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Cancer Cell May 2024 PMID 38670091

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers.

Sarah T Diepstraten, Yin Yuan, John E La Marca, Savannah Young, Catherine Chang, Lauren Whelan, Aisling M Ross, Karla C Fischer, Giovanna Pomilio, Rhiannon Morris, Angela Georgiou, Veronique Litalien, Fiona C Brown, Andrew W Roberts, Andreas Strasser

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Mentions

77
Peak: 29 in Apr 2024
across 4 sources since Apr 2024

Extended reach

177,672
potential audience

Total likes

193

Video views

156

Mentions per month

Apr 2024 – Dec 2024

Where it's discussed

  • X / Twitter53 posts
  • News12 articles
  • YouTube9 videos
  • Blogs3 articles

AI synopsis

What people are saying

Overall, the social discussions demonstrate strong support and interest, with examples like congratulatory messages for the authors and references to how the study offers promising new approaches. The tone of enthusiasm and emphasis on the research's significance reflect its perceived high impact in the field.

AgreementModerate agreement

Most discussions express support for the research, highlighting its importance in treating TP53-mutant cancers.

InterestHigh interest

Many posts show high interest, referencing the article’s potential to advance therapies and its scientific significance.

EngagementModerate engagement

Posts include congratulations to co-authors and references to the publication, indicating active engagement.

ImpactModerate impact

The discussions suggest the research is seen as impactful, with mentions of 'promising' and 'significant' advances in cancer treatment.

Abstract in brief

  • The article discusses how BH3mimetic drugs, which induce apoptosis in blood cancer cells, require functional p53 for maximum effectiveness, but in TP53-deficient cancers, this pathway is compromised, leading to potential treatment failure.
  • It explains that p53 activation occurs after mitochondrial permeabilization caused by BH3mimetics, which then increases BH3-only proteins to enhance cell death; however, TP53-deficient cancers lack this feedback loop.
  • The researchers found that activating the cGAS-STING pathway can bypass the need for p53 by upregulating BH3-only proteins, and combining STING agonists with BH3mimetics effectively kills TP53-mutant blood cancer cells, offering a promising new therapy approach.]
Read the full abstract

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Cancer Cell
@Cancer_Cell · X

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 90 likes · 22 shares · 72,149 followers View post →
Cancer Cell
@Cancer_Cell · X

Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.co/4WMhwhxQ2L

Apr 26, 2024 · 77 likes · 26 shares · 72,149 followers View post →
どうも留学中の血液内科医です。
@umedadamedameda · X

BAK/BAXが活性化されミトコンドリアの膜透過性が上昇(MOMP)＝アポトーシスと思ってたけど、さらにMOMPがTP53を活性化するフィードバックが重要で、TP53変異のある腫瘍で(文字数) Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers: Cancer Cell https://t.co/o5jQeIGQkB

May 2, 2024 · 12 likes · 2 shares · 1,080 followers View post →
Yu-Hung Wang
@Wang_Yu_Hung · X

Putting the #STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2hmXws2GjZ @Kiran_Batta https://t.co/NW7TrUaNK5

Apr 29, 2024 · 10 likes · 1 share · 834 followers View post →
LDCRC
@LDCRC_UL · X

The LDCRC wishes to congratulate @RossAisling who is listed as a co-author on the paper Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers. The full paper can be found here - https://t.co/sVsN5dGfcG #ldcrc #ul #cancerresearch

Oct 18, 2024 · 3 likes · 1 share · 142 followers View post →
The Innovation Oncology
@InnovOncology · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 2,853 followers View post →

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Health Research Institute
@HRI_UL · X

RT @LDCRC_UL: The LDCRC wishes to congratulate @RossAisling who is listed as a co-author on the paper Putting the STING back into BH3-mimet…

Oct 18, 2024 · 1 share · 2,487 followers View post →
LDCRC
@LDCRC_UL · X

The LDCRC wishes to congratulate @RossAisling who is listed as a co-author on the paper Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers. The full paper can be found here - https://t.co/sVsN5dGfcG #ldcrc #ul #cancerresearch

Oct 18, 2024 · 3 likes · 1 share · 142 followers View post →
nike
@wot_mikey · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 16, 2024 · 22 shares · 474 followers View post →
Moreaux Jérôme
@moreauxjerome · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 16, 2024 · 22 shares · 362 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 16, 2024 · 22 shares · 97 followers View post →
choiLab
@jungminchoilab · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 16, 2024 · 22 shares · 331 followers View post →
Roberto Arcadio
@Robertoarcadio_ · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

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Manoj Mayogi Mishra
@mayogisense · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

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Daichi Sadato
@DaichiSadato · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

