Overall, discussions demonstrate a keen interest in how the RAAS influences health conditions such as hypertension, COVID-19, and aging, using detailed terminology and emphasizing the system's role in disease modulation, which underscores their recognition of its broad medical importance.
AgreementModerate agreement
Most posts recognize the central importance of the RAAS in blood pressure, cardiovascular health, and disease, showing general agreement on its significance.
InterestHigh interest
Posts display high curiosity and focus, discussing mechanisms, therapeutic implications, and links to conditions like COVID-19, indicating strong interest.
EngagementModerate engagement
Several posts delve into detailed pathways, medication effects, and systemic interactions, reflecting active and thoughtful engagement.
ImpactModerate impact
The discussions highlight the potential for understanding and targeting RAAS to improve health outcomes, suggesting a moderate to significant impact on medical understanding and treatment strategies.
Abstract in brief
The review explains the renin-angiotensin-aldosterone system (RAAS), including how it works through a protein cascade, how it's regulated by feedback mechanisms, and its main functions.
The RAAS primarily influences blood pressure by controlling blood volume and the tone of blood vessels.
The discussion highlights the importance of RAAS in maintaining blood pressure and overall cardiovascular health.]
Reminder that lowering your salt intake may lower your blood pressure a few points, but adequate salt intake is important for keeping the renin-angiotensin-aldosterone system suppressed. https://t.co/xArg96bfT4
Oct 11, 2025 · 114 likes · 5 shares · 12,882 followersView post →
RW
Ralf Wittenbrink
@ralfwittenbrink.bsky.social · Bluesky
Durch die Aufklärung der zugrunde liegenden Mechanismen, die die Zelltransformation vorantreiben, wird das Potenzial von SARS-CoV-2 als Onkovirus hervorgehoben. Das Verständnis dieser Wechselwirkungen ist von entscheidender Bedeutung, um unser Verständnis von COVID-19 und der
*The Renin Angiotensin Aldosterone System. Covid disrupts it by interfering with ACE2, which throws off aldosterone balance. When aldosterone drops, potassium handling becomes unstable. Too much when the kidneys cannot excrete it, too little when the system overcorrects.
Nov 15, 2025 · 55 likes · 4 shares · 82,441 followersView post →
VV
Vipin M. Vashishtha
@vipintukur · X
The activation of NLRP3 inflammasomes by the N protein of SARS-CoV-2 and the dysregulation of the Renin–Angiotensin–Aldosterone System (RAAS). The activation of NLRP3 led to the cancer-causing hallmarks.
Oct 6, 2025 · 52 likes · 6 shares · 19,500 followersView post →
The complex process of Potassium Regulation in the body, primarily involving the kidneys and the Renin-Angiotensin-Aldosterone System (RAAS).
https://t.co/wtBYFbxJgr https://t.co/eblFoAOHy3
Oct 2, 2025 · 36 likes · 6 shares · 25,013 followersView post →
This video explains the renin-angiotensin-aldosterone system (RAAS), its functions, regulation, and role in maintaining blood pressure and cardiovascular health, using a protein cascade and feedback mechanisms.
This video explains the mechanisms of antihypertensive drugs including Renin Inhibitors, ACE Inhibitors, ARBs, and Mineralocorticoid Receptor Antagonists, focusing on their role in blood pressure control and…
RT @jbarthrules: Can you gain weight from topical Minoxidil 2%?
Surprisingly, yes, but it’s extremely rare.
Here’s how it happens:
Minoxid…
Dec 9, 2025 · 1 share · 1,321 followersView post →
S
SB
@sbABetterLeader · X
@BagaiDr RAAS.
The Renin Angiotensin Aldosterone System is the most important pathway in all of our vasculature. (Hint: Our vasculature is quite amazing and quite important.)
RAAS, which is controlled by ACE2, is vital to every blood vessel in our body.
Don't fuck with ACE2.
Can you gain weight from topical Minoxidil 2%?
Surprisingly, yes, but it’s extremely rare.
Here’s how it happens:
Minoxidil is a vasodilator.
