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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk.
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Feb 2024 – Nov 2025Where it's discussed
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X / Twitter27 posts
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News13 articles
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Facebook9 posts
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Reddit5 posts
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Blogs3 articles
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YouTube2 videos
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Bluesky1 posts
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AI synopsis
What people are saying
The overall tone reflects strong interest and some agreement, as exemplified by posts emphasizing leucine's role in promoting atherosclerosis and the molecular mechanisms involved, such as mentions of 'leucine enough to promote ASCVD' and references to the effects of high-protein diets. The use of technical language and discussions about dietary thresholds indicate a significant impact on ongoing research and nutritional debates.
Most discussions recognize the study's findings, with some expressing support or curiosity about the link between leucine, protein intake, and cardiovascular risk.
Participants show high interest, frequently referencing specific mechanisms like mTOR activation and the role of leucine, indicating active engagement with the content.
Comments range from brief mentions to detailed discussions about the molecular mechanisms and dietary implications, demonstrating moderate to deep engagement.
The conversations suggest the research could influence dietary considerations and future studies on cardiovascular risk, though some posts are more speculative or administrative.
Abstract in brief
- High protein intake, often seen as healthy, may activate mTOR signaling in macrophages, linked to ischaemic cardiovascular disease.
- Clinical studies reveal that leucine is the main amino acid triggering mTOR activation in macrophages, with significant effects only seen with protein intake over roughly 25g per meal.
- Research indicates that protein intake above 22% of dietary energy can promote atherosclerosis in male mice, highlighting the cardiovascular risks of excessive dietary protein.
Top posts
Most liked on X and BlueskyIdentification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/c31Y0Aw3pM Es gibt einen molekularen Mechanismus, durch den zu viel Protein im Essen das Arterioskleroserisiko erhöhen kann https://t.co/HTApMaGouK
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/g1E7rh1kxj
رگهای خونی آسیب بزنه و احتمال گرفتگی رگها (مثل سکته قلبی) رو بالا ببره. یعنی خوردن زیاد پروتئین، بهخصوص توی رژیمهایی که بیشتر از ۲۲٪ کالری کل از پروتئین میاد، ممکنه برای قلب مضر باشه، مخصوصاً توی آقایون. https://t.co/Jgn1p9CdhB
ロイシン濃度の増加は、高タンパク質食が存在しない場合でも、雄マウスのアテローム性動脈硬化を促進するのに十分であることが示されました。人間の場合、1食当たり25gを超えるタンパク質で免疫細胞を活性化させるに十分な血中ロイシン濃度の上昇が得られることがわかりましたhttps://t.co/uLWwZhALfq
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This video explains what whey protein is, how it is produced, and its primary functions in the body. It discusses its effectiveness in muscle recovery, increasing lean mass, and nutritional support, along with common…
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/JLwAINkP6M
رگهای خونی آسیب بزنه و احتمال گرفتگی رگها (مثل سکته قلبی) رو بالا ببره. یعنی خوردن زیاد پروتئین، بهخصوص توی رژیمهایی که بیشتر از ۲۲٪ کالری کل از پروتئین میاد، ممکنه برای قلب مضر باشه، مخصوصاً توی آقایون. https://t.co/Jgn1p9CdhB
RT @erlesen: Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.c…
I suppose I should mention that I perhaps have a pro-protein bias, but the evidence appears supportive of this approach. I plan to post about the Zhang study (https://t.co/ub5INMxORi) eventually but will save that for another day
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/8RvdVqu8Vq @aiims_newdelhi, @AIIMSBhubaneswr, @aiims_rpr, @AIIMSBhopal, @aiimsrishi, @AIIMSNagpur, @aiims_jodhpur @OfficialJipmer @aiims_newdelhi @MIT https://t.co/Uy6zRY9U9q
How is raising the number of steps taken each day associated with a reduced risk of cardiovascular diseases? Walking->⬆️MiR-126->⬇️mTOR->⬆️Mitophagy-> ⬇️cardiovascular risk. https://t.co/8RvdVqu8Vq For more https://t.co/yIjh60K0jv @DrFrankLipman @NIH @WHO @NobelPrize @ICMRDELHI https://t.co/dDy8MQLyEk https://t.co/QPtpo44YrS
RT @RyanLab_MBU:
RT @erlesen: Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.c…
RT @RyanLab_MBU:
RT @RyanLab_MBU:
RT @RyanLab_MBU:
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk www.nature.com/articles/s42... Es gibt einen molekularen Mechanismus, durch den zu viel Protein im Essen das Arterioskleroserisiko erhöhen kann www.hna.de/welt/eiweiss...
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/c31Y0Aw3pM Es gibt einen molekularen Mechanismus, durch den zu viel Protein im Essen das Arterioskleroserisiko erhöhen kann https://t.co/HTApMaGouK
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk. https://t.co/JLwAINlmWk
"Not only was ⬆️leucine enough to promote ASCVD, it was also required for high-protein diets to do so ⬆️ASCVD progression w/ ⬆️leucine diets was independent of altered total carb & prot supply" https://t.co/AjxMtqDFDh @GardnerPhD @dr_muniyappa @nutrition_facts
@NanciGuestRDPhD The DOI does not function.. otherwise it would now be in @Wikidata .. https://t.co/dbzf53B9eD
https://t.co/wZ2u2Ep6de High-Protein Diet Linked to Increased #cardiovascular Disease Risk. Researchers from the University of Pittsburgh School of Medicine published a study titled "Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling...