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プロトン（ワクチン6回接種済）
@5sPgm · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

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Carlos E. Vigil, MD,MS
@cvigilgonzales · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 808 followers View post →
Kai Song, PhD
@song_kk · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 351 followers View post →
Elmira Khabusheva
@drkhabusheva · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 735 followers View post →
Elmira Khabusheva
@sciencyelmira · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 757 followers View post →
Francesca Pentimalli
@FraPenti · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 153 followers View post →
YMED-X
@YmedX269 · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 229 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 1,322 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 1,426 followers View post →
Olga Payar
@Olgapaval · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 87 followers View post →
Bayar Jaff
@JaffBayar · X

RT @Cancer_Cell: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 22 shares · 604 followers View post →
Cancer Cell
@Cancer_Cell · X

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2Sstuyof4q https://t.co/yWvQ4XjDD0

May 15, 2024 · 90 likes · 22 shares · 72,149 followers View post →
Lachlin Vaughan
@Lachy_Syd · X

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers - ScienceDirect https://t.co/Zhf4JA6vZH

May 8, 2024 · 230 followers View post →
AIBO
@fyac3221157 · X

RT @masayuki_umeda_: BAK/BAXが活性化されミトコンドリアの膜透過性が上昇(MOMP)＝アポトーシスと思ってたけど、さらにMOMPがTP53を活性化するフィードバックが重要で、TP53変異のある腫瘍で(文字数) Putting the STING ba…

May 2, 2024 · 2 shares · 227 followers View post →
どうも留学中の血液内科医です。
@umedadamedameda · X

BAK/BAXが活性化されミトコンドリアの膜透過性が上昇(MOMP)＝アポトーシスと思ってたけど、さらにMOMPがTP53を活性化するフィードバックが重要で、TP53変異のある腫瘍で(文字数) Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers: Cancer Cell https://t.co/o5jQeIGQkB

May 2, 2024 · 12 likes · 2 shares · 1,080 followers View post →
the paper link
@the_paper_link · X

Trend up+160: Diepstraten ST, ..., Kelly GL (Cancer Cell) __Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers__ https://t.co/yVoBGl0CWw

Apr 29, 2024 · 137 followers View post →
Elmira Khabusheva
@drkhabusheva · X

RT @Wang_Yu_Hung: Putting the #STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2hmXws2GjZ @Kiran_Batta https:/…

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Elmira Khabusheva
@sciencyelmira · X

RT @Wang_Yu_Hung: Putting the #STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2hmXws2GjZ @Kiran_Batta https:/…

Apr 29, 2024 · 1 share · 757 followers View post →
Yu-Hung Wang
@Wang_Yu_Hung · X

Putting the #STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/2hmXws2GjZ @Kiran_Batta https://t.co/NW7TrUaNK5

Apr 29, 2024 · 10 likes · 1 share · 834 followers View post →
Girish Chandra
@GirishC51684321 · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 29, 2024 · 26 shares · 137 followers View post →
Abstream
@abstreamme · X

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers #science #publication #research #publications https://t.co/XW8zI24Q5C

Apr 28, 2024 · 785 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 576 followers View post →
The Innovation Oncology
@InnovOncology · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 2,853 followers View post →
TonyWHH
@WeihanHuang · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 33 followers View post →
choiLab
@jungminchoilab · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 331 followers View post →
Marinos Gkounes
@MarinosGkounes · X

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Apr 27, 2024 · 26 shares · 164 followers View post →
ivanpinzon
@ivanpin81236291 · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 57 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 27, 2024 · 26 shares · 97 followers View post →
Michaela Sonja
@MichaelaSonja1 · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 8 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 188 followers View post →
ลัคกี้ โหมดฤดูงาน
@sr_wiz · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 1,612 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 574 followers View post →
Elmira Khabusheva
@sciencyelmira · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 757 followers View post →
Elmira Khabusheva
@drkhabusheva · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

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Bayar Jaff
@JaffBayar · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

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Guillermo de Cárcer
@GdC_CCCB_lab · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

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Amy Gravell
@amy_gravell · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

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Shams Salah Mahdi
@ShamsPath · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 1,426 followers View post →
El Niño Alex
@elAlexDutch · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

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Cancer ImmunoTherapy
@Cancerimmun · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 69 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 1,322 followers View post →
プロトン（ワクチン6回接種済）
@5sPgm · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 584 followers View post →
Dieter
@Wuhle · X

RT @Cancer_Cell: Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.…

Apr 26, 2024 · 26 shares · 474 followers View post →
Cancer Cell
@Cancer_Cell · X

Online Now: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers https://t.co/4jzOpJq8cg https://t.co/4WMhwhxQ2L

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