N Engl J Med August 2023 PMID 37646679

CRISPR-Cas9 Editing of the and Promoters to Treat Sickle Cell Disease.

Akshay Sharma, Jaap-Jan Boelens, Maria Cancio, Jane S Hankins, Prafulla Bhad, Marjohn Azizy, Andrew Lewandowski, Xiaojun Zhao, Shripad Chitnis, Radhika Peddinti, Yan Zheng, Neena Kapoor, Fabio Ciceri, Timothy Maclachlan, Yi Yang

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Mentions

146
Peak: 56 in Sep 2023
across 6 sources since Aug 2023

Extended reach

1,315,184
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Total likes

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Aug 2023 – Aug 2024

Where it's discussed

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AI synopsis

What people are saying

Several discussions emphasize the positive outcomes of the study, such as the mention of three patients being cured without off-target effects revealing a significant advancement in treatment. Terms like 'hope' and 'promising early results' are frequently used, indicating an optimistic tone that resonates throughout the discussions and highlights the potential breakthroughs in this field.

AgreementStrong agreement

The majority of discussions express strong support for the CRISPR-Cas9 methodology and its potential applications, indicating consensus on the research's validity.

InterestHigh interest

Participants demonstrate a high level of curiosity and enthusiasm for the topic, as evidenced by the numerous discussions highlighting the implications and achievements of the study.

EngagementModerate engagement

While many posts celebrate the findings, only a few deeply analyze the science, suggesting moderate engagement overall.

ImpactHigh impact

There is a prevalent belief that the publication could have profound implications for treating sickle cell disease, as many comments reflect optimism about the future of gene therapy.

Abstract in brief

  • Sickle cell disease results from a defect in the adult hemoglobin globin subunit, leading to deformed red blood cells and serious health complications.
  • OTQ923 is a CRISPR-Cas9 edited therapy that disrupts globin gene promoters to increase fetal hemoglobin levels, which helps protect against these complications.
  • In clinical trials, participants receiving OTQ923 showed stable increases in fetal hemoglobin levels, indicating successful engraftment and potential for long-term treatment effectiveness.

Top posts

Most liked on X and Bluesky
د. عبدالمجيد الرفاعيAbdulmajeed Alrefaei
@DrAbdulmajeedFR · X

من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن من الخلايا الدم الحمراء و مستويات الهيموجلوبين

Sep 6, 2023 · 90 likes · 17 shares · 19,198 followers View post →
NEJM
@NEJM · X

Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hematology https://t.co/TUcVZhx84j

Sep 5, 2023 · 55 likes · 12 shares · 935,667 followers View post →
Kutub
@Kutub_joy · X

Treating #Sickle_Cell_Disease with #CRISPR CRISPR-Cas9 disruption of the HBG1 and HBG2 gene promoters was an effective strategy for induction of fetal hemoglobin in three patients. https://t.co/ktzkmY3x6V

Aug 31, 2023 · 8 likes · 1,373 followers View post →
Stem Cell Podcast
@stemcellpodcast · X

This week: #CRISPR editing for #SickleCellDisease!

Sep 8, 2023 · 7 likes · 2 shares · 8,956 followers View post →
ShorterLab
@ShorterLab · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease: https://t.co/m688uJqBsg

Aug 31, 2023 · 6 likes · 1 share · 12,044 followers View post →
MSK Library
@MSKLibrary · X

Featured today by @MSKLibrary: #CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat #SickleCell Disease @AkshaySharmaMD @JJ_boelens @MariaCancio3 @janbra1 @Seredev1 @jl_labelle @NEJM https://t.co/z8xy0aIOIT

Oct 6, 2023 · 6 likes · 3 shares · 2,965 followers View post →

All mentions

Mia
@mia3_rodriguez · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 7, 2024 · 69 shares · 467 followers View post →
UChicago Biological Sciences
@UChicagoBSD · X

Dr. LaBelle received this honor for his work on stem cell gene therapy for patients with sickle cell disease https://t.co/zqD66hlGIw

Apr 3, 2024 · 2,457 followers View post →
UChicago Biological Sciences
@UChicagoBSD · X

