The natural thermal sensitivity of SARS-CoV-2.

The first draft of my new video on climate change is here: https://t.co/v80sNtHcU1 Will the climate narrative collapse in the next few years? I think it may, because it's not based on sound science. Most people don't know that (1) temperatures on Earth were almost certainly https://t.co/9rH2tlgeDQ

@_ClimateCraze Is that right? I learnt recently that there were similar "dust bowls" in many parts of the world in the 1930s, including Australia, Ukraine, Argentina - far from the N Atlantic https://t.co/wReKIJVjZy https://t.co/vHnwOR5sTB

İnsan vucudu için ateş en büyük koruyucu silahlardan biridir.✅ Vucudun bağışıklık sisteminin çalıştığının baş göstergelerindendir.✅ Ateşiniz birazcık çıktı diye , avuç avuç ilaç yutmaya başlamayınız.

Here is the latest version of our letter about the natural thermal sensitivity of SARS-CoV-2, with corrected wording⬇️ (Somehow some text was deleted from the first paragraph of the previous version) https://t.co/N2SyLdkohh

Here's my video https://t.co/MehDTWpFax

RT @PatrickSSte: References etc are here, and in the YouTube description: https://t.co/pyCvgeKZe7

References etc are here, and in the YouTube description: https://t.co/pyCvgeKZe7

Temperatures falling in the last 6 thousand years: https://t.co/uxDfv1pmhL

@SolidEvidence SARS-CoV-2 is normally thermally-sensitive by the way: Letter https://t.co/gzF6UJ4AKL

@BenjaminYumi8 @JefferyParkins2 @_ClimateCraze It's good to focus on the last 800,000 years And explain the 100,000 ice age cycles Which climate scientists are unable to do There is a good explanation, one that that actually works, which I thought about in my video starting here: https://t.co/8JzCMovua0 https://t.co/jO1YGQu3fd

@Climatehope2 @CMorrisonEsq The ice-core data comes from an excellent paper by Vinther that takes changes in altitude into account . You'll find the reference in the description of my video: https://t.co/eSpt97TFCn I used it because I couldn't find any plausible global temperature reconstructions. None of

@joe51du I explain the problems starting at 42 minutes, then I explain the solution https://t.co/is2nOVAsKh

@joe51du Look into this - it's very interesting You might enjoy the middle part of my video https://t.co/jmGNym4DZc

@PGDynes Isn't it true that many more people die when the weather turns cold than hot? I looked at Chennai, where I could get data. Even in South India cold is much more dangerous than heat⬇️ https://t.co/VBH819Rn5E https://t.co/cTfxYaqcaz

@KiltonDornier @25_cycle @WeatherProf https://t.co/kyI0iy1sex

@technowurstbrot Thank you for those plots - they're interesting. I've seen some of them before - in fact some are in my video. Have I missed anything important out? The part about extreme weather is near the end - at about 1 hour 9 mins https://t.co/p44aQuOg6X

@TheGlobalWarmer Here are some "raw" datasets that have not been tampered with by climate scientists⬇️ Those are slides from my video, where I explain in more detail https://t.co/ihAeCFIF7D https://t.co/mCtr67lNBt

@25_cycle @WeatherProf I appreciate intelligent criticism. Here's my video. Is there something I don't understand, or have I overlooked anything? Like why climate scientists can't explain the existence of ice age cycles, which is certainly very odd https://t.co/p4F61FbaxK

@CMorrisonEsq Paul: "We ARE in a climate crisis" Are we? The answer depends on how you interpret the data, especially the temperature record of the Holocene Is it interpretation #1, #2, or #3? It makes a big difference https://t.co/p4F61FbaxK https://t.co/OxlXRK4QFZ

@EliotJacobson Moreover, look at the places where glaciers reveal logs and tree stumps when they retreat - all over the world https://t.co/sLW314uhuu https://t.co/aJWWIY1Ru2

@AndrewDessler Discussed in a video: https://t.co/1xL5VN7lKk

@MarcEHJones @WeatherProf Watch my video if you want to know why I think that https://t.co/SU59sTIKl7

@latimeralder I discussed that in my video Looking at this graph⬇️, current temperatures or maybe a little higher https://t.co/MiEuWiRsa1 https://t.co/NPwrolVn3x

@PGDynes What was the record temperature in the 1930s? The truth is, none of us know I only learnt recently that there were "dust bowls" in many parts of the world⬇️ Discussed here: https://t.co/fIF16UrmzK https://t.co/tyBnERapCx

To be fair, the serious question is whether there really is a serious problem with global warming I personally doubt there is https://t.co/K7lXVjcBfM https://t.co/IwSy6Iu4ja