If too much gets absorbed into the bloodstream, it can trigger the renin–angiotensin–aldosterone system (RAAS).
This leads to sodium + https://t.co/VVkpypQ53X
Dec 5, 2025 · 1 like · 1 share · 1,321 followersView post →
CP
Catalina Pogany
@pogany54 · X
RT @daoo100: @Doctors_GUILD Drugs that target the renin-angiotensin-aldosterone system (RAAS), specifically Angiotensin-Converting Enzyme (…
@Doctors_GUILD Drugs that target the renin-angiotensin-aldosterone system (RAAS), specifically Angiotensin-Converting Enzyme (ACE) inhibitors and Angiotensin II Receptor Blockers (ARBs), are considered most effective at promoting left ventricular hypertrophy (LVH) regression and heart
Dec 1, 2025 · 11 likes · 2 shares · 1,951 followersView post →
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SB
@sbABetterLeader · X
@fillthewhole @Saffiya_Khan1 The Renin Angiotensin Aldosterone System (RAAS) controls all blood vessels and all bleeding.
Including during pregnancy and menstruation (with some other steroid hormones).
The entire RAAS pathway is controlled by ACE2.
Yup, THAT ACE2. Fuck with ACE2 and people die.
Nov 26, 2025 · 1 like · 2,434 followersView post →
DR
Dr.Renée Rossi
@DrReneeRossi · X
RT @Ped_Neph: The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss pr…
Nov 26, 2025 · 4 shares · 223 followersView post →
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drjosflynn
@drjosflynn · X
RT @Ped_Neph: The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss pr…
Nov 26, 2025 · 4 shares · 8,116 followersView post →
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TRAstonDrs
@castltrastondrs.bsky.social · Bluesky
Infection of adipose tissue triggers immune activation, including infiltration by NK cells, macrophages,T cells, induces an interferon response . Chronic activation of the renin-angiotensin-aldosterone system (RAAS) in obesity further contributes to high ACE2 expression & reduced antiviral immunity
@Ped_Neph @drjosflynn The absence of the renin-angiotensin-aldosterone system in children with bilateral kidney loss is indeed a critical factor in the regulation of blood pressure. How do you think emerging therapies might address this gap in hormone regulation to stabilize blood pressure in such
RT @Ped_Neph: The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss pr…
Nov 25, 2025 · 4 shares · 779 followersView post →
IN
IPNA Pediatric Nephrology
@ped-neph.bsky.social · Bluesky
The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss predisposes them to hypotension. Read this Original Article on prolonged hypotension in children w/bilateral kidney absence.
link.springer.com/article/10.1...
The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss predisposes them to hypotension. Read this Original Article on prolonged hypotension in children w/bilateral kidney absence.
https://t.co/O1fVxJeZgJ https://t.co/WpAjihLgyy
Nov 25, 2025 · 14 likes · 4 shares · 6,593 followersView post →
RC
Radcliffe Cardiology
@radcliffeCARDIO · X
Dr Pardeep Jhund explains that in heart failure, the renin-angiotensin-aldosterone system (RAAS) remains active even when treatments block angiotensin II. This means aldosterone can still be produced, which may lead to fluid retention and heart damage.
@RenNotFun @eyuplovely @iqbalmohamedMP You want me to show you what, exactly?
That troons have massive medical issues, or that these are directly associated with the interaction between testosterone, estrogen and the renin-angiotensin-aldosterone system of fluid volume management?
