers View post →
Richard Buka
@richardbuka · X

1/ FRAIL-AF RCT of switch to DOAC or cont VKA in frail elderly with AF. VKA = better bleeding profile and no diff in stroke. Practice changing but many things to consider beyond what's in abstract. These were switchers, not newcomers! https://t.co/N5EB54WuFw

Dec 26, 2023 · 15 likes · 3 shares · 1,420 followers View post →
Matias Rodriguez G
@matiasrg · X

Mejores trabajos científicos 2023? ECLS SHOCK en SCA

Dec 21, 2023 · 10 likes · 1,391 followers View post →
Circulation
@CircAHA · X

RT @StrokeAHA_ASA: INTERVIEW: #BloggingStroke contributor @BraydonDymm interviews Dr. Geert-Jan Geersing on @CircAHA article "“Safety of Sw…

Dec 21, 2023 · 1 share · 77,325 followers View post →
Stroke AHA/ASA
@StrokeAHA_ASA · X

INTERVIEW: #BloggingStroke contributor @BraydonDymm interviews Dr. Geert-Jan Geersing on @CircAHA article "“Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation.” https://t.co/todCvPAn5R https://t.co/JgLjDnn3lJ

Dec 21, 2023 · 8 likes · 1 share · 37,319 followers View post →
L Corral-Gudino (tutorCyLlo)
@Luis_Corral_Gud · X

@formsanitaria No tengo muy claro lo de recomendar en ancianos frágiles los de acción dirrcta despues de ver los resultados de warfarina en el ensayo FRAIL AF https://t.co/qSKTt0EzC4

Dec 9, 2023 · 1 like · 7,336 followers View post →
Miriam
@Miriamrf20 · X

RT @pedreiramicina: En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear A…

Nov 25, 2023 · 6 shares · 5 followers View post →
Ph.Pengin
@Pharma_Penguin · X

高齢心房細動患者(75歳以上、GFIスコア≥3)を対象とした試験で、VKAからNOACへの切り替えは、出血合併症リスクが高く、血栓塞栓性合併症の減少とは関連しないことが明らかになりました https://t.co/QRysiouR2Q

Nov 16, 2023 · 61 followers View post →
UpdateInGeriatrics
@MacGeriUpdate · X

FRAIL-AF RCT https://t.co/6d6aO2obAP BOTTOM LINE: If patients are doing well on warfarin, switching to DOAC should be AVOIDED unless there is another strong compelling reason. https://t.co/oKcDLUhh0Y

Nov 15, 2023 · 610 followers View post →
Monika de Cabecera
@naietta · X

RT @pedreiramicina: En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear A…

Nov 15, 2023 · 6 shares · 2,524 followers View post →
みに丸
@ph_minimal · X

https://t.co/JLa1hbw3go 出血性合併症  VKA→DOAC切り替え vs VKA継続:HR1.69(95%CI 1.23-2.32) 血栓塞栓イベント有意差なし VKAはワルファリンではないらしい https://t.co/bEvaAHXxvG

Nov 14, 2023 · 1 like · 900 followers View post →
Mimikaelo❤️‍
@mimikaelo · X

RT @pedreiramicina: En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear A…

Nov 14, 2023 · 6 shares · 1,342 followers View post →
Jorge Pedreira
@pedreiramicina · X

En este contexto surge en el seno de la Universidad de Utrecht una pregunta razonable: ¿Será acaso más seguro emplear ACOD en pacientes ancianos frágiles por riesgo de sangrado? Link al ensayo: https://t.co/aT694wt1TO https://t.co/QMNPWCRzjj

Nov 14, 2023 · 14 likes · 6 shares · 875 followers View post →
Salva Moreno
@shall_ontty · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Nov 3, 2023 · 26 shares · 2,107 followers View post →
ふくろう
@owlccpk · X

RT @toki_wo_koe: JCでのまとめをつらつら。 これまでの、各DOACのlandmark study結果から、出血の観点から「DOAC>VKA」という流れは間違いない。 しかし、実臨床やっていると、フレイリティの高い高齢A-fib患者の抗凝固って困る。過去のRC…

Nov 2, 2023 · 2 shares · 200 followers View post →
pinacol
@pinacol · X

RT @toki_wo_koe: JCでのまとめをつらつら。 これまでの、各DOACのlandmark study結果から、出血の観点から「DOAC>VKA」という流れは間違いない。 しかし、実臨床やっていると、フレイリティの高い高齢A-fib患者の抗凝固って困る。過去のRC…