@r_reddington01 @elmundoes Xiangyu Zhang Universidad de Pittsburgh https://t.co/otobiIvptA
@NanciGuestRDPhD @FusionProgGuy @TheNutrivore @dylanarmbruste3 @theproof @NutritionMadeS3 @ScepticalDoctor @MohammedAlo @TheAlanAragon Find more info in their source data: https://t.co/GojwWzEFHR
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
ロイシン濃度の増加は、高タンパク質食が存在しない場合でも、雄マウスのアテローム性動脈硬化を促進するのに十分であることが示されました。人間の場合、1食当たり25gを超えるタンパク質で免疫細胞を活性化させるに十分な血中ロイシン濃度の上昇が得られることがわかりましたhttps://t.co/uLWwZhALfq
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/g1E7rh1kxj
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/OiisXWgDE7
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/fCrEaItWxG
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk | Nature Metabolism https://t.co/WCb7bOApOv
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk. https://t.co/JLwAINlmWk
@donlayman @BioLayne Please review this next… Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk https://t.co/86MP0wUTK8
10.1038/s42255-024-00984-2. Keywords. /Health and medicine/Human health/Dietetics/Diets; /Life sciences/Cell biology/Cells/Immune cells/Phagocytes/Macrophages ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
Link; https://www.nature.com/articles/s42255-024-00984-2 DOI: https://doi.org/10.1038/s42255-024-00984-2 Vielen Dank.
ลิงก์; https://www.nature.com/articles/s42255-024-00984-2 DOI : https://doi.org/10.1038/s42255-024-00984-2 ขอบคุณมาก.
... s42255-024-00984-2. DOI : https://doi.org/10.1038/s42255-024-00984-2. बहुत धन्यवाद. अपवोट करें 2 डाउनवोट करें 2 ...
Lien ; https://www.nature.com/articles/s42255-024-00984-2 DOI : https://doi.org/10.1038/s42255-024-00984-2 Merci beaucoup.
Link; https://www.nature.com/articles/s42255-024-00984-2 DOI : https://doi.org/10.1038/s42255-024-00984-2 Many thanks.
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
https://doi.org/10.1038/s42255-024-00984-2. (3) Diab, A., Dastmalchi, L. N., Gulati, M., & Michos, E. D. (2023). A Heart-Healthy Diet for ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
Yaptığın işe alış. Sonrasında neyi nasıl yaptığına odaklan. Plansız olduğun taktirde gerisinin bir önemi kalmayacak. Kreatin, protein tozu…
2024-02-19 , doi: 10.1038/s42255-024-00984-2. 一线治疗胃癌,替雷利珠单抗第3项适应证在美申报上市. ① 2月27日,百济神州宣布,美国FDA已受理替雷利 ...
Original Study DOI: 10.1038/s42255-024-00984-2. Related. Eating plants over protein may cut heart disease risk · Can a bat protein treat human ...
2024-02-19 , doi: 10.1038/s42255-024-00984-2. Nature子刊:过量烟酸代谢产物增加心血管疾病风险. Nature Medicine——[82.9]. ① 本研究揭示了烟酸 ...
... 10.1038/s42255-024-00984-2). Quelle: Nature, University of Pittsburgh. 22. Februar 2024 - Claudia Krapp. Tags:Aminosäure Arterien ...
Nat Metab, 2024 DOI: 10.1038/s42255-024-00984-2. Cite This Page: MLA; APA; Chicago. University of Pittsburgh. "Eating too much protein is bad ...
org/10.1038/s42255-024-00984-2. [2] Eating too much protein is bad for your arteries, and this amino acid is to blame. Retrieved Feb. 20 ...
Medical research: Investigating the potential effects of high protein intake. doi: 10.1038/s42255-024-00984-2. 英語の原文. 「注目のハイライト ...
doi: 10.1038/s4 2255-024-00984-2. Meet the Author. A picture of Rhianna-lily Smith. Rhianna-lily Smith. Junior Science Editor. Rhianna-lily ...
ただし結論として、タンパク質摂取量の違いがもたらす影響を全て評価するには、さらなる研究が必要だとも述べている。 doi:10.1038/s42255-024-00984-2.
D., of the University of Toronto. Journal. Nature Metabolism. DOI. 10.1038/s42255-024-00984-2. Article Title. Identification of a leucine ...
was published in Nature Metabolism at 16:00 UK time on Monday 19 February 2024. DOI: 10.1038/s42255-024-00984-2. Declared interests. Prof ...
doi: https://doi.org/10.1038/s42255-024-00984-2. Currently rated 4.3 by 8 people. Posted in: Medical Science News | Medical Research News.
D., of the University of Toronto. Journal. Nature Metabolism. DOI. 10.1038/s42255-024-00984-2. Article Title. Identification of a leucine ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
org/10.1038/s42255-024-00984-2 High protein intake is common in western societies and is often promoted as part of a healthy lifestyle ...
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