BMC Med September 2023 PMID 37743489

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.

Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blüher, Michael Stumvoll, Jun Li, Sven-Bastian Haange

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Mentions

69
Peak: 12 in Sep 2023
across 5 sources since Sep 2023

Extended reach

421,338
potential audience

Total likes

6,962

Video views

204,606

Mentions per month

Sep 2023 – Aug 2025

Where it's discussed

  • X / Twitter31 posts
  • News29 articles
  • YouTube3 videos
  • Facebook3 posts
  • Blogs3 articles

AI synopsis

What people are saying

The discussions collectively emphasize the benefits of polyphenol-rich diets, citing specific foods such as green tea, walnuts, and a green Mediterranean diet, and language like 'inverse association' and 'potentially reducing age' convey both agreement and optimism about the study's implications. The tone and word choices reflect enthusiasm and curiosity about diet's role in aging, indicating moderate to high engagement and perceived impact.

AgreementModerate agreement

Most posts support the positive effects of polyphenols on slowing biological aging, indicating general agreement.

InterestHigh interest

Discussions show high interest, with references to specific dietary interventions and aging implications.

EngagementModerate engagement

Posts engage with the study's findings, citing dietary examples like green tea and Mediterranean diets, reflecting moderate in-depth discussion.

ImpactModerate impact

The social discussions hint at the potential significance of these findings for aging research and dietary practices but are still at the preliminary discussion stage.

Abstract in brief

  • This study explored how polyphenol-rich diets might slow down biological aging by examining DNA methylation-based aging clocks in overweight or dyslipidemic adults over 18 months.
  • Participants followed different diets, including a Mediterranean diet, a green Mediterranean diet with green tea and Wolffia globosa, and a control group, with higher adherence to the GreenMED diet linked to more significant age attenuation.
  • The findings suggest that increased polyphenol intake, especially from green tea and Wolffia, can potentially reduce biological age as measured by DNA methylation, indicating a promising role for polyphenols in aging interventions.

Top posts

Most liked on X and Bluesky
Ben Greenfield
@bengreenfield · X

First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co/Ww4LkyLB9C - participants consumed things like green shake, walnuts, green tea, mitigated high red meat intake, etc. https://t.co/vvoGa6LCGH

Feb 10, 2024 · 32 likes · 5 shares · 95,043 followers View post →
Wolfgang Marx
@Marx_Wolf · X

Secondary analysis from an RCT (N=256) reports that:

Oct 4, 2023 · 21 likes · 4 shares · 1,277 followers View post →
John Damianos, M.D.
@john_damianosMD · X

Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t.co/NweiYFtObw

Sep 27, 2023 · 18 likes · 6 shares · 23,860 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial https://t.co/TRoIjkSRD8

Nov 2, 2024 · 8 likes · 2 shares · 9,719 followers View post →
Agingdoc
@agingdoc1 · X

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial https://t.co/3VCQJxgP5x @BMCMedicine

Sep 27, 2023 · 6 likes · 3 shares · 41,651 followers View post →
⅃ɵ෴eL
@joel27799310 · X

Sep 28, 2023 · 1 like · 1,065 followers View post →

All mentions

El Duende
@el__duende · X

RT @mike_lustgarten: The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlle…

Nov 2, 2024 · 2 shares · 340 followers View post →
Basil M. Gravanis
@PaleoPhotoPro · X

RT @mike_lustgarten: The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlle…

Nov 2, 2024 · 2 shares · 1,055 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial https://t.co/TRoIjkSRD8

Nov 2, 2024 · 8 likes · 2 shares · 9,719 followers View post →
Mind Your Science!
@MindYourSci · X

RT @bengreenfield: First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co…

Feb 11, 2024 · 5 shares · 132 followers View post →
Joy
@borteyjoy_ · X

RT @bengreenfield: First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co…

Feb 10, 2024 · 5 shares · 3,009 followers View post →
Jeff McClure
@JeffMcC21770 · X

RT @bengreenfield: First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co…

Feb 10, 2024 · 5 shares · 779 followers View post →
THE__WAC
@THE__WAC · X

RT @bengreenfield: First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co…

Feb 10, 2024 · 5 shares · 586 followers View post →
Daniel Fisk
@DanielFisk · X

RT @bengreenfield: First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co…

Feb 10, 2024 · 5 shares · 1,918 followers View post →
Ben Greenfield
@bengreenfield · X

