PubHawk
Blood December 2024 PMID 39158068

Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype.

Louise A Tilley, Vanja Karamatic Crew, Tosti J Mankelow, Samah A AlSubhi, Benjamin Jones, Abigail Borowski, Vered Yahalom, Lilach Finkel, Belinda K Singleton, Piers J Walser, Ashley M Toye, Timothy J Satchwell, Nicole M Thornton

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Mentions

291
Peak: 94 in Sep 2024
across 6 sources since Sep 2024

Extended reach

553,680
potential audience

Total likes

189

Video views

2,604

Mentions per month

Sep 2024 – Apr 2025

Where it's discussed

  • X / Twitter136 posts
  • News136 articles
  • Blogs8 articles
  • Bluesky5 posts
  • YouTube4 videos
  • Facebook2 posts

AI synopsis

What people are saying

Discussions praise the research's novelty and potential impact, using words like 'game changer' and 'big news,' which demonstrate excitement and seriousness, while referencing specific details such as the MAL gene's role and the connection to blood transfusion safety.

AgreementStrong agreement

Most discussions recognize the significance of discovering the MAL gene's role in rare blood types, expressing enthusiasm for the scientific breakthrough.

InterestHigh interest

Comments show high curiosity and fascination with advancements in blood grouping and genetics, indicating strong interest.

EngagementHigh engagement

Posts include references to detailed scientific findings, calls to read the article, and discussions about implications, reflecting deep engagement.

ImpactHigh impact

The discussions emphasize how this discovery could improve blood transfusions and understanding of blood groups, highlighting its potential widespread influence.

Abstract in brief

  • Deletions in the MAL gene lead to the absence of Mal protein, which in turn defines the rare inherited AnWjnegative blood group phenotype.
  • Whole exome sequencing showed that individuals with the AnWjnegative phenotype do not have mutations in the previously suspected CD44 or SMYD1 genes but instead have a homozygous large exonic deletion in the MAL gene, confirming its crucial role.
  • The study demonstrated that Mal protein is both necessary and sufficient for the expression of the AnWj antigen on red blood cells, establishing a new blood group system and helping to better understand blood antigen variability.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Technology Nerd
@ComInternetFax · X

✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mystery. This could save lives & improve transfusion safety!

Dec 31, 2024 · 13 likes · 17 shares · 2,150 followers View post →
Blood Journals Portfolio
@BloodPortfolio · X

Mar 31, 2025 · 10 likes · 1 share · 53,510 followers View post →
Blood Journals Portfolio
@BloodPortfolio · X

Apr 6, 2025 · 6 likes · 1 share · 53,510 followers View post →
Erica Wood
@ericawood.bsky.social · Bluesky

What is a blood group and how can its expression sometimes disappear? Check out this @bloodportfolio.bsky.social podcast where Dr Nicole Thornton discusses defining the genetic basis of the AnWj-negative phenotype. Read the article and accompanying editorial: doi.org/10.1182/blood.2024025099

Apr 2, 2025 · 5 likes · 1 share View post →
Blood Journals' Portfolio
@bloodjournals.hematology.org · Bluesky

Mar 31, 2025 · 4 likes · 1 share View post →
unicampoficial
@unicampoficial · X

Pesquisadores da Universidade de Bristol, no Reino Unido, desvendaram por completo um novo sistema de grupo sanguíneo, conhecido como MAL (proteína de mielina e linfócitos). É um tipo raríssimo, presente em 0,01% da população mundial. Saiba mais: https://t.co/IRXElRZBTS

Oct 16, 2024 · 3 likes · 33,812 followers View post →

All mentions

Blood Journals' Portfolio
@bloodjournals.hematology.org · Bluesky

Apr 6, 2025 · 1 like View post →
Blood Journals Portfolio
@BloodPortfolio · X

Apr 6, 2025 · 6 likes · 1 share · 53,510 followers View post →
Blood Journals' Portfolio
@bloodjournals.hematology.org · Bluesky

Apr 5, 2025 · 2 likes View post →
Blood Global Hematology
@BloodGlobalHema · X

Apr 4, 2025 · 1 like · 235 followers View post →
Blood Vessels, Thrombosis & Hemostasis
@BloodVTH · X

Apr 3, 2025 · 1 like · 248 followers View post →
Erica Wood
@ericawood.bsky.social · Bluesky

What is a blood group and how can its expression sometimes disappear? Check out this @bloodportfolio.bsky.social podcast where Dr Nicole Thornton discusses defining the genetic basis of the AnWj-negative phenotype. Read the article and accompanying editorial: doi.org/10.1182/blood.2024025099

Apr 2, 2025 · 5 likes · 1 share View post →
Blood Journals' Portfolio
@bloodjournals.hematology.org · Bluesky

