Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy.
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Aug 2023 – Apr 2025Where it's discussed
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AI synopsis
What people are saying
Several discussions highlight the efficacy of acoramidis, with phrases like 'exciting news' and 'triumphs in treating ATTR amyloidosis' emphasizing the positive tone around its approval. Comments about expanding treatment options and references to competition with existing therapies, like tafamidis, illustrate a deep engagement with the topic. The choice of enthusiastic language and an optimistic context contribute to a strong sense of community support for the potential advancements in treating transthyretin amyloid cardiomyopathy.
The majority of discussions showcase support for the findings related to acoramidis, indicating a general consensus on its effectiveness.
Many participants express high levels of curiosity about acoramidis and its implications for treatment, reflecting significant relevance.
While some posts delve into technical details about the trial and methodology, others offer general excitement about the drug's approval.
The conversations reveal a strong belief that the findings will have a significant effect on treatment options for the condition.
Abstract in brief
- Transthyretin amyloid cardiomyopathy involves the buildup of misfolded proteins in the heart, and acoramidis is a medication designed to stabilize these proteins, showing over 90% effectiveness in laboratory tests.
- In a phase 3 trial, 632 patients were randomly assigned to receive either acoramidis or a placebo for 30 months, evaluating outcomes like death rates, hospitalizations, and specific health indicators.
- The results demonstrated that acoramidis significantly outperformed the placebo in multiple health measures, with a high win ratio favoring acoramidis, while the frequency of side effects was similar in both groups.
Top posts
Most liked on X and BlueskyATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly better four-step primary hierarchical outcome containing components of mortality, morbidity, and function than placebo. https://t.co/0HOZBB9c91
Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not give the actual numbers of events? Benefit mostly driven by biomarkers -- no diff in death They don’t tell us total hospitalizations. What
2. Acoramidis, which stops misfolded transthyretin protein from being deposited as amyloid fibrils in the heart, in patients with transthyretin amyloid cardiomyopathy It was approved on the basis of this phase 3 trial https://t.co/8jpFozftn4 https://t.co/5HnUnNwP0t
Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options for our ATTR patients! Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | NEJM https://t.co/mmohITGBmQ
Exciting news from @US_FDA as we have a new drug approved for #Amyloidosis. Excited for more choices for our patients @Amyloidosis_ARC @BridgeBioPharma https://t.co/FUDmo5CxOb Original data from ATTRIBUTE-CM @NEJM https://t.co/QWnSrhmVeg
All mentions
Efficacy of Acoramidis in Transthyretin Amyloid Cardiomyopathy
Efficacy of Acoramidis in Transthyretin Amyloid Cardiomyopathy
This video discusses a step towards a cure for transthyretin amyloid cardiomyopathy with acoramidis, which stabilizes misfolded proteins in the heart. In a phase 3 trial, acoramidis significantly improved health…
RT @MasriAhmadMD: Recap on ATTRibute-CM (acoramidis vs placebo in ATTR-CM) and selected subsequent analyses https://t.co/z86XZVrs01 #card…
Recap on ATTRibute-CM (acoramidis vs placebo in ATTR-CM) and selected subsequent analyses https://t.co/z86XZVrs01 #cardiotwitter
ちなみにATTRibute-CM試験はNEJMに発表されていますが、primary endpointがいくつかの項目からなるHierarchical endpointだったこともあり、今回の解析が行われています。 https://t.co/p9VLolBdIm
1. https://t.co/cPgNPcAHw4 2. https://t.co/zyZSTJLixN 3. https://t.co/mouYm7Rz3E 4. https://t.co/6QvXhBvEPp 5. https://t.co/DjmSDlzazE 6. https://t.co/AwbRdVjVYy 7. https://t.co/D1gzJbxE5u
RT @SamuelBHume: 2. Acoramidis, which stops misfolded transthyretin protein from being deposited as amyloid fibrils in the heart, in patien…
RT @SamuelBHume: 2. Acoramidis, which stops misfolded transthyretin protein from being deposited as amyloid fibrils in the heart, in patien…
2. Acoramidis, which stops misfolded transthyretin protein from being deposited as amyloid fibrils in the heart, in patients with transthyretin amyloid cardiomyopathy It was approved on the basis of this phase 3 trial https://t.co/8jpFozftn4 https://t.co/5HnUnNwP0t
RT @YevgeniyBr: Exciting news from @US_FDA as we have a new drug approved for #Amyloidosis. Excited for more choices for our patients @Amy…
RT @YevgeniyBr: Exciting news from @US_FDA as we have a new drug approved for #Amyloidosis. Excited for more choices for our patients @Amy…
Exciting news from @US_FDA as we have a new drug approved for #Amyloidosis. Excited for more choices for our patients @Amyloidosis_ARC @BridgeBioPharma https://t.co/FUDmo5CxOb Original data from ATTRIBUTE-CM @NEJM https://t.co/QWnSrhmVeg
Open Access UCL Research: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy https://t.co/KweUEg5dce
RT @Ed_Alania:
Acoramidis トランスサイレチン安定化薬 https://t.co/v0P6dhVY0R https://t.co/JQBEO6efG1 https://t.co/yVzFC8dMtK https://t.co/pJ3blSoyOX
O Grupo de Estudo de Doenças do Miocárdio e Pericárdio destaca, no artigo do mês, o estudo “Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy”. Este ensaio explora o tratamento com acoramidis, um estabilizador de TTR que demonstrou resultados clínicos https://t.co/LcNXYBNdMw
RT @Nikhil15: Newest #ACC Teaching Points on the efficacy of Acoramdis in ATTR Cardiac Amyloidosis (ATTribute-CM Trial) Link to paper: htt…
