J Pineal Res August 2024 PMID 38860494

Melatonin decreases human adipose tissue insulin sensitivity.

Carolina Zambrano, Mireia Tena Garitaonaindia, Diego Salmerón, Fernando Pérez-Sanz, Cynthia Tchio, María Cecilia Picinato, Fermín Sánchez de Medina, Juan Luján, Frank A J L Scheer, Richa Saxena, Olga Martínez-Augustin, Marta Garaulet

Mentions

8
Peak: 5 in Jun 2024
across 2 sources since Jun 2024

Extended reach

25,626
potential audience

Total likes

16

Video views

11

Mentions per month

Jun 2024 – Jun 2025

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions highlight the significance of the research, with examples like the mention of how circulating melatonin impacts night eating and metabolic health, and references to videos explaining melatonin's effects. The tone is informative and supportive, emphasizing the relevance for health behaviors and potential future implications.

AgreementModerate agreement

Most discussions recognize the validity of the publication and its findings, with some explicitly supporting its conclusions about melatonin’s effects.

InterestHigh interest

The subject matter is relevant, especially concerning health, sleep, and metabolism, which prompts high interest.

EngagementModerate engagement

Comments show some level of engagement, such as sharing related videos and discussing implications, but limited in-depth analysis.

ImpactModerate impact

The discussions acknowledge that the findings are important for health and dietary practices, though the overall reach and influence are still developing.

Abstract in brief

  • Melatonin, a hormone involved in the sleep-wake cycle, may decrease insulin sensitivity in human fat tissue, especially in obese individuals, with effects varying between morning and evening.
  • Exposing fat tissue samples to melatonin and insulin revealed that melatonin can reduce insulin signaling (measured by pAKT/AKT ratio), notably in the evening, suggesting it could influence glucose metabolism depending on the time of day.
  • RNA sequencing showed that melatonin triggers rapid changes in gene expression in visceral fat tissue in the evening, indicating it might have immediate effects on how fat tissue responds to insulin at a molecular level.

Top posts

Most liked on X and Bluesky
Kat Kennedy, PhD
@sphynxkennedy · X

We know that night eating isn't great for us, and circulating melatonin is partially to blame. This group is doing such great work! #Chrononutrition https://t.co/FyH4bJm39t https://t.co/Ro0Dszl4aC

Jun 16, 2024 · 7 likes · 840 followers View post →
Nick Krontiris
@nick_krontiris · X

Melatonin decreases human adipose tissue insulin sensitivity (open access) https://t.co/ZS4zC3oach

Jun 15, 2024 · 4 likes · 1 share · 19,103 followers View post →
Dr. Jan-Frieder Harmsen
@247muscle · X

Jun 16, 2024 · 4 likes · 1 share · 3,666 followers View post →
Daniel Corchado
@med__gym · X

Jun 15, 2024 · 1,883 followers View post →
AKSHAY
@Danaveni_Akshay · X

RT @nick_krontiris: Melatonin decreases human adipose tissue insulin sensitivity (open access) https://t.co/ZS4zC3oach

Jun 15, 2024 · 1 share · 114 followers View post →
Ritual Health
@myritualhealth · X

Before you take melatonin, watch this Sources: Adverse effects of Mel on children https://t.co/v1tDkMleME Mel: a contraceptive https://t.co/7sgcSXlk4w 3 months of mel reduces insulin sensitivity in diabetics https://t.co/Bi0L6wy8r8 Video by Mikke House: https://t.co/gXbhmsLVh1 https://t.co/zJhJKQ9usP

Nov 8, 2024 · 4 followers View post →

All mentions

Ritual Health
@myritualhealth · X

Before you take melatonin, watch this Sources: Adverse effects of Mel on children https://t.co/v1tDkMleME Mel: a contraceptive https://t.co/7sgcSXlk4w 3 months of mel reduces insulin sensitivity in diabetics https://t.co/Bi0L6wy8r8 Video by Mikke House: https://t.co/gXbhmsLVh1 https://t.co/zJhJKQ9usP

Nov 8, 2024 · 4 followers View post →
Kat Kennedy, PhD
@sphynxkennedy · X

We know that night eating isn't great for us, and circulating melatonin is partially to blame. This group is doing such great work! #Chrononutrition https://t.co/FyH4bJm39t https://t.co/Ro0Dszl4aC

Jun 16, 2024 · 7 likes · 840 followers View post →
Dr. Jan-Frieder Harmsen
@247muscle · X

Jun 16, 2024 · 4 likes · 1 share · 3,666 followers View post →
Daniel Corchado
@med__gym · X

Jun 15, 2024 · 1,883 followers View post →
AKSHAY
@Danaveni_Akshay · X

RT @nick_krontiris: Melatonin decreases human adipose tissue insulin sensitivity (open access) https://t.co/ZS4zC3oach

Jun 15, 2024 · 1 share · 114 followers View post →
Nick Krontiris
@nick_krontiris · X

Melatonin decreases human adipose tissue insulin sensitivity (open access) https://t.co/ZS4zC3oach

Jun 15, 2024 · 4 likes · 1 share · 19,103 followers View post →