First longevity study I’ve seen via methylation data that shows that high polyphenol intake can slow aging: https://t.co/Ww4LkyLB9C - participants consumed things like green shake, walnuts, green tea, mitigated high red meat intake, etc. https://t.co/vvoGa6LCGH

Feb 10, 2024 · 32 likes · 5 shares · 95,043 followers View post →
ARYAN®
@gladeolie · X

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized contro… https://t.co/YMsdF95h1m

Feb 1, 2024 · 1,499 followers View post →
Nelliel
@Nellielytu · X

Slow aging secrets @dralexisstephe1 https://t.co/c5y5kB1ulk

Dec 3, 2023 · 46 followers View post →
freelunch
@Bananab3333 · X

https://t.co/7QQrNywMUE

Oct 13, 2023 · 236 followers View post →
Hannah Went
@EverythingEpi · X

What is the effect of polyphenols on epigenetic biological age? "This study showed that MED and green-MED diets with increased polyphenols intake, such as green tea and Mankai, are inversely associated with biological aging."

Oct 10, 2023 · 1 like · 552 followers View post →
Stephanie J Moore
@HealthinHand · X

RT @Marx_Wolf: Secondary analysis from an RCT (N=256) reports that:

Oct 6, 2023 · 4 shares · 470 followers View post →
ISNPR
@_ISNPR · X

RT @Marx_Wolf: Secondary analysis from an RCT (N=256) reports that:

Oct 5, 2023 · 4 shares · 1,657 followers View post →
Food Mood Doctor
@FoodMoodDoctor · X

RT @Marx_Wolf: Secondary analysis from an RCT (N=256) reports that:

Oct 5, 2023 · 4 shares · 1,544 followers View post →
angela davies
@angelad86569513 · X

@LeenaMahtani The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.

Oct 4, 2023 · 128 followers View post →
Wolfgang Marx
@Marx_Wolf · X

Secondary analysis from an RCT (N=256) reports that:

Oct 4, 2023 · 21 likes · 4 shares · 1,277 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled tria…

Oct 2, 2023 · 3 shares · 132 followers View post →
Juhana Harju
@JuhanaHarju · X

RT @john_damianosMD: Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t…

Sep 28, 2023 · 6 shares · 1,691 followers View post →
j..
@josue_ · X

RT @john_damianosMD: Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t…

Sep 28, 2023 · 6 shares · 97 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @john_damianosMD: Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t…

Sep 28, 2023 · 6 shares · 6,638 followers View post →
⅃ɵ෴eL
@joel27799310 · X

Sep 28, 2023 · 1 like · 1,065 followers View post →
Fundación Iberoamericana de Nutrición
@FinutOrg · X

RT @john_damianosMD: Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t…

Sep 28, 2023 · 6 shares · 4,043 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

#Mediterranean (MED) diet, and a #polyphenol-rich, low-red/processed meat Green-MED diet associate with biological #aging @BMCMedicine https://t.co/bwdrkRgeYB

Sep 27, 2023 · 1 like · 695 followers View post →
Adriana B
@Adribottero · X

RT @john_damianosMD: Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t…

Sep 27, 2023 · 6 shares · 728 followers View post →
John Damianos, M.D.
@john_damianosMD · X

Adherence to a Mediterranean #diet is inversely associated with biological aging. #MedTwitter #nutrition https://t.co/NweiYFtObw

Sep 27, 2023 · 18 likes · 6 shares · 23,860 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @agingdoc1: The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled tria…

Sep 27, 2023 · 3 shares · 6,638 followers View post →
Raffaello M. Cutri, MD
@raffaello_cutri · X

RT @agingdoc1: The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled tria…

Sep 27, 2023 · 3 shares · 109 followers View post →
Agingdoc
@agingdoc1 · X

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial https://t.co/3VCQJxgP5x @BMCMedicine

Sep 27, 2023 · 6 likes · 3 shares · 41,651 followers View post →
BMC Medicine
@BMCMedicine · X

Results from research from @anatyas et al. suggests that diets with increased polyphenols intake are inversely associated with biological aging: https://t.co/X43DnNOI8a https://t.co/VqBHkPPokH

Sep 25, 2023 · 9,196 followers View post →