Nov 22, 2025 · 5 shares · 612 followersView post →
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Glory
@oluwadarasimi_g · X
RT @KrimeeraPharma: @simplify_drugs
Nov 22, 2025 · 5 shares · 336 followersView post →
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Naz
@Poeticmedic1 · X
RT @KrimeeraPharma: @simplify_drugs
Nov 22, 2025 · 5 shares · 3,222 followersView post →
RS
Rafael Sirera
@ProfSirera · X
@simplify_drugs because they disrupt the renin–angiotensin–aldosterone system (RAAS), which is essential for normal fetoplacental development. https://t.co/1GFvOFF0Z5
Nov 22, 2025 · 4 likes · 1 share · 757 followersView post →
KP
KriMeera Pharma
@KrimeeraPharma · X
@simplify_drugs
Nov 22, 2025 · 13 likes · 5 shares · 3,625 followersView post →
FP
Francisco Pérez Allende Pérez
@FCO309178 · X
RT @NephroKarger: Sodium Retention in Liver #Disease: Is ENaC Activation Independent of the Renin-Angiotensin-Aldosterone System a Therapeu…
Nov 21, 2025 · 12 shares · 75 followersView post →
人日
人生365日の低飛行✈️
@summerbody321 · X
ナトリウム利尿ペプチドはレニン・アンジオテンシン・アルドステロン系に拮抗する
Natriuretic peptides antagonize the renin-angiotensin-aldosterone system
RT @drsthanus: Diagram of the renin-angiotensin-aldosterone system showing the sites of action of the β-adrenergic receptor blockers, the d…
Nov 18, 2025 · 7 shares · 4,492 followersView post →
DR
Dr.Linda Roper
@DrLindaRoper · X
RT @drsthanus: Diagram of the renin-angiotensin-aldosterone system showing the sites of action of the β-adrenergic receptor blockers, the d…
Nov 18, 2025 · 7 shares · 206 followersView post →
RP
Raffaele Di Giacomo, PhD
@sciqst · X
@drsthanus The renin-angiotensin-aldosterone system plays a pivotal role in regulating blood pressure and fluid balance. It's interesting to see how each component and medication interacts within this complex system. One thing to consider is how these interactions might vary in individuals
RT @drsthanus: Diagram of the renin-angiotensin-aldosterone system showing the sites of action of the β-adrenergic receptor blockers, the d…
Nov 18, 2025 · 7 shares · 238 followersView post →
AA
Ahmed Alzahapy
@alzahapy · X
RT @drsthanus: Diagram of the renin-angiotensin-aldosterone system showing the sites of action of the β-adrenergic receptor blockers, the d…
Nov 18, 2025 · 7 shares · 1,751 followersView post →
DS
Dr sthanu subramanian
@drsthanus · X
Diagram of the renin-angiotensin-aldosterone system showing the sites of action of the β-adrenergic receptor blockers, the direct rennin inhibitors, the angiotensin-converting enzyme inhibitors and the angiotensin II receptor blockers.
https://t.co/YsH0zYCawU https://t.co/r76RFRAGQq
Nov 18, 2025 · 31 likes · 7 shares · 25,013 followersView post →
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TeachMePhysiology
@tmphys · X
Did you get it right? ✅
The RAA system is incredibly important for blood pressure and fluid balance ⚖️
Check out our article on the Renin-Angiotensin-Aldosterone System
RT @1goodtern: *The Renin Angiotensin Aldosterone System. Covid disrupts it by interfering with ACE2, which throws off aldosterone balance.…
Nov 17, 2025 · 4 shares · 18,517 followersView post →
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Sass
@sasswashere · X
RT @1goodtern: *The Renin Angiotensin Aldosterone System. Covid disrupts it by interfering with ACE2, which throws off aldosterone balance.…
Nov 16, 2025 · 4 shares · 6,046 followersView post →
JT
Joanna Teglund
@JoannaTeglund · X
RT @1goodtern: *The Renin Angiotensin Aldosterone System. Covid disrupts it by interfering with ACE2, which throws off aldosterone balance.…
Nov 16, 2025 · 4 shares · 8,597 followersView post →
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Meesh
@Fading_Meesh · X
RT @1goodtern: *The Renin Angiotensin Aldosterone System. Covid disrupts it by interfering with ACE2, which throws off aldosterone balance.…
Nov 16, 2025 · 4 shares · 1,053 followersView post →
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tern
@1goodtern · X
*The Renin Angiotensin Aldosterone System. Covid disrupts it by interfering with ACE2, which throws off aldosterone balance. When aldosterone drops, potassium handling becomes unstable. Too much when the kidneys cannot excrete it, too little when the system overcorrects.
