Arterioscler Thromb Vasc Biol October 2023 PMID 37706297

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association.

Larry B Goldstein, Peter P Toth, Jennifer L Dearborn-Tomazos, Robert P Giugliano, Benjamin J Hirsh, Jessica M Peña, Magdy H Selim, Daniel Woo

Download social card

Mentions

125

Peak: 55 in Sep 2023

across 4 sources since Sep 2023

Extended reach

946,313

potential audience

Total likes

4,548

Video views

142,263

Mentions per month

Sep 2023 – Sep 2025

Where it's discussed

X / Twitter110 posts
News12 articles
YouTube2 videos
Bluesky1 posts

AI synopsis

What people are saying

Discussions highlight the consensus that aggressive LDL-C lowering is generally safe, with users referencing specific sources to support their views. Phrases such as 'great statement by Dr. Giugliano' and mentions of thorough manuscripts indicate a high level of respect for the research. However, some users express concerns about past claims linking cholesterol levels to dementia, illustrating the ongoing debate in the community. The tone is largely collaborative, with many posts enhancing understanding and seeking to dispel myths.

AgreementStrong agreement

The majority of posts reflect strong agreement with the findings, emphasizing that lowering cholesterol does not increase dementia risk.

InterestHigh interest

There is high interest, with many users engaging in ongoing discussions and sharing additional resources.

EngagementModerate engagement

While some users delve into details of the study, others remain more surface-level in their contributions.

ImpactHigh impact

Many participants perceive the findings as having significant implications for medical treatment strategies.

Abstract in brief

The American Heart Association's scientific statement evaluates whether aggressive lowering of LDL cholesterol affects brain health, particularly in relation to cognitive impairment and dementia.
Some studies suggest a potential link between statins (cholesterol-lowering drugs) and cognitive issues, but the majority of evidence from observational and randomized trials does not support this claim.
The risk of hemorrhagic stroke from statin therapy in patients without prior cerebrovascular disease is considered low, and there is insufficient data on this risk for patients with a history of such strokes, indicating the need for further research.

Read the full abstract

All mentions

Essential Blood Tests for Heart Health and Cognitive Function

This video discusses crucial blood tests that everyone should undergo during annual checkups to prevent serious health issues, including heart attacks. It also addresses the impact of LDL cholesterol levels on brain…

Dr Brad Stanfield · Aug 29, 2024 72,656 views

Impact of Cholesterol Levels on Brain Health and Dementia Risk

Do low blood cholesterol levels damage the brain and cause memory loss? This video explores the relationship between cholesterol levels and cognitive decline, addressing recent research on cardiovascular health and its…

Dr Brad Stanfield · Nov 25, 2023 69,608 views

John Pavon

@laisseraller01.bsky.social · Bluesky

youtu.be/bpBrRuIXUVI?...

Sep 24, 2025 View post →

Karen Goodwater

@Karenedmond38 · X

RT @johnhanson67: Does Lowering Cholesterol Cause Dementia? https://t.co/0dkryQpmH0 via @YouTube More evidence contrary to what big pharm…

May 5, 2025 · 1 share · 678 followers View post →

Internal Medicine

@DrTedO2 · X

Lowering your bad cholesterol does NOT cause dementia or stroke, but it does reduce your risk of heart attacks or death from CV disease. Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement… https://t.co/jieMgcs59e

Feb 25, 2025 · 682 followers View post →

David Lui 呂德威

@DavidLui_HKU · X

RT @DrDerekConnolly: @SABOURETCardio @mirvatalasnag @Fajehani @biljana_parapid @DrRaniKhatib @RashaKaddoura2 @DLBHATTMD @SilbermanManzo @li…

Feb 5, 2025 · 1 share · 473 followers View post →

Prof Derek Connolly

@DrDerekConnolly · X

@SABOURETCardio @mirvatalasnag @Fajehani @biljana_parapid @DrRaniKhatib @RashaKaddoura2 @DLBHATTMD @SilbermanManzo @lipiddoc @DrPascalMeier @DrToniyaSingh I agree... "Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association | Arteriosclerosis, Thrombosis, and Vascular Biology" https://t.co/3EwhWVvnmI

