In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2.
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Apr 2024 – Sep 2025Where it's discussed
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The group shows high enthusiasm for the research, with posts praising the discovery of how glycolytic metabolites like MGO can influence tumor suppression pathways, often using words like 'exciting' and 'very exciting' to convey their engagement. The tone and choice of words reflect a strong recognition of the research’s significance and its potential to impact cancer biology and treatment strategies.
Most discussions deeply support the significance of the findings, highlighting excitement and praise for the research’s implications.
Posts demonstrate high interest, with mentions of new mechanisms linking metabolism and cancer, and references to influential researchers and studies.
Discussions involve detailed mentions of molecular mechanisms like MGO’s role, and references to recent research publications, indicating deep engagement with the topic.
Many comments refer to the potential influence on cancer understanding and possible clinical implications, emphasizing the importance of this discovery.
Abstract in brief
- The study suggests that the glycolytic metabolite methylglyoxal (MGO) can temporarily inactivate the tumor suppressor protein BRCA2, bypassing the usual two-hit requirement for cancer development.
- MGO causes BRCA2 proteolysis, leading to its functional haploinsufficiency, which results in specific cancer-associated mutations (SBS signature) without the need for complete gene inactivation.
- This metabolic mechanism links increased glycolysis, common in cancer cells, to DNA damage and mutations, potentially explaining how metabolic changes promote cancer progression even without the full loss of tumor suppressors like BRCA2.]
Top posts
Most liked on X and Bluesky糖質の代謝が「がん化」を早める理由が判明? 最新の研究によると、糖質(グルコース)のエネルギー代謝が遺伝子に影響を及ぼして「がん化」を早める可能性があるということです。 がん抑制遺伝子の機能を低下させる代謝物「グリオキサール(MGO)」とは? https://t.co/hwhXf69UfH https://t.co/udw9Ep38d6
Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab! https://t.co/2iUTEX1qpo
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/wGCXSjifvl
【最新研究】 糖質の代謝が「癌化」を早める理由が判明? 癌抑制
All mentions
Glycolytic Metabolite Methylglyoxal Bypasses BRCA2 Tumor Suppression
The study suggests that the glycolytic metabolite methylglyoxal MGO can temporarily inactivate the tumor suppressor protein BRCA2, bypassing the usual two-hit requirement for cancer development. This metabolic mechanism…
Glycolytic Metabolite Methylglyoxal Bypasses BRCA2 Tumor Suppression
The study suggests that methylglyoxal, a glycolytic metabolite, can temporarily inactivate BRCA2, bypassing the usual two-hit requirement for cancer development, linking increased glycolysis to DNA damage and mutations.
Metabolic Impact on BRCA2 and Cancer Development Mechanisms
This study explores how the glycolytic metabolite methylglyoxal affects tumor suppressor BRCA2, bypassing traditional cancer development pathways. Findings suggest metabolic changes can promote DNA damage and mutations…
Glycolytic Metabolite Bypasses Cancer Suppressor BRCA2 Function
This video explains how the glycolytic metabolite methylglyoxal temporarily inactivates the tumor suppressor protein BRCA2, potentially promoting cancer by bypassing the two-hit requirement for tumor development…
昨日見たこの論文 https://t.co/ME88lDwNbY よく読んでなかったので勘違いしたかもしれないが γH2AXの役割はちょっと違うみたいですね。 これは改めてゆっくり見ます。
RT @rz733375: 論文はこれですね。 https://t.co/6K9jfxcdRN うわ かなり長文
論文はこれですね。 https://t.co/6K9jfxcdRN うわ かなり長文
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/1OhIXkQTDr
【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/P1hhHlR1RW @YouTubeより
RT @keisuke4713: 【最新研究】 糖質の代謝が「癌化」を早める理由が判明? 癌抑制
RT @keisuke4713: 【最新研究】 糖質の代謝が「癌化」を早める理由が判明? 癌抑制
RT @keisuke4713: 【最新研究】 糖質の代謝が「癌化」を早める理由が判明? 癌抑制
【最新研究】 糖質の代謝が「癌化」を早める理由が判明? 癌抑制
RT @mieko__0606: 【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/7zIrw9ulkh @YouTubeより
【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/psxRYWwO0m #糖質 #ファスティング #BRCA
@aCarnivoreDiet To support your claim here is a brand new study dated April 2024, that confirms that glucose and fructose bypasses a tumor suppressor mechanism of the BRCA2 gene. https://t.co/2uhxXhcP1Z It was presented by Prof. @nicknorwitz in a short video as well. https://t.co/B6YbLMMM69
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/B1TH5orMML
RT @mieko__0606: 【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/ib1PUtXpLP @YouTubeより
RT @mieko__0606: 【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/7zIrw9ulkh @YouTubeより
【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/2yEQXXPHZL @YouTubeより
RT @tyobi38: 【最新研究】糖質の代謝が「がん化」を早める理由が判明? https://t.co/SVaBxZAmgr
【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/7zIrw9ulkh @YouTubeより
