JCO Precis Oncol March 2024 PMID 38513170

Plasma Proteome-Based Test for First-Line Treatment Selection in Metastatic Non-Small Cell Lung Cancer.

Petros Christopoulos, Michal Harel, Kimberly McGregor, Yehuda Brody, Igor Puzanov, Jair Bar, Yehonatan Elon, Itamar Sela, Ben Yellin, Coren Lahav, Shani Raveh, Anat Reiner-Benaim, Niels Reinmuth, Hovav Nechushtan, David Farrugia

Mentions

60
Peak: 13 in May 2025
across 3 sources since Mar 2024

Extended reach

107,735
potential audience

Total likes

99

Video views

38

Mentions per month

Mar 2024 – May 2025

Where it's discussed

  • X / Twitter38 posts
  • News21 articles
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions highlight the groundbreaking nature of the PROphet test, with contributors describing it as a 'clinical validation' and noting its high potential for guiding personalized lung cancer treatments. The tone is enthusiastic and forward-looking, using words like 'exciting,' 'impactful,' and 'promising,' which reflect a strong consensus on the study’s importance and potential to transform clinical practices.

AgreementStrong agreement

Most discussions express strong support and enthusiasm for the study’s findings, highlighting its clinical validation and potential for personalized treatment.

InterestHigh interest

Posts consistently show high interest by emphasizing the significance of the research, with phrases like 'exciting news' and 'promising developments,' reflecting curiosity and relevance.

EngagementHigh engagement

Many contributors reference specific aspects of the publication, such as the clinical validity, biological rationale, and implications for treatment, indicating deep engagement.

ImpactHigh impact

The discussions convey a perception that this study could significantly influence future diagnostic and treatment approaches, as evidenced by words like 'paving the way' and 'game changer.'

Abstract in brief

  • The study developed a machine learning test called PROphet that analyzes plasma proteomic profiles to better predict which metastatic NSCLC patients will benefit from PD-1/PD-L1 inhibitor therapies, addressing limitations of current guidelines that rely mainly on PDL1 levels.
  • The trial, involving 540 patients on immunotherapy and 85 on chemotherapy across multiple centers, showed that PROphet accurately predicts clinical benefit, with high agreement between predictions and actual outcomes, and can further stratify patients beyond PDL1 expression levels.
  • The results indicate that PROphet could guide more personalized treatment decisions: PROphet-negative patients with high PDL1 levels tend to do better with combination therapy, while PROphet-positive patients have similar outcomes whether treated with immunotherapy alone or combined with chemotherapy.]

Top posts

Most liked on X and Bluesky
David Gandara
@drgandara · X

We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR 2025 we present the biological rationale and function of these proteins. Potential broad therapeutic implications https://t.co/7VMeNYVkHG @isliquidbiopsy https://t.co/iD9cnnbeJu

May 19, 2025 · 50 likes · 12 shares · 7,929 followers View post →
CrozrX
@CrozrX · X

Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 21, 2024 · 16 likes · 6 shares · 983 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic Non–Small Cell Lung Cancer

Jan 13, 2025 · 8 likes · 8,838 followers View post →
OncoHost
@OncoHost · X

Our recent publication clinically validating PROphet® #NSCLC is now the top feature in @JCOPO_ASCO! If you haven't read it yet, now's the time: https://t.co/8xgLTBb6lx #liquidbiopsy #proteomics #biomarker #precisiononcology @drgandara @APDicker @ChrisDingmanCCO @oferorama https://t.co/sjM11Zd8Pw

Apr 11, 2024 · 7 likes · 3 shares · 927 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

https://t.co/XnExsVa3Do

Jan 13, 2025 · 4 likes · 8,838 followers View post →
OncoHost
@OncoHost · X

@JCOPO_ASCO has published a study showcasing the clinical validity & utility of PROphet® NSCLC! Thank you to the patients, physicians & scientists who made this milestone possible. We're paving the way for promising developments in #precisiononcology! https://t.co/xS2ElGFYXI https://t.co/x8lm6IEfjB

