Obes Rev January 2025 PMID 39295512

Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity.

Jeffrey I Mechanick, W Scott Butsch, Sandra M Christensen, Osama Hamdy, Zhaoping Li, Carla M Prado, Steven B Heymsfield

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Mentions

82
Peak: 25 in Oct 2024
across 5 sources since Sep 2024

Extended reach

385,006
potential audience

Total likes

167

Video views

336

Mentions per month

Sep 2024 – Sep 2025

Where it's discussed

  • X / Twitter61 posts
  • News14 articles
  • Blogs3 articles
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The social discussions demonstrate a strong collective concern about muscle loss during obesity treatment with incretin-mimetic drugs, referencing strategies such as resistance exercise and proper nutrition. Words like 'minimize,' 'maximize,' and 'strategies' reflect proactive attitudes, contributing to a moderate overall engagement and recognition of potential health impacts.

AgreementModerate agreement

Most discussions support the article's focus on using resistance exercise and nutrition to prevent muscle loss, indicating general agreement.

InterestHigh interest

There is high interest, as many social discussions highlight concerns about muscle loss and strategies to mitigate it, showing engagement with the topic.

EngagementModerate engagement

Posts reference specific strategies like resistance training and nutritional management, suggesting moderate depth of participation.

ImpactModerate impact

The emphasis on the importance of lifestyle management hints at a potential influence on clinical approaches, though it remains somewhat speculative.

Abstract in brief

  • The rapid adoption of incretin mimetic drugs like semaglutide and tirzepatide for obesity treatment has raised concerns about long-term safety, particularly regarding their potential to cause significant muscle loss.
  • Research indicates that patients on these medications may lose about 10% of their muscle mass over 6 to 8 months, which is comparable to 20 years of natural muscle decline due to aging, risking overall health and functionality.
  • To prevent muscle loss during treatment, patients should engage in resistance exercise and ensure proper nutrition with sufficient high-quality protein and micronutrients, making comprehensive lifestyle management essential for maximizing benefits and minimizing risks.]

Top posts

Most liked on X and Bluesky
David_Propst_PA-C
@PrimaryCarePAC · X

Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/S81wbAw4E6

Sep 24, 2024 · 42 likes · 7 shares · 3,329 followers View post →
Sociedad SEEN
@sociedadSEEN · X

Oct 8, 2024 · 32 likes · 11 shares · 17,169 followers View post →
Michael Weintraub, MD
@MWeintraubMD · X

The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 27 likes · 10 shares · 4,547 followers View post →
筋肉博士
@muscle_penguin_ · X

肥満治療にGLP-1RAを使う上で筋肉の減少を最大限に減らすための戦略 適切な栄養管理:十分なタンパク質摂取は、筋肉の維持に不可欠 運動の実施:レジスタンストレーニング 個別化された治療計画:患者の状態や目標に合わせた治療計画を立てる https://t.co/RtfsSVIgEQ

Nov 22, 2024 · 26 likes · 1 share · 36,373 followers View post →
Dr Rani Khatib FESC
@DrRaniKhatib · X

Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equivalent to 20 yrs of age-related muscle loss. Strategies for minimizing muscle loss during use of IMs drugs for treatment of obesity https://t.co/dsMrPXq7WE https://t.co/R2ZEwFSUhb

Nov 20, 2024 · 18 likes · 12 shares · 5,418 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

@DrCarlaPrado @imwmhealth @DrZhaopingLi @heymsfield @DrNadolsky Okay, now go read the full study here: https://t.co/fKGEAJpHa1

Sep 24, 2024 · 5 likes · 3,329 followers View post →

All mentions

Dr Richard Palmquist
@DrRPalmquist · X

Review Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity Jeffrey I Mechanick et al. Obes Rev. 2025 Jan. https://t.co/5NxfjJDW5w

Sep 6, 2025 · 4,726 followers View post →
SANCYD
@SANCYDnutricion · X

Estrategias para minimizar la pérdida muscular durante el uso de medicamentos miméticos de incretina para el tratamiento de la obesidad. Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity - PubMed https://t.co/uS7hogcql1

