J Pharmacol Exp Ther January 2024 PMID 37739806

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

Cyrielle Billon, Emmalie Schoepke, Amer Avdagic, Arindam Chatterjee, Andrew A Butler, Bahaa Elgendy, John K Walker, Thomas P Burris

Full text PDF Download social card

Mentions

227

Peak: 17 in Sep 2023

across 6 sources since Sep 2023

Extended reach

166,637

potential audience

Total likes

391

Video views

2,601

Mentions per month

Sep 2023 – Jul 2025

Where it's discussed

News177 articles
X / Twitter36 posts
Blogs9 articles
YouTube2 videos
Reddit2 posts
Bluesky1 posts

AI synopsis

What people are saying

The overall sentiment reflects excitement about the drug's potential, illustrated by phrases like 'exercise mimetic' and 'promising for treating metabolic disease.' The tone varies from cautious skepticism, as seen in the comment about structure concerns, to enthusiastic support emphasizing possible health benefits and transformative impacts. Words like 'dramatic,' 'promising,' and 'game changer' contribute to the perception of high relevance and potential shift in treatment approaches.

AgreementModerate agreement

Most comments acknowledge the potential of the synthetic ERR agonist for treating metabolic syndrome, showing general support for the findings.

InterestHigh interest

There is a high level of curiosity, especially with posts describing the drug as an 'exercise mimetic' and discussing its promising effects, which sparks excitement.

EngagementModerate engagement

Discussions about the mechanisms and implications, such as the activation of ERRs and the drug's ability to mimic exercise, suggest moderate to deep engagement.

ImpactModerate impact

Many posts highlight the potential significance of this research, indicating that it could influence future therapies for metabolic diseases.

Abstract in brief

The study explores how a drug called SLUPP332, which activates estrogen-related receptors (ERR), can mimic the benefits of exercise in mice, such as increased energy use and fat burning.
When given to obese mice, SLUPP332 helped reduce body fat and improved how their bodies handle insulin, suggesting it could help treat obesity and metabolic syndrome.
The research indicates that activating ERR with drugs like SLUPP332 might be a promising new way to combat metabolic diseases, potentially offering an alternative to physical exercise.]

Read the full abstract

All mentions

ERR Agonist SLUPP332 Shows Promise for Treating Metabolic Syndrome

The study explores how a drug called SLUPP332 activates estrogen-related receptors to mimic exercise benefits, reduce body fat, and improve insulin handling in obese mice, indicating potential for treating obesity and…

VigorousClips · Apr 6, 2025 1,190 views

Scientific Insights into Peptide SLUPP332 and Metabolic Health

This video explores the scientific basis of the peptide SLUPP332, which activates estrogen-related receptors to mimic exercise benefits, such as fat burning and improved insulin sensitivity, offering potential for…

Mario Rubbino · Mar 5, 2025 1,038 views

Enhancing Muscle Growth and Mitochondrial Health for Anti-Aging Benefits

Resistance training influences muscle growth and mitochondrial biogenesis, crucial for energy production and function during aging or inactivity. Recent studies explore effective, time-efficient protocols to promote…

VigorousClips · Mar 6, 2025 374 views

Flux Labs

@fluxlabsusa · X

https://t.co/CQkuL4EGen

Jul 26, 2025 · 21 followers View post →

Pat Sharp

@patsharp.bsky.social · Bluesky

Based on its structure alone I wouldn’t go near this compound. pubmed.ncbi.nlm.nih.gov/37739806/

Jan 13, 2025 · 1 like · 1 share View post →

AASraw.co

@AasrawCo · X

SLU-PP-332 may alleviate Metabolic Syndrome!!! Source: https://t.co/KK7VG727QV #slupp332 #slupp332benefits #slupp332exercise #slupp332supply #buyslupp332 #fatburing #aasraw https://t.co/J7ScKlM5sY

Oct 18, 2024 · 1,529 followers View post →

Amynah Pradhan

@AmynahPradhan · X

RT @UHSPedu: Congrats to Dr. Cyrielle Billon, assistant professor of #pharmacology, who was part of a #research team that received a patent…

Jul 12, 2024 · 2 shares · 1,137 followers View post →

University of Health Sciences and Pharmacy in STL

@UHSPedu · X

Congrats to Dr. Cyrielle Billon, assistant professor of #pharmacology, who was part of a #research team that received a patent for work related to estrogen-related receptors.

Jul 12, 2024 · 7 likes · 2 shares · 2,565 followers View post →

garbagebiotech

@NoToBigPharma1 · X

@BARDA @theNCI @NIH @NIAIDNews Next disaster coming....my God, let's do the brain chips finally, humanity already totally dumb anyway https://t.co/AJaQRvwhd6

Apr 1, 2024 · 57 followers View post →

Myroa A. Gare

@Anvonance · X

A Synthetic ERR Agonist Alleviates Metabolic Syndrome https://t.co/I96sqR25pe

Mar 26, 2024 · 7 followers View post →

Walter Suárez Carmona

@a_fisiolog57853 · X

"INFORMACIÓN" Algunas referencias de interés: - A Synthetic ERR Agonist Alleviates Metabolic Syndrome (Billion et al., 2023) https://t.co/T3Sv3DbR1E https://t.co/5FDIzl2qL8

Mar 21, 2024 · 4 likes · 4,148 followers View post →

METCon_Consortium

@METCon_Group · X

RT @JonathanStineMD: Is this the next exciting therapeutic arena to explore?

Mar 15, 2024 · 1 share · 42 followers View post →

Jonathan G. Stine, MD MSc, FACP

@JonathanStineMD · X

Is this the next exciting therapeutic arena to explore?