Mar 21, 2024 · 4 likes · 2 shares · 927 followers View post →

All mentions

Nava Almog
@NavaAlmog · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 20, 2025 · 12 shares · 64 followers View post →
ofer sharon
@oferorama · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 20, 2025 · 12 shares · 25 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 20, 2025 · 12 shares · 190 followers View post →
Doktorus
@Doktorus2 · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 20, 2025 · 12 shares · 3,987 followers View post →
Sevde Altuntas, Ph.D.
@SevdeAltuntas · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 20, 2025 · 12 shares · 3,615 followers View post →
Umut. Dişel
@UmutDisel · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 20, 2025 · 12 shares · 1,278 followers View post →
monomachi
@monomachi52 · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 19, 2025 · 12 shares · 206 followers View post →
Ichiro Takata
@takata_ichiro · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 19, 2025 · 12 shares · 61 followers View post →
Bruna Pellini, MD
@BrunaPellini · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 19, 2025 · 12 shares · 2,357 followers View post →
Santhosh Ambika
@RenoHemonc · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 19, 2025 · 12 shares · 4,023 followers View post →
Elad Sharon
@EladSharonMD · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 19, 2025 · 12 shares · 3,864 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

RT @drgandara: We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR…

May 19, 2025 · 12 shares · 8,838 followers View post →
David Gandara
@drgandara · X

We have previously described a novel plasma proteomic predictor for immunotherapy of NSCLC. https://t.co/hyF2uRr32l At AACR 2025 we present the biological rationale and function of these proteins. Potential broad therapeutic implications https://t.co/7VMeNYVkHG @isliquidbiopsy https://t.co/iD9cnnbeJu

May 19, 2025 · 50 likes · 12 shares · 7,929 followers View post →
OncoHost
@OncoHost · X

The metrics of our JCO® Precision Oncology (JCO PO) publication – “Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic Non–Small Cell Lung Cancer” cannot be ignored!

Feb 3, 2025 · 927 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

https://t.co/XnExsVa3Do

Jan 13, 2025 · 4 likes · 8,838 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic Non–Small Cell Lung Cancer

Jan 13, 2025 · 8 likes · 8,838 followers View post →
OncoHost
@OncoHost · X

Thrilled to share the impact of our @JCOPO_ASCO paper:

Dec 11, 2024 · 1 like · 927 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @OncoHost: Thank you to Personalized Medicine Coalition (PMC) for featuring OncoHost in their monthly newsletter! Read the peer-reviewe…

May 2, 2024 · 1 share · 11,710 followers View post →
OncoHost
@OncoHost · X

Thank you to Personalized Medicine Coalition (PMC) for featuring OncoHost in their monthly newsletter! Read the peer-reviewed paper published in JCO Precision Oncology here: https://t.co/dLU1VuaNYC #NSCLC #personalizedmedicine #lungcancer #proteomics https://t.co/1xWeNZRfuN

May 2, 2024 · 2 likes · 1 share · 927 followers View post →
Lior Feigin Alperovich
@LiorFeigin · X

RT @OncoHost: Our paper in @JCOPO_ASCO clinically validating our PROphetNSCLC™ test is currently featured content on the journal's website!…

Apr 19, 2024 · 1 share · 622 followers View post →
OncoHost
@OncoHost · X

Our paper in @JCOPO_ASCO clinically validating our PROphetNSCLC™ test is currently featured content on the journal's website! Haven't had a chance to read it yet? Now's the time: https://t.co/8xgLTBb6lx #JCO #PrecisionOncology #LungCancerTreatment #LCSM https://t.co/LiW6dD1tc1

Apr 19, 2024 · 2 likes · 1 share · 927 followers View post →
Dawood Findakly, MD, FACP
@dawood_findakly · X