@ErikMagnethi @Variety It's true even in Southern India I looked at daily deaths and temperature in Chennai in my video⬇️ https://t.co/i28i7obPQv https://t.co/120DziAtUo

I'm not sure that's true We can block it if it really is going to destroy civilization I like to understand things if I can There are lots of points that no-one seems to be interested in that suggest it won't: https://t.co/mEMtSzPmud https://t.co/r3Mjb7iRDf

@PGDynes Such nonsense Some of the reasons why it is are explained here https://t.co/NPWGTIjnak

@ChrisMartzWX I looked at deaths in Chennai Even in South India today, cold is more dangerous than heat Discussed here: https://t.co/Q04LrhrWIJ https://t.co/V67xjsowL3

@ClimateAudit @RyanMaue So, interpretation #2, or maybe #3?⬇️ #1 seems to be nonsense https://t.co/SzO0fFP5bk https://t.co/hPPX0y6VJR

@feliciahsiehsw @PutAimovigOnNHS @vipintukur This letter is purely factual https://t.co/gzF6UJ4AKL

@CaptainAdvance1 @_ClimateCraze Watch my video if you don't know how Ellis and Palmer works and how badly climate scientists have behaved https://t.co/BTNptHKUyE

@xynyxs @ryankatzrosene @Marcusgibson Again @markcusgibson shows Canada and Alaska as cold. But this paper says “The peak Holocene warmth is traced over 140 sites ….… [they] provide clear evidence for warmer-than-present conditions at 120 of these sites.” https://t.co/iYjpwxTdPU https://t.co/1ZFqJdMBXf

@xynyxs @ryankatzrosene There are many other examples, some of which I mention in my video. Why was the Sahara green 6,000 years ago. Wikipedia says it's because the Eurasian land mass was much warmer in the summer and generated a much stronger African monsoon https://t.co/UESAydzGQU https://t.co/6VM2OOJKlp

@xynyxs @ryankatzrosene It's a still from my video https://t.co/6iJHEJTmXD I got those examples of tree stumps and logs mainly from articles rather than scientific papers Why isn't this much more well-known?

@TheDisproof (2) If temperature would otherwise have been falling rapidly - as it did after other recent interglacials - then CO2 warming was a good thing Discussed here: https://t.co/Ix5mjmXUzs https://t.co/1aitO3ofsJ

@PGDynes I agree it's very hard to prove this conclusively - there is always wriggle-room for climate scientists to jump on - but the evidence is pretty overwealming https://t.co/YlxmPJ0pcc

@PGDynes It's pretty obvious you're wrong The world, especially the Northern Hemisphere was much warming during the mid Holocene Logs and tree stumps revealed when glaciers retreat is just one line of evidence https://t.co/YlxmPJ0pcc https://t.co/sz7Wx9Rg5k

** I made a video about the lack of evidence and the misrepresentation in climate science recently: https://t.co/rXxoWKjyLU I'm not sure why I bothered - this is becoming obvious to everyone outside the BBC/New York Times bubble Trouble is, our government's in the center of

@janevandis > Billions will die and people will say… meh… fossil fuels are necessary Right now, cold weather is much more dangerous than hot weather https://t.co/8AuoHuj5wj https://t.co/XmVMBW0iU0

RT @PatrickSSte: @_ClimateCraze Is that right? I learnt recently that there were similar "dust bowls" in many parts of the world in the 19…

@PGDynes Still, far more people die from low temperatures than from high https://t.co/qiTTKUtuZu

@_ClimateCraze Is that right? I learnt recently that there were similar "dust bowls" in many parts of the world in the 1930s, including Australia, Ukraine, Argentina - far from the N Atlantic https://t.co/wReKIJVjZy https://t.co/vHnwOR5sTB

@JAtanackov @ryankatzrosene Meaning what? Is that Venus? Are you making the same point I was trying to make? https://t.co/TSs5PTCaLF

@ChrisGloninger First, we have to figure out whether climate change is actually a serious problem. I've been thinking about it - none of this is obvious to me: https://t.co/TSs5PTCaLF

@ryankatzrosene Why does your graph look so different to mine? I simply plotted the temperatures recorded by Oxford University⬇️ Those two dotted lines go up by 1.4C Discussed in my presentation, here: https://t.co/ock4kpD3Up https://t.co/MX3fvuQW2H

The problem of feedbacks working in both directions is discussed here⬇️ Ellis and Palmer explained in the following section https://t.co/crpOApOjfy

@GeraldKutney That would be a very good argument if science hadn't become extraordinarily susceptible to Noble Cause Corruption, in all areas that overlap with politics This is a recent development https://t.co/JeuCdJacOK

Ellis and Palmer's hypothesis seems to be the only plausible explanation for the ice age 100,000-year cycle https://t.co/kk8lDXU2Xw

