JCO Precis Oncol July 2024 PMID 39013135

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study.

John Nikitas, Kritika Subramanian, Nimrod Barashi Gozal, Andres Ricaurte-Fajardo, Eric Li, James A Proudfoot, Elai Davicioni, Ariel E Marciscano, Joseph R Osborne, Christopher E Barbieri, Wesley R Armstrong, Clayton P Smith, Luca F Valle, Michael L Steinberg, Paul C Boutros

Mentions

20
Peak: 10 in Jul 2024
across 2 sources since Jul 2024

Extended reach

52,650
potential audience

Total likes

63

Video views

24

Mentions per month

Jul 2024 – Oct 2024

Where it's discussed

  • X / Twitter19 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions demonstrate high interest and engagement, with posts praising the study’s findings, such as mentions of the link between genomic scores and nonlocalized prostate cancer, and emphasizing the potential clinical implications. The tone is supportive and focused on advancing understanding, reflecting a recognition of the study's influence on future research and treatment strategies.

AgreementModerate agreement

Most discussions support the findings, highlighting the link between genetic scores and disease visualization, with some posts explicitly endorsing the study's conclusions.

InterestHigh interest

Posts express high interest, referencing the publication, its methods, and implications for prostate cancer management, showing active engagement.

EngagementHigh engagement

Many comments cite specific details such as Decipher scores and PSMA PET/CT results, indicating deep engagement with the study's methodology and significance.

ImpactModerate impact

While the discussions are favorable and show recognition of the study’s importance, they are mostly informative and promotional, implying a moderate impact on the field and audiences.

Abstract in brief

  • The study aimed to explore the link between Decipher genomic classifier scores and metastatic spread as evidenced by PSMA PET/CT scans in prostate cancer patients.
  • Data from 586 patients (329 pretreatment, 257 post-radical prostatectomy) showed that higher Decipher scores correlated with a higher likelihood of nonlocalized disease, indicating worse outcomes.
  • Results indicated distinct differences in genetic profiles between localized and nonlocalized disease, with nonlocalized cases showing more mutations and specific transcriptomic signatures related to metabolism and androgen receptor signaling.

Top posts

Most liked on X and Bluesky
Amar Kishan
@AmarUKishan · X

Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication https://t.co/g1NPF8IJS5. @JCOPO_ASCO @thenasheffect

Oct 24, 2024 · 22 likes · 2 shares · 4,180 followers View post →
Elai Davicioni
@Davicioni · X

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study | JCO Precision Oncology https://t.co/5TGrxRFMmG

Jul 17, 2024 · 18 likes · 1 share · 632 followers View post →
WCM Molecular Imaging and Therapeutics
@MolecularWCM · X

Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper published in @JCOPO_ASCO on the relationship between decipher scores and PSMA PET. @HimanshuNagarMD @Chris_Barbieri1 @WCMRadiology @UCLA https://t.co/v2bSPhjQQj

Jul 18, 2024 · 11 likes · 5 shares · 483 followers View post →
Weill Cornell Medicine Radiology
@WCMRadiology · X

Sep 6, 2024 · 8 likes · 2 shares · 2,685 followers View post →
JCO Precision Oncology
@JCOPO_ASCO · X

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study: https://t.co/OpTvlhM77F @amarukishan #pcsm

Jul 30, 2024 · 3 likes · 2 shares · 5,307 followers View post →
Decipher by Veracyte
@Decipher_VCYT · X

A new study of 568 patients linked higher Decipher Prostate genomic scores with non-localized #ProstateCancer seen on PSMA PET/CT scans, both pre- and post-treatment. Read more in the full publication here: https://t.co/vP8HYa3jw6 https://t.co/69wtExJLDp

Sep 6, 2024 · 1 like · 1 share · 1,090 followers View post →

All mentions

Elai Davicioni
@Davicioni · X

RT @AmarUKishan: Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication h…

Oct 25, 2024 · 2 shares · 632 followers View post →
Sumanta K. Pal, MD, FASCO
@montypal · X

