Am J Psychiatry July 2024 PMID 38685859

Pharmacogenomic Clinical Support Tools for the Treatment of Depression.

Matthew L Baum, Alik S Widge, Linda L Carpenter, William M McDonald, Bruce M Cohen, Charles B Nemeroff

Mentions

47
Peak: 18 in Jul 2024
across 5 sources since Apr 2023

Extended reach

405,008
potential audience

Total likes

109

Video views

156

Mentions per month

Apr 2023 – Dec 2025

Where it's discussed

  • X / Twitter32 posts
  • Reddit6 posts
  • Blogs5 articles
  • YouTube2 videos
  • LinkedIn2 posts

AI synopsis

What people are saying

The overall tone reflects skepticism about new data, citing phrases like 'not supported by evidence' and 'current recommendations remain unchanged,' which emphasize the perceived lack of impact. Posts referencing official statements and systematic critiques highlight the persistent doubts about pharmacogenomic tools in depression treatment.

AgreementStrong disagreement

Most comments clearly express disagreement with the efficacy of pharmacogenomic tools for depression, emphasizing lack of supportive evidence.

InterestNeutral interest

The discussions show limited curiosity, mostly reiterating official conclusions rather than exploring new perspectives.

EngagementModerate engagement

Some posts delve into methodological critiques and interpretational issues, reflecting basic engagement.

ImpactLow impact

The general consensus suggests the findings reinforce current guidelines, with limited perceived groundbreaking influence.

Abstract in brief

  • The review updates the 2018 recommendations on using pharmacogenomic (PGx) tools for treating depression, based on studies from 2017 to 2022.
  • Eleven new clinical trials and five meta-analyses were examined; some showed significant benefits of PGx tools in speeding or improving treatment, but many had limitations like lack of blinding.
  • Despite new data, current evidence does not support using PGx tools for depression treatment, and future research should focus on improving study designs and including additional genetic markers.

Top posts

Most liked on X and Bluesky
Roger S. McIntyre, MD, FRCPC
@rogersmcintyre · X

Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selection in adults with major depression https://t.co/gF4Vk5TDmL

Jul 10, 2024 · 62 likes · 17 shares · 2,690 followers View post →
Dr. Carlos Arnaud
@carlos_arnaud · X

Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le funcionaría mejor para su #Depresión Mi respuesta: "No hay evidencia que eso nos resuelva ni nos indique hacia donde movernos" https://t.co/GGUfC5gY8q"

Oct 19, 2024 · 29 likes · 3 shares · 21,486 followers View post →
Daniel E. Gih MD
@DrDanielGih · X

New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools for the treatment of MDD. Pharmacogenomic Clinical Support Tools for the Treatment of Depression | American Journal of Psychiatry https://t.co/UKzHPMghqI

May 3, 2024 · 6 likes · 2 shares · 4,707 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

New data do not alter 2018 recommendations from the @APApsychiatric Council of Research Workgroup on Biomarkers and Novel Treatments that current research does not support the use of genetic tools in treatment selection for major depressive disorder. https://t.co/FaOKbVBKRm https://t.co/VipWr2LmQw

Apr 30, 2024 · 5 likes · 1 share · 11,607 followers View post →
P
@psychopharmacol · X

Review: Actual evidence does not support the use of currently available combinatorial pharmacogenomic tools for treatment selection in MDD https://t.co/toip5bOZUR

Jul 6, 2024 · 2 likes · 569 followers View post →
Brigham and Women’s Psychiatry Residents
@BWHPsyResidency · X

Grand Rounds for April 13, 2023 Matthew Baum, MD, PhD, D.Phil TITLE: “Update on pharmacogenomic clinical support tools for the treatment of depression” Kelly Brown, MD TITLE: “Core Clinical Experiences in General Psychiatry Training” https://t.co/2LcON4OHcL

Apr 14, 2023 · 2 likes · 493 followers View post →

All mentions

Tiffany
@MuseOfNeon · X

https://t.co/N39jbxTBpz I'm finding PGx testing is broadly not supported by either evidence or methodology...

