Nat Metab April 2024 PMID 38429390

Systemic proteome adaptions to 7-day complete caloric restriction in humans.

Maik Pietzner, Burulça Uluvar, Kristoffer J Kolnes, Per B Jeppesen, S Victoria Frivold, Øyvind Skattebo, Egil I Johansen, Bjørn S Skålhegg, Jørgen F P Wojtaszewski, Anders J Kolnes, Giles S H Yeo, Stephen O'Rahilly, Jørgen Jensen, Claudia Langenberg

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Discussions highlight the study’s focus on systemic proteome changes during a 7-day caloric restriction, with examples mentioning the extensive extracellular matrix remodeling and the potential health implications, such as cardiovascular and inflammatory effects. The tone is cautiously optimistic, with calls to examine the full paper and occasional remarks about the study's importance, reflecting a solid, if not highly passionate, engagement with the publication.

AgreementModerate agreement

Most discussions recognize the significance of the research, with some expressing straightforward support or understanding of its importance.

InterestModerate interest

The posts show moderate curiosity, with some users highlighting specific aspects like extracellular matrix remodeling or calling attention to the study's novelty.

EngagementModerate engagement

Posts include references to the proteomic changes and possible implications, suggesting active interest, but few delve deeply into methodological details or critical analysis.

ImpactModerate impact

The overall tone indicates that many perceive this research as impactful, especially given repeated mentions and sharing of the article's significance within scientific and medical communities.

Abstract in brief

A 7-day water-only fast results in significant weight loss and triggers nine distinct proteomic response profiles, with system-wide changes evident after 3 days of fasting, involving over 3,000 plasma proteins measured over time.
The systemic response to fasting affects multiple organs, showing conserved proteomic changes across individuals, notably involving extracellular matrix proteins like tenascinR, indicating profound non-metabolic adaptations.
Proteogenomic analysis suggests fasting may have both beneficial effects (such as on SWAP70 and HYOU1 related to cardiovascular and inflammatory health) and potential adverse effects, providing deeper insight into the complex health impacts of prolonged caloric restriction.

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Systemic Changes in Metabolism During a Seven-Day Fast

Researchers from Queen Mary University of London and the Norwegian School of Sports Sciences reveal systemic effects of a seven-day water-only fast. The study highlights dramatic shifts in blood proteins and metabolic…

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Lemann Brother

@Leonard52866930 · X

@DrBrunoGino o discurso já começa com a carteirada de "olha como eu sou dotô", nao tem muita credibilidade. Mas há estudos muitos bons mostrando riscos e benefícios. Systemic proteome adaptions to 7-day complete caloric restriction in humans | Nature Metabolism https://t.co/LPqt3W8nSE https://t.co/wfTzYlFGwd

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Lovewing.

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@1saki_chan @Witold633 @ish_silverstein @OskWars musiales mnie zle zrozumiec, nie ublizam ci z powodu twojego zawodu, tak czy inaczej skończ pierdolic i masz lekturki do poczytania z rzetelnych źródeł naukowych a nie twojej opinii https://t.co/mj6LKBwcHb https://t.co/8BglGKjjHi https://t.co/iddkV9jipb

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Systemic proteome adaptions to 7-day complete caloric restriction in humans | Nature Metabolism https://t.co/3b42o1aVTI

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Dr Daniel Valencia Torres

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RT @EstebanDL: Sabemos que los cambios del proteoma durante el ayuno muestran una remodelación extensa de la matriz extracelular en varios…

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Mind Your Science!

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Agingdoc

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Jeff Davies

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Systemic proteome adaptions to 7-day complete caloric restriction in humans | Nature Metabolism https://t.co/9EClEpydHP

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Jovita Mezquita Pla

@JovitaMezquita · X

Publicat a Nat. Metab. 2024 per Pietzner M, Uluvar B, Kolnes KJ et al. Systemic proteome adaptions to 7-day complete caloric restriction in humans. doi:10.1038/s42255-024-01008-9 (Epub ahead of print).

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おくさん/OKUSUN

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7日間の断食に対する分子的適応を系統的に分析した結果。体重だけでなく、測定されたタンパク質の3分の1はすべての臓器中で有意に変化してる。/ Systemic proteome adaptions to 7-day complete caloric restriction in humans, Nature Metabolism https://t.co/proon9gem8

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Oleg A. Chagin

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Systemic proteome adaptions to 7-day complete caloric restriction in humans | Nature Metabolism https://t.co/t27aGyzCxr

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TimePie (focus on anti-aging science)

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Systemic proteome adaptions to 7-day complete caloric restriction in humans @pietznerm @ Claudia Langenberg et al. https://t.co/Krw2MVEwXQ

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Nature Metabolism

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Keith Robertson

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@ChrisPalmerMD Here it is

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Bruno Ramos-Molina, PhD

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Systemic proteome adaptions to 7-day complete caloric restriction in humans | Nature Metabolism

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Alper Aydın (Dietitian )

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Nature Metabolism

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Systemic proteome adaptions to 7-day complete caloric restriction in humans.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Hunger and Neuronal Modifications Influence Aging and Longevity

Impact of 7-Day Fasting on Organ Responses

Systemic Changes in Metabolism During a Seven-Day Fast