Discussions highlight the groundbreaking nature of the trial, with phrases like 'first time,' 'huge congratulations,' and 'significant and clinically meaningful' to underscore its importance. The use of detailed data, such as the 91.2% survival at 48 months, combined with optimism about future access and treatment, shows deep engagement and recognition of the potential paradigm shift in renal cell carcinoma management.
AgreementStrong agreement
Most discussions strongly support the study’s findings, emphasizing the significant survival benefits shown in the trial.
InterestHigh interest
The discussions demonstrate high interest, with mentions of the trial’s importance, new advancements, and potential clinical implications.
EngagementHigh engagement
Participants engage deeply, referencing specific data points, trial details, and expert opinions, indicating thorough discussion.
ImpactHigh impact
The widespread recognition, noting it as a breakthrough in renal cancer treatment, signals high impact on the medical community and clinical practices.
Abstract in brief
Pembrolizumab significantly improved overall survival and disease-free survival in patients with high-risk clear-cell renal-cell carcinoma after surgery, as shown in the KEYNOTE-564 trial.
Patients receiving pembrolizumab had a 91.2% overall survival rate at 48 months, compared to 86.0% for those on placebo, with consistent benefits across key subgroups.
Although pembrolizumab was associated with a higher rate of serious and severe adverse events, no deaths were directly attributed to the treatment.
The anti–programmed death 1 antibody pembrolizumab was approved by the @US_FDA as adjuvant therapy after surgery for renal-cell carcinoma on the basis of improvements in disease-free survival observed in KEYNOTE-564. Data on overall survival are needed. https://t.co/oVQXvyffL4 https://t.co/e7OBFEK5KM
Original Article: Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma (KEYNOTE-564 phase 3 trial) https://t.co/oVQXvyffL4
Editorial: Adjuvant Immunotherapy for Kidney Cancer — A New Strategy with New Challenges https://t.co/jwrTjRL83u
#Nephrology https://t.co/OIerKYVNCF
3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC, a subset of patients still experience RCC recurrence (https://t.co/8hGQjmqZr6). Thus, remains the clinical need to improve outcomes of patients with
Feb 5, 2025 · 19 likes · 6 shares · 43,278 followersView post →
This video discusses risk factors, staging, and therapy options for localized renal cell carcinoma, including evidence for adjuvant systemic therapy and recent clinical trial findings on pembrolizumab.
This video reviews the latest evidence on adjuvant pembrolizumab in renal cell carcinoma based on recent NEJM publication. It covers the impact on overall survival, long-term outcomes, safety profile, and clinical…
RT @DrChoueiri: 3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC,…
Feb 6, 2025 · 6 shares · 2,140 followersView post →
FS
Fabio Schutz
@FabioSchutz78 · X
RT @DrChoueiri: 3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC,…
Feb 5, 2025 · 6 shares · 3,803 followersView post →
SF
Sumanta K. Pal, MD, FASCO
@montypal · X
RT @DrChoueiri: 3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC,…
Feb 5, 2025 · 6 shares · 22,183 followersView post →
SC
Simon C
@scserendipity1 · X
RT @DrChoueiri: 3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC,…
Feb 5, 2025 · 6 shares · 2,718 followersView post →
IO
IMG Oncologists
@IMG_Oncologists · X
RT @DrChoueiri: 3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC,…
Feb 5, 2025 · 6 shares · 2,611 followersView post →
TM
Toni Choueiri, MD
@DrChoueiri · X
3/ Unlike melanoma, RCC has a lower mutation burden. While adjuvant pembrolizumab improved DFS and OS of patients with RCC, a subset of patients still experience RCC recurrence (https://t.co/8hGQjmqZr6). Thus, remains the clinical need to improve outcomes of patients with
Feb 5, 2025 · 19 likes · 6 shares · 43,278 followersView post →
A
Angels
@Eikecalonse · X
RT @DrChoueiri: 1/ The long-awaited OS results from #KEYNOTE-564 are out @NEJM! The 1st phase 3 trial to demonstrate a survival benefit for…
Oct 7, 2024 · 209 shares · 554 followersView post →
RC
Ricardo Carvalho
@rcarvalhoonco · X
RT @l2presearch: Overall survival with adjuvant pembrolizumab in renal cell carcinoma — the shock of the lightning https://t.co/dEn1M2vG2b
Aug 8, 2024 · 1 share · 2,272 followersView post →
RC
Ricardo Carvalho
@rcarvalhoonco · X
RT @tompowles1: Adjuvant pembrolizumab shows a significant and clinically meaningful OS benefit in intermediate and high risk clear cell r…
Aug 8, 2024 · 55 shares · 2,272 followersView post →
RC
Ricardo Carvalho
@rcarvalhoonco · X
RT @NEJM: Original Article: Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma (KEYNOTE-564 phase 3 trial) https://t.co/o…
Aug 8, 2024 · 8 shares · 2,272 followersView post →
Y
Yang
@Yang80583422 · X
RT @EAU_Uroonco: The RCC Article of the Month highlights the Keynote-564 phase III trial on pembrolizumab as adjuvant therapy for RCC post-…
The RCC Article of the Month highlights the Keynote-564 phase III trial on pembrolizumab as adjuvant therapy for RCC post-nephrectomy. In expert commentary, Dr. Teele Kuusk emphasises the importance of risk-adapted discussions tailored to each patient.