RT @CRForumUS: 2024 Top 10 Clinical Research Achievement Awards: Congratulations to James LaBelle, MD, PhD, @UChiPritzker, on the study "CR…

Feb 12, 2024 · 2 shares · 2,457 followers View post →
Clinical Research Forum
@CRForumUS · X

2024 Top 10 Clinical Research Achievement Awards: Congratulations to James LaBelle, MD, PhD, @UChiPritzker, on the study "CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease"! https://t.co/3B6OybHyGF #Top10ClinicalResearchAwards https://t.co/shNSLZalnD

Feb 12, 2024 · 6 likes · 2 shares · 530 followers View post →
Aangi Shah, MD
@AangiShahMD · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Dec 10, 2023 · 69 shares · 84 followers View post →
熊本大学小児科【公式】
@kumaped · X

【抄読会】 https://t.co/SlkahY1ovU 鎌状赤血球症は、ヘモグロビンを構成するβ鎖にホモ接合体で遺伝子異常があると発症する。低酸素になると赤血球が鎌状に変形するため、抹消血管内皮に付着して、血栓形成に至る。その結果として、骨、脾臓、肺、腎臓などで血管閉塞クリーゼが生じる。

Dec 7, 2023 · 1 like · 1,177 followers View post →
johnjljacobs
@johnjljacobs · X

Gene therapy in humans seems efficient in phase 1/2 trial for hematological disorder (technically relative simple). This calls for good EU / USA international legislation. CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease. https://t.co/pnSjJvkrwx

Nov 25, 2023 · 1,946 followers View post →
Cynthia Rochen
@RochenCynthia · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Nov 14, 2023 · 69 shares · 23 followers View post →
Maria Cancio
@MariaCancio3 · X

RT @MSKLibrary: Featured today by @MSKLibrary: #CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat #SickleCell Disease @AkshayShar…

Oct 6, 2023 · 3 shares · 226 followers View post →
Jaap J Boelens
@JJ_boelens · X

RT @MSKLibrary: Featured today by @MSKLibrary: #CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat #SickleCell Disease @AkshayShar…

Oct 6, 2023 · 3 shares · 1,349 followers View post →
Akshay Sharma MD
@AkshaySharmaMD · X

RT @MSKLibrary: Featured today by @MSKLibrary: #CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat #SickleCell Disease @AkshayShar…

Oct 6, 2023 · 3 shares · 5,751 followers View post →
MSK Library
@MSKLibrary · X

Featured today by @MSKLibrary: #CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat #SickleCell Disease @AkshaySharmaMD @JJ_boelens @MariaCancio3 @janbra1 @Seredev1 @jl_labelle @NEJM https://t.co/z8xy0aIOIT

Oct 6, 2023 · 6 likes · 3 shares · 2,965 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

https://t.co/TaswlSxbRL

Oct 4, 2023 · 360 followers View post →
Faisal Almalki
@faisalkalmalki · X

What’s an interesting finding!! Three sickled patients were cured by CRISPER-Cas9 technique. No off target detected. 18 m follow up, HbF ⬆️ and sickle cell ⬇️. Congrats CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | NEJM https://t.co/4z3MGHzebL

Sep 9, 2023 · 449 followers View post →
جّـمًـيَـلَـةّ مًـثًـلَ آلَـقُـمًـر
@morganethll · X

RT @DRKAMALAYOUB: نجاح تقنية تعديل الجينات في علاج ثلاثة مرضى ممن لديهم داء فقر الدم المنجلي الشديد وحصول استجابة سريرية لهذا العلاج ضمن در…

Sep 9, 2023 · 1 share · 2,391 followers View post →
Akshay Sharma MD
@AkshaySharmaMD · X

RT @stemcellpodcast: This week: #CRISPR editing for #SickleCellDisease!

Sep 8, 2023 · 2 shares · 5,751 followers View post →
Saqib Ashraf
@saqibashraf47 · X

RT @stemcellpodcast: This week: #CRISPR editing for #SickleCellDisease!

Sep 8, 2023 · 2 shares · 342 followers View post →
Stem Cell Podcast
@stemcellpodcast · X

This week: #CRISPR editing for #SickleCellDisease!

