May 2024 PMID 38773112

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson's disease.

Hiroshi Nishiwaki, Jun Ueyama, Mikako Ito, Tomonari Hamaguchi, Keiichi Takimoto, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno

Mentions

91
Peak: 16 in Jun 2024
across 6 sources since May 2024

Extended reach

665,409
potential audience

Total likes

50

Video views

155

Mentions per month

May 2024 – Aug 2025

Where it's discussed

  • News44 articles
  • X / Twitter29 posts
  • Reddit8 posts
  • Facebook4 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions highlight key findings, such as decreased production of vitamins like B2 and biotin, with comments emphasizing potential clinical implications, as seen in phrases like 'implications for therapy' and 'possible future treatments.' The tone varies from informative to speculative, with some posts expressing excitement about therapy prospects, which underscores the overall moderate perception of its impact and interest.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, especially noting findings like decreased biosynthesis of key vitamins and the potential therapies, reflecting moderate support and recognition of the study's importance.

InterestHigh interest

Many posts express curiosity about the implications, mentioning practical applications like fecal transplants and therapy potentials, indicating a high level of curiosity and relevance.

EngagementModerate engagement

Some comments delve into the specifics of the methods and potential biological mechanisms, demonstrating a deeper interest, though many posts remain general or promotional.

ImpactModerate impact

Communications suggest this research could considerably influence future PD treatments and microbiome studies, but the discussions don't overly dramatize its significance, showing moderate perceived impact.

Abstract in brief

  • Researchers conducted a meta-analysis of gut microbiome data from Parkinson's disease (PD) patients across different countries, revealing distinct microbial differences compared to controls and highlighting an overall increase in microbial diversity in PD.
  • Key findings showed significant changes in specific bacteria, notably an increase in Akkermansia muciniphila and decreases in Roseburia intestinalis and Faecalibacterium prausnitzii, along with reduced levels of fecal short-chain fatty acids (SCFAs) and polyamines linked to riboflavin and biotin biosynthesis.
  • The study suggests that these microbial and metabolic changes may contribute to the development of PD by reducing intestinal mucus, potentially leading to neuroinflammation and the formation of

Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkinson’s Disease https://t.co/KKcjyGg470 3/3

Jun 18, 2024 · 26 likes · 7 shares · 505,783 followers View post →
Agingdoc
@agingdoc1 · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Jun 18, 2024 · 9 likes · 2 shares · 41,729 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Amazing analysis of microbiome with implications for therapy of Parkinson’s Disease

Jun 26, 2024 · 8 likes · 1 share · 18,458 followers View post →
Enea Fioretti
@EneaFioretti · X

@AurelianoStingi Per gli specialisti medici : https://t.co/PRf2tfIwyR “L'analisi del percorso ha mostrato che i geni nella biosintesi della riboflavina e della biotina erano marcatamente diminuiti nella malattia di Parkinson dopo aggiustamento per fattori confondenti. Cinque delle sei categorie

Jul 2, 2024 · 3 likes · 298 followers View post →
Awesomics
@Awesomics · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/bu6z1teGu3 (Nishiwaki/Ohno, OA) Pathway analysis showed that genes in biosyntheses of riboflavin & biotin markedly decreased in PD. Story: https://t.co/q1RSCHAjP9 #microbiome #Bvitamins https://t.co/NgSwbwKFKA

Aug 8, 2025 · 1 like · 6,730 followers View post →
Rene Sugar
@renesugar · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/YP6oEZd9BZ

Jun 18, 2024 · 1 like · 3,971 followers View post →

All mentions

Gut Microbiome and Parkinson's Disease Risk Analysis

Groundbreaking research reveals that gut bacteria play a crucial role in protecting our brain. Dietary changes like consuming almonds, spinach, and sweet potatoes can strengthen your gut and safeguard your nervous…

Dr. O · Aug 9, 2025 147 views
Awesomics
@Awesomics · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/bu6z1teGu3 (Nishiwaki/Ohno, OA) Pathway analysis showed that genes in biosyntheses of riboflavin & biotin markedly decreased in PD. Story: https://t.co/q1RSCHAjP9 #microbiome #Bvitamins https://t.co/NgSwbwKFKA

Aug 8, 2025 · 1 like · 6,730 followers View post →
René Alfonso
@ReneAlfon_zoo · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease | npj Parkinson's Disease https://t.co/Ha3KDTzNBG

Mar 23, 2025 · 412 followers View post →
Dr. Doom
@DrLeachman · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease | npj Parkinson's Disease https://t.co/D0nEdFP8Vg

Mar 23, 2025 · 6,129 followers View post →
Barry Bunin
@barrybunin · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease | npj Parkinson's Disease https://t.co/rd4IYen2iC

Mar 23, 2025 · 1,482 followers View post →
HAS-veille
@HAS_veille · X

RT @CTrivalle: Bientôt de la transplantation fécale dans la maladie de Parkinson ? Meta-analysis of shotgun sequencing of gut microbiota in…

