Overall, the discussions illustrate excitement surrounding the trial of felzartamab, with many users expressing that it offers hope for tackling antibody-mediated rejection in kidney transplants. For example, phrases like 'finally something promising' and inquiries about its potential to be 'the future of transplant' contribute to an optimistic tone, indicating a strong perception of its potential impact on patient care.
AgreementModerate agreement
Many discussions suggest general support for the findings of the trial, indicating that users see the potential in felzartamab as a treatment option.
InterestHigh interest
The overall interest level is high as participants frequently mention the ongoing discussions and webinars related to the findings.
EngagementModerate engagement
While the discussions show some depth, including references to safety profiles and trial outcomes, they also hint at a broader conversation rather than an in-depth critique of the methodology.
ImpactHigh impact
Posters believe the trial's results could significantly influence future kidney transplantation treatments, calling it a 'game changer' for managing antibody-mediated rejection.
Abstract in brief
Antibody-mediated rejection poses a significant risk to kidney transplant success, with CD38 inhibition through felzartamab showing promise as a treatment option.
In a phase 2 trial, 22 patients with prior antibody-mediated rejection were randomly assigned to receive either felzartamab or a placebo, focusing on safety and potential benefits over 6 months followed by an observation period.
Results indicated that felzartamab led to a higher rate of resolution of rejection and lower inflammation scores compared to placebo, suggesting it may be an effective therapeutic strategy for improving transplant outcomes.
Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney | #Nephrology #ERA24 https://t.co/V5eYPDAS9l
May 26, 2024 · 66 likes · 18 shares · 935,482 followersView post →
N
NEJM
@NEJM · X
In a new trial, researchers assessed the safety, side-effect profile, and preliminary efficacy of felzartamab for the treatment of antibody-mediated kidney-transplant rejection. Read the full trial results and Plain Language Summary: https://t.co/S6wvGwoQqB https://t.co/8GqGC2zpYN
1/10 Welcome to #TenTweetNephJC
Have u heard of the new kid on the block for Antibody mediated rejection?“Felzartamab” !
We reviewed data from the phase II trial of this anti CD38 monoclonal antibody
Oct 5, 2024 · 20 likes · 12 shares · 38,442 followersView post →
GH
Gunnar Henrik Heine
@gunnar_heine · X
DÖF in Berlin I
Felzatamab in AMR
Today 8:15 AM at @dgfn_ev #NephrologieKongress 2024
11. Oct @ HOMe
https://t.co/7yR1rYhlB3
@MarcusSaemann https://t.co/H3YF5eoM5g
Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection: https://t.co/S6wvGwoQqB
Editorial: Felzartamab and Antibody-Mediated Rejection in Kidney Transplants — Hope at Last? https://t.co/q34mOkwYvD
#Nephrology https://t.co/HBLgYqCHu3
In a special webinar in cooperation between MARKUS HOMe and Nephrology Dialysis and Transplantation, experts discuss landmark studies from the ERA 2024 convention in Stockholm. The focus includes the promising results…
Prof. Georg Böhmi discusses the prognosis with anti-CD38 antibodies in treating antibody-mediated rejection in kidney transplant recipients. This update follows findings from a Phase 2 trial, showing felzartamab's…
We recently conducted a phase 2 randomized trial investigating Felzartamab in patients with late (>180 days) ABMR. https://t.co/ERUmRtlrt3
For this analysis, all patient biopsies were further evaluated using the Molecular Microscope Diagnostic System (@TranscriptomeSI).
RT @MarkusAtHome: TOP 2: Felzartamab in ABMR by Drs. Mayer, @BohmigGeorg et al.
https://t.co/qmSAyzzwdm
In patients with antibody-mediate…
Jan 15, 2025 · 2 shares · 660 followersView post →
GH
Gunnar Henrik Heine
@gunnar_heine · X
RT @MarkusAtHome: TOP 2: Felzartamab in ABMR by Drs. Mayer, @BohmigGeorg et al.
https://t.co/qmSAyzzwdm
In patients with antibody-mediate…
Jan 15, 2025 · 2 shares · 2,415 followersView post →
M
markusathome
@MarkusAtHome · X
TOP 2: Felzartamab in ABMR by Drs. Mayer, @BohmigGeorg et al.
https://t.co/qmSAyzzwdm
In patients with antibody-mediated rejection, felzartamab had acceptable safety and side-effect profiles.
Check out our webinar about Felzartamab!
Jan 15, 2025 · 3 likes · 2 shares · 124 followersView post →
RT @NephJC: 1/10 Welcome to #TenTweetNephJC
Have u heard of the new kid on the block for Antibody mediated rejection?“Felzartamab” !
