Am J Psychiatry November 2023 PMID 37644811

A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis.

Hengyi Cao, Todd Lencz, Juan A Gallego, Jose M Rubio, Majnu John, Anita D Barber, Michael L Birnbaum, Delbert G Robinson, Anil K Malhotra

Mentions

14
Peak: 8 in Sep 2023
across 2 sources since Aug 2023

Extended reach

34,060
potential audience

Total likes

21

Video views

170

Mentions per month

Aug 2023 – Feb 2024

Where it's discussed

  • X / Twitter12 posts
  • YouTube2 videos

AI synopsis

What people are saying

Participants express strong interest and general agreement through phrases like 'excited to share our work' and 'promising predictor,' emphasizing the potential of connectome-based signatures for improving psychosis treatment. The tone and emphasis on brain connectivity, especially highlighting the cerebellum, contribute to a sense of optimism and perceived significance, but most comments remain at the level of enthusiasm rather than detailed critique or in-depth analysis.

AgreementModerate agreement

Most discussions highlight enthusiasm and support for the significance of the research findings, with words like 'excited' and 'promising' indicating strong agreement.

InterestHigh interest

Posts demonstrate high interest, focusing on the innovative aspects of connectomic signatures and their potential for personalized treatment.

EngagementModerate engagement

While some contributions express excitement and acknowledge coauthors, few delve deeply into methodological details or broader implications, suggesting moderate engagement.

ImpactModerate impact

The discussions recognize the potential impact of the research on predicting treatment outcomes and expanding understanding of psychosis, though these ideas remain somewhat aspirational.

Abstract in brief

  • This study found a specific brain connectivity pattern that can predict how individual patients with first-episode psychosis will respond to antipsychotic medication, using fMRI scans taken at the start of treatment.
  • The predictive model focused on connections related to the cerebellar and cortical regions, with certain connectivity patterns indicating better or worse treatment outcomes, and it was successful in both the initial and an independent validation sample.
  • Overall, this research suggests that brain connectivity features could serve as early biomarkers for personalizing treatment in psychosis, potentially leading to better, more targeted therapies.]

Top posts

Most liked on X and Bluesky
Hengyi Cao
@HengyiCao · X

Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coauthors! @zhhresearch @ToddLencz @jgallegomd @JRubioMD @docETP @akmalhotramd Again, the cerebellum stands out in the spotlight. https://t.co/nLhmtGP2Da

Sep 8, 2023 · 13 likes · 5 shares · 74 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

The functional organization of the brain may predict an individual's improvement in psychosis symptoms after antipsychotic treatment. https://t.co/TYnHjaVrTa https://t.co/SV6ULGL7R5

Sep 7, 2023 · 3 likes · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis https://t.co/cF28DOmkKA

Nov 17, 2023 · 2 likes · 1 share · 11,606 followers View post →
Carlos Mirapeix.
@psicopeix · X

A connectome-based functional signature as a promising early predictor for individualized response to antipsychotic treatment in first-episode psychosis, I assume that other psychopathologies and psychotherapy will also be investigated in the future. https://t.co/pqVVkPr5vR

Nov 1, 2023 · 1 like · 4,349 followers View post →
Dr. Jessica Giddens DNP (nurse)
@DrJGiddensRN · X

https://t.co/JTscOcWDSB

Feb 27, 2024 · 1 like · 2,757 followers View post →
leafs
@leafs_s_jp · X

これも小脳か A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis https://t.co/WEQY1UEDG1

Sep 9, 2023 · 1 like · 203 followers View post →

All mentions

Dr. Jessica Giddens DNP (nurse)
@DrJGiddensRN · X

https://t.co/JTscOcWDSB

Feb 27, 2024 · 1 like · 2,757 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis https://t.co/cF28DOmkKA

Nov 17, 2023 · 2 likes · 1 share · 11,606 followers View post →
Carlos Mirapeix.
@psicopeix · X

A connectome-based functional signature as a promising early predictor for individualized response to antipsychotic treatment in first-episode psychosis, I assume that other psychopathologies and psychotherapy will also be investigated in the future. https://t.co/pqVVkPr5vR

Nov 1, 2023 · 1 like · 4,349 followers View post →
Michael Birnbaum
@DocOTNY · X

RT @HengyiCao: Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coa…

Sep 9, 2023 · 5 shares · 387 followers View post →
leafs
@leafs_s_jp · X

これも小脳か A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis https://t.co/WEQY1UEDG1

Sep 9, 2023 · 1 like · 203 followers View post →
Roscoe Brady
@roscoebradyjr · X

RT @HengyiCao: Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coa…

Sep 9, 2023 · 5 shares · 479 followers View post →
Dr. Indrit Bègue
@indrit_begue · X

RT @HengyiCao: Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coa…

Sep 8, 2023 · 5 shares · 994 followers View post →
Todd Lencz
@ToddLencz · X

RT @HengyiCao: Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coa…

Sep 8, 2023 · 5 shares · 738 followers View post →
Zucker Hillside Psychiatric Neuroscience
@zhhresearch · X

RT @HengyiCao: Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coa…

Sep 8, 2023 · 5 shares · 557 followers View post →
Hengyi Cao
@HengyiCao · X

Excited to show our new work on a trait-like connectomic signature for psychosis treatment prediction. Thank you for all coauthors! @zhhresearch @ToddLencz @jgallegomd @JRubioMD @docETP @akmalhotramd Again, the cerebellum stands out in the spotlight. https://t.co/nLhmtGP2Da

Sep 8, 2023 · 13 likes · 5 shares · 74 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

The functional organization of the brain may predict an individual's improvement in psychosis symptoms after antipsychotic treatment. https://t.co/TYnHjaVrTa https://t.co/SV6ULGL7R5

Sep 7, 2023 · 3 likes · 11,606 followers View post →
MRIPubAlert
@MRIPubAlert · X

A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis. URL: https://t.co/dmfhPuGTtW

Aug 30, 2023 · 79 followers View post →