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Nat Neurosci May 2024 PMID 38589584

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.

Ezgi Hacisuleyman, Caryn R Hale, Natalie Noble, Ji-Dung Luo, John J Fak, Misa Saito, Jin Chen, Jonathan S Weissman, Robert B Darnell

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What people are saying

The comments collectively praise the research as a major advancement, with phrases like 'reprograms dendritic translation' and 'unveiling a new mechanism' indicating excitement. The tone and focus on technical details and potential impacts highlight a high level of interest and engagement, underscoring the importance perceived in this scientific contribution.

AgreementStrong agreement

All discussions express strong support for the significance of the research, emphasizing its groundbreaking findings.

InterestHigh interest

The posts demonstrate high curiosity, with comments highlighting the novelty of the mechanism involving dendritic translation and neuronal activity.

EngagementModerate engagement

Most comments reflect thoughtful engagement, referencing the scientific methods used and the implications for neuroscience.

ImpactHigh impact

Multiple discussions imply that this work could have a profound influence on understanding neuronal processes and future research directions.

Abstract in brief

  • Neuronal activity quickly changes dendritic protein production by regulating the binding of eIF4G2 to upstream open reading frames (uORFs), affecting local translation.
  • Using advanced techniques like proximity labeling, immunoprecipitation, ribosome profiling, and mass spectrometry, the study showed that depolarization (via KCl or DHPG) leads to changes in dendritic mRNAs and proteins, especially increasing translation of uORFs and downstream coding sequences tied to learning and energy processes.
  • This activity-dependent regulation involves the phosphorylation and recruitment of eIF4G2, which controls local protein synthesis, unveiling a new mechanism linking neuronal activity to dendritic remodeling through uORF translation.]
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Neuroscience News
@NeuroscienceNew · X

“Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding” by Robert B. Darnell et al. Nature Neuroscience https://t.co/7YIBZ8zKnG 3/3

Apr 9, 2024 · 18 likes · 4 shares · 507,039 followers View post →
EIRNABio
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Jul 6, 2024 · 10 likes · 2 shares · 1,222 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding https://t.co/03TIfch557 https://t.co/vh0y2XtyMM

Apr 16, 2024 · 24,140 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @NeuroscienceNew: “Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding” by Robert B. Darnell et al. Natur…

Apr 10, 2024 · 4 shares · 2,816 followers View post →
Abstream
@abstreamme · X

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding #science #publication #research #publications https://t.co/x0zuni0Xdp

Apr 9, 2024 · 789 followers View post →
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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding https://t.co/MEG9Nlz3PK

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Dr Imran Sheikh
@DrImranSheikh · X

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding https://t.co/03TIfch557 https://t.co/vh0y2XtyMM

Apr 16, 2024 · 24,140 followers View post →
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[Nat. Neurosci.] Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding https://t.co/iJsmvJRNbq

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Nathalia Le Hen
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RT @NeuroscienceNew: “Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding” by Robert B. Darnell et al. Natur…

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RT @NeuroscienceNew: “Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding” by Robert B. Darnell et al. Natur…

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RT @NeuroscienceNew: “Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding” by Robert B. Darnell et al. Natur…

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Neuroscience News
@NeuroscienceNew · X

“Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding” by Robert B. Darnell et al. Nature Neuroscience https://t.co/7YIBZ8zKnG 3/3

Apr 9, 2024 · 18 likes · 4 shares · 507,039 followers View post →
Abstream
@abstreamme · X

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding #science #publication #research #publications https://t.co/x0zuni0Xdp

Apr 9, 2024 · 789 followers View post →