We rev…
Oct 5, 2024 · 12 shares · 1,558 followersView post →
ST
Sayali Thakare
@SayaliBThakare · X
RT @NephJC: 1/10 Welcome to #TenTweetNephJC
Have u heard of the new kid on the block for Antibody mediated rejection?“Felzartamab” !
We rev…
Oct 5, 2024 · 12 shares · 2,182 followersView post →
SS
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X
RT @NephJC: 1/10 Welcome to #TenTweetNephJC
Have u heard of the new kid on the block for Antibody mediated rejection?“Felzartamab” !
We rev…
Oct 5, 2024 · 12 shares · 21,702 followersView post →
KG
Kajaree Giri
@KajareeG · X
RT @NephJC: 1/10 Welcome to #TenTweetNephJC
Have u heard of the new kid on the block for Antibody mediated rejection?“Felzartamab” !
We rev…
Oct 5, 2024 · 12 shares · 1,128 followersView post →
NC
Nephrology Journal Club
@NephJC · X
1/10 Welcome to #TenTweetNephJC
Have u heard of the new kid on the block for Antibody mediated rejection?“Felzartamab” !
We reviewed data from the phase II trial of this anti CD38 monoclonal antibody
Oct 5, 2024 · 20 likes · 12 shares · 38,442 followersView post →
AC
Adrian Covic
@accovic · X
RT @gunnar_heine: DÖF in Berlin I
Felzatamab in AMR
Today 8:15 AM at @dgfn_ev #NephrologieKongress 2024
11. Oct @ HOMe
https://t.co/7yR1rYh…
DÖF in Berlin I
Felzatamab in AMR
Today 8:15 AM at @dgfn_ev #NephrologieKongress 2024
11. Oct @ HOMe
https://t.co/7yR1rYhlB3
@MarcusSaemann https://t.co/H3YF5eoM5g
➡️Up next #NephJC, on Sept 24/25 we will discuss RCT Felzartamab in Antibody-Mediated Rejection
pubmed.ncbi.nlm.nih.gov/38804514/
Above X/Tweetorial created by @brian_rifkin
And in 2 weeks join us for some transplant nephrology stuff when we discuss:
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection
#NephJC
https://t.co/fRpvMvCtmX
In a new trial, researchers assessed the safety, side-effect profile, and preliminary efficacy of felzartamab for the treatment of antibody-mediated kidney-transplant rejection. Read the full trial results and Plain Language Summary: https://t.co/S6wvGwoQqB https://t.co/8GqGC2zpYN
Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection: https://t.co/S6wvGwoQqB
Editorial: Felzartamab and Antibody-Mediated Rejection in Kidney Transplants — Hope at Last? https://t.co/q34mOkwYvD
#Nephrology https://t.co/HBLgYqCHu3
RT @Fletcher_RA: Last week I learned that @MatthiasDiebold and team used the Git repository I created for eGFR slope to check & validate th…
May 30, 2024 · 5 shares · 103 followersView post →
NT
Navdeep Tangri
@NavTangri · X
RT @Fletcher_RA: Last week I learned that @MatthiasDiebold and team used the Git repository I created for eGFR slope to check & validate th…
May 30, 2024 · 5 shares · 1,560 followersView post →
MD
Matthias Diebold
@MatthiasDiebold · X
RT @Fletcher_RA: Last week I learned that @MatthiasDiebold and team used the Git repository I created for eGFR slope to check & validate th…
May 30, 2024 · 5 shares · 155 followersView post →
LA
Lilia Andrea
@LiliaAndreataf1 · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 30, 2024 · 28 shares · 377 followersView post →
GM
Greco Mark Malijan
@grecombm · X
RT @Fletcher_RA: Last week I learned that @MatthiasDiebold and team used the Git repository I created for eGFR slope to check & validate th…
May 30, 2024 · 5 shares · 1,040 followersView post →
BN
Brendon Neuen
@brendonneuen · X
RT @Fletcher_RA: Last week I learned that @MatthiasDiebold and team used the Git repository I created for eGFR slope to check & validate th…
May 30, 2024 · 5 shares · 4,696 followersView post →
RF
Robert Fletcher
@Fletcher_RA · X
Last week I learned that @MatthiasDiebold and team used the Git repository I created for eGFR slope to check & validate the results of their trial of felzartamab for antibody-mediated rejection in @NEJM
May 30, 2024 · 10 likes · 5 shares · 85 followersView post →
AM
Alexander Borrero-Arvelo, MD
@neph_nation · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 29, 2024 · 18 shares · 100 followersView post →
N
ninagoerlich
@ninagoerlich · X
RT @Linkermann_Lab: Awaited data on CD38 inhibition for our ABMR patients. Felzartamab resulted in lower donor-derived cell-free DNA levels…