RT @Nikhil15: Newest #ACC Teaching Points on the efficacy of Acoramdis in ATTR Cardiac Amyloidosis (ATTribute-CM Trial) Link to paper: htt…
RT @Nikhil15: Newest #ACC Teaching Points on the efficacy of Acoramdis in ATTR Cardiac Amyloidosis (ATTribute-CM Trial) Link to paper: htt…
Newest #ACC Teaching Points on the efficacy of Acoramdis in ATTR Cardiac Amyloidosis (ATTribute-CM Trial) Link to paper: https://t.co/0M5HfCakYR Link to our clinical trial summary: https://t.co/vq5r7YmLec @amgbonaguro #ACCFIT @ACMCIMRes @cardiologyacmc https://t.co/6HaTBPyH9z https://t.co/C4tg7Uc8jD
RT @MondaEmanuele: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM https://t.co/tC4VSSQ5L3 https://t.co/…
RT @MondaEmanuele: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM https://t.co/tC4VSSQ5L3 https://t.co/…
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM https://t.co/tC4VSSQ5L3 https://t.co/Kfh5XhD5pt
RT @Ed_Alania:
RT @accpcardprn: Does tafamidis have some competition in ATTR cardiomyopathy management?
Does tafamidis have some competition in ATTR cardiomyopathy management?
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | PracticeUpdate https://t.co/CAGWno2b35
RT @GiuseppeGalati_:
RT @GiuseppeGalati_:
RT @GiuseppeGalati_:
RT @GiuseppeGalati_:
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | NEJM https://t.co/d2rioPsLbT
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
Trending on PubMed: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy. https://t.co/3tIaqmtU5Q
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
RT @NEJM: ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly…
ATTRibute-CM trial: In patients with transthyretin amyloid cardiomyopathy, the receipt of acoramidis resulted in a significantly better four-step primary hierarchical outcome containing components of mortality, morbidity, and function than placebo. https://t.co/0HOZBB9c91
RT @NEJM: In patients with transthyretin amyloid cardiomyopathy, the TTR stabilizer acoramidis resulted in a better primary hierarchical ou…
RT @Ed_Alania:
RT @NEJM: Original Article: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM trial) https://t.co/0HO…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @Ed_Alania:
RT @Ed_Alania:
RT @NEJM: Original Article: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM trial) https://t.co/0HO…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @NEJM: Original Article: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM trial) https://t.co/0HO…
Original Article: Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM trial) https://t.co/0HOZBB9JYz #Cardiology https://t.co/OKp8ZIfxtZ
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
#clinicalcardiology "Win Ratios" are tough.. but this looks like we will have another drug in our armamentarium for TTR-Amyloid! Assuming we will never have a head to head trial (Tafamadis vs. Acoramids)? @NEJM https://t.co/M6mf0ETD8e https://t.co/e9dJ3g5JDL
RT @Ed_Alania:
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @RyanTedfordMD: A huge congratulations to the investigators & my @MUSChealth colleague #DanJudge for his leadership of this study! @MUS…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @BU_Amyloidosis: Exciting news: Acoramidis triumphs in treating ATTR amyloidosis. It brings hope to those affected. Together, we are mak…
RT @Ed_Alania:
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy acoramidis resulted in a significantly better four-step primary hierarchical outcome https://t.co/Kaeq12oFX2
RT @SumeetMitter: ATTRibute-CM now out in NEJM. Was an honor to be a site PI @MountSinaiHeart early in my career. Excited to enhance acce…
RT @Ed_Alania:
RT @Ed_Alania:
RT @Ed_Alania:
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @chriskairis1: Transthyretin amyloid cardiomyopathy. Finally TTR stabilizer is the only evidence-based therapy, which have been shown t…
RT @Ed_Alania:
@kalashnikity @TDBSubstack @BaffledDoctors @CumberpatchM @Evermoredetroit @RealGeorgeWebb1 @CoyoteSanctuary @kmidjr68 @julie74439076 @LaserFocus2000 @amy_mcdavis @hippydippygirl @53v3n0fn1n3 @SaltyDi @w_s_gosset @HousatonicLive @RWMaloneMD Maybe some movement on the de-Fibril-lation front, at least for Transthyretin amyloidosis (ATTR-CM) https://t.co/tJ8vxHrDj5 https://t.co/ygcGcxIWjS
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @RyanTedfordMD: A huge congratulations to the investigators & my @MUSChealth colleague #DanJudge for his leadership of this study! @MUS…
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @Drjhoffmanmiami: Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options…
Exciting news: Acoramidis triumphs in treating ATTR amyloidosis. It brings hope to those affected. Together, we are making a positive impact on lives. #breakthrough #amyloidosis #innovation https://t.co/ODUTRWeN61
RT @KeyurBShahRIC: Very excited to have been part of this effort to expand treatment options for cardiac amyloidosis @VCUHealth @VCUHealthH…
RT @Ed_Alania:
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | NEJM https://t.co/qeppypOw3f
RT @Ed_Alania:
RT @Ed_Alania:
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @Ed_Alania:
RT @drjohnm: Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not…
RT @Ed_Alania:
RT @Ed_Alania:
RT @KeyurBShahRIC: Very excited to have been part of this effort to expand treatment options for cardiac amyloidosis @VCUHealth @VCUHealthH…
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
https://t.co/qRk16KK399
RT @Ed_Alania:
RT @Ed_Alania:
Congratulations to our PD #DanJudge on his incredible work as the international co-PI for this study!
