February 2024 PMID 38409323

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk.

Xiangyu Zhang, Divya Kapoor, Se-Jin Jeong, Alan Fappi, Jeremiah Stitham, Vasavi Shabrish, Ismail Sergin, Eman Yousif, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, Arif Yurdagul, Oren Rom, Slava Epelman, Joel D Schilling

Mentions

61
Peak: 24 in Feb 2024
across 8 sources since Feb 2024

Extended reach

116,922
potential audience

Total likes

202

Video views

2,678

Mentions per month

Feb 2024 – Nov 2025

Where it's discussed

  • X / Twitter27 posts
  • News13 articles
  • Facebook9 posts
  • Reddit5 posts
  • Blogs3 articles
  • YouTube2 videos
  • Bluesky1 posts
  • Instagram1 posts

AI synopsis

What people are saying

The overall tone reflects strong interest and some agreement, as exemplified by posts emphasizing leucine's role in promoting atherosclerosis and the molecular mechanisms involved, such as mentions of 'leucine enough to promote ASCVD' and references to the effects of high-protein diets. The use of technical language and discussions about dietary thresholds indicate a significant impact on ongoing research and nutritional debates.

AgreementModerate agreement

Most discussions recognize the study's findings, with some expressing support or curiosity about the link between leucine, protein intake, and cardiovascular risk.

InterestHigh interest

Participants show high interest, frequently referencing specific mechanisms like mTOR activation and the role of leucine, indicating active engagement with the content.

EngagementModerate engagement

Comments range from brief mentions to detailed discussions about the molecular mechanisms and dietary implications, demonstrating moderate to deep engagement.

ImpactModerate impact

The conversations suggest the research could influence dietary considerations and future studies on cardiovascular risk, though some posts are more speculative or administrative.

Abstract in brief

  • High protein intake, often seen as healthy, may activate mTOR signaling in macrophages, linked to ischaemic cardiovascular disease.
  • Clinical studies reveal that leucine is the main amino acid triggering mTOR activation in macrophages, with significant effects only seen with protein intake over roughly 25g per meal.
  • Research indicates that protein intake above 22% of dietary energy can promote atherosclerosis in male mice, highlighting the cardiovascular risks of excessive dietary protein.

Top posts

Most liked on X and Bluesky
Dylan Ryan
@RyanLab_TCD · X

Mar 4, 2024 · 22 likes · 4 shares · 2,463 followers View post →
Agingdoc
@agingdoc1 · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

Feb 20, 2024 · 8 likes · 43,225 followers View post →
Reiner 
@erlesen · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/c31Y0Aw3pM Es gibt einen molekularen Mechanismus, durch den zu viel Protein im Essen das Arterioskleroserisiko erhöhen kann https://t.co/HTApMaGouK

Mar 3, 2024 · 6 likes · 2 shares · 7,857 followers View post →
Sai P Pydi
@saip_pydi · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/g1E7rh1kxj

Feb 19, 2024 · 6 likes · 662 followers View post →
Cardio
@PesarCardio · X

رگ‌های خونی آسیب بزنه و احتمال گرفتگی رگ‌ها (مثل سکته قلبی) رو بالا ببره. یعنی خوردن زیاد پروتئین، به‌خصوص توی رژیم‌هایی که بیشتر از ۲۲٪ کالری کل از پروتئین میاد، ممکنه برای قلب مضر باشه، مخصوصاً توی آقایون. https://t.co/Jgn1p9CdhB

May 26, 2025 · 3 likes · 1,204 followers View post →
サイエンスあれこれ
@sarekore · X

ロイシン濃度の増加は、高タンパク質食が存在しない場合でも、雄マウスのアテローム性動脈硬化を促進するのに十分であることが示されました。人間の場合、1食当たり25gを超えるタンパク質で免疫細胞を活性化させるに十分な血中ロイシン濃度の上昇が得られることがわかりましたhttps://t.co/uLWwZhALfq

Feb 20, 2024 · 1 like · 940 followers View post →

All mentions

Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/JLwAINkP6M

May 26, 2025 · 2,070 followers View post →
Cardio
@PesarCardio · X

رگ‌های خونی آسیب بزنه و احتمال گرفتگی رگ‌ها (مثل سکته قلبی) رو بالا ببره. یعنی خوردن زیاد پروتئین، به‌خصوص توی رژیم‌هایی که بیشتر از ۲۲٪ کالری کل از پروتئین میاد، ممکنه برای قلب مضر باشه، مخصوصاً توی آقایون. https://t.co/Jgn1p9CdhB

May 26, 2025 · 3 likes · 1,204 followers View post →
Reiner 
@erlesen · X

RT @erlesen: Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.c…

Apr 30, 2024 · 2 shares · 7,857 followers View post →
Eugene Lucas, MD
@elucasmd · X

I suppose I should mention that I perhaps have a pro-protein bias, but the evidence appears supportive of this approach. I plan to post about the Zhang study (https://t.co/ub5INMxORi) eventually but will save that for another day

Apr 27, 2024 · 516 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/8RvdVqu8Vq @aiims_newdelhi, @AIIMSBhubaneswr, @aiims_rpr, @AIIMSBhopal, @aiimsrishi, @AIIMSNagpur, @aiims_jodhpur @OfficialJipmer @aiims_newdelhi @MIT https://t.co/Uy6zRY9U9q