RT @OncoHost: Our recent publication clinically validating PROphet® #NSCLC is now the top feature in @JCOPO_ASCO! If you haven't read it…

Apr 12, 2024 · 3 shares · 1,240 followers View post →
David Gandara
@drgandara · X

RT @OncoHost: Our recent publication clinically validating PROphet® #NSCLC is now the top feature in @JCOPO_ASCO! If you haven't read it…

Apr 12, 2024 · 3 shares · 7,929 followers View post →
Lior Feigin Alperovich
@LiorFeigin · X

RT @OncoHost: Our recent publication clinically validating PROphet® #NSCLC is now the top feature in @JCOPO_ASCO! If you haven't read it…

Apr 11, 2024 · 3 shares · 622 followers View post →
OncoHost
@OncoHost · X

Our recent publication clinically validating PROphet® #NSCLC is now the top feature in @JCOPO_ASCO! If you haven't read it yet, now's the time: https://t.co/8xgLTBb6lx #liquidbiopsy #proteomics #biomarker #precisiononcology @drgandara @APDicker @ChrisDingmanCCO @oferorama https://t.co/sjM11Zd8Pw

Apr 11, 2024 · 7 likes · 3 shares · 927 followers View post →
OncoHost
@OncoHost · X

Thanks to @TheCancerLetter for sharing our exciting news! Read all about our PROphet #NSCLC test's clinical validity and utility in @JCOPO_ASCO here: https://t.co/WmCmtPyBfk https://t.co/Ry0Puhf8Uo

Apr 4, 2024 · 2 likes · 927 followers View post →
Chris Dingman
@ChrisDingmanCCO · X

RT @CrozrX: Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 28, 2024 · 6 shares · 30 followers View post →
OncoHost
@OncoHost · X

RT @APDicker: Exciting to be part of a talented multi-disciplinary team to advance the cause for patients with lung cancer https://t.co/gE1…

Mar 26, 2024 · 1 share · 927 followers View post →
KRASKickers
@KRASKickers · X

RT @CrozrX: Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 23, 2024 · 6 shares · 3,614 followers View post →
Hiroaki Kanemura
@hirokane05 · X

RT @CrozrX: Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 22, 2024 · 6 shares · 122 followers View post →
Mattia Federico Merc
@MercMattia · X

RT @CrozrX: Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 22, 2024 · 6 shares · 279 followers View post →
Adam Dicker
@APDicker · X

Exciting to be part of a talented multi-disciplinary team to advance the cause for patients with lung cancer https://t.co/gE1uVeoIu5 @KimmelCancerCtr @TJUHospital @drgandara @NCIDirector

Mar 22, 2024 · 3 likes · 1 share · 1,185 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

RT @CrozrX: Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 21, 2024 · 6 shares · 8,838 followers View post →
David Gandara
@drgandara · X

RT @CrozrX: Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 21, 2024 · 6 shares · 7,929 followers View post →
CrozrX
@CrozrX · X

Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic

Mar 21, 2024 · 16 likes · 6 shares · 983 followers View post →
S G
@smgmd3 · X

RT @OncoHost: @JCOPO_ASCO has published a study showcasing the clinical validity & utility of PROphet® NSCLC! Thank you to the patients, p…

Mar 21, 2024 · 2 shares View post →
Lior Feigin Alperovich
@LiorFeigin · X

RT @OncoHost: @JCOPO_ASCO has published a study showcasing the clinical validity & utility of PROphet® NSCLC! Thank you to the patients, p…

Mar 21, 2024 · 2 shares · 622 followers View post →
OncoHost
@OncoHost · X

@JCOPO_ASCO has published a study showcasing the clinical validity & utility of PROphet® NSCLC! Thank you to the patients, physicians & scientists who made this milestone possible. We're paving the way for promising developments in #precisiononcology! https://t.co/xS2ElGFYXI https://t.co/x8lm6IEfjB

Mar 21, 2024 · 4 likes · 2 shares · 927 followers View post →