Nov 2, 2023 · 2 shares · 1,613 followers View post →
ときヲ
@toki_wo_koe · X

JCでのまとめをつらつら。 これまでの、各DOACのlandmark study結果から、出血の観点から「DOAC>VKA」という流れは間違いない。 しかし、実臨床やっていると、フレイリティの高い高齢A-fib患者の抗凝固って困る。過去のRCTでは除外されているポピュレーション #循薬ネット https://t.co/ox4ew2zVjl https://t.co/ZF5NFOv0Em

Nov 2, 2023 · 18 likes · 2 shares · 2,584 followers View post →
Chloe James
@chloe_james789 · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Nov 2, 2023 · 26 shares · 47 followers View post →
Agustín Rodríguez Alén
@AgustinRgzAlen · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 31, 2023 · 26 shares · 417 followers View post →
Miguel Angel Pozas
@mapozas · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 31, 2023 · 26 shares · 18 followers View post →
Cristina Sierra
@CristinaSA82 · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 30, 2023 · 26 shares · 45 followers View post →
Mohammad Alshahrani
@Drshahran · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 352 followers View post →
Hemostasia Sant Pau
@HemostasiaStPau · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 456 followers View post →
Julio Chavez
@JulioChavezMD · X

Outcomes of switching frail patients to DOACs …not too soon https://t.co/2Swft2RhLm

Oct 29, 2023 · 4 likes · 503 followers View post →
Radovan Malý
@RadovanMaly · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 911 followers View post →
Saskia Middeldorp
@MiddeldorpS · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 5,345 followers View post →
Mostafa Faisal
@MostafaFaisal14 · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 1,050 followers View post →
Antonio Palomar
@GarcPalomar · X

RT @BITNavarra: Cambio de un anticoagulante anti-vitamina K (AVK) a un anticoagulante de acción directa (ACOD) en pacientes ancianos frágil…

Oct 29, 2023 · 103 shares · 4,185 followers View post →
Pau Alcubilla
@paualcu · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 345 followers View post →
Peter Tiratrakoonseree, MD
@Tanatuch_P · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 232 followers View post →
Jose Maria Ruiz
@josemariaruizsb · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 266 followers View post →
Andrew J Wilson
@WilsonAndrewDr · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 1,887 followers View post →
Giuseppe Rescigno
@GiuRescigno · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 29, 2023 · 26 shares · 47 followers View post →
trombo.info
@tromboinfo · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 1,588 followers View post →
davidmcgowan
@dem6464 · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 167 followers View post →
Manolo Granja
@manolo_granja · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 124 followers View post →
Hayaan Kamran
@kamran_hayaan · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 441 followers View post →
Ghazi Alotaibi
@Ghazialot · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 1,134 followers View post →
Santhosh Ambika
@RenoHemonc · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 4,014 followers View post →
Jose Sandoval S, MD FACP
@HemSandoval · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 1,322 followers View post →
HemoHealth
@HemoHealth · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 91 followers View post →
Uriel Suárez
@UsuarezMD · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 3,339 followers View post →
Edson Makambwa
@EdsonMakambwa · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 41 followers View post →
Unidad de ETV Hospital Gregorio Marañón
@ETVgregorio · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 416 followers View post →
sriver
@inselmit2bergen · X

RT @ProfMakris: Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch R…

Oct 28, 2023 · 26 shares · 157 followers View post →
Michael Makris
@ProfMakris · X

Switching frail elderly patients from VKA antagonists to DOACs resulted in a significantly higher rate of bleeding. Dutch RCT published in @circulation. https://t.co/iEoDlVgr7V https://t.co/NRVLp4BTdS

Oct 28, 2023 · 72 likes · 26 shares · 13,930 followers View post →
循環器病薬剤師ネットワーク(#循薬ネット)
@Cardio_Pharm_JP · X

対象論文 https://t.co/fQv805EzKQ

Oct 27, 2023 · 4,400 followers View post →
Kevin Parrott
@kevin_parrottMD · X

@yourheartdoc1 @medmalreviewer https://t.co/l7YySdrVkU

Oct 26, 2023 · 190 followers View post →
Alosa Health
@AlosaHealth · X

Switching from warfarin to a DOAC in older adults (>75 years) with frailty and #afib may be associated with an increased risk of bleeding, without any difference in thrombotic events. @CircAHA https://t.co/8NZUjZHJxy

Oct 24, 2023 · 252 followers View post →
ときヲ
@toki_wo_koe · X

対象論文 は、これ。 https://t.co/ox4ew2zVjl

Oct 24, 2023 · 2,584 followers View post →
ときヲ
@toki_wo_koe · X

RT @Cardio_Pharm_JP: 対象論文: https://t.co/fQv805EzKQ ビタミン K アンタゴニスト (VKA) で管理されている心房細動 (AF) のフ高齢フレイル患者を非ビタミン K 経口抗凝固薬 (NOAC) に切り替えるべきかどうかの検…

