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Nat Methods October 2023 PMID 37735569

Spatiotemporal, optogenetic control of gene expression in organoids.

Ivano Legnini, Lisa Emmenegger, Alessandra Zappulo, Agnieszka Rybak-Wolf, Ricardo Wurmus, Anna Oliveras Martinez, Cledi Cerda Jara, Anastasiya Boltengagen, Talé Hessler, Guido Mastrobuoni, Stefan Kempa, Robert Zinzen, Andrew Woehler, Nikolaus Rajewsky

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Mentions

29
Peak: 5 in Sep 2023
across 3 sources since Sep 2023

Extended reach

46,899
potential audience

Total likes

30

Video views

75

Mentions per month

Sep 2023 – Jan 2025

Where it's discussed

  • News16 articles
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  • YouTube2 videos

AI synopsis

What people are saying

Discussions frequently highlight the innovative use of optogenetics and gene manipulation, with phrases like 'fantastic work' and references to how the research advances understanding of gene control in organoids. The tone reflects admiration and anticipation of broader influence, demonstrating active engagement and recognition of the publication's potential impact.

AgreementModerate agreement

Most discussions express approval and appreciation for the research's significance, indicating agreement with its importance.

InterestModerate interest

Participants show curiosity and appreciation for the innovative techniques, reflecting moderate interest.

EngagementModerate engagement

Comments include general praise, mentions of the methods, and notes on the potential for future research, signaling active involvement.

ImpactModerate impact

The posts suggest that this work could significantly influence future studies in gene regulation, organoid research, and neurodevelopmental models.

Abstract in brief

  • This study combines optogenetics and gene manipulation techniques to control gene expression in organoids with precise spatial and temporal patterns, allowing researchers to better study human development and disease models.
  • By locally activating Sonic Hedgehog (SHH) signaling in neurodevelopmental organoids, the researchers demonstrated that they could induce specific patterning, providing new insights into how SHH influences gene regulation during brain development.
  • The authors highlight the potential of using optogenetic perturbations together with spatial transcriptomics as a powerful way to reprogram cell fates and understand tissue organization in organoids.
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Carmelo Ferrai
@CarmeloFerrai · X

Fantastic work from ⁦@ILegnini⁩ during his time ⁦@N_Rajewsky⁩ lab on: Spatiotemporal, optogenetic control of gene expression in organoids |⁦@naturemethods⁩ https://t.co/CDxFSns4mm

Sep 29, 2023 · 14 likes · 2,490 followers View post →
Madam Mitochondria
@Madam_Mito · X

Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Sep 27, 2023 · 13 likes · 6 shares · 10,311 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 6, 2025 · 6 shares · 10,311 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Mar 28, 2024 · 6 shares · 10,311 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 4, 2024 · 6 shares · 10,311 followers View post →
Finde Deine Energie.
@VoiceDialogue_ · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 6, 2025 · 6 shares · 971 followers View post →

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Manoj Mayogi Mishra
@mayogisense · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 7, 2025 · 6 shares · 572 followers View post →
Finde Deine Energie.
@VoiceDialogue_ · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 6, 2025 · 6 shares · 971 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 6, 2025 · 6 shares · 10,311 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Mar 28, 2024 · 6 shares · 10,311 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Jan 4, 2024 · 6 shares · 10,311 followers View post →
Kursad Turksen
@kursadturksen · X

Spatiotemporal, optogenetic control of gene expression in organoids https://t.co/AVO6VhuGay

Nov 26, 2023 · 231 followers View post →
Carmelo Ferrai
@CarmeloFerrai · X

Fantastic work from ⁦@ILegnini⁩ during his time ⁦@N_Rajewsky⁩ lab on: Spatiotemporal, optogenetic control of gene expression in organoids |⁦@naturemethods⁩ https://t.co/CDxFSns4mm

Sep 29, 2023 · 14 likes · 2,490 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Madam_Mito: Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Sep 27, 2023 · 6 shares · 181 followers View post →
Madam Mitochondria
@Madam_Mito · X

Spatiotemporal, optogenetic control of gene expression in organoids | Nature Methods https://t.co/4xW0DNqGZN

Sep 27, 2023 · 13 likes · 6 shares · 10,311 followers View post →
Life Science Journal Content
@lsn_jc · X

Spatiotemporal, optogenetic control of gene expression in organoids #science #publication #research #journal https://t.co/sOZbl71t3w

Sep 26, 2023 · 263 followers View post →
Abstream
@abstreamme · X

Spatiotemporal, optogenetic control of gene expression in organoids #science #publication #research #publications https://t.co/gKUduxXBXa

Sep 24, 2023 · 789 followers View post →