Apr 2, 2025 · 2 likes · 1 share View post →
Blood Neoplasia
@Bloodneoplasia · X

Apr 2, 2025 · 3 likes · 513 followers View post →
Blood Advances
@BloodAdvances · X

Apr 1, 2025 · 32,384 followers View post →
Blood Journals Portfolio
@BloodPortfolio · X

Mar 31, 2025 · 10 likes · 1 share · 53,510 followers View post →
Blood Journals' Portfolio
@bloodjournals.hematology.org · Bluesky

Mar 31, 2025 · 4 likes · 1 share View post →
Lara Casim
@laramarizcasim · X

RT @iamklubsybear: Magiging 46 na ang BGS

Mar 13, 2025 · 292 shares · 1 followers View post →
Milkt, RMT
@aintbingsu · X

RT @iamklubsybear: Magiging 46 na ang BGS

Mar 11, 2025 · 292 shares · 58 followers View post →
CIEMAT Innovación Biomédica
@BioInn_CIEMAT · X

Feb 10, 2025 · 653 followers View post →
Gina de Miranda
@GinadeMiranda2 · X

#NewBloodGroupDiscovered https://t.co/a0eHuMVHfm

Jan 17, 2025 · 3,827 followers View post →
Megan Kelly
@gisellestopped · X

https://t.co/CsFPUbrM4D

Jan 17, 2025 · 1,866 followers View post →
Serge NDAGIJIMANA, MD
@ndagijeserge · X

RT @ndagijeserge: @NationAfrica https://t.co/NjXcUocFQa Interesting!

Jan 14, 2025 · 1 share · 4,671 followers View post →
Serge NDAGIJIMANA, MD
@ndagijeserge · X

@NationAfrica https://t.co/NjXcUocFQa Interesting!

Jan 14, 2025 · 2 likes · 1 share · 4,671 followers View post →
Lara Youssef, MD, MPH, CP
@Dr_LaraYoussef · X

Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype https://t.co/eCAmG6weq1

Jan 5, 2025 · 61 followers View post →
Madelin
@MadaOprea · X

O nouă grupă de sânge https://t.co/MTImWt4bY4

Jan 4, 2025 · 1 share · 510 followers View post →
Nature's Medicines
@NatMed_Research · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 2,951 followers View post →
Wellness Luggage
@luggageandbaggs · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 2,403 followers View post →
Health Promotor
@ukingdomshoppin · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 4,317 followers View post →
Health Affiliate
@HudbayAffiliate · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 3,448 followers View post →
Science Updates
@cpa61 · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 35,987 followers View post →
Newyork Fitness
@NewYorkPass · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 4,777 followers View post →
Australian Adventure
@AdventAustralia · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 11,468 followers View post →
Online Pharmacy
@PharmacyOnline8 · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Jan 1, 2025 · 17 shares · 6,261 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 189 followers View post →
bon pearson
@twitmomcat22 · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 320 followers View post →
Lily Huang
@healthhikes · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 40 followers View post →
Karim Al-Haddad
@KarimSciFan · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 9 followers View post →
Seema Trivedi
@seematrivedy · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 218 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 6,735 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 10,260 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 2,873 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @ComInternetFax: ✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mys…

Dec 31, 2024 · 17 shares · 123,493 followers View post →
Technology Nerd
@ComInternetFax · X

✨ Big news in blood science! After 50 years, researchers discovered the MAL blood group, solving the AnWj antigen mystery. This could save lives & improve transfusion safety!

Dec 31, 2024 · 13 likes · 17 shares · 2,150 followers View post →
sittie
@stthmrmt · X

RT @iamklubsybear: Magiging 46 na ang BGS

Dec 1, 2024 · 292 shares · 128 followers View post →
Flor Joyce
@ploooyploooy · X

RT @iamklubsybear: Magiging 46 na ang BGS

Dec 1, 2024 · 292 shares · 15 followers View post →
Ally, RMT
@allyrmt · X

RT @iamklubsybear: Magiging 46 na ang BGS

Dec 1, 2024 · 292 shares · 613 followers View post →
keesh, fRMT
@medtechiee · X

RT @iamklubsybear: Magiging 46 na ang BGS

Nov 27, 2024 · 292 shares View post →
AI, Drugs & Robots
@AIDrugsYRobots · X

https://t.co/jYTmPlfUzW https://t.co/wjgvjHPxBz https://t.co/4edGHaUgs2 #blood #mal #anwj #antigen #bloodantigen #anwjnegative #transfusion #bloodtype #gruposanguineo #genetics #inmuno #science #biology #medicine #health

