Sci Adv November 2023 PMID 37922348

Copper drives prion protein phase separation and modulates aggregation.

Mariana Juliani do Amaral, Satabdee Mohapatra, Aline Ribeiro Passos, Taiana Sousa Lopes da Silva, Renato Sampaio Carvalho, Marcius da Silva Almeida, Anderson Sá Pinheiro, Susanne Wegmann, Yraima Cordeiro

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Discussions reflect strong support and interest, exemplified by comments praising the research collaborations and emphasizing copper's role in prion protein phase separation, which indicates a high level of engagement and recognition of potential scientific impact.

AgreementModerate agreement

Most discussions emphasize the importance of the research findings, showing support for the role of copper in prion protein behavior.

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The discussions indicate high enthusiasm, with many expressing curiosity and enthusiasm about the topic and its implications.

EngagementModerate engagement

Posts include references to the detailed mechanisms and collaborative work, reflecting thoughtful engagement beyond surface-level reactions.

ImpactModerate impact

Several comments highlight the significance of this research for understanding neurodegenerative diseases, suggesting perceived high impact.

Abstract in brief

Copper plays a key role in promoting prion protein (PrP) phase separation and aggregation, especially under oxidative stress conditions.
The interaction of copper (Cu) with PrP can inhibit its normal structure and expose hydrophobic regions, leading to a shift from liquid-like condensates to solid, amyloid-like aggregates.
Over time, PrP copper condensates act as a protective buffer against copper toxicity, but prolonged oxidative stress causes these condensates to transition into harmful protein aggregates, contributing to neurodegeneration in prion diseases.]

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When physics meets biology: #PrionProtein orchestrates liquid–liquid #phaseSeparation with copper @ScienceAdvances https://t.co/cwy7s7INSU https://t.co/XX9tF1ybgG

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RT @marijamaral: My first-author paper looking into how copper and oxidation modulate #prion protein #phaseseparation is out

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Mariana J. do Amaral

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My first-author paper looking into how copper and oxidation modulate #prion protein #phaseseparation is out

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RT @Pha_Tran_Papers: Copper drives prion protein phase separation and modulates aggregation https://t.co/hKeNVjw4Q8

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Mychael Lourenco

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RT @yraima_cordeiro: Well done, Mariana and colleagues! Copper drives prion protein phase separation and modulates aggregation https://t.c…

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Yraima Cordeiro

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Well done, Mariana and colleagues! Copper drives prion protein phase separation and modulates aggregation https://t.co/qSxwpkQwvm

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Prion Protein Forms Dynamic Liquid Condensates to Regulate ...

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doi.org/10.1126/sciadv.adi7347. Be the first to rate this article. Posted in: Proteomics | Cell Biology | Life Sciences News. Comments (0).

Dec 4, 2023 View →

When physics meets biology: prion protein orchestrates liquid-liquid ...

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DOI. 10.1126/sciadv.adi7347. Method of Research. Experimental study. Subject of Research. Cells. Article Title. Copper drives prion protein ...

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Copper drives prion protein phase separation and modulates ...

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Sci. Adv.9,eadi7347(2023).DOI:10.1126/sciadv.adi7347. Export citation. Select the format you want to export the citation of this publication ...

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Copper drives prion protein phase separation and modulates aggregation.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Cellular Prion Protein's Role in Astrocyte Apoptosis and Brain Health

Understanding Prions and Their Role in Brain Disease Mechanisms