Sep 8, 2023 · 7 likes · 2 shares · 8,956 followers View post →
{ ابو ابراهيم } ♋
@H2eder · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 7, 2023 · 17 shares · 885 followers View post →
Mohammed
@Mohammed275739 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 7, 2023 · 17 shares · 23 followers View post →
Cord UK
@uk_cord · X

RT @AusStemCell: 'Gene-tweaked stem cells offer hope against sickle cell disease.' Paper: https://t.co/7qQYJnmhAx https://t.co/tRVMZGcY3q

Sep 7, 2023 · 2 shares · 6 followers View post →
Zahra Aryan, MD, MPH
@aryan_zahra · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 7, 2023 · 12 shares · 269 followers View post →
✨ فِردوُس ✨
@frrdoss · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 7, 2023 · 17 shares · 58 followers View post →
إثراء البحث العلمي | دراسات عليا
@EthraaRES · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 7, 2023 · 17 shares · 2,381 followers View post →
Fatawi
@Fatawi1 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 7, 2023 · 17 shares · 656 followers View post →
حسين
@HuMit99 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 7, 2023 · 17 shares · 220 followers View post →
Mohammed A. Alfattah محمد بن عبدالعزيز الفتاح
@DrMohdAlfattah · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 190 followers View post →
Maitha
@Maitha420479964 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 384 followers View post →
Dhaneen Mahdi
@Dhaneen_M · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 121 followers View post →
bioNAWAF
@BioNAWAF · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 1,707 followers View post →
الأنيميا المنجلية @
@Sikclecell · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 2,165 followers View post →
Ebrahim Al Baqer
@ealbaqer · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 882 followers View post →
Ghaida Alharbi
@Ghaida1202 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 626 followers View post →
Eng. Ayoub Ahmed
@eng_aaube29 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 562 followers View post →
Arwa
@arwa1319 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 322 followers View post →
الحدث الأكاديمي
@HM2015s · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 11,268 followers View post →
ملتقى علوم الاحياء
@Biology1802 · X

RT @DrAbdulmajeedFR: من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن…

Sep 6, 2023 · 17 shares · 54,617 followers View post →
د. عبدالمجيد الرفاعيAbdulmajeed Alrefaei
@DrAbdulmajeedFR · X

من الاخبار البحثية المشجعة #تقنية_كريسبر تقدم طريقة علاجية جديدة للانيميا المنجلية و ذلك باستهداف HBG1 و HBG2 مما حسن من الخلايا الدم الحمراء و مستويات الهيموجلوبين

Sep 6, 2023 · 90 likes · 17 shares · 19,198 followers View post →
Abdulmajid Alanazi
@3aber_Sabeel000 · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 6, 2023 · 12 shares · 204 followers View post →
Naif Almontashiri
@naifalmontashir · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 6, 2023 · 12 shares · 24,961 followers View post →
I want to be...
@jub_Jaejoong · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 20 followers View post →
Miquell O. Miller, MD, MS
@MiquellMillerMD · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 1,031 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

“#CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease" Sharma A [..] LaBelle JL. N Engl J Med. 2023-08-31. https://t.co/isWWQ1eO9R NCT04443907 https://t.co/iD1H4WyDWt (Novartis Pharmaceuticals OTQ923)

Sep 5, 2023 · 2 likes · 1,917 followers View post →
Pierrette Mimi Poinsett MD
@yayayarndiva · X

RT @zacharie_lt: @NEJM article on #CRISPR treatment for #Sicklecell #SickleCellAwarenessMonth #BlackTwitter https://t.co/giKKtmMPQp

Sep 5, 2023 · 1 share · 11,662 followers View post →
Zacharie Liman-Tinguiri
@zacharie_lt · X

@NEJM article on #CRISPR treatment for #Sicklecell #SickleCellAwarenessMonth #BlackTwitter https://t.co/giKKtmMPQp

Sep 5, 2023 · 1 like · 1 share · 58 followers View post →
Ana Bacelar
@tricoleucocito · X

RT @RamonGarciaSanz: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | NEJM https://t.co/GJeDxciEad

Sep 5, 2023 · 1 share · 1,031 followers View post →
Christian Putnam (US)
@PutnamUs43732 · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 25 followers View post →
Dr. Ramón García Sanz
@RamonGarciaSanz · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | NEJM https://t.co/GJeDxciEad