Oct 29, 2024 · 145 followers View post →
Qtcle
@Qtcle151713 · X

RT @iamklubsybear: Magiging 46 na ang BGS

Oct 20, 2024 · 292 shares View post →
unicampoficial
@unicampoficial · X

Pesquisadores da Universidade de Bristol, no Reino Unido, desvendaram por completo um novo sistema de grupo sanguíneo, conhecido como MAL (proteína de mielina e linfócitos). É um tipo raríssimo, presente em 0,01% da população mundial. Saiba mais: https://t.co/IRXElRZBTS

Oct 16, 2024 · 3 likes · 33,812 followers View post →
Radoslaw Kaczmarek
@RKaczmarekDr · X

RT @CzerwinsMarcin: Rare inherited AnWj-negative blood group phenotype is caused by deletions in the MAL gene encoding myelin and lymphocyt…

Oct 16, 2024 · 1 share · 1,587 followers View post →
Marcin Czerwinski
@CzerwinsMarcin · X

Rare inherited AnWj-negative blood group phenotype is caused by deletions in the MAL gene encoding myelin and lymphocyte protein, resulting in loss of Mal protein https://t.co/z6yjnhm3Bv #blood_groups https://t.co/N3oRB9SNmh

Oct 16, 2024 · 1 like · 1 share · 3,024 followers View post →
reoviridae, RMT ⋆ﾟ
@tunalogs · X

RT @iamklubsybear: Magiging 46 na ang BGS

Oct 7, 2024 · 292 shares · 80 followers View post →
José Alberto
@josealberto_gc · X

Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype https://t.co/lOQFeKxPr1

Oct 4, 2024 · 1,466 followers View post →
NegriBodies, fRMT
@RMTKYUTIE · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 29, 2024 · 292 shares · 30 followers View post →
Marcin Czerwinski
@CzerwinsMarcin · X

New blood group! Autosomally-recessive AnWj-negative phenotype is caused by a large exonic deletion in MAL gene encoding the membrane proteolipid, Myelin and Lymphocyte protein (Mal), important in cell transport and membrane stability. https://t.co/HdWDB9imB4 #blood_groups https://t.co/Yfvj4LkBtR

Sep 27, 2024 · 3 likes · 3,024 followers View post →
ً
@ylaxxi · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 23, 2024 · 292 shares · 2 followers View post →
Medtech Writes, RMT
@medtechwritesph · X

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Sep 22, 2024 · 292 shares · 29 followers View post →
ً
@karmicdrifts · X

@trblchi yes, pretty. ito. https://t.co/jvtsc06INg

Sep 22, 2024 · 114 followers View post →
RMT MARCH 2024 ✨
@cocotoffeenut · X

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Sep 21, 2024 · 292 shares · 36 followers View post →
coconut
@IamChuleh · X

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Sep 21, 2024 · 292 shares · 2,136 followers View post →
gab_a3lise
@gab_a3lise · X

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Sep 21, 2024 · 292 shares · 56 followers View post →
cHowderr
@kwenenieh · X

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Sep 21, 2024 · 292 shares · 736 followers View post →
RMT
@rmthp26 · X

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Sep 21, 2024 · 292 shares · 321 followers View post →
Aishcreme, RMT
@sweethashima · X

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Sep 21, 2024 · 292 shares · 88 followers View post →
SUNKISS²²¹
@icebear_187 · X

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RJ, RMT ✨
@__raalph · X

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Sep 21, 2024 · 292 shares · 81 followers View post →
jen, frmt ☻
@catalasebluu · X

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Sep 21, 2024 · 292 shares · 9 followers View post →
glycojenase
@glycojenase · X

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Sep 21, 2024 · 291 shares · 9 followers View post →
dayanne, RMT ♡
@diannepn_x · X

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Sep 21, 2024 · 292 shares · 89 followers View post →
annie
@motherhanbinnie · X

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Sep 21, 2024 · 292 shares · 111 followers View post →
mariella ♡
@poesiacorner · X

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Sep 21, 2024 · 292 shares · 912 followers View post →
Angeli
@emmmeyyyy · X

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Sep 21, 2024 · 292 shares · 836 followers View post →
sari ( ´∀｀)
@solelydnbll · X

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Sep 21, 2024 · 292 shares · 14,337 followers View post →
yoOhoOO᭡ ❀˖°
@noteweecaa · X

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Sep 21, 2024 · 292 shares · 108 followers View post →
basiads_
@basiads_ · X

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ish in her rev era
@creatinish · X

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Sep 21, 2024 · 292 shares · 141 followers View post →
Shailesh
@skucha96 · X

@nihardesai7 Sir, pdf please Email id : skucha96@gmail.com https://t.co/j8k8e3OpdH

Sep 20, 2024 · 178 followers View post →
BJ
@bjproteinRMT · X

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Sep 20, 2024 · 292 shares · 5,690 followers View post →
hirvsNspices
@hirvsNspices · X

