Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.

Ezgi Hacisuleyman, Caryn R Hale, Natalie Noble, Ji-Dung Luo, John J Fak, Misa Saito, Jin Chen, Jonathan S Weissman, Robert B Darnell

May 2024 Nat Neurosci

Synopsis of Social media discussions

The comments collectively praise the research as a major advancement, with phrases like 'reprograms dendritic translation' and 'unveiling a new mechanism' indicating excitement. The tone and focus on technical details and potential impacts highlight a high level of interest and engagement, underscoring the importance perceived in this scientific contribution.

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All discussions express strong support for the significance of the research, emphasizing its groundbreaking findings.

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Interest
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The posts demonstrate high curiosity, with comments highlighting the novelty of the mechanism involving dendritic translation and neuronal activity.

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Most comments reflect thoughtful engagement, referencing the scientific methods used and the implications for neuroscience.

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Impact
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Multiple discussions imply that this work could have a profound influence on understanding neuronal processes and future research directions.

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Abstract Synopsis

  • Neuronal activity quickly changes dendritic protein production by regulating the binding of eIF4G2 to upstream open reading frames (uORFs), affecting local translation.
  • Using advanced techniques like proximity labeling, immunoprecipitation, ribosome profiling, and mass spectrometry, the study showed that depolarization (via KCl or DHPG) leads to changes in dendritic mRNAs and proteins, especially increasing translation of uORFs and downstream coding sequences tied to learning and energy processes.
  • This activity-dependent regulation involves the phosphorylation and recruitment of eIF4G2, which controls local protein synthesis, unveiling a new mechanism linking neuronal activity to dendritic remodeling through uORF translation.]