February 2024 PMID 38476603

Apigenin: a natural molecule at the intersection of sleep and aging.

Daniel J Kramer, Adiv A Johnson

Mentions

57
Peak: 20 in Feb 2024
across 5 sources since Feb 2024

Extended reach

1,124,923
potential audience

Total likes

842

Video views

5,856

Mentions per month

Feb 2024 – Oct 2025

Where it's discussed

  • X / Twitter46 posts
  • Reddit5 posts
  • YouTube2 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

The group's discussions exhibit a positive outlook on the article, with examples like mentions of apigenin’s role in increasing NAD+ and improving sleep, and questions about practical consumption, demonstrating both understanding and interest in real-world applications. The tone combines enthusiasm with curiosity, reflecting acknowledgment of the research’s significance but also careful consideration of its direct implications.

AgreementModerate agreement

Most discussions acknowledge the potential benefits of apigenin in boosting NAD+ levels, referencing its effects on sleep, aging, and health, indicating a generally positive consensus.

InterestHigh interest

The posts show high interest by mentioning specific mechanisms, such as inhibition of CD38, and practical implications like consuming parsley or chamomile, reflecting curiosity and relevance.

EngagementModerate engagement

Posts include both sharing summaries and asking questions, like whether consuming parsley could impact health, showing active engagement without deep technical debates.

ImpactModerate impact

While many recognize potential health benefits, discussions suggest a cautious optimism about translating animal study results into human health strategies, indicating moderate perceived impact.

Abstract in brief

  • Apigenin is a natural compound that can boost levels of NAD, a key molecule involved in aging and metabolism, by inhibiting the enzyme CD38, which consumes NAD.
  • In animal studies, apigenin has shown to improve memory, reduce cancer growth, promote sleep, and extend lifespan in models like mice, flies, and worms.
  • Human studies with chamomile extract, which contains apigenin, suggest benefits such as reduced anxiety, better mood, pain relief, and improved sleep quality, highlighting its potential for aging and sleep health.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/3gaa40TRau

Mar 14, 2024 · 45 likes · 17 shares · 45,203 followers View post →
J P Fanton
@HealthyFellow · X

#Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @hubermanlab @DrPalmquist @Grimhood @DrOrnaND @LoriShemek @ralzahrani2020 @SatchinPanda @kirkparsley https://t.co/IUM5oHRVdZ

Feb 27, 2024 · 26 likes · 10 shares · 25,950 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/RITVP7fYVw

Apr 30, 2024 · 19 likes · 3 shares · 307,737 followers View post →
J P Fanton
@HealthyFellow · X

#Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @hubermanlab @Grimhood @DrPalmquist @COSseaton @HLFINC @sleepresearcher @NaturopathNews @AANP @NutWorld @vitaminretailer

Feb 1, 2024 · 15 likes · 8 shares · 25,950 followers View post →
Eve.S.
@yeeseak · X

https://t.co/O4NfyaJsvN

Oct 9, 2024 · 7 likes · 880 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

睡眠と老化の交差点にある天然分子 "代謝の中心となる極めて重要な補酵素であるNAD+は、加齢とともに特徴的な低下を示します。マウスでは、 NAD+消費糖タンパク質CD38を阻害する天然フラボノイドであるアピゲニンを投与することで、 NAD+レベルを上昇させることができます。"https://t.co/YYy3u9kBGX

Aug 28, 2025 · 2 likes · 2,617 followers View post →

All mentions

老化を遅らせることに成功しているかも
@roukaokurasu · X

睡眠と老化の交差点にある天然分子 "代謝の中心となる極めて重要な補酵素であるNAD+は、加齢とともに特徴的な低下を示します。マウスでは、 NAD+消費糖タンパク質CD38を阻害する天然フラボノイドであるアピゲニンを投与することで、 NAD+レベルを上昇させることができます。"https://t.co/YYy3u9kBGX

Aug 28, 2025 · 2 likes · 2,617 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

Jun 15, 2025 · 2 likes · 2,617 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