May 29, 2024 · 2 shares · 615 followersView post →
LC
Life Science Journal Content
@lsn_jc · X
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection
#science #publication #research #journal
https://t.co/icDHt0TIjl
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 28, 2024 · 28 shares · 17 followersView post →
LA
Lyzinhawer Alza
@LyzinhawerA · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 28, 2024 · 18 shares · 22 followersView post →
JA
jhamilet aracelly
@aracellyjhami · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 28, 2024 · 28 shares · 67 followersView post →
AG
Alexandre Gérard
@AlexandreGerard · X
Un anti-CD38 prometteur dans le rejet humoral ? Mais avec un effet uniquement suspensif a priori, avec récidive à l'arrêt ⤵️
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal of Medicine https://t.co/sV4oPYr2Zm
https://t.co/QiIqOdCalU
May 28, 2024 · 4 likes · 1,335 followersView post →
TO
Theriaque_officiel
@Theriaque_CNHIM · X
Greffe rénale: le #felzartamab montre des premiers signes prometteurs d'efficacité contre le rejet humoral (phase II)
https://t.co/rD7Y56nMQe
https://t.co/znBdSChaOP
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 27, 2024 · 28 shares · 328 followersView post →
T
TranscriptomeSciInc
@TranscriptomeSI · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 27, 2024 · 18 shares · 119 followersView post →
A
AnnMD
@AnnMD00 · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 27, 2024 · 28 shares · 11 followersView post →
DM
Dr.Roberto Collazo-Maldonado
@collazor1 · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 27, 2024 · 18 shares · 1,905 followersView post →
T
TranscriptomeSciInc
@TranscriptomeSI · X
We are excited to report the publication of our recent collaborative study with Vienna and Berlin, published in @nejm. @MayerKatherinaa @MatthiasDiebold @kodo_kd @FarsadE https://t.co/xU3pip4yEL
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 27, 2024 · 28 shares · 389 followersView post →
CM
Covadonga López del Moral
@lopezdelmoralc · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 27, 2024 · 18 shares · 145 followersView post →
KR
Kim Reidy
@KimReidy2 · X
RT @JochenReiser: Finally something promising for one of the biggest problems in transplantation.
May 27, 2024 · 4 shares · 972 followersView post →
ES
Eva Schrezenmeier
@schrezenmeier · X
RT @Linkermann_Lab: Awaited data on CD38 inhibition for our ABMR patients. Felzartamab resulted in lower donor-derived cell-free DNA levels…
May 27, 2024 · 2 shares · 229 followersView post →
KF
Krishna Komanduri, MD, FASTCT
@drkomanduri · X
RT @JochenReiser: Finally something promising for one of the biggest problems in transplantation.
May 27, 2024 · 4 shares · 12,964 followersView post →
JR
javier rodriguez
@javier_rdgz · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 27, 2024 · 28 shares · 286 followersView post →
CH
Christian Hinze
@realchinz · X
RT @JochenReiser: Finally something promising for one of the biggest problems in transplantation.
May 27, 2024 · 4 shares · 222 followersView post →
AL
Andreas Linkermann
@Linkermann_Lab · X
Awaited data on CD38 inhibition for our ABMR patients. Felzartamab resulted in lower donor-derived cell-free DNA levels. Congrats to Georg Böhmig/Vienna team, and also the Berlin-team!
https://t.co/n15djseHnk
May 27, 2024 · 8 likes · 2 shares · 759 followersView post →
RG
Roberto Gutiérrez
@DrRobertoGuti · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 27, 2024 · 28 shares · 783 followersView post →
A
Abstream
@abstreamme · X
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection
#science #publication #research #publications
https://t.co/pf3Ik7iVpB
May 27, 2024 · 8 likes · 1 share · 36,064 followersView post →
MM
Manoj Mayogi Mishra
@mayogisense · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 27, 2024 · 18 shares · 575 followersView post →
WF
Wisit Cheungpasitporn MD FACP | FASN | FAST
@wisit661 · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 27, 2024 · 18 shares · 2,762 followersView post →
RM
Ramón Ruiz M.