Oct 15, 2023 · 1 share · 2,584 followers View post →
循環器病薬剤師ネットワーク(#循薬ネット)
@Cardio_Pharm_JP · X

対象論文: https://t.co/fQv805EzKQ ビタミン K アンタゴニスト (VKA) で管理されている心房細動 (AF) のフ高齢フレイル患者を非ビタミン K 経口抗凝固薬 (NOAC) に切り替えるべきかどうかの検討です。 こんな患者さんばっかりじゃないですか?対象症例群の背景とか気になります

Oct 15, 2023 · 4 likes · 1 share · 4,400 followers View post →
Darshan H Brahmbhatt
@Doctor_Darshan · X

@jfdwolff @EileenBurns13 @cpgale3 Biggest area of harm reduction is cessation of unnecessarily prolonged DAPT use - certainly v. limited role beyond 12m, and probably 3m. Though the data are missing. The FRAIL-AF study teaches us that just because you feel good, doesn't make you right. https://t.co/bZN4AQIJEs 3/n

Oct 15, 2023 · 1 like · 1,483 followers View post →
Usha Tedrow
@utedrow · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 28] A Discussion of Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antago…

Oct 10, 2023 · 3 shares · 2,731 followers View post →
Esseim Sharma, MD, FHRS
@EsseimS · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 28] A Discussion of Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antago…

Oct 10, 2023 · 3 shares · 401 followers View post →
William H. Sauer, MD
@True_EP · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 28] A Discussion of Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antago…

Oct 10, 2023 · 3 shares · 8,382 followers View post →
Heart Rhythm Society
@HRSonline · X

NEW EPISODE OF THE LEAD! [Ep. 28] A Discussion of Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial

Oct 10, 2023 · 5 likes · 3 shares · 37,771 followers View post →
semeg_es
@semeg_es · X

RT @FarmaMadridAP: (Circulation) Resultados de seguridad en el intercambio de anticoagulante oral anti-vitamina K (AVK) a anticoagulante di…

Oct 7, 2023 · 11 shares · 6,260 followers View post →
Antonio Palomar
@GarcPalomar · X

RT @FarmaMadridAP: (Circulation) Resultados de seguridad en el intercambio de anticoagulante oral anti-vitamina K (AVK) a anticoagulante di…

Oct 7, 2023 · 11 shares · 4,185 followers View post →
Magnus Esbjornsson
@MagEsbjornsson · X

@vmuecke_k @yannik_munich Diese Leitlinien werden weiter unterstüzt durch die Erkenntnisse der neulich publizierten Studie FRAIL-AF, in der Patienten die auf NOAK umgestellt wurden, häufiger Blutungen erlitten haben: https://t.co/LMnqWEOJWj

Oct 7, 2023 · 1 like · 73 followers View post →
Elke Irish Lady of KERRY
@Sutherland3131 · X

RT @vmuecke_k: „Marcumar ist doch old school. Das gibt man nicht mehr!“ Oft von jüngeren Klinikärzte:innen gehört, stimmt aber nicht! Be…

Oct 6, 2023 · 6 shares · 1,194 followers View post →
Axel M.
@4metoo · X

RT @vmuecke_k: „Marcumar ist doch old school. Das gibt man nicht mehr!“ Oft von jüngeren Klinikärzte:innen gehört, stimmt aber nicht! Be…

Oct 3, 2023 · 6 shares · 596 followers View post →
Canis089
@Canis089 · X

RT @vmuecke_k: „Marcumar ist doch old school. Das gibt man nicht mehr!“ Oft von jüngeren Klinikärzte:innen gehört, stimmt aber nicht! Be…

Oct 3, 2023 · 6 shares · 446 followers View post →
Peter Franz
@P_Franz_74 · X

RT @vmuecke_k: „Marcumar ist doch old school. Das gibt man nicht mehr!“ Oft von jüngeren Klinikärzte:innen gehört, stimmt aber nicht! Be…

Oct 3, 2023 · 6 shares · 892 followers View post →
BVB-Fan in HH
@eumelfink09 · X

RT @vmuecke_k: „Marcumar ist doch old school. Das gibt man nicht mehr!“ Oft von jüngeren Klinikärzte:innen gehört, stimmt aber nicht! Be…

Oct 3, 2023 · 6 shares · 1,820 followers View post →
Melanie McMinn, MD FACP
@melmcMD · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/YauFBF4Mh7

Sep 30, 2023 · 156 followers View post →
Mohammad Jamali, MD
@MomoJamali · X

به نظرم اين مطالعه مهمترين مطالعه ي مطرح شده در كنگره ي قلب اروپا باشه. نتايج با اون چيزي كه فكر مي كرديم خيلي فرق داره. https://t.co/2B7pyXJBLv

Sep 10, 2023 · 2 likes · 1,558 followers View post →
purushottam mittal
@PurumittalDr · X

RT @elmir1omerovic: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patient…

Sep 4, 2023 · 1 share · 1,208 followers View post →
Elmir Omerovic
@elmir1omerovic · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/NOyW6KLiJw What does this trial teach us?