Nov 15, 2025 · 55 likes · 4 shares · 82,441 followersView post →
CH
Christina Hilton
@christinavhilt2 · X
Anyone struggling with kidney or heart health, you should read this paper.....eat more walnuts
Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin-angiotensin-aldosterone system and intestinal microbiota
https://t.co/XKLycM6FGK
5. Hormonal changes- Diabetes can trigger an overactivation of the renin-angiotensin aldosterone system, both of which play roles in regulating blood pressure and can lead to vasoconstriction (narrowing of blood vessels).
Managing Diabetes through lifestyle changes,
What plays a key role in blood pressure regulation is the renin-angiotensin-aldosterone system (RAAS).
In this system, the kidneys release renin in response to low blood pressure or low sodium, triggering the production of angiotensin II through the angiotensin-converting enzyme https://t.co/l3kvk8mVzK
Nov 7, 2025 · 16 likes · 2 shares · 83,411 followersView post →
RP
Raffaele Di Giacomo, PhD
@sciqst · X
@jclinicalinvest @CCosardereli @HopkinsMedicine The renin-angiotensin-aldosterone system (RAAS) plays a fascinating role in the aging process and its potential modification presents intriguing therapeutic avenues. How do you see RAAS modulation impacting the management of age-related diseases in the future? Furthermore, in
@dlingenfelter And as always, the Renin Angiotensin Aldosterone System is at play with the Innate Immune System.
The ACE2 - Angio II Axis is heavily linked to cellular H+ / O2 / CO2 / Glucose balance for White Blood Cells.
Including Mast Cells / Basophils. Lots of ACE/AT1R receptors
Nov 6, 2025 · 2 likes · 2,434 followersView post →
I
iknowurmomverywell
@Iknowurmomwell · X
@rand_longevity curious to know if u heard about the importance of the renin angiotensin aldosterone system on longevity ? we see that in a wide range of affections it's disregulated (in cancer, parkinson, alzheimer ect..)
that thing has been kinda left out for a bit, it's not studied much.
The spike protein is a prime candidate for this, since its receptor-binding domain (RBD) directly targets an enzyme that regulates the renin–angiotensin–aldosterone system (RAAS) - a key pathway controlling blood pressure, inflammation, and vascular tone.
Nov 3, 2025 · 24 likes · 1 share · 8,687 followersView post →
AI
A Frances Innes
@InnesFrances · X
RT @sbABetterLeader: @ZdenekVrozina @linds_longcovid Also, that shared pathway to mitochondrial dysfunction is the Renin Angiotensin Aldost…
@ZdenekVrozina @linds_longcovid Also, that shared pathway to mitochondrial dysfunction is the Renin Angiotensin Aldosterone System.
RAAS controls all electrolytes, O2 and CO2, glucose and H+. All crucial for mitochondria.
Oh and RAAS is already linked to aging:
https://t.co/vARIMAKzSe
Nov 2, 2025 · 24 likes · 3 shares · 2,434 followersView post →
MP
Meri Perkins
@mlperk1 · X
RT @vipintukur: The activation of NLRP3 inflammasomes by the N protein of SARS-CoV-2 and the dysregulation of the Renin–Angiotensin–Aldoste…
Nov 1, 2025 · 6 shares · 1,297 followersView post →
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SB
@sbABetterLeader · X
@dbdugger @ThailandMedicaX @loveindiaandus1 It's even simpler than this..... It's RAAS.
The Renin Angiotensin Aldosterone System controls ALL fluid and electrolyte flow and ALL bloodflow that fights the outside world.
The eyes and brain are awash (literally) in fluid. So RAAS controls it.
RAAS is modulated by ACE2....
Oct 30, 2025 · 1 like · 2,434 followersView post →
AM
Afiq Abd Malek
@afiqmalek · X
B-type natriuretic peptide (BNP) - actions:
✅vasodilator: can decrease cardiac afterload
✅diuretic and natriuretic
✅suppresses both sympathetic tone and the renin-angiotensin-aldosterone system
Even giving the general advice to population on cutting the dietary salt goes against the rationale, that a fall in sodium will stimulate the Renin Angiotensin Aldosterone System (RAAS) which will cause arteries to constrict & sodium & water retention to raise BP.