@girugtruiz · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 27, 2024 · 28 shares · 106 followersView post →
NJ
Nestor Jimenez
@DrNestorJimenez · X
RT @JonathanNefro: En trasplante renal con rechazo por anticuerpos agudo y crónico, Felzartamab (anti-CD38), comparado a placebo, fue segur…
May 26, 2024 · 28 shares · 879 followersView post →
TS
Tired & Sakit
@tulunsokit · X
RT @brendonneuen: Icing on the cake for me after a fantastic #ERA24:
@MatthiasDiebold let me know the SMART-C GitHub (CREDENCE GFR slope c…
May 26, 2024 · 11 shares · 3,724 followersView post →
J
JorgeEdoChava75
@QicenoJorge · X
RT @hswapnil: Then we had the anti-CD38 mAB Fertalazamab in ABMR for kidney transplant. Also in @NEJM
#ERA24
https://t.co/Y0fnyj56W1
4/
May 26, 2024 · 1 share · 1,004 followersView post →
D
DGG
@DGG7334 · X
RT @JochenReiser: Finally something promising for one of the biggest problems in transplantation.
May 26, 2024 · 4 shares · 113 followersView post →
JP
Jochen Reiser MD PhD
@JochenReiser · X
Finally something promising for one of the biggest problems in transplantation.
May 26, 2024 · 11 likes · 4 shares · 4,698 followersView post →
JJ
Javi Juega
@JJuega · X
RT @MCrespoBarrio: Interesting results from A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal…
May 26, 2024 · 4 shares · 352 followersView post →
BF
Beatriz Fernandez Fernandez
@beaff26 · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 2,319 followersView post →
DA
Dr. ALCupich
@alcupich · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 566 followersView post →
OV
Ondrej Viklicky
@OViklicky · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 277 followersView post →
B
Böhmig
@BohmigGeorg · X
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal of Medicine https://t.co/eQrW719Ecv
May 26, 2024 · 12 likes · 1 share · 10 followersView post →
GB
Gregor Bond
@BondGregor · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 417 followersView post →
MA
Manal Alotaibi
@Maealotaibi · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 445 followersView post →
NA
Nelson Alvarez
@nelson_alv · X
Felzartamab tuvo perfiles aceptables de seguridad y efectos secundarios en pacientes con rechazo mediado por anticuerpos.
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection
https://t.co/U7yEjjmFmp
$BIIB $MOR #HIBio
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal of Medicine https://t.co/loWvReDuee https://t.co/GMPZLZavt1
May 26, 2024 · 1 like · 18,794 followersView post →
KT
Kat T❗️N A tongo
@Tinkapotepinka · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 652 followersView post →
AB
Annette Bruchfeld
@AnnetteBruchfe1 · X
RT @MCrespoBarrio: Interesting results from A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal…
May 26, 2024 · 4 shares · 2,296 followersView post →
DJ
Dr. Shashank Joshi
@AskDrShashank · X
RT @NEJM: Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney |…
May 26, 2024 · 18 shares · 32,583 followersView post →
N
NEJM
@NEJM · X
Original Article: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection https://t.co/S6wvGwoQqB
@ERAkidney | #Nephrology #ERA24 https://t.co/V5eYPDAS9l
May 26, 2024 · 66 likes · 18 shares · 935,482 followersView post →
EM
Edoardo Melilli
@EdoardoMelilli · X
RT @MCrespoBarrio: Interesting results from A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal…
May 26, 2024 · 4 shares · 3,255 followersView post →
MM
Manoj Mayogi Mishra
@mayogisense · X
RT @KSusztak: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | @NEJM https://t.co/s9mamYQ6BR
May 25, 2024 · 3 shares · 575 followersView post →
PD
Paraish S. Misra, M.D.
@ParaishM · X
RT @KSusztak: A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | @NEJM https://t.co/s9mamYQ6BR
May 25, 2024 · 3 shares · 133 followersView post →
MR
Michelle Rheault
@rheault_m · X
RT @MCrespoBarrio: Interesting results from A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal…
May 25, 2024 · 4 shares · 16,276 followersView post →
MB
Marta Crespo Barrio
@MCrespoBarrio · X
Interesting results from A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal of Medicine
May 25, 2024 · 17 likes · 4 shares · 1,162 followersView post →
CL
Cravedi Lab
@cravedilab · X
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection | New England Journal of Medicine https://t.co/bw7bXLaRZ6
Dialicare, Hemodiálisis, Jalisco | Municipio de Tlajomulco de Zúñiga
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doi: 10.1056/NEJMoa2400763 El tratamiento con felzartamab suprimió la actividad del rechazo mediado por anticuerpos en pacientes con trasplante renal ...
Felzartamab in AMR | PDF | Transplant Rejection | Kidney ...
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