Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study.

John Nikitas, Kritika Subramanian, Nimrod Barashi Gozal, Andres Ricaurte-Fajardo, Eric Li, James A Proudfoot, Elai Davicioni, Ariel E Marciscano, Joseph R Osborne, Christopher E Barbieri, Wesley R Armstrong, Clayton P Smith, Luca F Valle, Michael L Steinberg, Paul C Boutros

July 2024 JCO Precis Oncol

Synopsis of Social media discussions

The discussions demonstrate high interest and engagement, with posts praising the study’s findings, such as mentions of the link between genomic scores and nonlocalized prostate cancer, and emphasizing the potential clinical implications. The tone is supportive and focused on advancing understanding, reflecting a recognition of the study's influence on future research and treatment strategies.

A
Agreement
 Moderate agreement

Most discussions support the findings, highlighting the link between genetic scores and disease visualization, with some posts explicitly endorsing the study's conclusions.

I
Interest
 High level of interest

Posts express high interest, referencing the publication, its methods, and implications for prostate cancer management, showing active engagement.

E
Engagement
 High engagement

Many comments cite specific details such as Decipher scores and PSMA PET/CT results, indicating deep engagement with the study's methodology and significance.

I
Impact
 Moderate level of impact

While the discussions are favorable and show recognition of the study’s importance, they are mostly informative and promotional, implying a moderate impact on the field and audiences.

Social Mentions

YouTube

1 Videos

Twitter

19 Posts

Metrics

Video Views

24

Total Likes

63

Extended Reach

52,650

Social Features

20

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Transcriptomic Analysis of Primary and Nonlocalized Prostate Cancer

Transcriptomic Analysis of Primary and Nonlocalized Prostate Cancer

Dr. Kishan discusses the link between Decipher genomic scores and metastatic spread in prostate cancer, based on a multicenter study of 586 patients, highlighting genetic differences between localized and nonlocalized disease.

ASCO Podcasts

October 16, 2024

24 views

  • Elai Davicioni
    @Davicioni (Twitter)

    RT @AmarUKishan: Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication h…
    view full post

    October 25, 2024

    2

  • Sumanta K. Pal, MD, FASCO
    @montypal (Twitter)

    RT @AmarUKishan: Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication h…
    view full post

    October 24, 2024

    2

  • Amar Kishan
    @AmarUKishan (Twitter)

    Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication https://t.co/g1NPF8IJS5. @JCOPO_ASCO @thenasheffect
    view full post

    October 24, 2024

    22

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  • Tboone302
    @tboone302 (Twitter)

    RT @JCOPO_ASCO: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positr…
    view full post

    October 1, 2024

    2

  • WCM Molecular Imaging and Therapeutics
    @MolecularWCM (Twitter)

    RT @WCMRadiology:
    view full post

    September 6, 2024

    2

  • Andres Ricaurte Fajardo
    @AndresRicaurte1 (Twitter)

    RT @WCMRadiology:
    view full post

    September 6, 2024

    2

  • Andy Hanson
    @AndrewH11556067 (Twitter)

    RT @Decipher_VCYT: A new study of 568 patients linked higher Decipher Prostate genomic scores with non-localized #ProstateCancer seen on PS…
    view full post

    September 6, 2024

    1

  • Decipher by Veracyte
    @Decipher_VCYT (Twitter)

    A new study of 568 patients linked higher Decipher Prostate genomic scores with non-localized #ProstateCancer seen on PSMA PET/CT scans, both pre- and post-treatment. Read more in the full publication here: https://t.co/vP8HYa3jw6 https://t.co/69wtExJLDp
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    September 6, 2024

    1

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  • Weill Cornell Medicine Radiology
    @WCMRadiology (Twitter)


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    September 6, 2024

    8

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  • Amar Kishan
    @AmarUKishan (Twitter)

    RT @JCOPO_ASCO: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positr…
    view full post

    July 30, 2024

    2

  • JCO Precision Oncology
    @JCOPO_ASCO (Twitter)

    Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study: https://t.co/OpTvlhM77F @amarukishan #pcsm
    view full post

    July 30, 2024

    3

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  • Kritika Subramanian
    @krkksub (Twitter)

    RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…
    view full post

    July 21, 2024

    5

  • Weill Cornell Medicine Radiology
    @WCMRadiology (Twitter)

    RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…
    view full post

    July 19, 2024

    5

  • Jana Ivanidze
    @jana_ivanidze (Twitter)

    RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…
    view full post

    July 18, 2024

    5

  • Andres Ricaurte Fajardo
    @AndresRicaurte1 (Twitter)

    RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…
    view full post

    July 18, 2024

    5

  • Lauren Kriger Groner
    @LaurenGroner (Twitter)

    RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…
    view full post

    July 18, 2024

    5

  • WCM Molecular Imaging and Therapeutics
    @MolecularWCM (Twitter)

    Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper published in @JCOPO_ASCO on the relationship between decipher scores and PSMA PET. @HimanshuNagarMD @Chris_Barbieri1 @WCMRadiology @UCLA https://t.co/v2bSPhjQQj
    view full post

    July 18, 2024

    11

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  • Chris Barbieri
    @Chris_Barbieri1 (Twitter)

    RT @Davicioni: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron…
    view full post

    July 17, 2024

    1

  • Elai Davicioni
    @Davicioni (Twitter)

    Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study | JCO Precision Oncology https://t.co/5TGrxRFMmG
    view full post

    July 17, 2024

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Abstract Synopsis

  • The study aimed to explore the link between Decipher genomic classifier scores and metastatic spread as evidenced by PSMA PET/CT scans in prostate cancer patients.
  • Data from 586 patients (329 pretreatment, 257 post-radical prostatectomy) showed that higher Decipher scores correlated with a higher likelihood of nonlocalized disease, indicating worse outcomes.
  • Results indicated distinct differences in genetic profiles between localized and nonlocalized disease, with nonlocalized cases showing more mutations and specific transcriptomic signatures related to metabolism and androgen receptor signaling.