September 2024 PMID 39226363

Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance.

Nan Zhang, Rui Zhang, Lei Jiang, Zhaoyu Gao, Wenzhen Xia, Xiaoying Ma, Yushi Qin, Di Zhang, Jiazheng Li, Pei Tian, Qi Zhang, Wanchang Wang, Kaixia Zhang, Shan Xu, Na Zhao

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121

Peak: 95 in Sep 2024

across 5 sources since Sep 2024

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817

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7,136

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Sep 2024 – Nov 2024

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AI synopsis

What people are saying

Several posts highlight the inverse relationship between colorectal cancer and Alzheimer's, indicating a keen interest in the findings. For instance, discussions drew attention to the role of specific gut bacteria and their potential protective effects against cancer. The tone of enthusiasm and inquiry, using phrases like 'highly relevant' and 'important implications', indicates a collective eagerness to explore how these insights could inform future research and health strategies.

AgreementModerate agreement

Most discussions express a general support for the research findings, acknowledging the connection between gut microbiota and colorectal cancer risk in Alzheimer's patients.

InterestHigh interest

There is a strong curiosity evident in the posts, with users looking for more information and engaging with the study's implications.

EngagementModerate engagement

While some discussions briefly mention the findings, several delve into the implications and mechanisms involved, indicating moderate engagement.

ImpactHigh impact

Participants perceive this research as having significant implications for understanding disease relationships and potential therapeutic avenues.

Abstract in brief

Research suggests that there's a link between Alzheimer's disease (AD) and lower rates of colorectal cancer (CRC), possibly due to changes in gut microbiota.
In experiments with AD-like mice, lower rates of CRC were observed, alongside reduced intestinal inflammation compared to control mice, indicating that gut bacteria may help prevent cancer.
However, when these mice received fecal microbiota transplants from healthy controls, the protective effects were lost, highlighting the role of specific gut bacteria in maintaining this cancer resistance linked to inflammation.
Overall, the study shows how gut health may influence brain function and cancer risk, suggesting that promoting a healthy microbiome could have benefits for both conditions.

Read the full abstract

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Aspirin and Its Role in Colorectal Cancer Risk Reduction

Aspirin reduces the risk of colorectal cancer. A new study from Norway indicates that low-dose aspirin may lower this risk. The US Preventive Services Task Force has updated its guidance on aspirin for colorectal cancer…

Drbeen Medical Lectures · Oct 11, 2024 7,136 views

Ovais Shafi

@ovais_docmed · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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darcy darnoc

@darcydarnoc · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance | PNAS https://t.co/metLG6Mz2B

Oct 24, 2024 · 3,147 followers View post →

Sky Health, LLC

@GotSkyHealth · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance | PNAS https://t.co/DgqqSlLG6P #Alzheimers #ColonCancer #GutHealth #microbiome #health #research #science #inflammation

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backspin

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https://t.co/KPG85cZen8

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JaclynBerney

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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LinaJones

@virtuous_CZ · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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darcy darnoc

@darcydarnoc · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance | PNAS https://t.co/metLG6Mz2B

Sep 24, 2024 · 1 like · 3,147 followers View post →

Frank Stassen

@StassenFrank · X

Als laatste nog het grafische abstract van de auteurs. Wil je de studie zelf nalezen, dan is hier de link. https://t.co/16Sn7Rpt6g https://t.co/Bd5bOvqkND

Sep 24, 2024 · 1 like · 1,530 followers View post →

Ariakas Enoreth

@Aenoreth · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance https://t.co/j8Q9wnSKXa

Sep 20, 2024 · 1,008 followers View post →

サイエンスあれこれ

@sarekore · X

その細菌がもつリポ多糖が、認知機能と大腸がんの発症リスクを低下させていることがわかりました。PNAS誌https://t.co/2p9758qZJA

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Wollen_k

@wollen1987 · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Daniel S.

@asecretcrow · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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AngryPhDstudent❗️❗️❗️

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RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Brain-Immune Communication Lab

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RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Shams Salah Mahdi

@ShamsPath · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Clara DNW

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RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

Sep 11, 2024 · 16 shares · 410 followers View post →

Eme ☕

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RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Andrew Octavian Sasmita

@AOSasmita · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Dervis Salih

@DervisSalih1 · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Waggoner Lab

@LabWaggoner · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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Charles Jourdan Reyes, Ph.D.

@reyes_jourdan · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

Sep 10, 2024 · 16 shares · 624 followers View post →

kuzn’

@Kuzn11shibeco · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

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مبارك بن سعد

@mub_saad · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

Sep 10, 2024 · 16 shares · 588 followers View post →

Ryan Logan

@wickedneuro · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

Sep 10, 2024 · 16 shares · 2,938 followers View post →

Dr Soraya M

@DrSorayaM · X

RT @LukensJohnR: Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory toleran…

Sep 10, 2024 · 16 shares · 2,880 followers View post →

John Lukens

@LukensJohnR · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance https://t.co/hUeqsHwY0C https://t.co/b22zxA6160

Sep 10, 2024 · 63 likes · 16 shares · 14,061 followers View post →

Australasian Human Microbiome Research Network

@microbiome_net · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 9, 2024 · 77 shares · 1,104 followers View post →

Diane Dewhirst

@NJdoc · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 7, 2024 · 77 shares · 20,640 followers View post →

(かんべ)

@ConclusionAnd · X

疫学的に知られていたアルツハイマー病（AD）患者で大腸ガン（CDC）患者が少ない理由をマウスモデルで示した研究。 https://t.co/ljsBwCiIXD

Sep 6, 2024 · 7 likes · 772 followers View post →

Vince Beltran, Ph.D.

