Nature October 2023 PMID 37794183

Rare variant associations with plasma protein levels in the UK Biobank.

Ryan S Dhindsa, Oliver S Burren, Benjamin B Sun, Bram P Prins, Dorota Matelska, Eleanor Wheeler, Jonathan Mitchell, Erin Oerton, Ventzislava A Hristova, Katherine R Smith, Keren Carss, Sebastian Wasilewski, Andrew R Harper, Dirk S Paul, Margarete A Fabre

Mentions

83
Peak: 66 in Oct 2023
across 6 sources since Oct 2023

Extended reach

2,856,414
potential audience

Total likes

212

Video views

2,027

Mentions per month

Oct 2023 – Sep 2025

Where it's discussed

  • X / Twitter69 posts
  • News5 articles
  • Blogs3 articles
  • Bluesky2 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Many discussions highlight the unveiling of significant associations between rare genetic variants and plasma protein levels, noting phrases like 'new insights into disease mechanisms' and 'potential biomarkers for diseases.' The tone is often optimistic and excited, reflecting the study's promise in advancing medical research and applications.

AgreementModerate agreement

The majority of discussions show a favorable view of the publication and its findings.

InterestHigh interest

There's a strong curiosity around the implications of rare variants for disease mechanisms and treatments.

EngagementModerate engagement

While many posts are informative, some show deeper exploration of the study's significance and methodologies.

ImpactHigh impact

Posts indicate a widespread belief that the findings could lead to meaningful advancements in genomics and proteomics.

Abstract in brief

  • Integrating human genomics and proteomics can uncover disease mechanisms and identify potential biomarkers and drug targets.
  • Our study highlights the importance of rare protein-coding variants, finding 5,433 associations with plasma protein levels that were largely missed in previous studies.
  • We also demonstrate practical applications of our findings, including potential biomarkers for diseases and insights into the effects of clonal hematopoiesis on protein levels.

Top posts

Most liked on X and Bluesky
Ryan Dhindsa
@RyanDhindsa · X

Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature today https://t.co/M4YOHCzAqn Summary statistics are publicly available at https://t.co/YB9bNtGX1k and an interactive portal https://t.co/9wQ82ig4hx

Oct 4, 2023 · 147 likes · 47 shares · 1,463 followers View post →
nature
@Nature · X

Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 5, 2023 · 33 likes · 7 shares · 2,613,016 followers View post →
BioDecoded
@BioDecoded · X

Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/bVJSDWqjNj #genomics https://t.co/urhqIdnwkr

Oct 8, 2023 · 4 likes · 3 shares · 8,899 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Original article 3: Dhindsa, R. S. et al. Rare variant associations with plasma protein levels in the UK Biobank. Nature 622, 339–347 (2023)

Nov 1, 2023 · 3 likes · 1 share · 92,675 followers View post →
Pastel BioScience
@PastelBio · X

Rare variant associations with plasma protein levels in the UK Biobank - https://t.co/zP2PEiNiBA --- #proteomics #prot-paper https://t.co/wvGCMgtwID

Oct 5, 2023 · 2 likes · 5,377 followers View post →
Pat Adams
@PathologyPat · X

Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/A3rNPcydT6

Oct 25, 2023 · 1 like · 1,514 followers View post →

All mentions

EZSci
@EZiSci · X

Rare genetic variants significantly impact plasma protein levels, offering new insights into disease mechanisms, biomarkers, and drug targets. #Genomics #Proteomics #UKBiobank https://t.co/gAK8LuhTOX https://t.co/8sXrRnRojB

Sep 6, 2024 · 1 like · 732 followers View post →
علمي علمك
@3lmy3elmak · X

الطفرات الجينية النادرة لها تأثير كبير على مستويات البروتين في البلازما، مما يوفر رؤى جديدة حول آليات الأمراض والعلامات الحيوية وأهداف الأدوية. #جينوميات #بروتيوميات #UKBiobank https://t.co/AQsh4KRWm4 https://t.co/B4nlwg7O6j

Sep 6, 2024 · 29 followers View post →
EZSci
@EZiSci · X

https://t.co/0aubmcwhbT

Dec 7, 2023 · 732 followers View post →
Karsten Suhre
@ksuhre · X

RT @NatureRevGenet: Original article 3: Dhindsa, R. S. et al. Rare variant associations with plasma protein levels in the UK Biobank. Natur…