【最新研究】糖質の代謝が「がん化」を早める理由が判明?がん抑制遺伝子の機能を低下させる「グリオキサール(MGO)」とは? https://t.co/ib1PUtXpLP @YouTubeより
RT @norip1sato: 糖質の代謝が「がん化」を早める理由が判明? 最新の研究によると、糖質(グルコース)のエネルギー代謝が遺伝子に影響を及ぼして「がん化」を早める可能性があるということです。 がん抑制遺伝子の機能を低下させる代謝物「グリオキサール(MGO)」とは?…
RT @norip1sato: 糖質の代謝が「がん化」を早める理由が判明? 最新の研究によると、糖質(グルコース)のエネルギー代謝が遺伝子に影響を及ぼして「がん化」を早める可能性があるということです。 がん抑制遺伝子の機能を低下させる代謝物「グリオキサール(MGO)」とは?…
【最新研究】糖質の代謝が「がん化」を早める理由が判明? https://t.co/SVaBxZAmgr
https://t.co/zSlCYEDdOC
RT @norip1sato: 糖質の代謝が「がん化」を早める理由が判明? 最新の研究によると、糖質(グルコース)のエネルギー代謝が遺伝子に影響を及ぼして「がん化」を早める可能性があるということです。 がん抑制遺伝子の機能を低下させる代謝物「グリオキサール(MGO)」とは?…
RT @norip1sato: 糖質の代謝が「がん化」を早める理由が判明? 最新の研究によると、糖質(グルコース)のエネルギー代謝が遺伝子に影響を及ぼして「がん化」を早める可能性があるということです。 がん抑制遺伝子の機能を低下させる代謝物「グリオキサール(MGO)」とは?…
糖質の代謝が「がん化」を早める理由が判明? 最新の研究によると、糖質(グルコース)のエネルギー代謝が遺伝子に影響を及ぼして「がん化」を早める可能性があるということです。 がん抑制遺伝子の機能を低下させる代謝物「グリオキサール(MGO)」とは? https://t.co/hwhXf69UfH https://t.co/udw9Ep38d6
RT @m2bio: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/QM8UtXSctK @M2Biome $mres
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/QM8UtXSctK @M2Biome $mres
#Sugar consumption has been linked to #BreastCancer, and now we understand a potential mechanism behind it: https://t.co/pMQBKw2r4w
https://t.co/7c1aUdf5mu
https://t.co/mmXOjrmd4f
Changes in glucose metabolism can temporarily disable the tumor-suppressing functions of the BRCA2 gene, leading to mutations linked to cancer development. https://t.co/433Rd4uYoD
RT @ScottSAmyx: Scientists Discover a Missing Link Between Diet And Cancer Risk A glycolytic metabolite bypasses “two-hit” tumor suppressi…
Scientists Discover a Missing Link Between Diet And Cancer Risk A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/gl4eU0Yyqi
RT @boretrol: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/AjPH2KjhGC
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/AjPH2KjhGC
.@ChrisPalmerMD considering this recent article on Cell, Would you recommend Keto to those with BRCA2 mutations? https://t.co/Sq8LrctZkD
A byproduct of glucose metabolism (MGO) temporarily de-activates the tumor suppressor gene BRCA2, leading to more breast cancer. Oh, and you know what IMPROVES insulin resistance.... Estrogen. https://t.co/4NNl4GD1vT
RT @weldeiry: Interesting
19
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/sFdy61pGTP
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @ivanoamelio: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/wGCXSjifvl
Methylglyoxal (MGO) - A glycolytic metabolite bypasses ‘‘two-hit’’ tumor suppression by BRCA2 https://t.co/iZ9MWHJCzS https://t.co/NbUJL8xyVH
RT @rwsobol: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/0S6qj1tixo
RT @ivanoamelio: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/wGCXSjifvl
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/wGCXSjifvl
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/0S6qj1tixo
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2
Trending on PubMed: A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2. https://t.co/jHQIxaZvjS
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/fSac8i5f0k
No estudo, pesquisadores do Instituto de Câncer de Singapura utilizam o conhecimento da oncobiologia para demonstrar o mecanismo celular que explica a associação entre ultraprocessados e o câncer. O artigo foi publicado na última edição da revista Cell. https://t.co/FzEciK88Qd
RT @rhowe212: @paullewismoney The actual study: https://t.co/CFpJMrmruV
@paullewismoney The actual study: https://t.co/CFpJMrmruV
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
元論文→ Reference: Kong LR, Gupta K, Wu AJ, et al. A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2. Cell. 2024. doi: 10.1016/j.cell.2024.03.006 https://t.co/ICmvr9vZWz
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
RT @CellCellPress: Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 #science #publication #research #journal https://t.co/Sfeput0Jxo
RT @weldeiry: Interesting
New insights ties obesity to oncogenesis a may inform dysregulated metabolism (e.g. TSC) to focal cortical dysplasia. A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2: Cell https://t.co/LKo8CwRP5F
RT @weldeiry: Interesting
BRCA2タンパク質を分解することで、同様にDNA変異を蓄積しやすくなることもわかりました。Cell誌 >MGOはマヌカハニーに含まれる有効成分ということになっているのだが・・・https://t.co/ohvkO7KCkh
RT @weldeiry: Interesting
Interesting
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/4IZC8nro8J https://t.co/m0k7KD9k5Q
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/zTI8Z2dj1I
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 #science #publication #research #publications https://t.co/3qBkxXt0uD
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 @CellCellPress https://t.co/c5wXHz56Fl https://t.co/SeWgmX3Bzf
RT @FrezzaLab: A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab!…
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab! https://t.co/2iUTEX1qpo