Feb 5, 2025 · 4 likes · 1 share · 3,934 followers View post →

LLicit

@LLicit_Tweet · X

@MasalaFry69 @DoctorTro "LRP-1 (LDL receptor–related protein-1) may be activated by APO A-1 and APO E to

Feb 3, 2025 · 142 followers View post →

André Zimerman

@AndreZimerman · X

@Roshan_Karia @NEJMEvidence @TIMIStudyGroup @rgiugliano @DrM_ODonoghue No strong evidence to support this claim. We didn't find anything in FOURIER. Even if true, the net reduction in overall strokes largely outweighs any potential minor increase in hem. stroke. Here's a great statement by Dr. Giugliano and cols: https://t.co/ZbHTZEEm9M

Dec 26, 2024 · 15 likes · 1,839 followers View post →

DeepDeed

@thedeepdeed · X

@KimmoMatikainen Tää kannattaa huomioida! https://t.co/aS58AzPprF

Nov 1, 2024 · 683 followers View post →

GiZmO & RaZzMaTaZz

@GizmoRazz · X

@CaryKelly11 I've seen some Drs on YT say low cholesterol increases your chances of dementia and/or that cholesterol meds (statins) may cause dementia and why dementia is so much more prevalent nowadays than it was in the past. https://t.co/4foPdnp10k

Aug 2, 2024 · 2 likes · 425 followers View post →

riggers

@deportriggers · X

@bulkbiker @DoctorTro That statins protect against neurodgeneration is one of the most robust findings of neurological research. You just need to catch up on recent literature, not benjamin bilktard parroting debunked 19th century theories https://t.co/ME6oxJWBVe

Jul 8, 2024 · 111 followers View post →

Prof Derek Connolly

@DrDerekConnolly · X

@drandrewsharp @BudoffMd yes....she has atherosclerosis there is no too low with LDL https://t.co/rJJtftNbyK.

May 26, 2024 · 1 like · 3,934 followers View post →

Rahul Rege, MD

@RahulRege2 · X

Excellent discussion last night hosted by Dr. Benjamin Hirsh for NELA Nights! Check out this statement from the AHA by Dr. Hirsh and colleagues for more information! @nationallipid @EugeniaGianos https://t.co/b34Bg7zCE5 https://t.co/DjK2ZBQTjI

May 16, 2024 · 5 likes · 173 followers View post →

Prof Derek Connolly

@DrDerekConnolly · X

@LiverpoolCCS @LHCHFT @LJMU_Health @LivHPartners complements this AHA Statement Greg https://t.co/ArGlclzxgd well done !

Mar 19, 2024 · 1 like · 3,934 followers View post →

文献メモ

@bunken_kensaku · X

【文献メモ】 Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association https://t.co/2Ld5wKLEv4

Feb 27, 2024 · 1 like · 271 followers View post →

johnnyroy

@johnhanson67 · X

Does Lowering Cholesterol Cause Dementia? https://t.co/0dkryQpmH0 via @YouTube More evidence contrary to what big pharma promotes.

Dec 17, 2023 · 4 likes · 1 share · 1,393 followers View post →

Damian

@namimzz · X

@mike_lustgarten Causation is also a problem. For example low ldl was associated with higher risk for dementia. This is probably not causal: https://t.co/PfAh9L0bs7 https://t.co/SQm50jCmKJ

Dec 4, 2023 · 94 followers View post →

Rohit Gupta

@rohit_bmw · X

Does Low Cholesterol DAMAGE Your Brain? (new study) https://t.co/YQbWeph1SZ via @YouTube

Nov 27, 2023 · 5,894 followers View post →

Yuji Marutani | The Exiled Emperor

@YujiMarutani · X

Does Low Cholesterol DAMAGE Your Brain? (new study) https://t.co/Qg1j799MSc via @YouTube

Nov 25, 2023 · 1,577 followers View post →

Alex Meyer, MD

@meyeronfire5 · X

RT @DevinHaddadMD: https://t.co/3XhRbBnuwC

Nov 16, 2023 · 1 share · 224 followers View post →

Devin Haddad, MD

@DevinHaddadMD · X

https://t.co/3XhRbBnuwC

Nov 15, 2023 · 2 likes · 1 share · 541 followers View post →

Dr. Carl Hindy

@DrCarlHindy · X

Here’s a current statement from the American Heart Association … “Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association” https://t.co/3KfiaKgryo