Jun 26, 2024 · 2 likes · 1 share · 6,138 followersView post →
LL
L2P Research Labs
@l2presearch · X
Overall survival with adjuvant pembrolizumab in renal cell carcinoma — the shock of the lightning https://t.co/dEn1M2vG2b
May 17, 2024 · 1 like · 1 share · 155 followersView post →
EP
EDGAR ANDRES PULIDO
@edgarpugil · X
RT @dr_yakupergun: Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma: KEYNOTE-564
@OncoAlert https://t.co/WTeL61qDha h…
May 12, 2024 · 21 shares · 28 followersView post →
H
Hsiehting
@htlin222 · X
KEYNOTE-564
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma | New England Journal of Medicine https://t.co/ZHXHghmtW6
RT @rkalyes1: Hope after the knife for patients with Renal cell Carcinoma!
The bigger question is when we would access to these life prolon…
May 8, 2024 · 2 shares · 11,329 followersView post →
AM
Ainamani Precious Moreen
@JoyMoreen1 · X
RT @rkalyes1: Hope after the knife for patients with Renal cell Carcinoma!
The bigger question is when we would access to these life prolon…
May 7, 2024 · 2 shares · 3,163 followersView post →
RL
Robert Kalyesubula,MD, FISN(USA), PhD-FRCP(London)
@rkalyes1 · X
Hope after the knife for patients with Renal cell Carcinoma!
The bigger question is when we would access to these life prolonging drugs here in Africa.
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma | New England Journal of Medicine https://t.co/9ZcP4s0Po2?
May 7, 2024 · 8 likes · 2 shares · 19,414 followersView post →
IP
Isaura R. Penin
@irodriguezpenin · X
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma | New England Journal of Medicine https://t.co/zgr8dQadDj
Adjuvant pembrolizumab was associated with a significant and clinically meaningful improvement in overall survival, as compared with placebo, among participants with clear-cell renal-cell carcinoma at increased risk for recurrence after surgery. https://t.co/0UJY9FmxuO https://t.co/7Kfiwh3pIm
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma
This study has shown that adjuvant Keytruda (pembrolizumab) was associated with a significant and clinically meaningful improvement in overall survival, as compared with placebo, among participants with https://t.co/svy1GMW49X
Original Article: Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma (KEYNOTE-564 phase 3 trial) https://t.co/oVQXvyffL4
Editorial: Adjuvant Immunotherapy for Kidney Cancer — A New Strategy with New Challenges https://t.co/jwrTjRL83u
#Nephrology https://t.co/OIerKYVNCF
The anti–programmed death 1 antibody pembrolizumab was approved by the @US_FDA as adjuvant therapy after surgery for renal-cell carcinoma on the basis of improvements in disease-free survival observed in KEYNOTE-564. Data on overall survival are needed. https://t.co/oVQXvyffL4 https://t.co/e7OBFEK5KM
Glad to have been a small part of this trial showing improved survival in renal cell carcinoma. @TheUSONetwork enrolled over 12% of the patients! @Doshi1G @SarahCannonDocs @TexasOncology
https://t.co/DzXtKOGQyb
Adjuvant pembro vs placebo for renal cell carcinoma: Net OS estimate gain at 2 years: 5%. (91% vs 86%) Severe toxicity (G3-4) net increase: 17% (18.6% Vs 1,2%). Placebomumab seems to be still a decent option for many patients and health systems.
https://t.co/UVFIuRzI5c
@tompowles1 @DanaFarber @DrChoueiri @QMUL @QMULBartsTheLon @CRUKCOLcentre The results, published in @NEJM, mark the first time an adjuvant therapy has shown this kind of benefit in kidney cancer after 50 years of research. Huge congratulations to the team. https://t.co/sV3vtWeGBE
Apr 19, 2024 · 1 like · 4,323 followersView post →
CV
Cancer Library VCC
@VCCLibrary · X
Overall Survival with Adjuvant #Pembrolizumab in Renal-Cell Carcinoma KEYNOTE-564 https://t.co/JcNbMeaiLb #Cancer
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma
https://t.co/Rs15bGh2rm
Congrats @DrChoueiri and KEYNOTE 564 investigators.
"The estimated overall survival at 48 months was 91.2% in the pembrolizumab group, as compared with 86.0% in the placebo group; the
Immunotherapy for kidney cancer: Types, efficacy, and more
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Overall survival with adjuvant pembrolizumab in renal-cell carcinoma. https://www.nejm.org/doi/full/10.1056/NEJMoa2312695; Cytokines and their side effects ...
Tracy L Rose Renal Cell Carcinoma A Review 2024 | PDF
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2020;38 NEJMoa2312695 (1):6.e1-6.e7. doi:10.1016/j.urolonc.2019.08.011 ... doi:10.1056/ metastatic renal cell cancer (mRCC): data from the carcinoma. N ...
doi: 10.1056/. NEJMoa2312695]. Over a median follow-up of 9.3 years, kidney failure or renal death occurred in. 3 years in the immediate ART group and. 5 years ...
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Overall survival with adjuvant pembrolizumab in renal-cell carcinoma. N Engl J Med. 2024; 390:1359–1371. doi: 10.1056/. NEJMoa2312695]. Over a median follow- ...