@JohnBeaudoinSr @DrHenryEaly I don't find that obvious, which is why I made that video https://t.co/8osvRG53ym

@DrHenryEaly @JohnBeaudoinSr One question is whether there is actually a serious problem with global warming in the first place https://t.co/mSPbS9T7Bx

@ChrisMartzWX Osman 2021 was particularly odd, because they showed the natural thermometers that they used. They somehow adjusted away the warmer temperatures 6,000 years ago https://t.co/OpsOZ8I8IY https://t.co/VFQMZmEwsj

@ChrisGloninger Explained in more detail in my seminar around the 1:18 mark⬇️ https://t.co/t9rBtpIcNO

@ChrisGloninger I discuss this in my seminar along with lots of other things most people don't know https://t.co/t9rBtpIcNO

@CyfraithEcocide @gdank229397 @ryankatzrosene I mentioned this and other points that are not well-known in my seminar https://t.co/q8rjf4HKmg

@JimBowersclimb @dullly @JRice79294326 @_ClimateCraze https://t.co/ccM7vyq9B0

@SiOldridge @KathrynPorter26 @jessralston2 I looked at some of these questions in my seminar https://t.co/we5MGeoCbr

@SiOldridge @KathrynPorter26 @jessralston2 It's so hard to know what is real, and whether there really is a serious problem, when the mainstream analysis is so inconsistent https://t.co/we5MGeoCbr https://t.co/OLGiETfZPs

@KathrynPorter26 @jessralston2 I discussed some of the fundamental issues in my seminar⬇️ https://t.co/we5MGeoCbr

@IPCC_CH @WMO I discussed some of the most important issues in my seminar https://t.co/we5MGepa0Z

@JimBowersclimb @dullly @JRice79294326 @_ClimateCraze The inconsistencies in mainstream climate science are very ODD https://t.co/UG95bgFF3q

@ryankatzrosene @gdank229397 https://t.co/UG95bgFF3q https://t.co/LPOGpc6tAd

@gdank229397 @ryankatzrosene Discussed here: https://t.co/HiwvzrgO2W

@ryankatzrosene Video here: https://t.co/qEYZJUZmqJ

@EyesOnThePriz12 I agree but people do believe it. Most people - even experts - think, "surely so many people can't be wrong" At that point you have to somehow get them to look at the evidence, which is what my video tries to get them to do Here if you didn't see it https://t.co/6XEAOqxMLA

@Artemisfornow I was so frustrated by the lack of information and the low quality of the debate that I made a video, here https://t.co/6XEAOqxMLA

@fe87972 @CO2Coalition Video is here - I'm told it's pitched at a good level for a wide audience and well presented https://t.co/Ie8faayjod

@covid_quest @GreatLakesPeck *similar weather in the 1930s I put these examples in my video⬇️, which is mainly about the fundamentals - ice ages etc and also the odd behavior of scientists and the media https://t.co/DvKDoRnP5G

I give some background and discuss some issues: https://t.co/0IBjNN0qYm

@DaleGribble_666 @davidissim @_ClimateCraze By the way I put all the climate things that have been bothering me for many years into the video. Have I missed any important points? https://t.co/hNlOhkNU0U

@FriedrichFiles @DaleGribble_666 @davidissim @_ClimateCraze These are slides from my video, covering the things that have bothered me for the last 8 years about the climate narrative⬇️ Have I missed anything important? https://t.co/ZdLG4V3cym

@FriedrichFiles @_ClimateCraze Ellis and Palmer explanation starts here: https://t.co/joMMBvh6EW

@ryankatzrosene https://t.co/kX4CMYtdTv

@60Minutes https://t.co/kX4CMYtdTv

@Dodders75 Video is here https://t.co/ykoNnE9wpF

@DaleGribble_666 @davidissim @_ClimateCraze This is all discussed in my video, together with other important information the public is not aware of⬇️ And data that climate scientists OUGHT to be aware of, but probably aren't : ( https://t.co/K3Wzw6bmH2

https://t.co/Tma14dMqgR

Discussed in my video here https://t.co/A3W5Q4hXSu

Video. Climategate starts here: https://t.co/A3W5Q4hXSu

@davidissim @_ClimateCraze All explained in the video⬇️ https://t.co/FkZnlI4UHN

As a friend of mine pointed out, you can't understand climate if you don't understand Ellis and Palmer's hypothesis Start here: https://t.co/Ui15NA92aj

@_ClimateCraze Discussed around 1:06:00 https://t.co/NiJcJJhReG

@boneyardak An interesting question is why Northern Alaska, but not Southern Alaska was ice-free during the last ice age, despite being close to the pole Ellis and Palmer point out that wind-blown dust can explain it Explanation here: https://t.co/pLk3Km4AmF

