JAMA Cardiol June 2024 PMID 38630494

Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial.

Ravi B Patel, Frank E Silvestry, Jan Komtebedde, Scott D Solomon, Gerd Hasenfuß, Sheldon E Litwin, Barry A Borlaug, Matthew J Price, Rami Kawash, Scott L Hummel, Donald E Cutlip, Martin B Leon, Dirk J van Veldhuisen, Andreas J Rieth, Scott McKenzie

Mentions

71
Peak: 5 in Apr 2024
across 4 sources since Apr 2024

Extended reach

163,513
potential audience

Total likes

22

Video views

1,847

Mentions per month

Apr 2024 – Jun 2024

Where it's discussed

  • News56 articles
  • X / Twitter10 posts
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions express strong support and curiosity about the research, with examples like 'reverse remodeling' and mentions of 'favorable effects' indicating perceived clinical importance. The tone is positive and recalls specific results, such as the lack of RV dysfunction over two years, reflecting moderate engagement and high perceived impact of the findings.

AgreementModerate agreement

Most discussions support the positive effects of the atrial shunt device, emphasizing findings such as 'reverse remodeling' and 'favorable effects' from recent studies.

InterestHigh interest

The discussions demonstrate high interest, with repeated references to specific research outcomes, clinical implications, and ongoing questions about long-term effects.

EngagementModerate engagement

Several posts delve into detailed analysis, such as the mention of 'no change in RV systolic function' and 'long-term effects,' showing moderate physical and technical engagement.

ImpactModerate impact

Participants seem to believe the research could influence future treatments for heart failure with preserved ejection fraction, indicated by phrases like 'favorable effects' and references to what the data mean for clinical practice.

Abstract in brief

  • The REDUCE LAP-HF II trial analyzed the efficacy of the Corvia Medical Inc IASD System II atrial shunt in patients with heart failure, showing potential benefits for responders without underlying vascular or rhythm issues.
  • The study involved randomizing participants to receive either the atrial shunt or a sham control, focusing on changes in heart function measured via echocardiograms over 24 months.
  • Results indicated that the shunt significantly reduced left ventricular volume and improved heart function metrics compared to sham controls, with a high rate of successful shunt placements among participants.

Top posts

Most liked on X and Bluesky
JAMA Cardiology
@JAMACardio · X

Over 2 years of follow-up, atrial shunting in patients with HFpEF and HFmrEF led to reverse remodeling of left-sided chambers and increases in volume of right-sided chambers but no change in RV systolic function compared with sham. https://t.co/qtdBf3VumJ https://t.co/BLpkoc2bAE

Apr 17, 2024 · 7 likes · 2 shares · 47,809 followers View post →
JAMA Cardiology
@JAMACardio · X

Interview with Sanjiv J. Shah, MD, author of "Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial" hosted by James E. Udelson, MD. @HFpEF https://t.co/zKvgy0sfFd

Apr 18, 2024 · 4 likes · 47,809 followers View post →
JAMA Cardiology
@JAMACardio · X

Over 2 years of follow-up, atrial shunting in patients with HFpEF and HFmrEF led to reverse remodeling of left-sided chambers and increases in volume of right-sided chambers but no change in RV systolic function compared with sham. https://t.co/aEhCWnHlSi

Jun 20, 2024 · 1 like · 47,809 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction The REDUCE LAP-HF II Randomized Clinical Trial no evidence of RV dysfunction over the initial 2 years https://t.co/GGOpZ0RXIv

Jun 13, 2024 · 1 like · 2,653 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction The REDUCE LAP-HF II Randomized Clinical Trial no evidence of RV dysfunction over the initial 2 years https://t.co/GGOpZ0RXIv

Apr 18, 2024 · 1 like · 2,653 followers View post →
Corvia Medical, Inc.
@corviamedical · X

What is the long-term effect of an #atrialshunt? Recently published data in @JAMACardio by @RBPatelMD shows favorable effects of the Corvia Atrial Shunt on cardiac structure & function in #heartfailure patients. #HFpEF #cardiotwitter https://t.co/wMGwBUNxtc

May 10, 2024 · 1 like · 1 share · 79 followers View post →

All mentions

TPCH Library
@tpchlibrary · X

Congratulations to #TPCH's S. McKenzie for their contribution to the publication "Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial" https://t.co/6STdkJpzr5

Jun 23, 2024 · 214 followers View post →
JAMA Cardiology
@JAMACardio · X

Over 2 years of follow-up, atrial shunting in patients with HFpEF and HFmrEF led to reverse remodeling of left-sided chambers and increases in volume of right-sided chambers but no change in RV systolic function compared with sham. https://t.co/aEhCWnHlSi

Jun 20, 2024 · 1 like · 47,809 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction The REDUCE LAP-HF II Randomized Clinical Trial no evidence of RV dysfunction over the initial 2 years https://t.co/GGOpZ0RXIv

Jun 13, 2024 · 1 like · 2,653 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @corviamedical: What is the long-term effect of an #atrialshunt? Recently published data in @JAMACardio by @RBPatelMD shows favorable ef…

May 10, 2024 · 1 share · 11,713 followers View post →
Corvia Medical, Inc.
@corviamedical · X

What is the long-term effect of an #atrialshunt? Recently published data in @JAMACardio by @RBPatelMD shows favorable effects of the Corvia Atrial Shunt on cardiac structure & function in #heartfailure patients. #HFpEF #cardiotwitter https://t.co/wMGwBUNxtc

May 10, 2024 · 1 like · 1 share · 79 followers View post →
JAMA Cardiology
@JAMACardio · X

Interview with Sanjiv J. Shah, MD, author of "Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial" hosted by James E. Udelson, MD. @HFpEF https://t.co/zKvgy0sfFd

Apr 18, 2024 · 4 likes · 47,809 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction The REDUCE LAP-HF II Randomized Clinical Trial no evidence of RV dysfunction over the initial 2 years https://t.co/GGOpZ0RXIv

Apr 18, 2024 · 1 like · 2,653 followers View post →
Riccardo M. Inciardi, MD, PhD
@RInciardi · X

RT @JAMACardio: Over 2 years of follow-up, atrial shunting in patients with HFpEF and HFmrEF led to reverse remodeling of left-sided chambe…

Apr 17, 2024 · 2 shares · 148 followers View post →
Ravi Patel
@RBPatelMD · X

RT @JAMACardio: Over 2 years of follow-up, atrial shunting in patients with HFpEF and HFmrEF led to reverse remodeling of left-sided chambe…

Apr 17, 2024 · 2 shares · 764 followers View post →
JAMA Cardiology
@JAMACardio · X

Over 2 years of follow-up, atrial shunting in patients with HFpEF and HFmrEF led to reverse remodeling of left-sided chambers and increases in volume of right-sided chambers but no change in RV systolic function compared with sham. https://t.co/qtdBf3VumJ https://t.co/BLpkoc2bAE

Apr 17, 2024 · 7 likes · 2 shares · 47,809 followers View post →