Sep 4, 2025 · 1 like · 805 followers View post →
navroga
@navroga · X

RT @carlos_arnaud: Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le…

Oct 19, 2024 · 3 shares · 25 followers View post →
drPatricioReyPsiquiatra
@drpatriciorey · X

Herramientas de apoyo clínico farmacogenómico para el tratamiento de la depresión https://t.co/wZT4wWrFnZ

Oct 19, 2024 · 510 followers View post →
Dr. Elsi Dazo
@josemercedes88 · X

RT @carlos_arnaud: Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le…

Oct 19, 2024 · 3 shares · 527 followers View post →
Dr. Carlos Arnaud
@carlos_arnaud · X

Me preguntó hace unos días un paciente que si le mandaba a realizar estudio #Farmacogenético para ver que medicamento le funcionaría mejor para su #Depresión Mi respuesta: "No hay evidencia que eso nos resuelva ni nos indique hacia donde movernos" https://t.co/GGUfC5gY8q"

Oct 19, 2024 · 29 likes · 3 shares · 21,486 followers View post →
Austin
@QuantumSane · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Oct 18, 2024 · 17 shares · 200 followers View post →
د.عاصم العقيل
@asemalaqeel · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Sep 20, 2024 · 17 shares · 280,076 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

3. “Pharmacogenomic Clinical Support Tools for the Treatment of Depression,” by Matthew L. Baum, M.D., Ph.D., et al. 3/4 https://t.co/0IJzo8pYBV

Jul 19, 2024 · 11,607 followers View post →
Shakila Meshkat
@shakilameshkat · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 12, 2024 · 17 shares · 107 followers View post →
Olu Ajilore, MD, PhD - @pshrink.bsky.social
@pshrink · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 2,064 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 10,953 followers View post →
Raymond Lam
@DrRaymondLam · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 2,122 followers View post →
Tiago Gil
@tiagogil · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 129 followers View post →
Alexander Young
@DrAlexYoung · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 275 followers View post →
David Medina
@davimedinTwits · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 109 followers View post →
Edilberto Peña
@Edilberto_pena · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 17,865 followers View post →
Liam Ramsey
@liamramsey17 · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 197 followers View post →
Joshua Rosenblat, MD, MSc, FRCPC
@JD_Rosenblat · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 3,349 followers View post →
Robertas Strumila
@RStrumila · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 196 followers View post →
Taylor A. Braund
@Taylor_Braund · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 559 followers View post →
Michael Ostacher, MD, MPH
@RecoveryDoctor · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 3,664 followers View post →
Robert Howard
@ProfRobHoward · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 18,278 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @rogersmcintyre: Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selec…

Jul 11, 2024 · 17 shares · 380 followers View post →
Roger S. McIntyre, MD, FRCPC
@rogersmcintyre · X

Evidence still does not support the routine use of pharmacogenomic testing as routine guidance to antidepressant selection in adults with major depression https://t.co/gF4Vk5TDmL

Jul 10, 2024 · 62 likes · 17 shares · 2,690 followers View post →
P
@psychopharmacol · X

Review: Actual evidence does not support the use of currently available combinatorial pharmacogenomic tools for treatment selection in MDD https://t.co/toip5bOZUR

Jul 6, 2024 · 2 likes · 569 followers View post →
Teresa Hartman
@thartman2u · X

RT @DrDanielGih: New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools…

May 3, 2024 · 2 shares · 3,494 followers View post →
Ben Dralle, MD
@ben_dralle · X

RT @DrDanielGih: New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools…

May 3, 2024 · 2 shares · 1,115 followers View post →
Daniel E. Gih MD
@DrDanielGih · X

New data do not alter the 2018 recommendations. Current evidence does not support the use of currently available PGx tools for the treatment of MDD. Pharmacogenomic Clinical Support Tools for the Treatment of Depression | American Journal of Psychiatry https://t.co/UKzHPMghqI

May 3, 2024 · 6 likes · 2 shares · 4,707 followers View post →
Joshua Rosenblat, MD, MSc, FRCPC
@JD_Rosenblat · X

RT @APAPubJournals: New data do not alter 2018 recommendations from the @APApsychiatric Council of Research Workgroup on Biomarkers and Nov…

Apr 30, 2024 · 1 share · 3,349 followers View post →
P
@psychopharmacol · X

Review: The evidence does not support the use of currently available combinatorial pharmacogenomic tools for treatment selection in MDD. Priority efforts include fully blinded study designs and inclusion of promising genetic variants https://t.co/toip5bOZUR

Apr 30, 2024 · 1 like · 569 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

New data do not alter 2018 recommendations from the @APApsychiatric Council of Research Workgroup on Biomarkers and Novel Treatments that current research does not support the use of genetic tools in treatment selection for major depressive disorder. https://t.co/FaOKbVBKRm https://t.co/VipWr2LmQw

Apr 30, 2024 · 5 likes · 1 share · 11,607 followers View post →
Brigham and Women’s Psychiatry Residents
@BWHPsyResidency · X

Grand Rounds for April 13, 2023 Matthew Baum, MD, PhD, D.Phil TITLE: “Update on pharmacogenomic clinical support tools for the treatment of depression” Kelly Brown, MD TITLE: “Core Clinical Experiences in General Psychiatry Training” https://t.co/2LcON4OHcL

Apr 14, 2023 · 2 likes · 493 followers View post →
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