Apr 8, 2024 · 902 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

How is raising the number of steps taken each day associated with a reduced risk of cardiovascular diseases? Walking->⬆️MiR-126->⬇️mTOR->⬆️Mitophagy-> ⬇️cardiovascular risk. https://t.co/8RvdVqu8Vq For more https://t.co/yIjh60K0jv @DrFrankLipman @NIH @WHO @NobelPrize @ICMRDELHI https://t.co/dDy8MQLyEk https://t.co/QPtpo44YrS

Apr 8, 2024 · 902 followers View post →
Swati Sharma
@Swati_0803 · X

RT @RyanLab_MBU:

Mar 5, 2024 · 4 shares · 94 followers View post →
Christof Meinhold
@nutri_cologne · X

RT @erlesen: Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.c…

Mar 5, 2024 · 2 shares · 2,512 followers View post →
Bims: Biomed News
@Bims_BiomedNews · X

RT @RyanLab_MBU:

Mar 5, 2024 · 4 shares · 2,131 followers View post →
FrezzaLab
@FrezzaLab · X

RT @RyanLab_MBU:

Mar 4, 2024 · 4 shares · 26,908 followers View post →
Marco Sciacovelli
@MSciacovelliLab · X

RT @RyanLab_MBU:

Mar 4, 2024 · 4 shares · 341 followers View post →
Dylan Ryan
@RyanLab_TCD · X

Mar 4, 2024 · 22 likes · 4 shares · 2,463 followers View post →
Reiner
@erlangen.bsky.social · Bluesky

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk www.nature.com/articles/s42... Es gibt einen molekularen Mechanismus, durch den zu viel Protein im Essen das Arterioskleroserisiko erhöhen kann www.hna.de/welt/eiweiss...

Mar 3, 2024 · 1 like View post →
Reiner 
@erlesen · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/c31Y0Aw3pM Es gibt einen molekularen Mechanismus, durch den zu viel Protein im Essen das Arterioskleroserisiko erhöhen kann https://t.co/HTApMaGouK

Mar 3, 2024 · 6 likes · 2 shares · 7,857 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk. https://t.co/JLwAINlmWk

Mar 3, 2024 · 2,070 followers View post →
Mahima Gulati MD, FACE, FACLM, M.Sc., DipABLM
@MahimaGulatiMD · X

"Not only was ⬆️leucine enough to promote ASCVD, it was also required for high-protein diets to do so ⬆️ASCVD progression w/ ⬆️leucine diets was independent of altered total carb & prot supply" https://t.co/AjxMtqDFDh @GardnerPhD @dr_muniyappa @nutrition_facts

Feb 28, 2024 · 2,118 followers View post →
Gerard Meijssen
@GerardMeijssen · X

@NanciGuestRDPhD The DOI does not function.. otherwise it would now be in @Wikidata .. https://t.co/dbzf53B9eD

Feb 23, 2024 · 1,056 followers View post →
medicalnews
@medicalnews20 · X

https://t.co/wZ2u2Ep6de High-Protein Diet Linked to Increased #cardiovascular Disease Risk. Researchers from the University of Pittsburgh School of Medicine published a study titled "Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling...

Feb 23, 2024 · 1,161 followers View post →
BicicletasSVQ
@BicicletasSVQ · X

@r_reddington01 @elmundoes Xiangyu Zhang Universidad de Pittsburgh https://t.co/otobiIvptA

Feb 20, 2024 · 1,121 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

@NanciGuestRDPhD @FusionProgGuy @TheNutrivore @dylanarmbruste3 @theproof @NutritionMadeS3 @ScepticalDoctor @MohammedAlo @TheAlanAragon Find more info in their source data: https://t.co/GojwWzEFHR

Feb 20, 2024 · 3,328 followers View post →
Agingdoc
@agingdoc1 · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

Feb 20, 2024 · 8 likes · 43,225 followers View post →
サイエンスあれこれ
@sarekore · X

ロイシン濃度の増加は、高タンパク質食が存在しない場合でも、雄マウスのアテローム性動脈硬化を促進するのに十分であることが示されました。人間の場合、1食当たり25gを超えるタンパク質で免疫細胞を活性化させるに十分な血中ロイシン濃度の上昇が得られることがわかりましたhttps://t.co/uLWwZhALfq

Feb 20, 2024 · 1 like · 940 followers View post →
Sai P Pydi
@saip_pydi · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/g1E7rh1kxj

Feb 19, 2024 · 6 likes · 662 followers View post →
drjasonmccloskey
@drjmccloskey · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/OiisXWgDE7

Feb 19, 2024 · 72 followers View post →
Edgard Pais
@Edgard_2015 · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/fCrEaItWxG

Feb 19, 2024 · 214 followers View post →
José Luis Sánchez
@JoseLuisFacMed · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/WCb7bOApOv

Feb 19, 2024 · 31 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk. https://t.co/JLwAINlmWk

Feb 19, 2024 · 2,070 followers View post →
Robin
@robin_mthw · X

@donlayman @BioLayne Please review this next… Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/86MP0wUTK8

Feb 19, 2024 · 58 followers View post →
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[Artikel] Identifizierung eines Leucin-vermittelten Schwelleneffekts ...
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Link; https://www.nature.com/articles/s42255-024-00984-2 DOI: https://doi.org/10.1038/s42255-024-00984-2 Vielen Dank.

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[บทความ] การระบุผลกระทบเกณฑ์ที่เกิดจากลิวซีนซึ่งควบคุมสัญญาณ ...
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Lien ; https://www.nature.com/articles/s42255-024-00984-2 DOI : https://doi.org/10.1038/s42255-024-00984-2 Merci beaucoup.

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[Article] Identification of a leucine-mediated threshold effect ...
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