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Sep 20, 2024 · 292 shares · 49 followers View post →
wayne.
@incessityx · X

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Sep 20, 2024 · 292 shares · 433 followers View post →
Fleby Fagsao
@FagsaoFleby · X

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Sep 20, 2024 · 292 shares · 117 followers View post →
J.co, RMT
@JechoBalauag · X

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Hana
@itshnnhhh · X

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Sep 20, 2024 · 291 shares · 221 followers View post →
ryu☁️
@astraxenecaaa · X

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Sep 20, 2024 · 291 shares · 54 followers View post →
페이
@pay__wj · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 20, 2024 · 292 shares · 348 followers View post →
Antonio Álvarez Eguiarte
@micuartavida · X

#MAL, otro grupo sanguíneo humano... https://t.co/FFTf2dO1Sm

Sep 20, 2024 · 33 followers View post →
the lazy penguino
@_lazypenguin · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 20, 2024 · 292 shares · 32 followers View post →
Mc Lou
@mcloumarcos · X

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@_amxviii · X

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@stvnipuncture · X

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@daenabanana · X

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Neil
@jasooonium · X

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knee-kohl
@ntdrd_rmt · X

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Sep 20, 2024 · 292 shares · 4 followers View post →
rím, rmt
@rimelito · X

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Sep 20, 2024 · 292 shares · 139 followers View post →
✨Athena, RMT. ✨
@RmtStudy · X

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Farina
@farinaailyn · X

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J❣️
@wldk_4 · X

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Joshua Cang
@cangdynasty · X

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@EmmanuelRMT · X

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@kysIindsay · X

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@akosipashaa · X

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P.rettgeri
@KozumeRawr · X

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Sep 20, 2024 · 292 shares · 10 followers View post →
MAJURO
@im_tgzi · X

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@Asi_fRMT · X

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mei
@meidtech_md · X

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P. vivax
@shyluis2 · X

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Sep 20, 2024 · 292 shares · 22 followers View post →
krmt
@ksrmt_ · X

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dendri-cell, RMT
@dendricell · X

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Sep 20, 2024 · 292 shares · 876 followers View post →
Asociación Puertorriqueña Energía Verde (APEV)
@energiaverdepr · X

https://t.co/cPAMFKiN4G Ahora, este nuevo estudio, que publicará la revista de la Sociedad Estadounidense de Hematología Blood, ha establecido que el antígeno AnWj se transporta dentro de la proteína Mal, y su presencia o ausencia se debe a variaciones genéticas específicas.

Sep 20, 2024 · 985 followers View post →
ha?⭐️
@scrt818 · X

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@mehhdddd · X

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@thatkidvid_ · X

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@zeroKinetics · X

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hanna
@jxhannz · X

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Sep 20, 2024 · 292 shares · 99 followers View post →
Shailesh
@skucha96 · X

@nihardesai7 Sir, Please can I get this pdf?? Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype https://t.co/j8k8e3OX3f

Sep 20, 2024 · 178 followers View post →
Alex, RMT.
@_lxdrmykl · X

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@ellamaine97 · X

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@rhuzgykk · X

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@raycelle__ · X

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@c_edcee · X

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@itscheskaj · X

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@rmtniaiah · X

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@frmtksy · X

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@jingggtmf · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 20, 2024 · 292 shares · 641 followers View post →
lijan, rmt, mls(ascpi)cm
@RubydeLeon67 · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 20, 2024 · 292 shares · 257 followers View post →
Gaeleline
@BlueYshara · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 105 followers View post →
maerikahannah
@maerikahannah · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 446 followers View post →
laurenz ⚡
@Pete_prions · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 228 followers View post →
ysa
@kweyneee · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 66 followers View post →
dandalandan✨
@prado_sison · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 151 followers View post →
alexa, RMT
@iestudiee · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 57 followers View post →
as.
@shanebido · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 28 followers View post →
iodamoeba butschlii, RMT
@RaMbuTanMD · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 348 followers View post →
meca, RMT
@unsatisfiedRMT · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 203 followers View post →
aish
@sharparin_mti · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 48 followers View post →
han | student medtech
@fairymarisloane · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 58 followers View post →
Cy ✧˖*°࿐
@izcairo · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 120 followers View post →
Eloise
@Eloise_jah · X

RT @iamklubsybear: Magiging 46 na ang BGS

Sep 19, 2024 · 292 shares · 73 followers View post →
شرف السفياني
@sharafalsofiani · X

#علماء يكتشفون فصيلة #دم جديدة بعد غموض دام 50 عامًا. https://t.co/eYCCmeQ5du https://t.co/6tVhSHEHk1

Sep 18, 2024 · 2 likes · 24,331 followers View post →