Dual-Capped Helical Interface Mimics.

Tianxiong Mi, Zhe Gao, Zeynep Mituta, Kevin Burgess

April 2024 J Am Chem Soc

Synopsis of Social media discussions

The discussions show enthusiasm and curiosity, highlighting the innovative aspects like the 'rigid and resistant' caps and their ability to bind target proteins, which reflects the scientific community's recognition of the research's significance and potential applications.

A
Agreement
 Moderate agreement

Most discussions express support or curiosity about the research, indicating general agreement with its importance.

I
Interest
 High level of interest

The use of hashtags and references to chemistry and technology demonstrate high interest in the scientific and technological implications.

E
Engagement
 Moderate level of engagement

Posts include mentions of specific features like the 'dual-capped' system and target proteins, reflecting moderate engagement.

I
Impact
 Moderate level of impact

The frequent references to reputable sources and potential applications suggest the discussions recognize a noteworthy impact of the publication.

Social Mentions

YouTube

2 Videos

Twitter

9 Posts

Metrics

Video Views

243

Total Likes

33

Extended Reach

418,998

Social Features

11

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Dual-Capped Helical Interface Mimicry for Protein Interaction Stability

Dual-Capped Helical Interface Mimicry for Protein Interaction Stability

This work introduces a new method called Dual-Capped Helical Interface that stabilizes protein mimics with bicyclic caps, enhancing stability and resistance to degradation. The approach improves mimic rigidity and effectiveness in binding target proteins.

Kevin Burgess

October 9, 2024

122 views

Dual Capping Approach Enhances Helical Mimetics Stability and Functionality

Dual Capping Approach Enhances Helical Mimetics Stability and Functionality

This work discusses a new method called DualCapped Helical Interface that stabilizes helices with specialized caps, improving stability and cell uptake. The approach uses bicyclic caps at both ends, making mimics more rigid and resistant to degradation.

Kevin Burgess

August 13, 2024

122 views

  • J. Am. Chem. Soc.
    @J_A_C_S (Twitter)

    RT @isciverse: Dual-Capped Helical Interface Mimics @J_A_C_S #Chemistry #Chemed #Science #TechnologyNews #news #technology #AcademicTwitte…
    view full post

    April 6, 2024

    2

  • Fábio Fonseca
    @FbioFon84085623 (Twitter)

    RT @J_A_C_S: Dual-Capped Helical Interface Mimics | Journal of the American Chemical Society @TAMU @TAMUChemistry #Helical #Interface #Mimi…
    view full post

    April 6, 2024

    5

  • Humberto ramírez Her
    @HumbertoramrezH (Twitter)

    RT @J_A_C_S: Dual-Capped Helical Interface Mimics | Journal of the American Chemical Society @TAMU @TAMUChemistry #Helical #Interface #Mimi…
    view full post

    April 5, 2024

    5

  • Carme Zaragoza
    @CarmeZaragoza (Twitter)

    RT @J_A_C_S: Dual-Capped Helical Interface Mimics | Journal of the American Chemical Society @TAMU @TAMUChemistry #Helical #Interface #Mimi…
    view full post

    April 5, 2024

    5

  • Chemistry Department
    @TAMUChemistry (Twitter)

    RT @J_A_C_S: Dual-Capped Helical Interface Mimics | Journal of the American Chemical Society @TAMU @TAMUChemistry #Helical #Interface #Mimi…
    view full post

    April 5, 2024

    5

  • Chun-Yen Lin
    @ChunYenLin2 (Twitter)

    RT @J_A_C_S: Dual-Capped Helical Interface Mimics | Journal of the American Chemical Society @TAMU @TAMUChemistry #Helical #Interface #Mimi…
    view full post

    April 5, 2024

    5

  • J. Am. Chem. Soc.
    @J_A_C_S (Twitter)

    Dual-Capped Helical Interface Mimics | Journal of the American Chemical Society @TAMU @TAMUChemistry #Helical #Interface #Mimics #Peptide https://t.co/NAOICIKsbG
    view full post

    April 5, 2024

    16

    5

  • Manoj Mayogi Mishra
    @mayogisense (Twitter)

    RT @isciverse: Dual-Capped Helical Interface Mimics @J_A_C_S #Chemistry #Chemed #Science #TechnologyNews #news #technology #AcademicTwitte…
    view full post

    April 5, 2024

    2

  • Top Science
    @isciverse (Twitter)

    Dual-Capped Helical Interface Mimics @J_A_C_S #Chemistry #Chemed #Science #TechnologyNews #news #technology #AcademicTwitter #AcademicChatter https://t.co/79OI64bz2M https://t.co/3t3LAgaKcu
    view full post

    April 5, 2024

    2

    2

Abstract Synopsis

  • This text discusses a new method called DualCapped Helical Interface that mimics protein interactions by stabilizing helices with specially designed caps, improving stability and cell uptake.
  • Unlike previous methods that mainly used staples between side chains, this approach uses bicyclic caps at both ends of the helix, making the mimic more rigid and resistant to degradation.
  • The dualcapped system was shown to be stable, effectively bind to target proteins like cyclins, and resist breakdown in serum, offering a promising new tool for drug design.]