RT @Ed_Alania: https://t.co/iSHX7pgKf3
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @ZHeart11768530: Efficacy & Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM In pts with transthyretin amyloid CMP, TT…
RT @KeyurBShahRIC: Very excited to have been part of this effort to expand treatment options for cardiac amyloidosis @VCUHealth @VCUHealthH…
RT @Drjhoffmanmiami: Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options…
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @Drjhoffmanmiami: Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options…
RT @ZHeart11768530: Efficacy & Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM In pts with transthyretin amyloid CMP, TT…
Efficacy & Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM In pts with transthyretin amyloid CMP, TTR stabilizer acoramidis resulted in a better primary hierarchical outcome (including mortality, morbidity, and function) than placebo: https://t.co/VwIbKxawJD https://t.co/ObsM4iHR3O
RT @RyanTedfordMD: A huge congratulations to the investigators & my @MUSChealth colleague #DanJudge for his leadership of this study! @MUS…
RT @Ed_Alania:
RT @SumeetMitter: ATTRibute-CM now out in NEJM. Was an honor to be a site PI @MountSinaiHeart early in my career. Excited to enhance acce…
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @KeyurBShahRIC: Very excited to have been part of this effort to expand treatment options for cardiac amyloidosis @VCUHealth @VCUHealthH…
RT @Drjhoffmanmiami: Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options…
https://t.co/jaM7tDbdDe
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | NEJM https://t.co/zJSq1KjxTO
Difficult to analyze ATTRibute-CM https://t.co/6PShLjoHDW Multiple changing endpoints. Hmm. Win-ratio is fine, but why not give the actual numbers of events? Benefit mostly driven by biomarkers -- no diff in death They don’t tell us total hospitalizations. What
RT @Ed_Alania: https://t.co/iSHX7pgKf3
RT @Ed_Alania:
RT @Ed_Alania:
https://t.co/tQL9I9PiYO
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @Ed_Alania:
RT @Ed_Alania:
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
Datos positivos $BBIO resultados de Fase3 en NEJM. Acormidis frente a placebo mejoras: muertes, cambios en NT-proBNP, transtiretina. https://t.co/SGdhN3VWU1
$BBIO positive Phase3 results published in NEJM. Acoramidis better than placebo highlihts: death, change in NT-proBNP, serum transthyretin. https://t.co/SGdhN3VWU1
RT @Ed_Alania:
Transthyretin amyloid cardiomyopathy. Finally TTR stabilizer is the only evidence-based therapy, which have been shown to be efficacious in clinical practice without severe adverse events. @MasriAhmadMD @Amyloidosis_ARC @amyloid_papers @ISA_Amyloidosis https://t.co/cSvFNggZjo
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @MasriAhmadMD: ATTRibute-CM paper is out in @NEJM Acoramidis vs placebo in #ATTR cardiomyopathy https://t.co/ikvFC9NK0w #CatdioTwitt…
RT @Ed_Alania:
RT @Ed_Alania:
RT @Drjhoffmanmiami: Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options…
$BBIO Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy @NEJM https://t.co/Y9gPQZ47s4
RT @Drjhoffmanmiami: Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options…
Proud to be a part of this study @SylvesterCancer - we need some competition in the TTR stabilizer space… more options for our ATTR patients! Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | NEJM https://t.co/mmohITGBmQ
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy | NEJM https://t.co/ZUzXrvQMky
$BBIO Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy Results of the ATTRibute-CM Trial @escardio Slides: https://t.co/QLJ93HIXjQ https://t.co/849WtPAMFn