@levin_beltran · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 5, 2024 · 77 shares · 11,762 followers View post →

PNASNews

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Michelle Fitzmaurice

@DrMFitzmaurice · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 5, 2024 · 77 shares · 756 followers View post →

Emad El-Omar

@emadelomar · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 3,879 followers View post →

Microbiome Research Centre

@MRC_microbiome · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 2,916 followers View post →

THE FOOD TIMES

@thefoodtimes · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Showboat7

@Showboat7 · X

Gut Microbiota https://t.co/8dalLeoyrI

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Showboat7

@Showboat7 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Stormetta

@Janiebt · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 1,096 followers View post →

GLASS_PhD

@joybeingfree99 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Natalia Kovtun

@NataliaKovtun6 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Alba

@Alba53056840 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 367 followers View post →

Albert Putnam

@AlbertPutnam · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 2,447 followers View post →

Elizabeth

@elizaaabeth2000 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 33 followers View post →

imquang

@imquang · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Archita Mishra

@armish1910 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Wimen

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Andy Blidy

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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J.F.García-Rodríguez

@jfgarciartroito · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Johan Van Weyenbergh

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 4,742 followers View post →

JC Stanford

@JCDarnestown · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 125 followers View post →

Hany Ragy

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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...

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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FrLecardonnel

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Semih Alpsoy

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Dr. Gennadi Glinsky, MD, Ph.D.

@gglinskii · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance https://t.co/3F866y2eA7

Sep 4, 2024 · 2,065 followers View post →

Dr. Gennadi Glinsky, MD, Ph.D.

@gglinskii · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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(Nai Khanom) Tom V Shīndé

@Tejas_V_Shinde · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Anant Jawahar Raina

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Verklempt

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Ramon Guinea

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 1,290 followers View post →

Baronian Consulting

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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AntifaNanaLovesYou&StandsAgainstFascism

@DixieT13 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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@SofiaVi185 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 392 followers View post →

Dr Sumer Sethi

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 39,137 followers View post →

Jackie Sander

@jackiesander3 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 4, 2024 · 77 shares · 3 followers View post →

Melinda Lydick

@MelindaLydick · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 345 followers View post →

Kujon Naukowski

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 32 followers View post →

Saubashya Sur, PhD

@SaubashyaSur · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 770 followers View post →

Dr. Shashank Joshi

@AskDrShashank · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 32,512 followers View post →

DrNithi

@DrNithi · X

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance | PNAS https://t.co/ui9Haxtnk1

Sep 3, 2024 · 6,517 followers View post →

Jay

@994rela · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 1,044 followers View post →

Raj Menon

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 157 followers View post →

Elvira NH

@ElviraNH · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 1,167 followers View post →

Richard Ważny @rcjw.bsky.social

@WaznyRichard · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 940 followers View post →

Helen Haskell

@hhask · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 5,567 followers View post →

Mathew Ingram

@mathewi · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 79,564 followers View post →

jorgenponder — om coronavirusepidemin

@jorgenponder · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 2,771 followers View post →

Neuron Atlas

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 75 followers View post →

Shannon Thompson

@sha_in_tally · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Michael Wagner

@MichiWagner4 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 12,524 followers View post →

Tom Englezos

@tomenglezos · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 1,270 followers View post →

Rexanna Keats

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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とき

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 1,200 followers View post →

SpaceAix

@cathcoste · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Frantz Fanon

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 8,016 followers View post →

The Scritcher

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RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 1,414 followers View post →

joe conery

@meetgrinder · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Sue M.

@purplesgem · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 4,979 followers View post →

Eldon Edwards

@eldonredwards · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 2,604 followers View post →

an1ma an1ma

@AAn1ma · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 247 followers View post →

Alzheimer's Prevention

@AlzheimersPrev2 · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 373 followers View post →

craig s matsuda

@craigmatsuda · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 2,274 followers View post →

Charles Arthur

@charlesarthur · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 69,130 followers View post →

Yuling Chow

@yulingchow · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 795 followers View post →

Ester Gea-Mallorquí

@estergeama · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 4,860 followers View post →

José Ríos

@jose1rt · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

Sep 3, 2024 · 77 shares · 526 followers View post →

Tom Jones

@tommyjtookalook · X

RT @EricTopol: Epidemiologically, there's an inverse relationship of colon cancer and Alzheimer's disease, but the mechanism is unknown. ht…

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Eric Topol

@EricTopol · X

Sep 3, 2024 · 323 likes · 77 shares · 678,712 followers View post →

Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Aspirin and Its Role in Colorectal Cancer Risk Reduction