"マウスでは、 NAD +消費糖タンパク質CD38を阻害する天然フラボノイドであるアピゲニンを投与することで、 NAD +レベルを上昇させることができます。動物モデルでは、アピゲニンは睡眠と寿命の両方に良い影響を与えます。"https://t.co/RKVsLOKL28

Jun 15, 2025 · 2 likes · 2,617 followers View post →
Eve.S.
@yeeseak · X

https://t.co/O4NfyaJsvN

Oct 9, 2024 · 7 likes · 880 followers View post →
DagobertIX
@DagobertIX · X

@MTL_Invests This is a good review on Apigenin https://t.co/ELQafoqify

Sep 5, 2024 · 1 like · 284 followers View post →
Sharon Jackson
@SharonJ67654935 · X

RT @Mangan150: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/RITVP7fYVw

May 1, 2024 · 3 shares · 5,046 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/RITVP7fYVw

Apr 30, 2024 · 19 likes · 3 shares · 307,737 followers View post →
frank
@frankwikson · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 26, 2024 · 17 shares · 26 followers View post →
Orlando_uy
@Orlando_uy · X

Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/uEdS8b2wjz

Mar 26, 2024 · 694 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Apigenin: a natural molecule at the intersection of sleep and aging @FrontNutrition

Mar 16, 2024 · 2 likes · 781 followers View post →
Maskul
@MaskulNitespore · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 15, 2024 · 17 shares · 486 followers View post →
Slawomir
@Slawomi18369321 · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 15, 2024 · 17 shares · 84 followers View post →
Integrative Psychiatry Oklahoma
@Intpsychok · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 15, 2024 · 17 shares · 140 followers View post →
JR
@JR78202114 · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 507 followers View post →
Science
@Long_life_sci · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 34 followers View post →
KALLEL Labs
@labs_sir · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 117 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 129 followers View post →
The Longevist
@Dr_coachbear · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 481,519 followers View post →
Juhana Harju
@JuhanaHarju · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 1,683 followers View post →
Dr. Nandan Kumar
@NandanDuddukuri · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 384 followers View post →
✟ CHRISTian Nudist Ninja ✟
@Naturist_Ninja · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 17 followers View post →
Bioecomatics
@bioecomatic · X

RT @agingdoc1: Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/…

Mar 14, 2024 · 17 shares · 112 followers View post →
Agingdoc
@agingdoc1 · X

Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/az1dbdhg8D | @FrontNutrition https://t.co/3gaa40TRau

Mar 14, 2024 · 45 likes · 17 shares · 45,203 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Apigenin: a natural molecule at the intersection of sleep and aging https://t.co/aCbN5KSYeh

Mar 13, 2024 · 2,235 followers View post →
Men Metrics
@MenMetrics · X

@CharlesMBrenner This paper states that in mice apigenin (found in parsley/chamomile) increases NAD+ via inhibition of the NADase enzyme CD38. Would it make a difference to our health if we consume some parsley/chamomile occasionally? Thank you for your work! https://t.co/fudWOmBd0w https://t.co/FOE16PYGvx

Mar 6, 2024 · 3 followers View post →
Science-George
@Science_George · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Mar 1, 2024 · 10 shares · 3,731 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 28, 2024 · 10 shares · 3,149 followers View post →
Frontiers - Nutrition
@FrontNutrition · X

New Research: Apigenin: a natural molecule at the intersection of sleep and aging: NAD+, a pivotal coenzyme central to metabolism, exhibits a characteristic decline with age. In mice, NAD+ levels can be elevated via treatment with apigenin, a… https://t.co/QN8pTiv9la #Nutrition