Sep 4, 2023 · 5 likes · 1 share · 417 followers View post →
青島周一
@syuichiao89 · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Pat… https://t.co/ayBC1mRQ1l

Sep 4, 2023 · 8,611 followers View post →
Flora
@Flora3389 · X

RT @syaddana_neuro: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patient…

Sep 3, 2023 · 4 shares · 45 followers View post →
pinacol
@pinacol · X

【RCT】フレイルのある75歳以上の心房細動患者へのINRガイド下VKAからDOACへの切り替えは、VKAの継続と比較して、大出血または臨床的に重要な非大出血を増加させた。(無益性により中止) #ペ読 https://t.co/juzaO2aMst

Sep 3, 2023 · 7 likes · 1,613 followers View post →
Igor Morr
@igormorr · X

Take a look at this paper from Read by QxMD: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial: No Switch https://t.co/KdXX96RVQa https://t.co/nhfciqmyvw

Sep 1, 2023 · 3,945 followers View post →
Christophe Trivalle
@CTrivalle · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/xCCF2hox6b

Aug 31, 2023 · 2 likes · 8,287 followers View post →
Pilar Garcia-Iglesias
@Amleto3333 · X

RT @hematogeriatria: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patien…

Aug 30, 2023 · 2 shares · 197 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/qsCXDBYNya

Aug 30, 2023 · 3 likes · 1,289 followers View post →
Gemma Rodriguez
@gemmarpalomar · X

RT @danisevisan:

Aug 30, 2023 · 2 shares · 233 followers View post →
Maria Queralt Gorgas
@qgorgas · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/MhbCbg34Gm

Aug 30, 2023 · 1,465 followers View post →
Hospital Medicine Virtual Journal Club
@HMVJC · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial https://t.co/0VWSZf8lUH

Aug 29, 2023 · 630 followers View post →
Francisco J Guerrero
@franguerrero72 · X

La importancia de valorar el perfil del paciente en la toma de decisiones Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Circulation https://t.co/touXuM2txN

Aug 29, 2023 · 1,294 followers View post →
María García Gil
@mariagg26 · X

RT @danisevisan:

Aug 28, 2023 · 2 shares · 2,795 followers View post →
Xtian_ sci hub
@Xtian_tuck · X

RT @hematogeriatria: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patien…

Aug 28, 2023 · 2 shares · 30,445 followers View post →
GEHEG
@hematogeriatria · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/DEtREUjCfN

Aug 28, 2023 · 4 likes · 2 shares · 2,089 followers View post →
Amira A
@Passionate2024 · X

RT @syaddana_neuro: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patient…

Aug 28, 2023 · 4 shares · 541 followers View post →
Hong-Jie Jhou, MD
@JhouJie · X

RT @syaddana_neuro: Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patient…

Aug 28, 2023 · 4 shares · 236 followers View post →
Alejandro Cuesta
@Doc_AleCuesta · X

Mucho cuidado en cambiar de anticoagulante en pacientes >75 años. Si viene bien con warfarínicos, dejémoslo así. Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist in Frail Older Patients with AF: Results of the FRAIL-AF RCT https://t.co/N1kTg2ronH

Aug 28, 2023 · 5 likes · 2,117 followers View post →
Sridhara S Yaddanapudi MD
@syaddana_neuro · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/eLsrzDvsud

Aug 28, 2023 · 12 likes · 4 shares · 2,553 followers View post →
Anna Bonet Esteve
@annabonet · X

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial | Circulation https://t.co/VLBGempmQL

Aug 28, 2023 · 4 likes · 912 followers View post →
Daniel Sevilla
@danisevisan · X

Aug 28, 2023 · 9 likes · 2 shares · 848 followers View post →
Shibata Masashi@GP×EBM
@EbmShibanyan · X

ESC関連の中ではこの研究が気になりました。 Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial |https://t.co/1L3WzkW67H

Aug 27, 2023 · 1 like · 1,681 followers View post →
Frances Mair
@FrancesMair · X

https://t.co/lTXBGab0vV Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in #Frail Older Patients with #AtrialFibrillation: Results of the FRAIL-AF Randomized Controlled Trial - worth a read! @ProfDConnelly recommended @PHanlon17

Aug 27, 2023 · 1 like · 4,822 followers View post →