RT @PatrickSSte: Here's my video https://t.co/MehDTWpFax

For detailed explanations of the figures, and many other important points, see my video: https://t.co/MehDTWpFax

Here's my video https://t.co/MehDTWpFax

https://t.co/uJOquM2h8K

https://t.co/7Ht4O7Vv6K

@MarkMartens42 You might be interested in my presentation of all the things that have been bothering me in the climate narrative for the last 10 years https://t.co/Idv7GrdQWI

@BjornLomborg By the way, I showed your plot of the area burned by wildfire - I had a quibble that it would be better to show the absolute areas, not the relative areas, so that we can see the percentage change for ourselves https://t.co/enFM71ZcYL

@tiinaligema @darrengrimes_ I suggest in the video it's NOT a conspiracy. It's Noble Cause Corruption, which is in some ways worse, because no one knows the truth https://t.co/TfFvCrNuZF

Orbital cycles are important in Earth's climate - they triggered ice ages! discussed in my video at ~47 minutes, where I draw something approximating to an eccentric orbit https://t.co/V0Ny0YsY9i

Explained in my video https://t.co/m4uJHZE23I

(Putting the link in a reply as I've been told we should) https://t.co/RQD2IcpmzQ

@Jordan_W_Taylor I've tried to ask some of those questions here Much of this is not well-known - very strangely https://t.co/GzvFhepPGr

@VGrubsky @Jordan_W_Taylor Victor, I've put some arguments that I don't think are well-known into my video on the climate narrative https://t.co/GzvFhepPGr

@Shakey_Ape You'd be interested in this. All comments and criticisms appreciated! https://t.co/GzvFhepPGr

@montie The debate on climate is amazingly ill-informed. Many of the most important points have been hidden by the scientific establishment and the media https://t.co/GzvFhepPGr

@gadboit What is the basic science behind the 100,000-year ice age/interglacial cycle? Bizarrely, mainstream climate science can't explain it And it ignores the only good published explanation ! https://t.co/jnaTOVd6RN

The first draft of my new video on climate change is here: https://t.co/v80sNtHcU1 Will the climate narrative collapse in the next few years? I think it may, because it's not based on sound science. Most people don't know that (1) temperatures on Earth were almost certainly https://t.co/9rH2tlgeDQ

@hamandpineappl1 @sealteamUK @erturklab @cellhostmicrobe But virtually all respiratory viruses, including SARS-CoV-2, are thermally sensitive in the lab and in animals Reviews in medical virology https://t.co/k5hRLaB7iM Letter https://t.co/gzF6UJ4AKL

@MichaelSFuhrer SARS-CoV-2 is thermally sensitive in cells and in animals: https://t.co/gzF6UJ4AKL

@GauteNilsen @KickdashGamer @aparachick @dlingenfelter @DavidJoffe64 I disagree. The virus chooses whether or not to enter cells, transcribe protein, replicate its RNA, and probably whether to package up its genetic material and leave the cell, by sensing temperature https://t.co/gzF6UJ58Aj

RT @PatrickSSte:

@DaBeaverMeister Besides why make it complicated? CoV-2 and virtually all other respiratory viruses are very clearly thermally sensitive in the lab (replicate faster at low temperatures) https://t.co/gzF6UJ4AKL

@WendyOrent @SolidEvidence @virologyanon @BBTfangirl > Have you any idea how crowded those markets are? Yes because I've been to several. The ones with live animals are also very cold and damp. This is relevant because CoV-2 is thermally sensitive, as my co-author and I pointed out https://t.co/gzF6UJ4AKL

RT @PatrickSSte: @evolving_string Anyway there is no mystery - SARS-CoV-2 is thermally sensitive, meaning it is more active at temperatures…

@ejustin46 SC2 is no exception: it shows thermal sensitivity in the wet-lab and in animals: 2/2 https://t.co/gzF6UJ4AKL

@Harvard2H Could be But not necessarily Virtually all respiratory viruses are thermally-sensitive: they replicate faster below normal body temp. Keep the host mobile - nose and throat are cooler than lungs https://t.co/k5hRLaB7iM SC2 is no exception: https://t.co/gzF6UJ4AKL

@BallouxFrancois Of course not. Second wave mainly arose from the natural winter seasonality of CoV-2 Which is thermally sensitive in the wet lab and in animals https://t.co/gzF6UJ58Aj

@mbw61567742 @MJnanostretch @DKlemitz @BiophysicsFL @Biorealism @OdysseyBohemian Most scientists seem to believe that SARS-2 infected the gut of bats However, it is somewhat seasonal and thermally sensitive in the wet lab (more active at low temperatures).⬇️ This is true of virtually all other respiratory viruses https://t.co/gzF6UJ4AKL

RT @PatrickSSte:

Fall (autumn) temperatures are dropping. Since lab studies

@JPWeiland I wonder how you deal with seasonality. Do you simply add a "fudge factor"? The key point here is almost certainly the natural thermal sensitivity of SARS-CoV-2 (replicates faster at temperatures below body temp), easily seen in the wet-lab https://t.co/gzF6UJ4AKL

@celinegounder I wonder whether, if people understood the natural thermal sensitivity of CoV2, flu, metapneumovirus etc, many of these long CoV cases could have been avoided eg avoiding chilling 10.1016/j.imj.2022.08.005 Also see my pinned post

@breakfast_dogs @VaccaRules Well you have to read our papers! For CoV-2 there are a few key papers (there may be more by now) Part of it is about entry into the cell - but there's more to it than that https://t.co/gzF6UJ58Aj

This interpretation is supported by the lack of replication of the mild CoV-NL63 at 37°C We suggest the thermal sensitivity of virtually all respiratory viruses allows them to avoid infecting the lungs - which would cause a fever, immobilise the host 3/ https://t.co/gzF6UJ4AKL

@WashburneAlex Eg 2: (my own work) why do we get more colds in winter? Letter https://t.co/gzF6UJ4AKL Reviews in medical virology https://t.co/k5hRLaB7iM 3/

@ErikMagnethi @KanekoaTheGreat All you can really say is all respiratory viruses (but not other viruses) have winter seasonality There's a good explanation Letter https://t.co/gzF6UJ4AKL Reviews in medical virology https://t.co/k5hRLaB7iM

@KanekoaTheGreat CoV-2, like virtually all respiratory viruses (leaving aside lab strains of flu etc) is thermally sensitive https://t.co/gzF6UJ4AKL

@royalsociety @john_jxw @LinneanSociety Especially as it turned out I was right - about CoV-2 as well as all the others https://t.co/gzF6UJ4AKL

@Johnincarlisle @YouTube See our papers eg https://t.co/k5hRLaB7iM https://t.co/gzF6UJ4AKL or my pinned tweet

@ukhadds @kparve @0bj3ctivity @SuebeeTexan @SolidEvidence @RadCentrism @notkent @MarvinH2_G2 @kallmemeg > a change in outdoor temperature Yes! > resulting in shifts in population behavior, including reduced ventilation .. more people being inside Why do you say that? It’s too slow Don’t you accept biochem thermal sensitivity shown by these studies⬇️ 5/ https://t.co/gzF6UJ4AKL

@SFatumo I think our letter is also important - but ignored https://t.co/gzF6UJ58Aj

RT @PatrickSSte: Around this time of year, everyone starts to worry about whether Covid is seasonal, and whether we'll see a surge of cases…

@Saffiya_Khan1 @UKHSA Lettter in Infectious Medicine https://t.co/gzF6UJ4AKL

Around this time of year, everyone starts to worry about whether Covid is seasonal, and whether we'll see a surge of cases in the autumn Why do scientists ignore the simple answer that becomes obvious when you look closely at the biochemistry of CoV-2? https://t.co/gzF6UJ4AKL https://t.co/OGyXfLLON7

@brownecfm It would help the rational management of CoV a lot if the authorities understood seasonality at a fundamental level https://t.co/gzF6UJ4AKL

@SGriffin_Lab Well, how can we possibly do that unless we understand the causes of the winter seasonality of respiratory viruses in general? Is SARS-CoV-2 seasonal? Several lines of evidence from the wet-lab show it almost certainly is https://t.co/gzF6UJ4AKL https://t.co/8toddBGj95

@john_actuary Well, the weather has been cold https://t.co/gzF6UJ4AKL https://t.co/J5NNBpMtMc

@chrischirp @NicolaKSDavis Well, I guess the first thing to do is figure out whether Covid has winter seasonality Spoiler: it almost certainly does because CoV-2 is thermally-sensitive in the wet-lab https://t.co/gzF6UJ4AKL https://t.co/yP9EGjdabp

@Ray_J__ Our letter: https://t.co/gzF6UJ4AKL

@kallmemeg @TWenseleers @ArisKatzourakis @PaulLomax @RemindMe_OfThis OK trying again - my previous (now deleted) message was ignored CV-2 will almost certainly evolve reduced virulence, & be like virtually all other respiratory viruses - mild How do we know that? Because, like the others, it has thermal sensitivity https://t.co/gzF6UJ4AKL ⬇️ 1/ https://t.co/EXz1ghPBC3

@SolidEvidence @0bj3ctivity @RadCentrism @notkent @MarvinH2_G2 @kallmemeg ". . . SARS-CoV-2 coronavirus . . . recent research indicates that this virus does have some temperature sensitivity that may influence its transmission according to environmental temperature" He's right there https://t.co/gzF6UJ4AKL