Sep 5, 2023 · 2 likes · 1 share · 2,571 followers View post →
เจ๋
@mxmilemxm · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 4 followers View post →
FAISAL A. ALMULHEM
@FaisalAlmulhem · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 48 followers View post →
Deepi
@caffeinated4me · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 452 followers View post →
الدكتور كمال أيوب
@DRKAMALAYOUB · X

نجاح تقنية تعديل الجينات في علاج ثلاثة مرضى ممن لديهم داء فقر الدم المنجلي الشديد وحصول استجابة سريرية لهذا العلاج ضمن دراسة اولية . https://t.co/YywMBzUXUZ

Sep 5, 2023 · 5 likes · 1 share · 23,794 followers View post →
Andrés Vásconez, MD, FAAP.
@wavasconez · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Sep 5, 2023 · 69 shares · 428 followers View post →
Jan Hartmann, MD
@JanHartmannMD · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 308 followers View post →
Kam Ghadimi
@KamGhadimiMD · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | ⁦@NEJM⁩ https://t.co/X0VkFUgKxW

Sep 5, 2023 · 4 likes · 1,376 followers View post →
たぬぽん
@west_east_NA · X

RT @NEJM: Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hemat…

Sep 5, 2023 · 12 shares · 477 followers View post →
NEJM
@NEJM · X

Original Article: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/wa3S5ZdpsA #hematology https://t.co/TUcVZhx84j

Sep 5, 2023 · 55 likes · 12 shares · 935,667 followers View post →
Madhuri Koti
@CanImmun · X

RT @NEJM: With CRISPR-Cas9, a repressor of fetal hemoglobin expression was disrupted in hematopoietic stem cells from three persons with si…

Sep 4, 2023 · 201 shares · 455 followers View post →
The ReNeural Project
@ReNeural · X

RT @AusStemCell: 'Gene-tweaked stem cells offer hope against sickle cell disease.' Paper: https://t.co/7qQYJnmhAx https://t.co/tRVMZGcY3q

Sep 4, 2023 · 2 shares · 403 followers View post →
Stem Cell Foundation
@AusStemCell · X

'Gene-tweaked stem cells offer hope against sickle cell disease.' Paper: https://t.co/7qQYJnmhAx https://t.co/tRVMZGcY3q

Sep 4, 2023 · 4 likes · 2 shares · 14,870 followers View post →
Miles Horton
@MilesHorton9 · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Sep 4, 2023 · 69 shares · 342 followers View post →
Future Trends
@ShapingTomorro · X

https://t.co/fWZxAbk0Cd

Sep 3, 2023 · 74 followers View post →
Yan Leyfman, MD
@YLeyfman · X

Researchers have successfully used CRISPR-CAS-9 to perform gene editing of the fetal hemoglobin gene, disrupting expression and leading to restoring of hematopoiesis. https://t.co/es7RUxeKeP

Sep 2, 2023 · 1 like · 3,189 followers View post →
Sarah Whiteside
@SarahKWhiteside · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Sep 1, 2023 · 69 shares · 544 followers View post →
Marco Mariani
@mariani_m97 · X

RT @FilippoMontemu1: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | NEJM https://t.co/j44TdK3SCj This is…

Sep 1, 2023 · 1 share · 112 followers View post →
Ind J Med Ped Oncology
@IJMPOofficial · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Sep 1, 2023 · 69 shares · 2,307 followers View post →
Peter Chen
@Ptr_CHN · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Sep 1, 2023 · 69 shares · 41 followers View post →
Seeker89
@FSeeker89 · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | NEJM https://t.co/AQQJJZ15Sd

Sep 1, 2023 · 1 like · 3 followers View post →
Christopher Graham
@ChrisGrahamMD · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 49 followers View post →
urigoren
@urigoren · X

RT @IdoWolf1: המהפכה הגנטית כבר כאן! בעזרת מערכת קריספר-קאס עורכים DNA של חולים עם סוג מיוחד של אנמיה תורשתית וגורמים להם לייצר המוגלובין ח…