Nov 2, 2023 · 1 share · 2,567 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Original article 3: Dhindsa, R. S. et al. Rare variant associations with plasma protein levels in the UK Biobank. Nature 622, 339–347 (2023)

Nov 1, 2023 · 3 likes · 1 share · 92,675 followers View post →
Pat Adams
@PathologyPat · X

Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/A3rNPcydT6

Oct 25, 2023 · 1 like · 1,514 followers View post →
Collin Nzunda
@CollinNzunda · X

RT @BioDecoded: Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/bVJSDWqjNj #genomics https://…

Oct 20, 2023 · 3 shares · 943 followers View post →
Jonathan Frazer
@Jonnygfrazer · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 16, 2023 · 47 shares · 1,195 followers View post →
Dhruv
@dhruv2038 · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 10, 2023 · 7 shares · 4,110 followers View post →
Saubashya Sur, PhD
@SaubashyaSur · X

RT @BioDecoded: Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/bVJSDWqjNj #genomics https://…

Oct 9, 2023 · 3 shares · 765 followers View post →
Conscious Tone
@ToneConscious · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 9, 2023 · 7 shares · 53 followers View post →
Seungho Oh @seunghooh@genomic.social
@dancewithsun · X

RT @BioDecoded: Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/bVJSDWqjNj #genomics https://…

Oct 9, 2023 · 3 shares · 98 followers View post →
BioDecoded
@BioDecoded · X

Rare variant associations with plasma protein levels in the UK Biobank | Nature https://t.co/bVJSDWqjNj #genomics https://t.co/urhqIdnwkr

Oct 8, 2023 · 4 likes · 3 shares · 8,899 followers View post →
Life Science Journal Content
@lsn_jc · X

Rare variant associations with plasma protein levels in the UK Biobank #science #publication #research #journal https://t.co/GisdfFzs8f

Oct 8, 2023 · 263 followers View post →
Hematopoiesis
@HSC_papers · X

Rare variant associations with plasma protein levels in the UK Biobank https://t.co/Ov513EY1eM https://t.co/UIbbnBF63Q

Oct 8, 2023 · 911 followers View post →
Hyunyong (Howard) Koh, MD, PhD
@HyunyongKoh · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 7, 2023 · 47 shares · 364 followers View post →
Dr Mario HMG
@mgmglobal · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 6, 2023 · 7 shares · 2,523 followers View post →
Krzysztof Potempa
@BRAINCURES · X

@MenePangalos @AstraZeneca @SlavePetrovski @RyanDhindsa Rare variant associations with plasma protein levels in the UK Biobank @uk_biobank Ryan Dhindsa @ollyburren @ben_b_sun @kerencarss @DrAndrewHarper @dirk_paul @heikorunz @dimvitsios @euanashley @chrisdwhelan @MenePangalos Quanli Wang @SlavePetrovski https://t.co/ZnpycsH0ec #CGR https://t.co/NONq0q9l18

Oct 6, 2023 · 2,669 followers View post →
Sergey Minaev
@sminaev2015 · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 31,466 followers View post →
Dr. Chloé Sarnowski, Ph.D.
@SarnowskiChloe · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 582 followers View post →
Sahba Ferdowsi DO (conciergedoc)
@DrFerdowsi · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 9,645 followers View post →
Marcel Schulz - @marcelschulz@genomic.social
@TheMarcelSchulz · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 940 followers View post →
choiLab
@jungminchoilab · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 330 followers View post →
yutang
@yutang_mpb_eth · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 154 followers View post →
Hao Yin
@HaoYin20 · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 12,227 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 705 followers View post →
Ray Chou
@RealLeiZhou · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 223 followers View post →
Omid S. Alavijeh
@OAlavijeh · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 237 followers View post →
Dimitrios Vitsios
@dimvitsios · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 294 followers View post →
Keren Carss
@kerencarss · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 1,370 followers View post →
Min Seo Kim, MD, MSDH
@MinSeoKim_MD · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 2,587 followers View post →
Michelle Grunin, Ph.D.
@MGrunin5 · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 289 followers View post →
Abstream
@abstreamme · X

Rare variant associations with plasma protein levels in the UK Biobank #science #publication #research #publications https://t.co/9VpPPFvGik