@MarvinH2_G2 @ArisKatzourakis @kallmemeg @PaulLomax @RemindMe_OfThis It probably doesn't care much about seasonal behavior But it might well care about the best temperature to replicate at if it wants to spread to new hosts https://t.co/gzF6UJ4AKL https://t.co/KCtbWwqwyb

@0bj3ctivity @SolidEvidence @RadCentrism @notkent For a start both @MarvinH2_G2 & @kallmemeg think seasonality is driven by changes in behavior It almost certainly isn't It's a simple observation that CV2 like almost all other respiratory viruses is thermally sensitive in wetlab More active at low temp https://t.co/gzF6UJ4AKL https://t.co/S0hyyoTExQ

@SolidEvidence @RadCentrism @notkent As I mentioned to you before, several studies have shown CoV-2 is thermally sensitive in the lab - more active at low temperatures https://t.co/gzF6UJ4AKL Since it's hot now, we expect the virus to be less active When temperature dips in fall we can expect cases to go up 1/

@mvankerkhove Agreed, Cov-19 hasn't gone away For one thing, CoV2 is thermally sensitive - which is easily seen in the wet-lab: https://t.co/gzF6UJ4AKL THermal sensitivity helps it to stay in the nose and throat - & is the simplest explanation for why we can expect it to come back in fall https://t.co/qNH0ZvqxFT

@ukhadds @DrRussellBrown @DrJBhattacharya Ahh. I understand - aerosol scientist Yes 33C is a good temperature to look at - although we believe that there are differences between strains, depending on what climate/season they have adapted to Did you see this: https://t.co/gzF6UJ4AKL https://t.co/jdEpPcXEsj

@mdc_martinus @ukhadds @DrRussellBrown @DrJBhattacharya Our review: https://t.co/k5hRLaB7iM SARS-CoV-2 is thermally sensitive in the wet-lab https://t.co/gzF6UJ4AKL

RT @PatrickSSte:

This thermal-sensitivity can be clearly seen in the wet-lab for both SARS-CoV-2 https://t.co/gzF6UJ4AKL . . . and for the other respiratory viruses https://t.co/k5hRLaB7iM Is there something we don't understand?

RT @PatrickSSte:

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@msabouri Refs for low temp activation: Letter to Infectious Medicine https://t.co/gzF6UJ4AKL Reviews in medical virology https://t.co/k5hRLaB7iM

@CarstensenPovl @JuliaLBach8 No, but lab expriments may https://t.co/gzF6UJ4AKL https://t.co/VfV4k1Y2vm

Increased bile acid production may protect against respiratory illness - I have no idea if this is really important Seems overly complex, however, since we know many or most respiratory viruses are themselves thermally sensitive https://t.co/gzF6UJ4AKL https://t.co/k5hRLaB7iM https://t.co/DuuDcfUnQ6

RT @PatrickSSte:

What is very dissappointing and frustrating is that the two papers that @JuliaLBach8 and I published, and the other one I published, have been ignored : ( Reviews in medical virology https://t.co/k5hRLaB7iM 2016 review https://t.co/nb1RobC2qi Letter https://t.co/gzF6UJ4AKL 3/

@GordonDomini @EWoodhouse7 @ClareCraigPath @EphemeralEther @USMortality @ProfessorAkston @JuliaLBach8 CoV-2 is thermally-sensitive in the lab and in animals https://t.co/gzF6UJ4AKL 5/

@rieser_mathsci I wouldn't use a SIR model for a respiratory illness anyway because there are so many asymptomatic carriers, who can become sick, particularly if they are chilled We wrote about this⬇️ Letter https://t.co/gzF6UJ4AKL Reviews in Medical Virology https://t.co/k5hRLaB7iM

@michaelzlin Thank you for pointing out the gate-keeping issue (I had thought it was more like scientific snobbery) I wonder if it's possible to displace wrong understanding anymore 2 egs: https://t.co/gzF6UJ4AKL https://t.co/KGyqtdRDaL (As it happens, both by me + coauthor)

@Robber_Baron_ Aug 2022 https://t.co/16tTICVKnY

@harishseshadri2 @michaelzlin @AntGDuarte People such as @ydeigin say if you add a furin site to a SARS-related CoV it becomes respiratory (not gut-based) Could it be S-2 was a bat CoV that had jumped to the respiratory route? Why else was it thermally-sensitive and seasonal right from the start?https://t.co/gzF6UJ4AKL

@ydeigin @WendyOrent @stevenemassey Aren't BANAL viruses supposed to replicate in the gut? They might evolve very quickly if they became respiratory even with an FCS Although I've never believed the progenitor of CoV2 was 100% gut-based because CoV2 was seasonal from its first appearance https://t.co/gzF6UJ4AKL