Nov 8, 2023 · 2 likes · 33,260 followers View post →

ISAYoung

@ISA_AII_Young · X

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association https://t.co/pifBym3Cgw

Nov 6, 2023 · 1 like · 460 followers View post →

Anand Rohatgi

@dranandrohatgi · X

Great @AHAScience statement to help d/w patients safety of #statins. https://t.co/ghdCT9UeUr

Nov 5, 2023 · 3 likes · 552 followers View post →

JORGE FERNANDEZ

@drjorfer · X

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association | Arteriosclerosis, Thrombosis, and Vascular Biology✅☑️✅☑️ https://t.co/7MsjsxcHuI

Oct 22, 2023 · 1 like · 1,021 followers View post →

K Imran Mahmud

@drkimahmud · X

RT @DrDerekConnolly: An

Oct 18, 2023 · 9 shares · 138 followers View post →

Dr. Shalini Singhal

@drshalinisdiet · X

RT @rajeevgg: Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the…

Oct 18, 2023 · 2 shares · 11,125 followers View post →

anoop misra

@docanoopmisra · X

RT @rajeevgg: Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the…

Oct 17, 2023 · 2 shares · 29,146 followers View post →

Rajeev Gupta

@rajeevgg · X

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association. Wonderful statement.. https://t.co/p5ktkPYgbH

Oct 17, 2023 · 1 like · 2 shares · 720 followers View post →

UKCPA Cardiovascular Committee

@UKCPACardiac · X

RT @DrDerekConnolly: An

Oct 16, 2023 · 9 shares · 759 followers View post →

Vij Van

@van_vij · X

RT @DrDerekConnolly: An

Oct 16, 2023 · 9 shares · 407 followers View post →

susanconnolly

@susanbconnolly · X

RT @DrDerekConnolly: An

Oct 16, 2023 · 9 shares · 1,689 followers View post →

Hany Ragy

@Hragy · X

RT @DrDerekConnolly: An

Oct 16, 2023 · 9 shares · 80,477 followers View post →

sotiris antoniou

@santon74 · X

RT @DrDerekConnolly: An

Oct 16, 2023 · 9 shares · 1,413 followers View post →

Mamas A. Mamas

@mmamas1973 · X

RT @DrDerekConnolly: An

Oct 16, 2023 · 9 shares · 79,913 followers View post →

Prof Derek Connolly

@DrDerekConnolly · X

Oct 15, 2023 · 23 likes · 9 shares · 3,934 followers View post →

Dr. Luiz Silva

@DrLuizSilva1 · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 10, 2023 · 8 shares · 392 followers View post →

Chidambara .ML.

@chidambara09 · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 10, 2023 · 8 shares · 11,711 followers View post →

Anssi H. Manninen | Mass Balance Man

@KingManninen · X

https://t.co/D9M9gY536f

Oct 10, 2023 · 1,055 followers View post →

Anupam Khemariya

@AnupamKhemariya · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 10, 2023 · 8 shares · 104 followers View post →

xuejingemily

@Jingxue64154654 · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 10, 2023 · 8 shares · 15 followers View post →

Hojun Rhee MD

@dUPktOojEnoulHK · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 10, 2023 · 8 shares · 85 followers View post →

Rafael Radaeli

@rfradaeli · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 9, 2023 · 8 shares · 383 followers View post →

orion77

@orion7710 · X

RT @BrezanSimonMD: Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement F…

Oct 9, 2023 · 8 shares · 1,491 followers View post →

Simon Brežan MD

@BrezanSimonMD · X

Aggressive #LDL-C Lowering and the #Brain: Impact on Risk for #Dementia and #HemorrhagicStroke: A Scientific Statement From the American Heart Association https://t.co/r2A2nfYqH9 #AHA, 09. 2023 #CardioTwitter #MedTwitter

Oct 9, 2023 · 13 likes · 8 shares · 781 followers View post →

Natalia Nausica

@NataliaNausica · X