Dec 3, 2024 · 3 shares · 4,140 followers View post →
Fce-and-co
@fceandco · X

RT @CTrivalle: Bientôt de la transplantation fécale dans la maladie de Parkinson ? Meta-analysis of shotgun sequencing of gut microbiota in…

Dec 3, 2024 · 3 shares · 1,082 followers View post →
Christophe Trivalle
@CTrivalle · X

Bientôt de la transplantation fécale dans la maladie de Parkinson ? Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease | npj Parkinson's Disease https://t.co/FgQd3U0yIs

Dec 3, 2024 · 3 shares · 8,280 followers View post →
Rob Cain
@cain_rob · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease | npj Parkinson's Disease https://t.co/c2pyci5jOl

Jul 8, 2024 · 935 followers View post →
Enea Fioretti
@EneaFioretti · X

@AurelianoStingi Per gli specialisti medici : https://t.co/PRf2tfIwyR “L'analisi del percorso ha mostrato che i geni nella biosintesi della riboflavina e della biotina erano marcatamente diminuiti nella malattia di Parkinson dopo aggiustamento per fattori confondenti. Cinque delle sei categorie

Jul 2, 2024 · 3 likes · 298 followers View post →
Ken Gusler
@kgusler · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease - https://t.co/MCZ4GIfyUY

Jun 26, 2024 · 20,023 followers View post →
Sahba Ferdowsi DO (conciergedoc)
@DrFerdowsi · X

RT @weldeiry: Amazing analysis of microbiome with implications for therapy of Parkinson’s Disease

Jun 26, 2024 · 1 share · 9,641 followers View post →
Roger Blackwell
@rogerablackwell · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/gexMGWtQfP

Jun 26, 2024 · 2,305 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Amazing analysis of microbiome with implications for therapy of Parkinson’s Disease

Jun 26, 2024 · 8 likes · 1 share · 18,458 followers View post →
Scigote
@scigote · X

RT @NeuroscienceNew: “Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkins…

Jun 24, 2024 · 7 shares · 215 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/Qnb9M33Zcv https://t.co/d7FBgALmiR

Jun 24, 2024 · 24,141 followers View post →
Alessandro ⚡
@_lumichrome · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/Pshrw7uFcd https://t.co/F03x42YQbv

Jun 24, 2024 · 160 followers View post →
Lazara Bacallao
@bacallaolazara1 · X

RT @NeuroscienceNew: “Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkins…

Jun 20, 2024 · 7 shares · 496 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Jun 19, 2024 · 2 shares · 133 followers View post →
Rene Sugar
@renesugar · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease https://t.co/YP6oEZd9BZ

Jun 18, 2024 · 1 like · 3,971 followers View post →
cs hernandez
@cshernandez123 · X

RT @NeuroscienceNew: “Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkins…

Jun 18, 2024 · 7 shares · 499 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

RT @agingdoc1: Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Jun 18, 2024 · 2 shares · 5,442 followers View post →
Agingdoc
@agingdoc1 · X

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Jun 18, 2024 · 9 likes · 2 shares · 41,729 followers View post →
Sarah
@Sarah07909750 · X

RT @NeuroscienceNew: “Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkins…

Jun 18, 2024 · 7 shares · 1,425 followers View post →
Cure for Vineeth
@curevineeth · X

RT @NeuroscienceNew: “Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkins…

Jun 18, 2024 · 7 shares · 181 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease” by Hiroshi Nishiwaki et al. npj Parkinson’s Disease https://t.co/KKcjyGg470 3/3

Jun 18, 2024 · 26 likes · 7 shares · 505,783 followers View post →
a watcher
@awa19232818 · X

05月22日|名古屋大学 発表 ビタミンB投与がパーキンソン病治療につながる可能性|腸内細菌叢解析から解明 神経遺伝情報学 助教 西脇寛 ら ビタミンBの生合成酵素に関連する腸内細菌遺伝子がパーキンソン病患者で減少 https://t.co/xmUl9Xx4xB https://t.co/m1FcjvTg4q https://t.co/jN7MGCz1EL

May 26, 2024 · 415 followers View post →
a watcher
@awa19232818 · X

05月22日|名古屋大学 発表 ビタミンB投与がパーキンソン病治療につながる可能性|腸内細菌叢解析から解明 神経遺伝情報学 助教 西脇寛 ら ビタミンBの生合成酵素に関連する腸内細菌遺伝子がパーキンソン病患者で減少 https://t.co/xmUl9Xx4xB https://t.co/m1FcjvTg4q

May 26, 2024 · 415 followers View post →
Maneesh Paul
@maneeshpaul · X

RT @microvioma: ⚡️NEW STUDY ⚡️ Meta-analysis of shotgun sequencing of gut microbiota in #Parkinson disease : This study aims to identify c…

May 23, 2024 · 1 share · 186 followers View post →
Microvioma
@microvioma · X

⚡️NEW STUDY ⚡️ Meta-analysis of shotgun sequencing of gut microbiota in #Parkinson disease : This study aims to identify common gut microbial features in PD across different countries https://t.co/zVrUAOtZkg @maneeshpaul #neurodegenerativedisease #mentalhealthcare #gutbrain

May 23, 2024 · 1 like · 1 share · 27 followers View post →