@EWoodhouse7 @Alsadius @JeremyTColes @jen_pic @slikrik2003 @ClareCraigPath Additional letter addressing updates to COVID https://t.co/16tTICVKnY

@SolidEvidence @VBruttel @jn44014998 Which seemed to be what virtually all virologists beleived, at least at the start of the pandemic I don't beleive that. As I tried to persuade you a few months ago IMO resp viruses want to replicate, but keep you moving around https://t.co/k5hRLaB7iM https://t.co/gzF6UJ4AKL

@DrLiMengYAN1 Interestingly, CoV-2 is thermally-sensitive in golden hamsters - as it is in the wet-lab https://t.co/gzF6UJ4AKL https://t.co/X3rCVAwnkX

@Marc_Veld @sfedelelondon There's always mutational space for that It may involve RNA secondary structure Or subtle things like RNA/protein-driven liquid-liquid phase separation - eg the paper mentioned in our letter by Iserman et al https://t.co/gzF6UJ4AKL

@Marc_Veld @sfedelelondon I'm not actually following your argument Doesn't going to the lungs make a virus more pathogenic? Isn't that what you would call tropism (driven in this case by thermal sensitivity)? https://t.co/gzF6UJ4AKL

@MojoRose1 @jamesamcgee @DancingBlue_Sky @Balgor11 @thereal_truther @TheDrJon @AJKayWriter @EWoodhouse7 @tanteOMI @ProfessorAkston @Lucy26398575 https://t.co/16tTICVKnY

@ProfessorAkston @JuliaLBach8 @EWoodhouse7 @AJKayWriter @ALittleTweet @Lucy26398575 Reviews in medical virology https://t.co/k5hRLaB7iM Recent letter https://t.co/gzF6UJ4AKL https://t.co/tMsPLbyLhU

@EvolveDotZoo BTW temperature dependent viral tropism seems to be pretty much proven - SARS-CoV-2 (as well as flu etc) is indeed thermally-sensitive in the wet-lab and in animals https://t.co/gzF6UJ4AKL

@Daoyu15 @emilyakopp CoV-2 is thermally-sensitive - it replicates faster below the normal body temperature of its host. The nose and throat are some of the coldest parts of the body. This thermal sensitivity can be seen in the wet-lab and in animals - see our letter: cont/ https://t.co/gzF6UJ58Aj

@ScottAdamsSays @Syrah_Shiraz @ElijahSchaffer @elonmusk I suspect long Covid occurs when the virus goes downwards (to lungs) or inwards (to sinus etc) Almost certainly driven by temperature in Covid & almost all respiratory viruses When I had Covid a couple of times I was very careful to keep constantly warm: https://t.co/gzF6UJ4AKL

@ColinDavdButler @JeremyFarrar One reason I’m convinced most respiratory viruses are in fact “trying” NOT to make us sick (metaphorically speaking) is almost all are/seem to be thermally-sensitive. CoV-2 is clearly thermally-sensitive in the lab/ in animals – see our review & letter: https://t.co/gzF6UJ58Aj 6/

@carlheneghan And did you know that (wild) influenza virus is thermally-sensitive in the lab? Just like SARS-CoV-2 https://t.co/gzF6UJ4AKL

@evolving_string Anyway there is no mystery - SARS-CoV-2 is thermally sensitive, meaning it is more active at temperatures below normal body temperature in the lab and in animals https://t.co/gzF6UJ4AKL The same is true of (wild-type) influenza

@BiophysicsFL @vuzyfi Sorry to be annoying, I've deleted & reworded the question Why doesn't eg MERS-CoV have a furin site? Besides IMO its likely the progenitor of CoV-2 in bats was respiratory, because CoV-2 is seasonal & THERMALLY-SENSITIVE in the lab CoV-2 is in sewage https://t.co/gzF6UJ58Aj

@maxdkozlov @Nature @russellfunk @dashunwang @yian_yin Our disruptive science has been completely ignored: https://t.co/gzF6UJ4AKL Previously rejected by all the Nature titles that publish short letters. Even if it's not right (it seems to be!) this needs be investigated So why didn't the editors send it for review?