Feb 28, 2024 · 3,919 followers View post →
Atman Das marinebiodrugs@gmail.com
@atmbiopro · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 28, 2024 · 10 shares · 3,991 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 28, 2024 · 10 shares · 10,286 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 28, 2024 · 10 shares · 2,895 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 28, 2024 · 10 shares · 196 followers View post →
Dr. د. عبدالواحد الزهراني
@ralzahrani2020 · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 27, 2024 · 10 shares · 4,934 followers View post →
Best Health 4 You
@besthealthyou · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 27, 2024 · 10 shares · 507 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 27, 2024 · 10 shares · 334 followers View post →
Richard
@PGC1a_RB · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @Scien…

Feb 27, 2024 · 10 shares · 15,255 followers View post →
J P Fanton
@HealthyFellow · X

#Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/huzfm9YXv3 @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @hubermanlab @DrPalmquist @Grimhood @DrOrnaND @LoriShemek @ralzahrani2020 @SatchinPanda @kirkparsley https://t.co/IUM5oHRVdZ

Feb 27, 2024 · 26 likes · 10 shares · 25,950 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 2, 2024 · 8 shares · 196 followers View post →
CHSeaton
@COSseaton · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 5,911 followers View post →
Health Promotor
@ukingdomshoppin · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 4,296 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 3,149 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 133,127 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 2,895 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 10,286 followers View post →
Prof Nenad Naumovski (PhD)
@NaumovskiNenad · X

RT @HealthyFellow: #Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @Scien…

Feb 1, 2024 · 8 shares · 1,216 followers View post →
J P Fanton
@HealthyFellow · X

#Apigenin: A natural molecule at the intersection of #sleep & #aging https://t.co/e7MyWVp2JG @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @hubermanlab @Grimhood @DrPalmquist @COSseaton @HLFINC @sleepresearcher @NaturopathNews @AANP @NutWorld @vitaminretailer

Feb 1, 2024 · 15 likes · 8 shares · 25,950 followers View post →
6 Best Teas to Help You Sleep, According to Registered Dietitians
News

doi:10.3389/fnut.2024.1359176. Safari M, Asadi A, Aryaeian N, et al. The effects of melissa officinalis on depression and anxiety in type 2 ...

Apr 1, 2025 View →
Apigenin: why does it work? : r/NootropicsDepot
Reddit

... relaxation aspect: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full · Psychonautica91. OP • 1y ago.

Feb 11, 2025 View →
芹菜素:它为什么有效? : r/NootropicsDepot
Reddit

... 关于放松方面的内容: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full · Psychonautica91. 原始发帖人 • 10个 ...

Feb 11, 2025 View →
Apigenin: kenapa ia berkesan? : r/NootropicsDepot
Reddit

... : https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full · Psychonautica91. PENYIAR ASAL • 10 bln lalu.

Feb 11, 2025 View →
Night Terrors & Hallucinations : r/nightterrors
Reddit

... 10.3389/fnut.2024.1359176/full. The research is both early and a bit scant. I'm extremely allergic to chamomile, so I haven't messed around ...

Sep 23, 2024 View →
研究进展| 芹菜素与人类健康关系探讨|活性|球蛋白|细胞|芹菜素|黄酮_ ...
News

DOI:10.3389/fnut.2024.1359176. 翻译/撰写:李雄(实习). 编辑:梁安琪;责任编辑:张睿梅. 封面图片来源:图虫创意. 为了帮助食品及生物学科科技人员 ...

Jun 26, 2024 View →
¿Alguien probó la apigenina? : r/G6PD
Reddit

... 10.3389/fnut.2024.1359176/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/. ¿Sería lógico pensar que al inhibir el CD38 nuestro NAD ...

Jun 25, 2024 View →
Tally Health launches pro-longevity sleep supplement
Blogs

... 10.3389/fnut.2024.1359176/full [14] https://link.springer.com/article/10.1007/s11357-024-01094-3. Share this article: Email Facebook Twitter ...

Apr 11, 2024 View →
Apigenin, Sleep, and Aging – Fight Aging!
Blogs

Link: https://doi.org/10.3389/fnut.2024.1359176. Comment Submission. Post a comment; thoughtful, considered opinions are valued. New comments ...

Mar 26, 2024 View →