The overall tone reflects skepticism about new data, citing phrases like 'not supported by evidence' and 'current recommendations remain unchanged,' which emphasize the perceived lack of impact. Posts referencing official statements and systematic critiques highlight the persistent doubts about pharmacogenomic tools in depression treatment.
AgreementStrong disagreement
Most comments clearly express disagreement with the efficacy of pharmacogenomic tools for depression, emphasizing lack of supportive evidence.
InterestNeutral interest
The discussions show limited curiosity, mostly reiterating official conclusions rather than exploring new perspectives.
EngagementModerate engagement
Some posts delve into methodological critiques and interpretational issues, reflecting basic engagement.
ImpactLow impact
The general consensus suggests the findings reinforce current guidelines, with limited perceived groundbreaking influence.
Abstract in brief
The review updates the 2018 recommendations on using pharmacogenomic (PGx) tools for treating depression, based on studies from 2017 to 2022.
Eleven new clinical trials and five meta-analyses were examined; some showed significant benefits of PGx tools in speeding or improving treatment, but many had limitations like lack of blinding.
Despite new data, current evidence does not support using PGx tools for depression treatment, and future research should focus on improving study designs and including additional genetic markers.
Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selection in adults with major depression
https://t.co/gF4Vk5TDmL
Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le funcionaría mejor para su #Depresión
Mi respuesta:
"No hay evidencia que eso nos resuelva ni nos indique hacia donde movernos"
https://t.co/GGUfC5gY8q"
Oct 19, 2024 · 29 likes · 3 shares · 21,486 followersView post →
DM
Daniel E. Gih MD
@DrDanielGih · X
New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools for the treatment of MDD.
Pharmacogenomic Clinical Support Tools for the Treatment of Depression | American Journal of Psychiatry https://t.co/UKzHPMghqI
May 3, 2024 · 6 likes · 2 shares · 4,707 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
New data do not alter 2018 recommendations from the @APApsychiatric Council of Research Workgroup on Biomarkers and Novel Treatments that current research does not support the use of genetic tools in treatment selection for major depressive disorder. https://t.co/FaOKbVBKRm https://t.co/VipWr2LmQw
Review: Actual evidence does not support the use of currently available combinatorial pharmacogenomic tools for treatment selection in MDD https://t.co/toip5bOZUR
Grand Rounds for April 13, 2023
Matthew Baum, MD, PhD, D.Phil
TITLE: “Update on pharmacogenomic clinical support tools for the treatment of depression”
Kelly Brown, MD
TITLE: “Core Clinical Experiences in General Psychiatry Training” https://t.co/2LcON4OHcL
American Journal of Psychiatry Deputy Editor Daniel S Pine MD discusses the article Pharmacogenomic Clinical Support Tools for the Treatment of Depression by Matthew L Baum MD PhD and colleagues. The review updates 2018…
American Journal of Psychiatry Deputy Editor Daniel S Pine MD discusses recent research on pharmacogenomic tools in depression treatment, highlighting new trials and meta-analyses from 2017 to 2022. Current evidence…
RT @carlos_arnaud: Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le…
Oct 19, 2024 · 3 shares · 527 followersView post →
DA
Dr. Carlos Arnaud
@carlos_arnaud · X
Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le funcionaría mejor para su #Depresión
Mi respuesta:
"No hay evidencia que eso nos resuelva ni nos indique hacia donde movernos"
https://t.co/GGUfC5gY8q"
Oct 19, 2024 · 29 likes · 3 shares · 21,486 followersView post →
A
Austin
@QuantumSane · X
RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…
Oct 18, 2024 · 17 shares · 200 followersView post →
دا
د.عاصم العقيل
@asemalaqeel · X
RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…
Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selection in adults with major depression
https://t.co/gF4Vk5TDmL
Review: Actual evidence does not support the use of currently available combinatorial pharmacogenomic tools for treatment selection in MDD https://t.co/toip5bOZUR
RT @DrDanielGih: New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools…
May 3, 2024 · 2 shares · 3,494 followersView post →
BM
Ben Dralle, MD
@ben_dralle · X
RT @DrDanielGih: New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools…
May 3, 2024 · 2 shares · 1,115 followersView post →
DM
Daniel E. Gih MD
@DrDanielGih · X
New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools for the treatment of MDD.
Pharmacogenomic Clinical Support Tools for the Treatment of Depression | American Journal of Psychiatry https://t.co/UKzHPMghqI
May 3, 2024 · 6 likes · 2 shares · 4,707 followersView post →
JF
Joshua Rosenblat, MD, MSc, FRCPC
@JD_Rosenblat · X
RT @APAPubJournals: New data do not alter 2018 recommendations from the @APApsychiatric Council of Research Workgroup on Biomarkers and Nov…
Review: The evidence does not support the use of currently available combinatorial pharmacogenomic tools for treatment selection in MDD. Priority efforts include fully blinded study designs and inclusion of promising genetic variants https://t.co/toip5bOZUR
New data do not alter 2018 recommendations from the @APApsychiatric Council of Research Workgroup on Biomarkers and Novel Treatments that current research does not support the use of genetic tools in treatment selection for major depressive disorder. https://t.co/FaOKbVBKRm https://t.co/VipWr2LmQw
Grand Rounds for April 13, 2023
Matthew Baum, MD, PhD, D.Phil
TITLE: “Update on pharmacogenomic clinical support tools for the treatment of depression”
Kelly Brown, MD
TITLE: “Core Clinical Experiences in General Psychiatry Training” https://t.co/2LcON4OHcL
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