#AvoidLiteSalt https://t.co/VeTMY0lKbK
@WifeOfCloud also, consider HBOT, good for healing tiny damaged blood vessels (happens oftenly in pots case) and consider checking this book from a french renowned researcher, he ties most of the clotshot issue to a derregulation of the Renin angiotensin-aldosterone system and explain
RT @1goodtern: "The explosion in the incidence of a pathology which depends in particular on the Renin/Angiotensin/Aldosterone system (link…
Oct 17, 2025 · 3 shares · 1,470 followersView post →
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Gina
@Saffiya_Khan1 · X
RT @1goodtern: "The explosion in the incidence of a pathology which depends in particular on the Renin/Angiotensin/Aldosterone system (link…
Oct 17, 2025 · 3 shares · 18,517 followersView post →
JB
Jan Breeman
@janbreeman48 · X
RT @1goodtern: "The explosion in the incidence of a pathology which depends in particular on the Renin/Angiotensin/Aldosterone system (link…
Oct 17, 2025 · 3 shares · 255 followersView post →
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tern
@1goodtern · X
"The explosion in the incidence of a pathology which depends in particular on the Renin/Angiotensin/Aldosterone system (linked to the ACE2 receptor), just after the emergence and massive diffusion of a virus dependent on the ACE2 receptor is totally incomprehensible!" https://t.co/8m2wEDglTh
Oct 17, 2025 · 19 likes · 3 shares · 82,441 followersView post →
PA
Peptide Tracker App
@researchitgg · X
@boowiebear @React2W @InternetH0F The GH pulse from Ipamorelin can influence the renin-angiotensin-aldosterone system (RAAS), leading to transient sodium and water retention. It's a common, temporary effect.
Oct 14, 2025 · 1 like · 1,631 followersView post →
DG
Dr Andrew Greenland
@DrAGreenland · X
@DavidPerlmutter Important point that often gets overlooked. We tend to think of salt and sugar as separate metabolic issues, but excess sodium intake can activate the renin–angiotensin–aldosterone system (RAAS), raising cortisol and impairing insulin signalling. That combination increases
RT @iamjustapeater: Reminder that lowering your salt intake may lower your blood pressure a few points, but adequate salt intake is importa…
Oct 12, 2025 · 5 shares · 560 followersView post →
CO
cowboy online
@DeportHomos · X
RT @iamjustapeater: Reminder that lowering your salt intake may lower your blood pressure a few points, but adequate salt intake is importa…
Oct 11, 2025 · 5 shares · 2,627 followersView post →
BH
Blind Harper
@fweng_chung · X
RT @iamjustapeater: Reminder that lowering your salt intake may lower your blood pressure a few points, but adequate salt intake is importa…
Oct 11, 2025 · 5 shares · 170 followersView post →
JP
Just Another Peater
@iamjustapeater · X
Reminder that lowering your salt intake may lower your blood pressure a few points, but adequate salt intake is important for keeping the renin-angiotensin-aldosterone system suppressed. https://t.co/xArg96bfT4
Oct 11, 2025 · 114 likes · 5 shares · 12,882 followersView post →
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Optimizedhealth
@Mineralexpert · X
@godshandshealth @ScottAppliedSci This journal article about the connection between aldosterone and diabetes. Consider what I said and connect the dots.
https://t.co/CA8gGYaklp
A link between the renin-angiotensin-aldosterone system (RAAS) and cardiometabolic disorders has been recognized for decades. Acting
RT @vipintukur: The activation of NLRP3 inflammasomes by the N protein of SARS-CoV-2 and the dysregulation of the Renin–Angiotensin–Aldoste…
Oct 7, 2025 · 6 shares · 4,378 followersView post →
EM
Emanuela Micucci
@EmMicucci · X
RT @vipintukur: The activation of NLRP3 inflammasomes by the N protein of SARS-CoV-2 and the dysregulation of the Renin–Angiotensin–Aldoste…
Oct 7, 2025 · 6 shares · 1,312 followersView post →
VV
Vipin M. Vashishtha
@vipintukur · X
The activation of NLRP3 inflammasomes by the N protein of SARS-CoV-2 and the dysregulation of the Renin–Angiotensin–Aldosterone System (RAAS). The activation of NLRP3 led to the cancer-causing hallmarks.
