In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with cefepime–taniborbactam (β-lactam and β-lactamase inhibitor) than with meropenem. Read the CERTAIN-1 trial Research Summary: https://t.co/65YjNanqAM https://t.co/zfamw1COLb
Cefepime-Taniborbactam in Complicated Urinary Tract Infection.
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Feb 2024 – May 2025Where it's discussed
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What people are saying
The overall tone reveals strong agreement and enthusiasm about the study, with posts praising the drug's efficacy, such as 'superior to meropenem' and 'fighting MDR GNRs,' demonstrating high interest and perceived impact. While many comments support the advancements, some share brief links or general praise, indicating moderate ongoing engagement.
Most discussions express strong support or positive validation for the article's findings, emphasizing the drug's superiority and potential impact.
Posts demonstrate high interest, highlighting the significance of the new treatment and engaging in detailed commentary about its implications.
Many comments reference specific trial results and safety profiles, indicating a moderate level of reflective engagement, though some are just sharing links or brief mentions.
There is a consensus that the research could be transformative in treating resistant infections, with phrases like 'superior to meropenem' and 'significant advance' illustrating this perception.
Abstract in brief
- Carbapenem-resistant Enterobacterales species present a serious global health risk, prompting the investigation of cefepime-taniborbactam, a promising antibiotic and β-lactamase inhibitor combination.
- In a phase 3 trial, hospitalized adults with complicated urinary tract infections were randomized to receive either cefepime-taniborbactam or meropenem for 7 to 14 days, aiming to detect both microbiologic and clinical success.
- Results showed that 70.6% of patients treated with cefepime-taniborbactam achieved composite success, significantly higher than the 58.0% success rate in the meropenem group, indicating that cefepime-taniborbactam is a
Top posts
Most liked on X and BlueskyOriginal Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/CULoWE5US5
MARKUS at HOMe back in
Cefepime–Taniborbactam in Complicated Urinary Tract Infection 新しい抗生物質の組み合わせであるセフェピム・タニボルバクタムは、複雑性尿路感染症(UTI)および急性腎盂腎炎の治療において、特に一般的な治療法に耐性を持つグラム陰性菌に対して、メロペネムよりも有効であることが判明した。 https://t.co/br0Ct6U4Dn https://t.co/6TqxWO4f9N
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
All mentions
Advances in UTI Treatment Strategies and New Antibiotics Potential in 2024
Prof Dr Florian Wagenlehner discusses current and future therapies for urinary tract infections, including innovative antibiotics like cefepime-taniborbactam, showing promising results in treating complicated infections…
Addressing the Challenge of Carbapenemase-Producing Bacteria
Carbapenemase producers are challenging for clinicians due to their resistance to last-resort antibiotics and tendency for multidrug resistance. This episode features Dr. David Paterson and Dr. Souha Kanj discussing the…
RT @PGYpharmacy: Academic activity
Academic activity
RT @SeeFisch: THESE GUYS GOT 300 MILLION DOLLARS IN PUBLIC, TAX PAYER FUNDED MONEY TO MAKE THIS DRUG WHICH IS WORTHLESS Cefepime–Taniborba…
THESE GUYS GOT 300 MILLION DOLLARS IN PUBLIC, TAX PAYER FUNDED MONEY TO MAKE THIS DRUG WHICH IS WORTHLESS Cefepime–Taniborbactam in Complicated Urinary Tract Infection | New England Journal of Medicine https://t.co/JnHws8rUGy
RT @gunnar_heine: MARKUS at HOMe back in
MARKUS at HOMe back in
Cefepime-taniborbactam es superior a meropenem para el tratamiento de infección respiratoria complicada que incluye pielonefritis aguda, con un perfil de seguridad similar al de meropenem #meropenem #cefepimetaniborbactam #UTI https://t.co/t3bJlFVRcZ
