Proc Natl Acad Sci U S A March 2024 PMID 38513099

The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.

Mingu Kang, Yasumi Otani, Yanyu Guo, Jie Yan, Benjamin T Goult, Alan K Howe

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Peak: 22 in Mar 2024

across 3 sources since Aug 2023

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33,889

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Aug 2023 – Apr 2024

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AI synopsis

What people are saying

The discussions reflect positive reception with phrases like 'Excited to share' and mentions of the article being a 'new paper,' indicating interest and engagement. The tone emphasizes scientific importance, such as identifying talin as a mechanically gated AKAP, which suggests recognition of its potential impact on understanding cellular mechanotransduction.

AgreementModerate agreement

Most discussions express support or enthusiasm for the significance of the publication, indicating general agreement with the findings.

InterestModerate interest

Participants show moderate interest, with some highlighting the novelty and scientific implications, but no highly passionate reactions.

EngagementModerate engagement

Comments include references to the molecular mechanisms and links to broader cellular processes, demonstrating thoughtful engagement.

ImpactModerate impact

The discussions imply that this research could influence future studies in cell signaling and mechanotransduction, suggesting moderate perceived impact.

Abstract in brief

The text describes how talin, a crucial protein in focal adhesions, acts as a mechanically gated anchoring protein for PKA, linking mechanical force to cellular signaling.
It details the molecular interaction between PKA and talin, specifically how PKA binds to helix41 in the R9 domain of talin, requiring unfolding under mechanical force, which regulates this binding.
Experiments show that disrupting the PKA-talin interaction affects PKA activity and phosphorylation of other proteins involved in cell adhesion, highlighting this interaction's role in mechanotransduction during cell adhesion.

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All mentions

Talin: Mechanically-Gated A-Kinase Anchoring Protein Insights

This video summarizes our new publication on the focal adhesion protein talin, revealing its role as a mechanically-gated A-kinase anchoring protein. Discover how talin's binary switch patterns influence cellular…

Ben Goult · Mar 21, 2024 225 views

Talin as a Mechanically-Gated Akinase Anchoring Protein

This video summarizes our publication on the focal adhesion protein talin, identifying it as a mechanically-gated Akinase anchoring protein (AKAP). It visualizes how talin's 9th binary switch unfolds, revealing a…

Ben Goult · Mar 21, 2024 99 views

Carmelo Ferrai

@CarmeloFerrai · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Apr 5, 2024 · 19 shares · 2,498 followers View post →

Roy Goodacre

@RoyGoodacre · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 24, 2024 · 19 shares · 4,369 followers View post →

Sonia

@srochaliv · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 24, 2024 · 19 shares · 1,218 followers View post →

Turk Lab

@benturklab · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 24, 2024 · 19 shares · 293 followers View post →

Ben Goult

@bengoult · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 24, 2024 · 19 shares · 1,658 followers View post →

Manoj Mayogi Mishra

@mayogisense · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 22, 2024 · 19 shares · 577 followers View post →

Stephen Thorpe

@thorpesd · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 22, 2024 · 19 shares · 697 followers View post →

Jon Humphries

@JDHL18 · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 22, 2024 · 19 shares · 2,503 followers View post →

José Antonio Manso

@Jose_A_Manso · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 22, 2024 · 19 shares · 154 followers View post →

Matt Jones

@DrMCJones33 · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 22, 2024 · 19 shares · 1,131 followers View post →

Zheng Liu

@ZhengLiuLab · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 435 followers View post →

Mechanobiology Institute

@MBIsg · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 2,488 followers View post →

Prof(ret.) Dr Rune Linding 

@RuneLinding · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 3,062 followers View post →

ZechLab

@zech_lab · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 2,355 followers View post →

myosin actin crazy

@myosinactncrazy · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 1,405 followers View post →

Maik Bischoff

@MaikCBischoff · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 442 followers View post →

Marco Enriquez

@MarcoEnriquez18 · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 97 followers View post →

Ben Goult

@bengoult.bsky.social · Bluesky

The paper is summarised in this short animation youtu.be/J42J5dzMCdY?...

Mar 21, 2024 · 2 likes · 1 share View post →

Pereda Lab

@PeredaLab · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 527 followers View post →

Cian has gone to Bluesky and Mastodon

@cian_neuro · X

RT @bengoult: Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anch…

Mar 21, 2024 · 19 shares · 5,236 followers View post →

Ben Goult

@bengoult · X

Excited to share our new paper out today in @PNASNews "The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein" Instead of a

Mar 21, 2024 · 91 likes · 19 shares · 1,658 followers View post →

bioRxivpreprint

@biorxivpreprint.bsky.social · Bluesky

The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP) https://www.biorxiv.org/content/10.1101/2023.08.20.554038v1

Aug 21, 2023 View post →

The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.

Mentions per month

Where it's discussed

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Abstract in brief

Top posts

All mentions

Talin: Mechanically-Gated A-Kinase Anchoring Protein Insights

Talin as a Mechanically-Gated Akinase Anchoring Protein