Oct 6, 2025 · 52 likes · 6 shares · 19,500 followersView post →
RP
Raffaele Di Giacomo, PhD
@sciqst · X
@Turki_PharmD Your post raises an essential topic regarding the use of ACE inhibitors and ARBs in kidney diseases and hypertension. Their role as first-line treatment stems from their ability to modulate the renin-angiotensin-aldosterone system (RAAS), which could potentially prevent
Synergistic prognostic effect of the renin‐angiotensin‐aldosterone system and immune‐checkpoint inhibition in advanced lung cancer: The SPERICIL study - Efil - International Journal of Cancer - Wiley Online Library https://t.co/NNii1cTDUi
@RogerGustafsso2 @_cindygratton_ ..Similar to other viruses, such as human papillomavirus and Epstein–Barr virus, SARS-CoV-2 shows an oncogenic potential, which has been hypothetically proposed based on its mechanisms of action, including the renin–angiotensin–aldosterone system, viral mutagenicity, and
The Renin–Angiotensin–Aldosterone System in Cardiac Surgery and Angiotensin II Therapy for Vasoplegia journals.lww.com/anesthesia-a... #hvhebron #mintens [Text complet]
The Renin–Angiotensin–Aldosterone System in Cardiac Surgery and Angiotensin II Therapy for Vasoplegia https://t.co/i89KlOkuxc #hvhebron #mintens [Text complet]
@IHaveGrit96 Yeah.
Testosterone/Androgens thickens the left ventricular, but there's really no evidence this would cause a heart attack on it's own. even with damage to the "Renin-angiotensin-aldosterone system"
Add stimulants, especially Coke, tobacco, and clen? Now you're getting risky
@JackHadfield14 There's a more direct link. The Renin Angiotensin Aldosterone System.
Specifically, ANTI-AT1R Autoantibodies. Noted in POTS before covid, and noted in covid / long covid.
https://t.co/OVEM59Z62p
Oct 2, 2025 · 7 likes · 2,434 followersView post →
DS
Dr sthanu subramanian
@drsthanus · X
The complex process of Potassium Regulation in the body, primarily involving the kidneys and the Renin-Angiotensin-Aldosterone System (RAAS).
https://t.co/wtBYFbxJgr https://t.co/eblFoAOHy3
Oct 2, 2025 · 36 likes · 6 shares · 25,013 followersView post →
E
8Eevert ✨
@8Eevert · X
@JackHadfield14 > We found reduced ACE protein levels in people with Long COVID & ME/CFS
Would that count as “paradoxically low activity of the renin–angiotensin–aldosterone system”?
(Pathophysiology of Skeletal Muscle Disturbances in #MECFS, Wirth & Scheibenbogen 2021 https://t.co/jLAVVRLcyr) https://t.co/3qSquIh7Kz
@CadioArena Insulin resistance can stimulate the sympathetic nervous system, which increases heart rate and blood vessel constriction, leading to higher blood pressure.
Insulin resistance can activate the renin-angiotensin-aldosterone system, which promotes sodium and water retention, https://t.co/kRqWUePiLV
ACE also helps regulate the renin-angiotensin-aldosterone system (RAAS), which controls salt, water, and blood pressure.
If ACE is low, angiotensin II and aldosterone may also be low.
This is because ACE converts AngI into AngII
1. Product Description
Saralasin acetate hydrate (CAS 39698-78-7) is a synthetic octapeptide analog of angiotensin II developed to study the renin–angiotensin–aldosterone system (RAAS). #GMP
arizona-mall.com/product/sara...
