November 2024 PMID 39134740

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.

Priya Gupta, Marco Galimberti, Yue Liu, Sarah Beck, Aliza Wingo, Thomas Wingo, Keyrun Adhikari, Henry R Kranzler, Murray B Stein, Joel Gelernter, Daniel F Levey

Mentions

37
Peak: 7 in Feb 2024
across 6 sources since Jan 2024

Extended reach

89,523
potential audience

Total likes

147

Video views

234

Mentions per month

Jan 2024 – Jul 2025

Where it's discussed

  • X / Twitter17 posts
  • News9 articles
  • Blogs4 articles
  • Bluesky3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Overall, the discussions demonstrate moderate enthusiasm and engagement, emphasizing elements like the study's scale and its focus on the genetic basis of personality traits, with phrases such as 'largest study of its kind' and concerns about how the findings might be 'taken out of context.' The tone varies from academic appreciation to cautious skepticism, using words like 'complex,' 'investigation,' and 'overlap' to highlight scientific rigor, while some posts express wariness about potential misinterpretations.

AgreementModerate agreement

Most discussions recognize the significance of the study, though some express caution about interpretation and context.

InterestModerate interest

Participants show moderate interest, noting the relevance of the research, with some excitement and some neutral curiosity.

EngagementModerate engagement

Comments include references to authors, study size, and methodological details, indicating thoughtful engagement.

ImpactModerate impact

Discussions reflect an understanding of the potential importance of the findings in genetics and psychology, though some concern over misinterpretation is evident.

Abstract in brief

  • This study explores how genetics influence the Big Five personality traits (neuroticism, extraversion, agreeableness, conscientiousness, openness) and their links to mental health issues like depression and anxiety, using data from a large cohort including individuals of European and African ancestry.
  • The researchers found 208 genetic loci associated with neuroticism and identified new genetic connections for other traits, highlighting complex biological pathways and gene expressions involved in personality.
  • They also examined how these personality traits relate genetically to other health conditions, uncovering new associations and potential causal links between genetics, personality, and mental health.]

Top posts

Most liked on X and Bluesky
Dr. Stephanie
@punkrockscience.bsky.social · Bluesky

TFW you read an article title in your PubMed update and just. start. screaming. There is no way, zero, none, that this won’t get taken WILDLY out of context. At best. And that’s IF you think the “Big Five” traits are legit, which… ask two psychologists and you’ll probably get three opinions.

Aug 12, 2024 · 102 likes · 28 shares View post →
Jordan Smoller
@jorsmo · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.co/QQMa8Yp9Ak

Feb 1, 2024 · 21 likes · 6 shares · 3,832 followers View post →
Yale Psychiatry
@YalePsych · X

#yalepsych scientists, led by first author Dr. Priya Gupta and senior author Dr. Daniel F. Levey investigated the complex underlying genetic architecture of the "big five" personality traits in a cohort of 682,688 people, the largest study of its kind. https://t.co/a12wzma0Sy https://t.co/ax3trCkJzZ

Aug 15, 2024 · 12 likes · 3 shares · 31,210 followers View post →
SciencesNetwork
@SciencesNetwork · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/y1djw4J8Gq

Jan 17, 2024 · 1 like · 1 share · 345 followers View post →
medRxiv
@medrxivpreprint · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/OwPI7iJ3C1 #medRxiv

Jan 17, 2024 · 17,468 followers View post →
Aidan Wright
@aidangcw · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 3, 2024 · 6 shares · 15,492 followers View post →

All mentions

Diego Forero MD, PhD
@daforerog · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/nhtUZ4VO83

Jan 3, 2025 · 1,598 followers View post →
Ulrich Ettinger
@ulrichettinger.bsky.social · Bluesky

This new paper now on my (growing) reading list: "A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology". www.nature.com/articles/s41...

Nov 24, 2024 View post →
('・ω・`)b
@HIMI_toshi · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/F8chhGQDYh

Nov 21, 2024 · 273 followers View post →
SANDRAJOHNSTON
@sandra04850184 · X

RT @YalePsych: #yalepsych scientists, led by first author Dr. Priya Gupta and senior author Dr. Daniel F. Levey investigated the complex un…

Aug 15, 2024 · 3 shares · 942 followers View post →
Yale Psychiatry
@YalePsych · X

#yalepsych scientists, led by first author Dr. Priya Gupta and senior author Dr. Daniel F. Levey investigated the complex underlying genetic architecture of the "big five" personality traits in a cohort of 682,688 people, the largest study of its kind. https://t.co/a12wzma0Sy https://t.co/ax3trCkJzZ

Aug 15, 2024 · 12 likes · 3 shares · 31,210 followers View post →
Psychiatric Genomics Bot
@PsychGenPapers · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/ttfKkxsf0P

Aug 13, 2024 · 1 share · 180 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/EjuiwT7UiS

Aug 12, 2024 · 2,065 followers View post →
marylynnjuszczak
@marylynnjuszcza · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology https://t.co/Spywjg0vY3

Aug 12, 2024 · 2,725 followers View post →
Dr. Stephanie
@punkrockscience.bsky.social · Bluesky

TFW you read an article title in your PubMed update and just. start. screaming. There is no way, zero, none, that this won’t get taken WILDLY out of context. At best. And that’s IF you think the “Big Five” traits are legit, which… ask two psychologists and you’ll probably get three opinions.

Aug 12, 2024 · 102 likes · 28 shares View post →
Julian Konzok
@Julian_Konzok · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 4, 2024 · 6 shares · 74 followers View post →
Daniel P. Moriarity
@dp_moriarity · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 3, 2024 · 6 shares · 5,583 followers View post →
Aidan Wright
@aidangcw · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 3, 2024 · 6 shares · 15,492 followers View post →
Elisabetta C. del Re
@BettaCdelRe · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 2, 2024 · 6 shares · 156 followers View post →
Michael Ostacher, MD, MPH
@RecoveryDoctor · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 1, 2024 · 6 shares · 3,530 followers View post →
carey goldberg
@goldbergcarey · X

RT @jorsmo: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.…

Feb 1, 2024 · 6 shares · 1,895 followers View post →
Jordan Smoller
@jorsmo · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychop… https://t.co/QQMa8Yp9Ak

Feb 1, 2024 · 21 likes · 6 shares · 3,832 followers View post →
Unsilenced Science
@UnsilencedSci · X

RT @SciencesNetwork: A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopath…

Jan 17, 2024 · 1 share · 1,763 followers View post →
SciencesNetwork
@SciencesNetwork · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/y1djw4J8Gq

Jan 17, 2024 · 1 like · 1 share · 345 followers View post →
medRxivpreprint
@medrxivpreprint.bsky.social · Bluesky

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://www.medrxiv.org/content/10.1101/2024.01.17.24301428v1

Jan 17, 2024 View post →
medRxiv
@medrxivpreprint · X

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. https://t.co/OwPI7iJ3C1 #medRxiv

Jan 17, 2024 · 17,468 followers View post →