Oct 5, 2023 · 789 followers View post →
Pastel BioScience
@PastelBio · X

Rare variant associations with plasma protein levels in the UK Biobank - https://t.co/zP2PEiNiBA --- #proteomics #prot-paper https://t.co/wvGCMgtwID

Oct 5, 2023 · 2 likes · 5,377 followers View post →
PastelBio
@pastelbio.bsky.social · Bluesky

Rare variant associations with plasma protein levels in the UK Biobank - www.nature.com/artic... --- #proteomics #prot-paper

Oct 5, 2023 View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 5, 2023 · 7 shares · 571 followers View post →
Francisco
@Frank_Txu · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 823 followers View post →
fuzzyLife
@animesh1977 · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 1,738 followers View post →
Liliya Kopanitsa
@LiliyaLvk21mail · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 5, 2023 · 7 shares · 70 followers View post →
/ɹɑb/
@RobertBorland7 · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 5, 2023 · 7 shares · 956 followers View post →
C Chang
@seq212 · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 5, 2023 · 47 shares · 34 followers View post →
pinaky das
@DasPinaky · X

RT @Nature: Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 5, 2023 · 7 shares · 274 followers View post →
nature
@Nature · X

Nature research paper: Rare variant associations with plasma protein levels in the UK Biobank https://t.co/8xpfsZmgSc

Oct 5, 2023 · 33 likes · 7 shares · 2,613,016 followers View post →
Seungho Oh @seunghooh@genomic.social
@dancewithsun · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 98 followers View post →
Josep M Mercader
@josep_mercader · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 553 followers View post →
Stetson
@stetson_thacker · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 874 followers View post →
Eleanor
@eleanorwheeler · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 91 followers View post →
Alex Strudwick Young
@AlexTISYoung · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 6,866 followers View post →
Kuldeep Kumar
@kkumar_iitkgp · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 631 followers View post →
Adam Butterworth
@aidanbutty · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 1,790 followers View post →
Bastien Rioux
@B_Rioux · X

Rare variant associations with plasma protein levels in the UK Biobank https://t.co/yWQFOu2ScQ

Oct 4, 2023 · 242 followers View post →
Xavier F.
@xf_grely · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 161 followers View post →
David Ochoa
@d0choa · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 1,080 followers View post →
Kelvin Hui
@kelvinhui_cira · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 184 followers View post →
Slavé Petrovski
@SlavePetrovski · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 306 followers View post →
Benjamin Sun
@ben_b_sun · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 258 followers View post →
Joana Petrescu
@joanapetrescu · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 943 followers View post →
aaaa
@ngsstudent · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 562 followers View post →
Heiko Runz
@heikorunz · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 437 followers View post →
Yu Xu
@IamYuXu · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 237 followers View post →
Dirk Paul
@dirk_paul · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 341 followers View post →
Maxime Rousseaux
@maximewc · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 981 followers View post →
Sciences
@sciences.skyfleet.blue · Bluesky

Rare variant associations with plasma protein levels in the UK Biobank

Oct 4, 2023 View post →
Amit Sud
@amit_sud · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 667 followers View post →
Santosh Atanur
@santoshatanur · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 60 followers View post →
Caleb Lareau
@CalebLareau · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 3,592 followers View post →
David A. Alagpulinsa, PhD
@Alagsdave · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 381 followers View post →
Veera Rajagopal 
@doctorveera · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 19,052 followers View post →
Chris Whelan
@chrisdwhelan · X

RT @RyanDhindsa: Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature…

Oct 4, 2023 · 47 shares · 803 followers View post →
Ryan Dhindsa
@RyanDhindsa · X

Thrilled to see our paper on rare variant associations with plasma protein levels in the @uk_biobank published in @nature today https://t.co/M4YOHCzAqn Summary statistics are publicly available at https://t.co/YB9bNtGX1k and an interactive portal https://t.co/9wQ82ig4hx

Oct 4, 2023 · 147 likes · 47 shares · 1,463 followers View post →
Igor Wortel
@itwortel · X

Rare variant associations with plasma protein levels in the UK Biobank https://t.co/SrwWcZLyF0

Oct 4, 2023 · 1,720 followers View post →