A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.
Priya Gupta, Marco Galimberti, Yue Liu, Sarah Beck, Aliza Wingo, Thomas Wingo, Keyrun Adhikari, Henry R Kranzler, , Murray B Stein, Joel Gelernter, Daniel F Levey
November 2024Synopsis of Social media discussions
Overall, the discussions demonstrate moderate enthusiasm and engagement, emphasizing elements like the study's scale and its focus on the genetic basis of personality traits, with phrases such as 'largest study of its kind' and concerns about how the findings might be 'taken out of context.' The tone varies from academic appreciation to cautious skepticism, using words like 'complex,' 'investigation,' and 'overlap' to highlight scientific rigor, while some posts express wariness about potential misinterpretations.
Agreement
Moderate agreementMost discussions recognize the significance of the study, though some express caution about interpretation and context.
Interest
Moderate level of interestParticipants show moderate interest, noting the relevance of the research, with some excitement and some neutral curiosity.
Engagement
Moderate level of engagementComments include references to authors, study size, and methodological details, indicating thoughtful engagement.
Impact
Moderate level of impactDiscussions reflect an understanding of the potential importance of the findings in genetics and psychology, though some concern over misinterpretation is evident.
Social Mentions
YouTube
2 Videos
Bluesky
3 Posts
2 Posts
17 Posts
Blogs
4 Articles
News
9 Articles
Metrics
Video Views
234
Total Likes
147
Extended Reach
89,523
Social Features
37
Timeline: Posts about article
Top Social Media Posts
Dr. Stephanie
TFW you read an article title in your PubMed update and just. start. screaming.
There is no way, zero, none, that this won’t get taken WILDLY out of context. At best. And that’s IF you think the “Big Five” traits are legit, which… ask two psychologists and you’ll probably get three opinions.
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Jordan Smoller
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.co/QQMa8Yp9Ak
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Yale Psychiatry
#yalepsych scientists, led by first author Dr. Priya Gupta and senior author Dr. Daniel F. Levey investigated the complex underlying genetic architecture of the "big five" personality traits in a cohort of 682,688 people, the largest study of its kind. https://t.co/a12wzma0Sy https://t.co/ax3trCkJzZ
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SciencesNetwork
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.
https://t.co/y1djw4J8Gq
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medRxiv
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/OwPI7iJ3C1 #medRxiv
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Posts referencing the article
Genetic Insights into Personality Traits and Mental Health Links
This study explores how genetics influence personality traits and their connections to mental health issues such as depression and anxiety, highlighting complex biological pathways and potential causal links.
August 29, 2024
180 views
Genetics and Personality: Unraveling the Biological Basis of Traits
This study explores how genetics influence the Big Five personality traits and their links to mental health issues like depression and anxiety, identifying 208 genetic loci associated with neuroticism and uncovering complex biological pathways involved in personality development.
July 17, 2025
54 views
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A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/nhtUZ4VO83
view full postJanuary 3, 2025
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Ulrich Ettinger
@ulrichettinger.bsky.social (Bluesky)This new paper now on my (growing) reading list: "A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology". www.nature.com/articles/s41...
view full postNovember 24, 2024
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('・ω・`)b
@HIMI_toshi (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/F8chhGQDYh
view full postNovember 21, 2024
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SANDRAJOHNSTON
@sandra04850184 (Twitter)RT @YalePsych: #yalepsych scientists, led by first author Dr. Priya Gupta and senior author Dr. Daniel F. Levey investigated the complex un…
view full postAugust 15, 2024
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Yale Psychiatry
@YalePsych (Twitter)#yalepsych scientists, led by first author Dr. Priya Gupta and senior author Dr. Daniel F. Levey investigated the complex underlying genetic architecture of the "big five" personality traits in a cohort of 682,688 people, the largest study of its kind. https://t.co/a12wzma0Sy https://t.co/ax3trCkJzZ
view full postAugust 15, 2024
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Psychiatric Genomics Bot
@PsychGenPapers (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/ttfKkxsf0P
view full postAugust 13, 2024
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Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/EjuiwT7UiS
view full postAugust 12, 2024
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marylynnjuszczak
@marylynnjuszcza (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/Spywjg0vY3
view full postAugust 12, 2024
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Dr. Stephanie
@punkrockscience.bsky.social (Bluesky)TFW you read an article title in your PubMed update and just. start. screaming. There is no way, zero, none, that this won’t get taken WILDLY out of context. At best. And that’s IF you think the “Big Five” traits are legit, which… ask two psychologists and you’ll probably get three opinions.
view full postAugust 12, 2024
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Julian Konzok
@Julian_Konzok (Twitter)RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…
view full postFebruary 4, 2024
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Daniel P. Moriarity
@dp_moriarity (Twitter)RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…
view full postFebruary 3, 2024
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Aidan Wright
@aidangcw (Twitter)RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…
view full postFebruary 3, 2024
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Elisabetta C. del Re
@BettaCdelRe (Twitter)RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…
view full postFebruary 2, 2024
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Michael Ostacher, MD, MPH
@RecoveryDoctor (Twitter)RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…
view full postFebruary 1, 2024
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carey goldberg
@goldbergcarey (Twitter)RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…
view full postFebruary 1, 2024
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Jordan Smoller
@jorsmo (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.co/QQMa8Yp9Ak
view full postFebruary 1, 2024
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Unsilenced Science
@UnsilencedSci (Twitter)RT @SciencesNetwork: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopath…
view full postJanuary 17, 2024
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SciencesNetwork
@SciencesNetwork (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/y1djw4J8Gq
view full postJanuary 17, 2024
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medRxivpreprint
@medrxivpreprint.bsky.social (Bluesky)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://www.medrxiv.org/content/10.1101/2024.01.17.24301428v1
view full postJanuary 17, 2024
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medRxiv
@medrxivpreprint (Twitter)A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/OwPI7iJ3C1 #medRxiv
view full postJanuary 17, 2024
Abstract Synopsis
- This study explores how genetics influence the Big Five personality traits (neuroticism, extraversion, agreeableness, conscientiousness, openness) and their links to mental health issues like depression and anxiety, using data from a large cohort including individuals of European and African ancestry.
- The researchers found 208 genetic loci associated with neuroticism and identified new genetic connections for other traits, highlighting complex biological pathways and gene expressions involved in personality.
- They also examined how these personality traits relate genetically to other health conditions, uncovering new associations and potential causal links between genetics, personality, and mental health.]
Diego Forero MD, PhD
@daforerog (Twitter)