Correct answer:
**Restoration of renal perfusion relieves ischemic stimulation of juxtaglomerular cells, reducing renin release and thereby down-regulating the renin–angiotensin–aldosterone system.**
Restoration of renal perfusion relieves ischaemic stimulation of
COVID-19 likely comprises multiple endotypes driven by individual host-pathogen interactions, especially involving ACE2 and RAAS imbalance.
Understanding these mechanisms could someday enable personalized treatments and improve clinical outcomes.
link.springer.com/article/10.1...
Dysregulation of the renin-angiotensin-aldosterone system further promotes vasoconstriction, inflammation & smooth muscle proliferation, while a prothrombotic state increases the risk of plaque formation and instability.
mdpi-res.com/d_attachment...
www.sciencedirect.com/science/arti...
I am curious and concerned. The high rates of side effects are a problem. Much higher than what you'd see with say tirzepatide and could derail the whole thing. Is the weight loss because of the high rates of N/V?
And then this note on RAAS activity as well:
all POTS meds are used offlabel, but we know what they do and why they ought to help in POTS. I'm hypovolemic, likely due to disruption in the renin-angiotensin-aldosterone system? salt and fluids. fludrocortisone mimics aldosterone and should help even more.
On this day in COVID history, April 23, 2021:
COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system - Nature Communications
Source: Nature
https://www.nature.com/articles/s41467-021-22713-z
Effect of the renin–angiotensin–aldosterone system inhibitors on time to nucleic acid negative conversion in hypertensive patients with SARS-CoV-2 omicron infection: a propensity score matching study
www.nature.com/articles/s41...
The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II scientiasalut.gencat.cat/handle/11351... #ScientiaVH
It’s been found that many with these conditions have a dysfunctional RAAS system. The renin-angiotensin-aldosterone system is the system of hormones, enzymes, proteins, and reactions that regulate your blood volume, fluid balance, electrolyte balance, and blood pressure on a long-term basis.
“…researchers found that SARS-CoV-2 disrupts essential reactions in the mitochondria, the cell's energy-producing factories. Mitochondrial stress led to the release of compounds that act as danger signals, which in turn trigger immune sensors that activate the renin-angiotensin-aldosterone system”
200 likes and I share the story I made up as an analogy for the Renin-Angiotensin-Aldosterone System. I’ll give you a teaser; it includes karate gangs.
(That's an older article but it's easier to read than a bunch of biochemistry primers on the Renin-Angiotensin-Aldosterone system and ACE2 receptors lol)
But anyway, having enough blood volume is important for getting enough blood to your brain
Durch die Aufklärung der zugrunde liegenden Mechanismen, die die Zelltransformation vorantreiben, wird das Potenzial von SARS-CoV-2 als Onkovirus hervorgehoben. Das Verständnis dieser Wechselwirkungen ist von entscheidender Bedeutung, um unser Verständnis von COVID-19 und der
The renin-angiotensin-aldosterone system inhibitor dilemma in COVID-19: balancing cardiovascular benefits and viral risks
www.nature.com/articles/s41...
well well well, cold weather does affect some of the systems that are already wonky in POTS (ie, the sympathetic nervous system and the Renin-Angiotensin-Aldosterone System)
damn you paywall *shakes fist* I can only read the abstract
pubmed.ncbi.nlm.nih.gov/35618875/
The kidney regulates total body sodium and total body water independently. The renin angiotensin aldosterone system regulates total body sodium while ADH (water excretion) and thirst (water intake) regulates total body water.
Hyponatremia is a failure of the regulation of:
doi: 10.1007/s00424-024-02908-1 *The renin angiotensin aldosterone system. 3.Hypertension. Author manuscript; available in PMC: 2024 Aug 1. Published in ...
Direct Demonstration of Macula Densa-Mediated Renin Secretion ...
News
https://doi.org/10.1007/s00424-024-02908-1 · Crossref. Sadayoshi Ito,. Once in a Lifetime~Dream, Passion, Challenge, and Respect for Peers~, Endocrine Journal ...