Am J Psychiatry April 2024 PMID 38419495

Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability.

Soonjo Hwang, Ji-Woo Suk, Harma Meffert, Arica Lerdahl, William F Garvey, Ryan Edwards, Alison Delizza, Brigette Soltis-Vaughan, Katrina Cordts, Ellen Leibenluft, R J R Blair

Mentions

20
Peak: 11 in Apr 2024
across 3 sources since Feb 2024

Extended reach

150,155
potential audience

Total likes

40

Video views

1,916

Mentions per month

Feb 2024 – Aug 2024

Where it's discussed

  • X / Twitter17 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The overall discussions demonstrate strong support and intrigue, with phrases like 'promising clinical results' and detailed mentions of decreased activity in brain regions like the dorsomedial prefrontal cortex and posterior cingulate cortex. The tone's combination of scientific detail and optimistic outlook reflects a balanced yet impactful discussion of the study's potential implications for future treatments.

AgreementStrong agreement

Most discussions support the positive findings of the study, highlighting improvements in irritability and neural changes attributed to intranasal oxytocin.

InterestModerate interest

The posts indicate moderate interest, with many referencing clinical advances and neuroimaging results, though some focus on broader implications.

EngagementModerate engagement

Several discussions reference specific results, such as decreased brain activity in emotion-related regions and clinical ratings, showing a fair level of engagement.

ImpactHigh impact

The discussions suggest these findings may influence clinical approaches to irritability in youth, emphasizing potential therapeutic benefits and the importance of further research.

Abstract in brief

  • The study examined how intranasal oxytocin affects brain activity and symptoms in youths with severe irritability related to disruptive mood and behavior disorders, using clinical ratings and brain scans before and after treatment.
  • Youths who received oxytocin showed greater improvements in irritability and global severity ratings, along with decreased brain activity in emotion-related areas like the dorsomedial prefrontal cortex and posterior cingulate cortex, which was linked to clinical improvements.
  • The findings suggest that intranasal oxytocin may modify brain responses involved in emotion processing in irritable youths, potentially leading to reductions in irritability symptoms, although more research is needed for conclusive results.

Top posts

Most liked on X and Bluesky
Yann Le Strat
@YannLe_Strat · X

A l'avenir, on traitera peut être de façon plus ciblée des manifestations invalidantes qu'un ensemble de symptômes comme on le fait aujourd'hui. Par exemple, traiter l'irritabilité spécifiquement (et pas seulement le #TDAH). Cet essai l'illustre. https://t.co/S5DCqGmMET

Apr 13, 2024 · 17 likes · 3 shares · 2,390 followers View post →
Preventing Disorders of Aggression
@PsychopathyIs · X

A new RCT finds children with severe irritability improved after 3 weeks of daily intranasal oxytocin, an improvement correlated with decreased responsiveness in dorsomedial prefrontal cortex and posterior cingulate cortex. @APA_Publishing https://t.co/nI28h0PRDJ https://t.co/nYLkG7sdbI

Mar 4, 2024 · 6 likes · 1 share · 1,040 followers View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability | American Journal of Psychiatry https://t.co/ZcfgNQ7rmJ

May 16, 2024 · 4 likes · 72,524 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Promising clinical results and neuroimaging findings seen in a double-blind trial of intranasal oxytocin for irritability in youths. https://t.co/Nfi18dRzW4 https://t.co/vLONMxCUUx

Feb 29, 2024 · 4 likes · 11,607 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

New #podcast episode! Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability. https://t.co/whWu1sK3Uh https://t.co/jeCHy2JJ00

Apr 5, 2024 · 3 likes · 1 share · 11,607 followers View post →
P
@psychopharmacol · X

OL study: Youths who received oxytocin showed > improvement in CGI-S and CGI-I ratings for irritability vs. those who received placebo. fMRI BOLD responses to emotional stimuli in the DMPFC and posterior CC were reduced with oxytocin https://t.co/Ulpy4qHyEd

Apr 4, 2024 · 2 likes · 569 followers View post →

All mentions

Rafael O. Johnson R.
@Rojohnsonr · X

Oxitocina intranasal en jóvenes con irritabilidad https://t.co/Y2SBJCeYQM

May 22, 2024 · 347 followers View post →
Yasser Ad-Dab'bagh ياسر الدباغ
@yasseraddabbagh.bsky.social · Bluesky

Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability | American Journal of Psychiatry https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20230174?utm_campaign=journalupdate&utm_source=email&utm_medium=textlink&utm_content=ajp

May 16, 2024 View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability | American Journal of Psychiatry https://t.co/ZcfgNQ7rmJ

May 16, 2024 · 4 likes · 72,524 followers View post →
Gary Holden
@Info4Practice · X

New on https://t.co/8pxKdRDxAR | Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability | https://t.co/wH7jbvJxYZ https://t.co/oSX5PVVCVN

May 5, 2024 · 4,698 followers View post →
Gary Holden
@Info4Practice · X

New on https://t.co/8pxKdRE5qp | April 2024: Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability | https://t.co/Ldbzpj2851 https://t.co/KqjEDx2MhC

Apr 29, 2024 · 4,698 followers View post →
Mike Gara
@garami53 · X

Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability | American Journal of Psychiatry https://t.co/gVxtgOgI2D

Apr 19, 2024 · 1,734 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability Soonjo Hwang, M.D., et al. https://t.co/Lnxr9DyhZ6

Apr 19, 2024 · 1 like · 11,607 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the April 2024 issue. https://t.co/rVaA2Whuoj

Apr 19, 2024 · 1 like · 11,607 followers View post →
Diane Purper-Ouakil
@Ouakil8 · X

RT @YannLe_Strat: A l'avenir, on traitera peut être de façon plus ciblée des manifestations invalidantes qu'un ensemble de symptômes comme…

Apr 14, 2024 · 3 shares · 1,638 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @YannLe_Strat: A l'avenir, on traitera peut être de façon plus ciblée des manifestations invalidantes qu'un ensemble de symptômes comme…

Apr 13, 2024 · 3 shares · 334 followers View post →
Frederique Amsellem
@psyfredoo · X

RT @YannLe_Strat: A l'avenir, on traitera peut être de façon plus ciblée des manifestations invalidantes qu'un ensemble de symptômes comme…

Apr 13, 2024 · 3 shares · 202 followers View post →
Yann Le Strat
@YannLe_Strat · X

A l'avenir, on traitera peut être de façon plus ciblée des manifestations invalidantes qu'un ensemble de symptômes comme on le fait aujourd'hui. Par exemple, traiter l'irritabilité spécifiquement (et pas seulement le #TDAH). Cet essai l'illustre. https://t.co/S5DCqGmMET

Apr 13, 2024 · 17 likes · 3 shares · 2,390 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

New #podcast episode! Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability. https://t.co/whWu1sK3Uh https://t.co/jeCHy2JJ00

Apr 5, 2024 · 3 likes · 1 share · 11,607 followers View post →
P
@psychopharmacol · X

OL study: Youths who received oxytocin showed > improvement in CGI-S and CGI-I ratings for irritability vs. those who received placebo. fMRI BOLD responses to emotional stimuli in the DMPFC and posterior CC were reduced with oxytocin https://t.co/Ulpy4qHyEd

Apr 4, 2024 · 2 likes · 569 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

In an AJP Editorial, Argyris Stringaris @ucl @uoaofficial and Jamilah Silver @stonybrooku commend the authors of an RCT examining neural responses to intranasal oxytocin in youths with severe irritability. https://t.co/WmKW0z89Jc https://t.co/KZWUJTn8uI

Apr 2, 2024 · 11,607 followers View post →
Torleif Soderstrom
@TorleifSoder · X

RT @PsychopathyIs: A new RCT finds children with severe irritability improved after 3 weeks of daily intranasal oxytocin, an improvement co…

Mar 4, 2024 · 1 share · 1 followers View post →
Preventing Disorders of Aggression
@PsychopathyIs · X

A new RCT finds children with severe irritability improved after 3 weeks of daily intranasal oxytocin, an improvement correlated with decreased responsiveness in dorsomedial prefrontal cortex and posterior cingulate cortex. @APA_Publishing https://t.co/nI28h0PRDJ https://t.co/nYLkG7sdbI

Mar 4, 2024 · 6 likes · 1 share · 1,040 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Promising clinical results and neuroimaging findings seen in a double-blind trial of intranasal oxytocin for irritability in youths. https://t.co/Nfi18dRzW4 https://t.co/vLONMxCUUx

Feb 29, 2024 · 4 likes · 11,607 followers View post →