We enjoyed the half-day academic lecture titled “Cefepime-Taniborbactam in Complicated Urinary Tract Infection(UTI)” presented by Dr. Nawaf Alqahtani, R1 Pharmacy Resident https://t.co/SPdlFZz0vw
RT @dralicehan: #IDPhoeniX
RT @dralicehan: #IDPhoeniX
#JournalWatch @NEJM Cefe–taniborbactam - new kid on the block! Superior micro and clin success compared to mero in the CERTAIN-1 trial in pts w/ cUTI including pyelo. What niche will this have in the war against MDR GNRs? #critPRN https://t.co/fhiGyLNrPs
RT @dralicehan: #IDPhoeniX
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | New England Journal of Medicine https://t.co/1Gw3E9GKxB #勉強会ネタ備忘録
RT @infeccHRUmalaga: Ensayo clínico @NEJM de #Cefepime #Taniborbactam
Dr Hassan presented https://t.co/6MHPehaDKk - which was a great overview on MDR Gram Negative pathogens and treatment options in the pipeline, including cefepime-taniborbactam
https://t.co/5NELycwxpc
RT @ABsteward:
RT @ABsteward:
RT @ABsteward:
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/74Zmt3WxfG
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with cefepime–taniborbactam (β-lactam and β-lactamase inhibitor) than with meropenem. Read the CERTAIN-1 trial Research Summary: https://t.co/65YjNanqAM https://t.co/zfamw1COLb
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/ERuQunZBzc
Cefepime–Taniborbactam in Complicated Urinary Tract Infection #science #publication #research #journal https://t.co/og9WXa84Nc
Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/X1qQSFK52B
RT @EARL_med_tw:
RT @EARL_med_tw:
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @ABsteward:
RT @ABsteward:
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
Cefepime–Taniborbactam en infecciones de orina complicadas. Primer inhibidor de B-lactamasas con actividad frente a las enzimas clase A, B, C y D de Amber. https://t.co/gvh10Ag5KY
RT @ABsteward:
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
Cefepime–Taniborbactam in Complicated Urinary Tract Infection #science #publication #research #publications https://t.co/n9lmOsrWu4
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/CULoWE5US5
RT @ABsteward:
RT @ABsteward:
Cefepime–taniborbactam was superior to meropenem for the treatment of complicated UTI that included acute pyelonephritis, with a safety profile similar to that of meropenem. Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/WFSdMZgVGB
RT @MicrobLog_me_uk: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/INeNVgMeJ2
RT @MicrobLog_me_uk: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/INeNVgMeJ2
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/INeNVgMeJ2
RT @ArcaSuarez90: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
Cefepime–Taniborbactam in Complicated Urinary Tract Infection 新しい抗生物質の組み合わせであるセフェピム・タニボルバクタムは、複雑性尿路感染症(UTI)および急性腎盂腎炎の治療において、特に一般的な治療法に耐性を持つグラム陰性菌に対して、メロペネムよりも有効であることが判明した。 https://t.co/br0Ct6U4Dn https://t.co/6TqxWO4f9N
Estudo CERTAIN-1 (RCT, Fase 3) traz superioridade da combinação Cefepime-Taniborbactam no tratamento da ITU complicada por Enterobacterales. Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/zwRN8cHajN https://t.co/xGo0o3y3b6
RT @ArcaSuarez90: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/82d1U3riWr
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/KNpMq7YxPV
RT @kiccy7777: 【Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM】 新規抗菌薬で uperior to というのは 高価な類似薬ばかりの中、めずらしい https://t.…
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/F2PCrT5srZ
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/kJPgKYt3Y9
Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/Y0xupy6e7t
RT @kiccy7777: 【Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM】 新規抗菌薬で uperior to というのは 高価な類似薬ばかりの中、めずらしい https://t.…
【Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM】 新規抗菌薬で uperior to というのは 高価な類似薬ばかりの中、めずらしい https://t.co/6qYg57ijyg