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Nat Metab September 2023 PMID 37653043

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA.

Moonsun Sa, Eun-Seon Yoo, Wuhyun Koh, Mingu Gordon Park, Hyun-Jun Jang, Yong Ryoul Yang, Mridula Bhalla, Jae-Hun Lee, Jiwoon Lim, Woojin Won, Jea Kwon, Joon-Ho Kwon, Yejin Seong, Byungeun Kim, Heeyoung An

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Mentions

49
Peak: 7 in Sep 2023
across 5 sources since Aug 2023

Extended reach

606,043
potential audience

Total likes

42

Video views

836

Mentions per month

Aug 2023 – Apr 2024

Where it's discussed

  • News28 articles
  • X / Twitter10 posts
  • Blogs6 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions often reference the role of hypothalamic GABRA5-positive neurons and astrocytic GABA, with phrases like 'potential therapeutic approach' and 'control obesity,' highlighting the perceived importance of the research. The tone and choice of words reflect a serious, yet moderately engaged community that recognizes the findings' value for future obesity treatments.

AgreementModerate agreement

Most discussions support the significance of the study in understanding obesity mechanisms, indicating general consensus on its importance.

InterestModerate interest

Participants show moderate interest, with comments highlighting potential therapeutic implications and curiosity about the molecular details.

EngagementModerate engagement

Discussions include references to specific neuron types and mechanisms, showing a decent level of thoughtful engagement rather than superficial comments.

ImpactModerate impact

The shared comments emphasize the potential for new treatments targeting hypothalamic neurons, indicating recognition of the research's notable impact on obesity therapy.

Abstract in brief

  • The lateral hypothalamic area (LHA) plays a vital role in controlling food intake and energy balance, specifically through neurons that target fat tissues.
  • GABRA5-positive neurons in the LHA are identified as a unique group that regulates fat storage and thermogenesis, with their activity decreased in diet-induced obesity in male mice.
  • Targeting astrocytic GABA production can enhance the function of GABRA5 neurons, leading to reduced weight gain without affecting food consumption, suggesting a potential therapeutic approach for obesity.
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Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA” by C. Justin LEE et al. Nature Metabolism https://t.co/GfpyJ59Bby 2/2

Aug 31, 2023 · 9 likes · 1 share · 505,752 followers View post →
Nature Metabolism
@NatMetabolism · X

Online now! Author Correction: Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA https://t.co/83YHHtUn6G

Oct 16, 2023 · 4 likes · 79,619 followers View post →
디센트/decent
@decent_life_a · X

https://t.co/4SkAayG3gv 오...실제 논문도 나와있어서 한 번 읽어볼까 했는데 아쉽게 open access는 아니라서 내용을 자세히 확인은 못 해보네요. 졸업일자도 지나서 학교 도서관 서비스도 이용을 못해서 무료로 읽을 방법은 없는...

Sep 2, 2023 · 4 likes · 1,146 followers View post →
htw
@heniek_htw · X

Hypothalamic GABRA5-positive neurons control #obesity via astrocytic GABA https://t.co/Rs6ZXP0HzD https://t.co/W2ZZduOBDS

Aug 31, 2023 · 2 likes · 11,279 followers View post →
Adipose Papers
@adipose_papers · X

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA https://t.co/0SfKgaIwvg https://t.co/PNWpz6l5oG

Sep 1, 2023 · 1 like · 2,448 followers View post →
Unsilenced Science
@UnsilencedSci · X

Taking an experimental MAOB inhibitor might allow weight loss without dietary changes. "Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA" https://t.co/7NtyYOuHBf

Sep 2, 2023 · 1,761 followers View post →

All mentions

Researching the Brain
@Brain_Database · X

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA https://t.co/eA7fD9m8cY

Jan 17, 2024 · 1,039 followers View post →
Nature Metabolism
@NatMetabolism · X

Online now! Author Correction: Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA https://t.co/83YHHtUn6G

Oct 16, 2023 · 4 likes · 79,619 followers View post →
Steve Hajioff
@DrSteveHajioff · X

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA - Nature Metabolism https://t.co/wLw32tDLqA

Sep 6, 2023 · 666 followers View post →
サイエンスあれこれ
@sarekore · X

「KDS2010」も、食物摂取量に影響を与えることなくマウスの脂肪蓄積と体重を大幅に減少することができました。Nature Metabolism誌https://t.co/Yc3Wfmso4G

Sep 3, 2023 · 922 followers View post →
Unsilenced Science
@UnsilencedSci · X

Taking an experimental MAOB inhibitor might allow weight loss without dietary changes. "Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA" https://t.co/7NtyYOuHBf

Sep 2, 2023 · 1,761 followers View post →
디센트/decent
@decent_life_a · X

https://t.co/4SkAayG3gv 오...실제 논문도 나와있어서 한 번 읽어볼까 했는데 아쉽게 open access는 아니라서 내용을 자세히 확인은 못 해보네요. 졸업일자도 지나서 학교 도서관 서비스도 이용을 못해서 무료로 읽을 방법은 없는...

Sep 2, 2023 · 4 likes · 1,146 followers View post →
Mya
@Mya78883324 · X

RT @NeuroscienceNew: “Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA” by C. Justin LEE et al. Nature Metabolism…

Sep 1, 2023 · 1 share · 572 followers View post →
Adipose Papers
@adipose_papers · X

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA https://t.co/0SfKgaIwvg https://t.co/PNWpz6l5oG

Sep 1, 2023 · 1 like · 2,448 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA” by C. Justin LEE et al. Nature Metabolism https://t.co/GfpyJ59Bby 2/2

Aug 31, 2023 · 9 likes · 1 share · 505,752 followers View post →
htw
@heniek_htw · X

Hypothalamic GABRA5-positive neurons control #obesity via astrocytic GABA https://t.co/Rs6ZXP0HzD https://t.co/W2ZZduOBDS

Aug 31, 2023 · 2 likes · 11,279 followers View post →