RT @AmarUKishan: Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication h…

Oct 24, 2024 · 2 shares · 21,946 followers View post →
Amar Kishan
@AmarUKishan · X

Happy to join the JCO Precision Oncology Conversations podcast https://t.co/hlh7YjfpWG to discuss our recent publication https://t.co/g1NPF8IJS5. @JCOPO_ASCO @thenasheffect

Oct 24, 2024 · 22 likes · 2 shares · 4,180 followers View post →
Tboone302
@tboone302 · X

RT @JCOPO_ASCO: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positr…

Oct 1, 2024 · 2 shares · 38 followers View post →
WCM Molecular Imaging and Therapeutics
@MolecularWCM · X

RT @WCMRadiology:

Sep 6, 2024 · 2 shares · 483 followers View post →
Andres Ricaurte Fajardo
@AndresRicaurte1 · X

RT @WCMRadiology:

Sep 6, 2024 · 2 shares · 550 followers View post →
Andy Hanson
@AndrewH11556067 · X

RT @Decipher_VCYT: A new study of 568 patients linked higher Decipher Prostate genomic scores with non-localized #ProstateCancer seen on PS…

Sep 6, 2024 · 1 share · 148 followers View post →
Decipher by Veracyte
@Decipher_VCYT · X

A new study of 568 patients linked higher Decipher Prostate genomic scores with non-localized #ProstateCancer seen on PSMA PET/CT scans, both pre- and post-treatment. Read more in the full publication here: https://t.co/vP8HYa3jw6 https://t.co/69wtExJLDp

Sep 6, 2024 · 1 like · 1 share · 1,090 followers View post →
Weill Cornell Medicine Radiology
@WCMRadiology · X

Sep 6, 2024 · 8 likes · 2 shares · 2,685 followers View post →
Amar Kishan
@AmarUKishan · X

RT @JCOPO_ASCO: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positr…

Jul 30, 2024 · 2 shares · 4,180 followers View post →
JCO Precision Oncology
@JCOPO_ASCO · X

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study: https://t.co/OpTvlhM77F @amarukishan #pcsm

Jul 30, 2024 · 3 likes · 2 shares · 5,307 followers View post →
Kritika Subramanian
@krkksub · X

RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…

Jul 21, 2024 · 5 shares · 159 followers View post →
Weill Cornell Medicine Radiology
@WCMRadiology · X

RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…

Jul 19, 2024 · 5 shares · 2,685 followers View post →
Jana Ivanidze
@jana_ivanidze · X

RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…

Jul 18, 2024 · 5 shares · 2,120 followers View post →
Andres Ricaurte Fajardo
@AndresRicaurte1 · X

RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…

Jul 18, 2024 · 5 shares · 550 followers View post →
Lauren Kriger Groner
@LaurenGroner · X

RT @MolecularWCM: Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper publ…

Jul 18, 2024 · 5 shares · 2,504 followers View post →
WCM Molecular Imaging and Therapeutics
@MolecularWCM · X

Congratulations to our alumni @krkksub, fellow @AndresRicaurte1, chief @JOsbMD and co-authors for their latest paper published in @JCOPO_ASCO on the relationship between decipher scores and PSMA PET. @HimanshuNagarMD @Chris_Barbieri1 @WCMRadiology @UCLA https://t.co/v2bSPhjQQj

Jul 18, 2024 · 11 likes · 5 shares · 483 followers View post →
Chris Barbieri
@Chris_Barbieri1 · X

RT @Davicioni: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron…

Jul 17, 2024 · 1 share · 2,150 followers View post →
Elai Davicioni
@Davicioni · X

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study | JCO Precision Oncology https://t.co/5TGrxRFMmG

Jul 17, 2024 · 18 likes · 1 share · 632 followers View post →