June 2024 PMID 38900734

Activation of the integrated stress response in human hair follicles.

Derek Pye, Rachel Scholey, Sin Ung, Madoc Dawson, Asim Shahmalak, Talveen S Purba

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Mentions

Peak: 2 in Jun 2024

across 4 sources since Jun 2024

Extended reach

172,199

potential audience

Total likes

310

Video views

16,145

Mentions per month

Jun 2024 – Oct 2025

Where it's discussed

News45 articles
X / Twitter4 posts
YouTube3 videos
Blogs3 articles

AI synopsis

What people are saying

The discussions highlight the significance of the research by mentioning terms like 'closer to treating hair loss' and referencing phase 2a results, which suggest optimism and curiosity. The tone is conversational yet respectful of the scientific progress, emphasizing potential therapeutic benefits and the publication's credibility.

AgreementModerate agreement

The discussions show a general positive reception, with some users acknowledging the progress made by researchers and their enthusiasm for potential treatments.

InterestModerate interest

The posts reflect moderate interest, mentioning specific results and the publication, indicating engagement without exhaustive detail.

EngagementModerate engagement

Participants are engaging with the topic by asking for opinions, referencing the publication, and noting the research's significance, demonstrating meaningful interaction.

ImpactModerate impact

There is a sense that the research could be important for future treatment options, which gives it a moderate to high perceived impact.

Abstract in brief

The study investigates how disrupting mitochondrial pyruvate import in human hair follicles causes metabolic stress, activating the integrated stress response (ISR) and leading to cell cycle arrest, which potentially impacts hair growth.
Pharmacological inhibition of MPC triggers gene expression changes involving disrupted growth factor signaling and mitochondrial dysfunction, with the stress response mediated by ATF4 playing a key role.
Using an ISR inhibitor (ISRIB), researchers were able to reduce stress response activation and restore cell proliferation, suggesting potential therapeutic targets for hair growth disorders.]

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All mentions

Phase 2a Trial Results Show Promise for Regenerative Hair Loss Treatment

Pelage Pharmaceuticals announces positive Phase 2a clinical trial results for PP405, a potential therapy for hair loss. Inhibiting pyruvate oxidation in mitochondria can stimulate hair growth by reactivating dormant…

KwRx ????️ · Jun 25, 2025 7,598 views

UCLA Discoveries in Hair Growth Activation and Stress Response Mechanisms

UCLA scientists identified a molecule, PP 405, that activates dormant hair follicles and shows promising results in human trials. The study explores how this molecule inhibits a protein maintaining dormancy…

KwRx ????️ · Feb 8, 2025 6,906 views

Hair Follicle Health and Risks of Mitochondrial Pyruvate Carrier Inhibitors

This video discusses the potential risks of using PP 405, an MPC inhibitor, on hair follicle health, including possible follicle destruction, and explores liposomal minoxidil sulfate as a conditioning treatment.

KwRx ????️ · Oct 6, 2025 1,641 views

Tim Brady

@eps018us · X

@hairypapasmurf Papa what you think? Thanks https://t.co/6xAtGhNDYQ

Jun 14, 2025 · 426 followers View post →

Romano

@RNR_0 · X

@elianto_nL @MarioNawfal Phase 2a results https://t.co/eienBnByOh

May 11, 2025 · 1 like · 152,667 followers View post →

Fradi Frad Dreizehn

@frad_fradi · X

Activation of the integrated stress response in human hair follicles | PLOS ONE https://t.co/5R5SXW6sFY

Jun 25, 2024 · 2,443 followers View post →

Natural Resource Today

@ResourceToday · X

Researchers @OfficialUoM are one step closer to treating hair loss. Their research is published in the journal @PLOSONE. https://t.co/oPpGcd66y4

Jun 21, 2024 · 519 followers View post →