Aug 31, 2023 · 8 shares · 1,435 followers View post →
Elad Sharon
@EladSharonMD · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 3,843 followers View post →
Hematology Media Center (HMC)
@US_HMC · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 268 followers View post →
Madiha Iqbal MD
@MadihaIqbal13 · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 662 followers View post →
Alec -- CRISPR/acc
@lecPokrandt · X

https://t.co/IX3Lwec7NZ

Aug 31, 2023 · 352 followers View post →
Nykee ✨
@NykeeAbby · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 502 followers View post →
Cindy Morris, MSN, RN, CPHQ
@morriscindy1 · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 226 followers View post →
Rothstein Lab
@Rothstein_Lab · X

RT @ShorterLab: CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease: https://t.co/m688uJqBsg

Aug 31, 2023 · 1 share · 1,288 followers View post →
ShorterLab
@ShorterLab · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease: https://t.co/m688uJqBsg

Aug 31, 2023 · 6 likes · 1 share · 12,044 followers View post →
Christelle Salomon
@AlmostDrSalomon · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 337 followers View post →
john morley
@drjohnmorley · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease | NEJM https://t.co/DQ5fWXSlxw

Aug 31, 2023 · 8,322 followers View post →
Roni Shouval
@RShouval · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 1,415 followers View post →
Shiva N
@NickSh85 · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 88 followers View post →
Daniela Hermelin, MD
@HermelinMD · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 11,950 followers View post →
אריאל ג
@arielg972 · X

RT @IdoWolf1: המהפכה הגנטית כבר כאן! בעזרת מערכת קריספר-קאס עורכים DNA של חולים עם סוג מיוחד של אנמיה תורשתית וגורמים להם לייצר המוגלובין ח…

Aug 31, 2023 · 8 shares · 754 followers View post →
Pavlos Msaouel
@PavlosMsaouel · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 3,525 followers View post →
Kutub
@Kutub_joy · X

Treating #Sickle_Cell_Disease with #CRISPR CRISPR-Cas9 disruption of the HBG1 and HBG2 gene promoters was an effective strategy for induction of fetal hemoglobin in three patients. https://t.co/ktzkmY3x6V

Aug 31, 2023 · 8 likes · 1,373 followers View post →
Subhangi
@subhangichandan · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 234 followers View post →
Zainab Al Duhailib
@ZDuhailib · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 418 followers View post →
Vincent Rajkumar
@VincentRK · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 80,266 followers View post →
Jonathan Yen
@JonathanYenPhD · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 140 followers View post →
Assaf
@AssafTheGeek · X

RT @IdoWolf1: המהפכה הגנטית כבר כאן! בעזרת מערכת קריספר-קאס עורכים DNA של חולים עם סוג מיוחד של אנמיה תורשתית וגורמים להם לייצר המוגלובין ח…

Aug 31, 2023 · 8 shares · 202 followers View post →
Caitlin Zebley, MD PhD
@CaitlinZebley · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 301 followers View post →
Sara khan, MD
@DrSarakhanSk · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 370 followers View post →
Pat Adams
@PathologyPat · X

RT @AkshaySharmaMD: All 3 patients experienced reductions in complications related to #SickleCell disease and had an increase in hemoglobin…

Aug 31, 2023 · 2 shares · 1,513 followers View post →
AA&MDSIF
@aamdsif · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 4,405 followers View post →
Vishvdeep Khushoo
@vishvdeepkhush · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 949 followers View post →
Prashant Deshpande
@pradesh1001 · X

RT @AkshaySharmaMD: #PublicationAlert Incredibly proud to share our manuscript in @NEJM describing the first 3 #SickleCell dz patients who…

Aug 31, 2023 · 69 shares · 488 followers View post →
Dennis Lal
@LalDennis · X

CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease https://t.co/OfzR6bZDpm https://t.co/194ErN3ipA

Aug 31, 2023 · 1 like · 3,307 followers View post →
Tony McChrystal
@tonymac5 · X

Promising early results from trials of CRISPR edited HSPCs, which were infused into participants. https://t.co/Txj7ieYCsW

Aug 30, 2023 · 2 likes · 839 followers View post →