J Am Coll Cardiol October 2024 PMID 39217553

Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chronic Kidney Disease in the FLOW Trial.

Richard E Pratley, Katherine R Tuttle, Peter Rossing, Søren Rasmussen, Vlado Perkovic, Olav Wendelboe Nielsen, Johannes F E Mann, Richard J MacIsaac, Mikhail N Kosiborod, Zdravko Kamenov, Thomas Idorn, Marco Bo Hansen, Samy Hadjadj, George Bakris, Florian M M Baeres

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Mentions

65
Peak: 37 in Oct 2024
across 3 sources since Aug 2024

Extended reach

638,796
potential audience

Total likes

2,155

Video views

52,184

Mentions per month

Aug 2024 – May 2025

Where it's discussed

  • X / Twitter58 posts
  • News5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The collection of posts consistently emphasizes the significance of the FLOW trial, using phrases like 'substantially reduced risks' and 'significant reduction' to highlight the potential impact of semaglutide treatment on heart failure and cardiovascular outcomes. The tone, characterized by technical language and citations of specific statistics and analyses, underscores the high level of interest and perceived importance of this research within the medical community.

AgreementStrong agreement

Most discussions emphasize the positive effects of semaglutide, highlighting significant reductions in heart failure events and cardiovascular death, showing strong consensus support.

InterestHigh interest

The strong use of medical terminology, summaries of trial results, and references to specific analyses reflect high interest in the study's outcomes.

EngagementModerate engagement

While many discussions elaborate on the results, some posts merely share the findings or cite sources without much critical analysis, indicating moderate but not deep engagement.

ImpactHigh impact

The frequent references to structured clinical trials, statistical findings, and clinical implications demonstrate that these discussions are viewed as potentially transformative for medical practice.

Abstract in brief

  • People with type 2 diabetes and chronic kidney disease have a high risk of heart failure and cardiovascular death, making new treatments crucial.
  • The FLOW study found that semaglutide, a medication used for diabetes, significantly reduced severe kidney-related outcomes by 24% in participants with these conditions.
  • In a prespecified analysis, semaglutide also improved heart failure outcomes and reduced the risk of heart failure events and cardiovascular death over a median follow-up of 3.4 years compared to a placebo.

Top posts

Most liked on X and Bluesky
Jonathan Chávez
@JonathanNefro · X

Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascular y de falla cardiaca Se necesitan tratar 34 pacientes para ver 1 beneficiado En PostHoc del ensayo clínico FLOW JACC 2024 10.1016/j.jacc.2024.08.004 https://t.co/4zgmFJGIsC

Oct 20, 2024 · 76 likes · 22 shares · 37,974 followers View post →
JACC Journals
@JACCJournals · X

FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially reduced risks of heart failure events or cardiovascular death. https://t.co/SaGx7tf0ie #JACC #ESCCongress #HeartFailure #T2D #CKD #Semaglutide #CVD @RpratleyMD https://t.co/imPxyGPsiD

Aug 30, 2024 · 51 likes · 18 shares · 115,396 followers View post →
JACC Journals
@JACCJournals · X

#FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of #heartfailure events or CV death. https://t.co/OiUuD7Ryuz #JACC #T2D #Obesity @RpratleyMD @KatherineTuttl8 https://t.co/jdW23vIqfY

Oct 19, 2024 · 31 likes · 17 shares · 115,396 followers View post →
The Heart
@ZHeart11768530 · X

Oct 20, 2024 · 12 likes · 2 shares · 32,746 followers View post →
Peter Rossing
@P_Rossing · X

Swe the amazing Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD https://t.co/kowNb62ye4 @Stenodiabetes https://t.co/PQDeDsMYhP

Aug 30, 2024 · 12 likes · 2 shares · 1,528 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD FLOW Trial Semaglutide reduced the risk of time to first composite outcome of HF events or CV death, as well as HF events and CV death alone, in high-risk population with T2D and CKD https://t.co/3UulKvZ2U5 https://t.co/bFxef1rRfr

Oct 20, 2024 · 10 likes · 2 shares · 3,159 followers View post →

All mentions

Mounir Basalus (Ⲃⲁⲥⲓⲗⲓⲟⲥ)
@Basalus · X

4/ ❤️Semaglutide Reduces HF Events In T2D + CKD (FLOW), weekly sema ↓ HF events by 27% and CV death by 29%. ✅Benefits seen regardless of prior HF history.

