Cefepime-Taniborbactam in Complicated Urinary Tract Infection.

Florian M Wagenlehner, Leanne B Gasink, Paul C McGovern, Greg Moeck, Patrick McLeroth, MaryBeth Dorr, Aaron Dane, Tim Henkel,

February 2024

Synopsis of Social media discussions

The overall tone reveals strong agreement and enthusiasm about the study, with posts praising the drug's efficacy, such as 'superior to meropenem' and 'fighting MDR GNRs,' demonstrating high interest and perceived impact. While many comments support the advancements, some share brief links or general praise, indicating moderate ongoing engagement.

A
Agreement
 Strong agreement

Most discussions express strong support or positive validation for the article's findings, emphasizing the drug's superiority and potential impact.

I
Interest
 High level of interest

Posts demonstrate high interest, highlighting the significance of the new treatment and engaging in detailed commentary about its implications.

E
Engagement
 Moderate level of engagement

Many comments reference specific trial results and safety profiles, indicating a moderate level of reflective engagement, though some are just sharing links or brief mentions.

I
Impact
 High level of impact

There is a consensus that the research could be transformative in treating resistant infections, with phrases like 'superior to meropenem' and 'significant advance' illustrating this perception.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

125 Posts

Blogs

2 Articles

News

28 Articles

Metrics

Video Views

2,153

Total Likes

350

Extended Reach

2,541,864

Social Features

159

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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    RT @PGYpharmacy: Academic activity
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    Academic activity
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  • Marko
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    RT @SeeFisch: THESE GUYS GOT 300 MILLION DOLLARS IN PUBLIC, TAX PAYER FUNDED MONEY TO MAKE THIS DRUG WHICH IS WORTHLESS Cefepime–Taniborba…
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    September 24, 2024

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  • Conrad Fischer
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    THESE GUYS GOT 300 MILLION DOLLARS IN PUBLIC, TAX PAYER FUNDED MONEY TO MAKE THIS DRUG WHICH IS WORTHLESS Cefepime–Taniborbactam in Complicated Urinary Tract Infection | New England Journal of Medicine https://t.co/JnHws8rUGy
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    August 16, 2024

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  • @investigando
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    Cefepime-taniborbactam es superior a meropenem para el tratamiento de infección respiratoria complicada que incluye pielonefritis aguda, con un perfil de seguridad similar al de meropenem #meropenem #cefepimetaniborbactam #UTI https://t.co/t3bJlFVRcZ
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    June 4, 2024

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    We enjoyed the half-day academic lecture titled “Cefepime-Taniborbactam in Complicated Urinary Tract Infection(UTI)” presented by Dr. Nawaf Alqahtani, R1 Pharmacy Resident https://t.co/SPdlFZz0vw
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    April 23, 2024

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  • ACCP CRIT PRN
    @accpcritprn (Twitter)

    #JournalWatch @NEJM Cefe–taniborbactam - new kid on the block! Superior micro and clin success compared to mero in the CERTAIN-1 trial in pts w/ cUTI including pyelo. What niche will this have in the war against MDR GNRs? #critPRN https://t.co/fhiGyLNrPs
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  • Division of Infectious Diseases at Ohio State
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    Dr Hassan presented https://t.co/6MHPehaDKk - which was a great overview on MDR Gram Negative pathogens and treatment options in the pipeline, including cefepime-taniborbactam
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    March 8, 2024

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  • Maria Hazel Cohan, DNP, AGACNP-BC, AACC
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    February 22, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 22, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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  • @PPSJSU (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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  • @DrMadan11 (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    @KhalidW24675290 (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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  • Dr. Shashank Joshi
    @AskDrShashank (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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    @officeaksingh (Twitter)

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  • Audrey De Jong
    @audreydejongMD (Twitter)

    RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
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  • waqar dahri
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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • Mohammed Ali
    @Mohamme49095484 (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • Valentine C. Nriagu MD, MPH.
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    February 21, 2024

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    February 21, 2024

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    February 21, 2024

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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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  • Dr Ramdas Pananthattil
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    RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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    February 21, 2024

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    February 21, 2024

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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • KEIN KALUME
    @KALUMEKEIN1 (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • Christian Florely Pérez González
    @DraChristianFP1 (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • Samira Farouk, MD, MSCR
    @ssfarouk (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • Carlos Ildefonso, MD
    @carlosilde (Twitter)

    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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    RT @NEJM: In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with…
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    February 21, 2024

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  • NEJM
    @NEJM (Twitter)

    In patients with complicated urinary tract infection, clinical and microbiologic treatment success was significantly better with cefepime–taniborbactam (β-lactam and β-lactamase inhibitor) than with meropenem. Read the CERTAIN-1 trial Research Summary: https://t.co/65YjNanqAM https://t.co/zfamw1COLb
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    February 20, 2024

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    February 19, 2024

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    February 18, 2024

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    February 18, 2024

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  • Med Peds Hospitalist
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  • Moo....
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  • Ezeonufo Chukwunonso
    @Ezeonufo (Twitter)

    RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
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    February 18, 2024

    25

  • Baronian Consulting
    @BaronianConsult (Twitter)

    RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
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    February 18, 2024

    25

  • Peter Olbrich
    @petolb_huvr (Twitter)

    RT @NEJM: Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/C…
    view full post

    February 18, 2024

    25

  • NEJM
    @NEJM (Twitter)

    Original Article: Cefepime–Taniborbactam in Complicated Urinary Tract Infection https://t.co/65YjNanqAM #Urology https://t.co/CULoWE5US5
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    February 18, 2024

    87

    25

  • Laura Letona
    @Lletonag (Twitter)

    RT @ABsteward:
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    February 18, 2024

    49

  • Dhwani Desai, Pharm.D
    @Dh1eDesai7 (Twitter)

    RT @ABsteward:
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    February 18, 2024

    49

  • Amy Park, MD
    @dramypark (Twitter)

    Cefepime–taniborbactam was superior to meropenem for the treatment of complicated UTI that included acute pyelonephritis, with a safety profile similar to that of meropenem. Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/WFSdMZgVGB
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    February 17, 2024

    4

  • Mohammed Alabdulla
    @Mohamme72157286 (Twitter)

    RT @MicrobLog_me_uk: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/INeNVgMeJ2
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    February 16, 2024

    2

  • Sid Chopra
    @skchopra007 (Twitter)

    RT @MicrobLog_me_uk: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/INeNVgMeJ2
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    February 16, 2024

    2

  • Abid Hussain
    @MicrobLog_me_uk (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/INeNVgMeJ2
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    February 16, 2024

    4

    2

  • Lazaro Jose Jimenez Dominguez
    @LazaroJoseJD (Twitter)

    RT @ArcaSuarez90: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
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    February 16, 2024

    2

  • Mugen UJIIE (氏家 無限)
    @carpe_diem0820 (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection 新しい抗生物質の組み合わせであるセフェピム・タニボルバクタムは、複雑性尿路感染症（UTI）および急性腎盂腎炎の治療において、特に一般的な治療法に耐性を持つグラム陰性菌に対して、メロペネムよりも有効であることが判明した。 https://t.co/br0Ct6U4Dn https://t.co/6TqxWO4f9N
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    February 15, 2024

    6

  • L. Miranda
    @frarlley (Twitter)

    Estudo CERTAIN-1 (RCT, Fase 3) traz superioridade da combinação Cefepime-Taniborbactam no tratamento da ITU complicada por Enterobacterales. Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/zwRN8cHajN https://t.co/xGo0o3y3b6
    view full post

    February 15, 2024

  • Diego García Martínez de Artola
    @micromunidad (Twitter)

    RT @ArcaSuarez90: Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
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    February 15, 2024

    2

  • Jorge Arca Suárez
    @ArcaSuarez90 (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/1tU3ZOpFgb
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    February 15, 2024

    6

    2

  • Hitoshi Honda
    @Tokotoko1807 (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/82d1U3riWr
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    February 15, 2024

  • PROA_Marañón
    @PROA_maran (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/KNpMq7YxPV
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    February 15, 2024

    3

  • R
    @r_hexar (Twitter)

    RT @kiccy7777: 【Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM】 新規抗菌薬で　uperior to　というのは 高価な類似薬ばかりの中、めずらしい https://t.…
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    February 14, 2024

    2

  • ACP Ohio
    @OhioAcp (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/F2PCrT5srZ
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    February 14, 2024

  • Med Peds Hospitalist
    @medpedshosp (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/kJPgKYt3Y9
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    February 14, 2024

  • 2things
    @2thingsteam (Twitter)

    Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM https://t.co/Y0xupy6e7t
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    February 14, 2024

  • おれんじ色
    @orangeiro7 (Twitter)

    RT @kiccy7777: 【Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM】 新規抗菌薬で　uperior to　というのは 高価な類似薬ばかりの中、めずらしい https://t.…
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    February 14, 2024

    2

  • 岸田直樹,MD,MPH,PhD,CEO【救急総合内科医/感染症コンサルタント/歴史家/人口学研究】
    @kiccy7777 (Twitter)

    【Cefepime–Taniborbactam in Complicated Urinary Tract Infection | NEJM】 新規抗菌薬で　uperior to　というのは 高価な類似薬ばかりの中、めずらしい https://t.co/6qYg57ijyg
    view full post

    February 14, 2024

    4

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Abstract Synopsis

  • Carbapenem-resistant Enterobacterales species present a serious global health risk, prompting the investigation of cefepime-taniborbactam, a promising antibiotic and β-lactamase inhibitor combination.
  • In a phase 3 trial, hospitalized adults with complicated urinary tract infections were randomized to receive either cefepime-taniborbactam or meropenem for 7 to 14 days, aiming to detect both microbiologic and clinical success.
  • Results showed that 70.6% of patients treated with cefepime-taniborbactam achieved composite success, significantly higher than the 58.0% success rate in the meropenem group, indicating that cefepime-taniborbactam is a