Mar 15, 2024 · 5 likes · 1 share · 2,549 followers View post →

Stephen A. Boyd, Ph.D.

@StephenABoydPh1 · X

A surprisingly small molecule has a dramatic, positive impact on endurance, obesity and muscle mass. https://t.co/eQC5qjzou6

Oct 21, 2023 · 5 likes · 3,119 followers View post →

igdhk

@5yymfH · X

ERRアゴニストSLU-PP-332 運動模倣効果。マウス。 https://t.co/mbr5Auoynj

Oct 20, 2023 · 1 like · 2 followers View post →

サイエンスあれこれ

@sarekore · X

かかわらず、未投与のマウスに比べて脂肪の増加が10分の1になり、体重が12％減少しました。SLU-PP-332を投与されたマウスは生きているだけでより多くのエネルギーを消費したのです。今のところ、この薬により重篤な副作用は発生していません。次のステップは、https://t.co/qtBrU7S7GK

Oct 15, 2023 · 1 like · 928 followers View post →

Elisheva

@Elisheva_Jeshua · X

A Synthetic ERR Agonist Alleviates Metabolic Syndrome https://t.co/2XrtoHr1UU

Oct 5, 2023 · 989 followers View post →

りょうこ.com

@ryokoando · X

痩せる薬の研究、ちょっと面白そう。アブストを見る限り、運動の良い効果を注射を打つだけで享受できるような感じ。健康的だし、脂肪燃焼効果も高そう。これからは飲み薬化もするらしい。期待大 https://t.co/DHKWJs36ex

Oct 3, 2023 · 3 likes · 5,773 followers View post →

mira mcnair

@McnairMira · X

A Synthetic ERR Agonist Alleviates Metabolic Syndrome https://t.co/xlAADq7hHP

Oct 3, 2023 · 1,055 followers View post →

ETCカード失くし太郎

@k0matatsu · X

治験参加したすぎ https://t.co/MP5Cgt8jDg

Oct 3, 2023 · 552 followers View post →

Andrea Valeria

@anferr04 · X

RT @Veronxveron: Hoy en @mas1047 hablamos del fármaco que imita el #ejerciciofísico. Probado en

Oct 2, 2023 · 1 share · 576 followers View post →

Sergio Veron Health & Fitness Professional

@Veronxveron · X

Hoy en @mas1047 hablamos del fármaco que imita el #ejerciciofísico. Probado en

Oct 2, 2023 · 8 likes · 1 share · 109,659 followers View post →

Kari

@kaiotay · X

A Synthetic ERR Agonist Alleviates Metabolic Syndrome https://t.co/OP7074W4VI

Oct 1, 2023 · 31 followers View post →

Saba

@callmesabahn · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 28, 2023 · 13 shares · 565 followers View post →

ArazOğlu

@FarhadArazdan04 · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 28, 2023 · 13 shares · 924 followers View post →

تیام

@Tiaam86 · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 28, 2023 · 13 shares · 139 followers View post →

Vitamin C

@Qmsh2023 · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 28, 2023 · 13 shares · 67 followers View post →

Dr Andrew Mitchell

@mitcharj · X

A Synthetic ERR Agonist Alleviates Metabolic Syndrome https://t.co/xhg3zvaExF

Sep 27, 2023 · 3 likes · 3,757 followers View post →

از یاد رفته

@molok_khanom · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 105 followers View post →

Behzad Amini

@behzadamini · X

https://t.co/8HAaUJlIJF

Sep 27, 2023 · 108 followers View post →

کیک سه شیر

@_aphrodite_0 · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 183 followers View post →

Hesam Yousefi

@Hesam_Yousefi · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 74 followers View post →

LoveSickGirl

@sheydaghasemi · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 1,862 followers View post →

Khatoon

@Khatoon_hastam · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 662 followers View post →

@freedomwifelife · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 73 followers View post →

خیارشور اگرسیو

@catogenn · X

RT @medsanmedicine: آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 13 shares · 294 followers View post →

Saeed

@medsanmedicine · X

آرزوی قدیمی بشر براورده شد؟ داروی ورزش

Sep 27, 2023 · 243 likes · 13 shares · 8,143 followers View post →

Zib Atkins

@AyusWellness · X

A drug that mimics some of the effects of exercise shows promise for treating metabolic disease. - Activates ERRs. - Decreases fat mass. - Increases energy expenditure and fatty acid oxidation. - Actual exercise does this and much more! https://t.co/oFu0Vo6s38

Sep 27, 2023 · 4,529 followers View post →

Matt Sztajnkrycer

@NoobieMatt · X

This definitely caught my eye. An “exercise mimetic” drug. Lose weight, gain muscle, gain aerobic capacity, all from a single medication. Ping ⁦@MayoPharmRes⁩ https://t.co/EK4oQOIpst

Sep 26, 2023 · 2 likes · 7,430 followers View post →

cagsei

@cagsei · X

Egzersiz benzeri yeni bir ilaç, "egzersiz mimetikleri" olarak bilinen bir sınıfa ait olan bu bileşim farelerde kiloyu, ağırlığı azaltıyor ve kas aktivitesini artırıyormuş. https://t.co/2sQNLDv4BH https://t.co/w129reKgx1

Sep 26, 2023 · 53 followers View post →

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

ERR Agonist SLUPP332 Shows Promise for Treating Metabolic Syndrome

Scientific Insights into Peptide SLUPP332 and Metabolic Health

Enhancing Muscle Growth and Mitochondrial Health for Anti-Aging Benefits