May 29, 2025 · 4,967 followers View post →
Heart News
@HearttNews · X

The FLOW trial shows Semaglutide may improve heart failure outcomes in diabetes and chronic kidney disease patients. #HeartHealth #Diabetes #KidneyDisease https://t.co/zrGJZDsdl0 https://t.co/9ysUjpntbB

Apr 17, 2025 · 8 followers View post →
أخبار القلب
@A5barEl2alb · X

أظهرت تجربة FLOW أن Semaglutide قد يحسن نتائج فشل القلب في مرضى السكري ومرض الكلى المزمن. #صحة_القلب #السكري #مرض_الكلى https://t.co/SgKiAMlKQM https://t.co/rYuTtEiE2N

Apr 17, 2025 · 2 followers View post →
JACC Journals
@JACCJournals · X

(3/7) In #JACC, Dr. @RpratleyMD and colleagues published a secondary analysis of FLOW looking at #semaglutide's impact on #heartfailure outcomes in this population https://t.co/NBXW1RBqQy https://t.co/eHAfJni5WX

Jan 9, 2025 · 1 like · 115,396 followers View post →
ana
@wIwbot · X

Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chronic Kidney Disease in the FLOW Trial | Journal of the American College of Cardiology https://t.co/XdAQuVW9Bi

Nov 24, 2024 · 920 followers View post →
Blessing Muponda
@BMuponda · X

RT @ZHeart11768530:

Oct 23, 2024 · 2 shares · 103 followers View post →
Med by FAA ⚕️
@med_faa · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 212 followers View post →
Roberto Gutiérrez
@DrRobertoGuti · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 784 followers View post →
Nefrología Hospital Civil de Guadalajara
@NefrologiaHCFAA · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 1,160 followers View post →
Dr. Joshuan J. Barboza
@joshuanbarbozam · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 10,204 followers View post →
Juan Carlos Obaya
@jcobaya69 · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 858 followers View post →
Estefanía Argüello
@tefitasaloata · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 16 followers View post →
Lilia Andrea
@LiliaAndreataf1 · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 377 followers View post →
DaniReuma
@dani_reuma · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 21, 2024 · 22 shares · 365 followers View post →
LCONCEPCION
@lconcepcionmd · X

From the FLOWstudy:semaglutide Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chron... https://t.co/VZQmW3RpDb

Oct 21, 2024 · 98 followers View post →
Henry Gaviria
@henrygav5 · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 252 followers View post →
Carlos
@de_montecristo · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 2,735 followers View post →
Villahermosa se vistió de fiesta con la primavera
@Gust_1971 · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 502 followers View post →
jomincp
@jomincp · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 10 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 2,594 followers View post →
Freddy Shanner, MD
@FreddyShanner · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 322 followers View post →
Dr. Hugo Corrales - Endocrinología.
@hugoendocrino · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 6,478 followers View post →
A K
@annafval · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 203 followers View post →
Sebastián Tenorio Vargas
@SebasTenorio · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 534 followers View post →
Juan Carlos Elizalde:.
@JuanElizalde777 · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 2,397 followers View post →
Dr. ALCupich
@alcupich · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 562 followers View post →
María.
@callmevaaal · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 591 followers View post →
Dr. Ronald Caraballo NEFROLOGO
@ronald_nefro · X

RT @JonathanNefro: Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascu…

Oct 20, 2024 · 22 shares · 664 followers View post →
Jonathan Chávez
@JonathanNefro · X

Con diabetes y enfermedad renal crónica G3A3, semaglutide 1.0mg semanal, comparado a placebo, ↓27% el evento cardiovascular y de falla cardiaca Se necesitan tratar 34 pacientes para ver 1 beneficiado En PostHoc del ensayo clínico FLOW JACC 2024 10.1016/j.jacc.2024.08.004 https://t.co/4zgmFJGIsC

Oct 20, 2024 · 76 likes · 22 shares · 37,974 followers View post →
juan ramon
@RamonTasmania · X

RT @drbennisahmed: Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD FLOW Trial Semaglutide reduced the risk of time t…

Oct 20, 2024 · 2 shares · 93 followers View post →
Sintayehu Abebe
@sinta_gf · X

RT @ZHeart11768530:

Oct 20, 2024 · 2 shares · 452 followers View post →
The Heart
@ZHeart11768530 · X

Oct 20, 2024 · 12 likes · 2 shares · 32,746 followers View post →
UKCPA Cardiovascular Committee
@UKCPACardiac · X

RT @drbennisahmed: Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD FLOW Trial Semaglutide reduced the risk of time t…

Oct 20, 2024 · 2 shares · 758 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD FLOW Trial Semaglutide reduced the risk of time to first composite outcome of HF events or CV death, as well as HF events and CV death alone, in high-risk population with T2D and CKD https://t.co/3UulKvZ2U5 https://t.co/bFxef1rRfr