@EricRWeinstein Nature consistently turned down *this* disruptive hypothesis https://t.co/gzF6UJ58Aj

@VigilantFox @stkirsch Another simple thing that might be very effective is just keeping warm. CV2 is thermally-sensitive - more active at the low temperatures of your nose & throat than at the higher temperatures of the lungs/sinuses etc (CV2 probably "wants" us to stay mobile) https://t.co/gzF6UJ58Aj

4⃣My co-author @JuliaLBach8 and I also point out that recent wet-lab and animal studies show that SARS-CoV-2 really is thermally-sensitive – meaning it replicates faster BELOW normal body temperature – ie at the temperature of the nose and throat https://t.co/gzF6UJ4AKL https://t.co/5aQF6veBuX

@WHO @DrTedros .@DrTedros a very important point may for individuals to avoid chilling - especially as sickness develops We now know SARS-CoV-2 is thermally-sensitive (in the wet-lab & in animals). Chilling may increase the chance of infecting lower airways, sinuses etc https://t.co/gzF6UIMZmb

@robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis IndiSAGE @robertson_lab @SGriffin_Lab @ArisKatzourakis & @stuartjdneil did you see that CoV-2 is thermally-sensitive - more active below normal body temperature, in both wet-lab & animals Aris, I know you've followed this - you may not've seen our letter https://t.co/gzF6UIMZmb

@breakfast_dogs @BiophysicsFL I haven't followed this whole conversation but I have to say that the probable reason why both MERS and CoV-2 establish a foothold in the upper respiratory tract is that they are both thermally-sensitive, while CoV-1 is not https://t.co/gzF6UJ4AKL

RT @PatrickSSte:

RT @PatrickSSte:

@_thelandfill_ Joseph of course I enjoyed yr article about scientists being taken seriously I think I've applied most of yr suggestions though I could probably think more about expts that would falsify my theory But I don't know how to gain traction⬇️ https://t.co/gzF6UJ58Aj https://t.co/zk20XB7mYN

Firstly, it’s clear that (wild as opposed to lab-bred) SARS-CoV-2 and virtually all other respiratory viruses are demonstrably thermally-sensitive: they're more active in the wet-lab and in animals at temperatures a few degrees below normal body temp⬇️ https://t.co/gzF6UJ4AKL 3/ https://t.co/4A7fkd4mTq

(I'd have been much more interested in 33°C!) https://t.co/gzF6UIMZmb

.@mlipsitch did you see our hypothesis called temperature dependent viral tropism #tdvt Could it be an antidote to Popperian purgatory? https://t.co/gzF6UJ58Aj

.@citlanx what do you think of the temperature dependent viral tropism #tdvt hypothesis? Since CoV-2 and other respiratory viruses are thermally-sensitive in the wet-lab & in animals, it must be a plausible explanation of winter seasonality. Mustn't it? https://t.co/gzF6UJ58Aj

@citlanx @mahmudme01 @linseymarr Mr. E, if you have a moment, have a quick look at our review and letter: https://t.co/k5hRLaB7iM https://t.co/gzF6UJ4AKL Our hypothesis is very simple – and it’s what our grandparents would have recognised: put on your coat, hat and gloves in cold weather 1/

@jankulveit We now know that CoV-2 is thermally-sensitive in the wet-lab and in animals The latest study to show this is the preprint by S Weiss' group https://t.co/KyFvO7bChG At least 8 other studies have shown this 2/ https://t.co/gzF6UJ58Aj

We know now CoV-2 is thermally sensitive in the wet-lab and in animals⬇️ It's been suggested that this can allow the virus to stay in the nose & throat – & avoid the warmer lungs etc – so that it can keep its host mobile and be transmitted to new hosts 4/ https://t.co/gzF6UJ4AKL

RT @PatrickSSte: @EricTopol We also found out recently that CoV-2 is clearly thermally-sensitive in the wet-lab and in animals⬇️ So Covid-…

We also found out recently that CoV-2 is clearly thermally-sensitive in the wet-lab and in animals⬇️ So Covid-19 may instead be exacerbated by personal chilling, which increases the activity of respiratory viruses 3/ https://t.co/gzF6UJ4AKL

@EricTopol We also found out recently that CoV-2 is clearly thermally-sensitive in the wet-lab and in animals⬇️ So Covid-19 may instead be exacerbated by personal chilling which increases the activity of viruses 2/ https://t.co/gzF6UJ4AKL

@MichaelSFuhrer @BristOliver Can I suggest that one very important component is missing from simple models (and most complex ones) namely a harvesting effect based on the natural thermal sensitivity of SARS-CoV-2 https://t.co/LhuWh5C52T

@lisa_iannattone I worry about folks in the UK who will turn down the thermostat down this winter bc of high fuel prices, given the effects of being cold on viral dynamics: ❄️

İnsan vucudu için ateş en büyük koruyucu silahlardan biridir.✅ Vucudun bağışıklık sisteminin çalıştığının baş göstergelerindendir.✅ Ateşiniz birazcık çıktı diye , avuç avuç ilaç yutmaya başlamayınız.

Here is the latest version of our letter about the natural thermal sensitivity of SARS-CoV-2, with corrected wording⬇️ (Somehow some text was deleted from the first paragraph of the previous version) https://t.co/N2SyLdkohh