Oct 20, 2024 · 10 likes · 2 shares · 3,159 followers View post →
| Daniel Sierra LM |
@DanielSierraLM · X

RT @JACCJournals: #FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of…

Oct 19, 2024 · 17 shares · 2,489 followers View post →
Takuya Kishi @ねこ好き循環器内科医
@tkishi_cardiol · X

RT @JACCJournals: #FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of…

Oct 19, 2024 · 17 shares · 14,915 followers View post →
Elham Elmehdawi
@Elham1549664 · X

RT @JACCJournals: #FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of…

Oct 19, 2024 · 17 shares · 43 followers View post →
糸長 潤平
@jumpei_0217 · X

RT @JACCJournals: #FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of…

Oct 19, 2024 · 17 shares · 104 followers View post →
ChonyAlbert MD
@ChonyAlbertMD · X

RT @JACCJournals: #FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of…

Oct 19, 2024 · 17 shares · 948 followers View post →
Josh Ronen, MD, FACP
@jronenMD · X

RT @JACCJournals: #FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of…

Oct 19, 2024 · 17 shares · 127 followers View post →
JACC Journals
@JACCJournals · X

#FLOW trial: In participants with type 2 #diabetes and #CKD, weekly #semaglutide treatment substantially reduced risks of #heartfailure events or CV death. https://t.co/OiUuD7Ryuz #JACC #T2D #Obesity @RpratleyMD @KatherineTuttl8 https://t.co/jdW23vIqfY

Oct 19, 2024 · 31 likes · 17 shares · 115,396 followers View post →
SFC - Société Française de Cardiologie
@SFCardio · X

Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chronic Kidney Disease in the FLOW Trial

Sep 20, 2024 · 4,718 followers View post →
ig.
@ansells_cow · X

eg here they hint at it but I don’t know enough medicine to parse it out: https://t.co/9pfqAArkUp https://t.co/gn8B6BIVrb

Aug 31, 2024 · 1 like · 462 followers View post →
Katherine Tuttle
@KatherineTuttl8 · X

RT @P_Rossing: Swe the amazing Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD https://t.co/kowNb62ye4 @Stenodiabetes…

Aug 31, 2024 · 2 shares · 1,316 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

「CV死亡」のみでも0.71 [0.56-0.89]。 https://t.co/o6izbWQ7Cj

Aug 30, 2024 · 4,922 followers View post →
Dr.Rajiv Sankaranarayanan
@DrRajivsankar · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 3,975 followers View post →
Sintayehu Abebe
@sinta_gf · X

RT @ZHeart11768530:

Aug 30, 2024 · 1 share · 452 followers View post →
Diego Segura-Rodríguez
@SeguraCardio · X

https://t.co/lVzg5B0AaE

Aug 30, 2024 · 26,034 followers View post →
The Heart
@ZHeart11768530 · X

Aug 30, 2024 · 7 likes · 1 share · 32,746 followers View post →
susanconnolly
@susanbconnolly · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 1,693 followers View post →
David González Calle
@davidcalle1390 · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 9,208 followers View post →
Prof Derek Connolly
@DrDerekConnolly · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 3,953 followers View post →
Richard Pratley MD
@RpratleyMD · X

Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chron... https://t.co/AUhIPS78jh Just presented at #ESC and published in #JACC - semaglutide decreased risk of heart failure and CV death by 27% in the FLOW trial in T2D and CVD.

Aug 30, 2024 · 6 likes · 707 followers View post →
Carolina Manzur
@CarolinaManzurB · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 693 followers View post →
Peter Rossing
@P_Rossing · X

Swe the amazing Effects of Semaglutide on Heart Failure Outcomes in Diabetes and CKD https://t.co/kowNb62ye4 @Stenodiabetes https://t.co/PQDeDsMYhP

Aug 30, 2024 · 12 likes · 2 shares · 1,528 followers View post →
Shelley Zieroth
@ShelleyZieroth · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 10,015 followers View post →
Brendon Neuen
@brendonneuen · X

RT @JACCJournals: FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially r…

Aug 30, 2024 · 18 shares · 4,697 followers View post →
JACC Journals
@JACCJournals · X

FLOW trial: In participants with type 2 diabetes and chronic kidney disease, weekly semaglutide treatment substantially reduced risks of heart failure events or cardiovascular death. https://t.co/SaGx7tf0ie #JACC #ESCCongress #HeartFailure #T2D #CKD #Semaglutide #CVD @RpratleyMD https://t.co/imPxyGPsiD

Aug 30, 2024 · 51 likes · 18 shares · 115,396 followers View post →
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