Jun 12, 2025 · 3,017 followers View post →
葉峻榳醫師
@DrYehChunTing · X

⬧腸泌素相關藥物(如 Semaglutide 和 Tirzepatide)雖然能有效減重,但可能導致肌肉流失,約相當於 20 年老化造成的流失量。 ⬧維持肌肉的兩大關鍵策略:充足的營養攝取、規律的運動訓練。 https://t.co/UwBv8wRWyE https://t.co/1FGuctmFTq

May 22, 2025 · 37 followers View post →
Rick Lanman
@ricklanman.bsky.social · Bluesky

Need more studies but at minimum probably should see a nutritionist and a physical therapist if losing weight on a GLP1R agonist drug. pubmed.ncbi.nlm.nih.gov/39295512/

Feb 23, 2025 View post →
Redzal Abu Hanifah
@docredzal · X

Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/h37ZVjxrG1

Feb 16, 2025 · 29 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/wxyKDc2Lsd…

Feb 13, 2025 · 2 shares · 133 followers View post →
Redzal Abu Hanifah
@docredzal · X

Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/E8UwyyfpTG

Feb 2, 2025 · 29 followers View post →
William Lagakos
@caloriesproper2 · X

Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity. Resistance exercise https://t.co/HZbuN0MIDp

Jan 31, 2025 · 2,759 followers View post →
筋肉博士
@muscle_penguin_ · X

肥満治療にGLP-1RAを使う上で筋肉の減少を最大限に減らすための戦略 適切な栄養管理:十分なタンパク質摂取は、筋肉の維持に不可欠 運動の実施:レジスタンストレーニング 個別化された治療計画:患者の状態や目標に合わせた治療計画を立てる https://t.co/RtfsSVIgEQ

Nov 22, 2024 · 26 likes · 1 share · 36,373 followers View post →
McMaster Heart Function Education
@MacHeartFailure · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 510 followers View post →
Arshad Rashid
@arshadkema · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 1,016 followers View post →
luis Rodriguez
@luisRod60597844 · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 25 followers View post →
Gabriel Pérez
@gperez441 · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 286 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 2,548 followers View post →
The Leeds CaReMe Innovative Clinic
@CaReMeLeeds · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 184 followers View post →
Dany
@danyros.pharmsky.app · Bluesky

Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equivalent to 20 yrs of age-related muscle loss. Strategies for minimizing muscle loss during use of IMs drugs for treatment of obesity onlinelibrary.wiley.com/doi/10.1111/...

Nov 20, 2024 · 1 like · 3 shares View post →
Philipp Lopatka
@LopatkaPhilipp · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 196 followers View post →
Swapnil Parve, MD, PhD, FACC, FACP, FEFIM
@drpnil · X

RT @DrRaniKhatib: Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equiva…

Nov 20, 2024 · 12 shares · 108 followers View post →
Dr Rani Khatib FESC
@DrRaniKhatib · X

Users of incretin-mimetics in obesity trials lost ≥10% of muscle mass during the 68 -72 week interventions, approx equivalent to 20 yrs of age-related muscle loss. Strategies for minimizing muscle loss during use of IMs drugs for treatment of obesity https://t.co/dsMrPXq7WE https://t.co/R2ZEwFSUhb

Nov 20, 2024 · 18 likes · 12 shares · 5,418 followers View post →
Dr Moh
@Holistic__Medic · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Nov 14, 2024 · 10 shares · 734 followers View post →
Bongani Mayosi Health Sciences Library (BMHSL)
@uct_bmhsl · X

RT @pash22: Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/tfoRuuQqwS via…

Nov 6, 2024 · 1 share · 1,598 followers View post →
Ash Paul
@pash22 · X

Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/tfoRuuQqwS via @heymsfield et al @PharmRJ

Nov 4, 2024 · 1 like · 1 share · 32,290 followers View post →
Doc Gerry Tan
@docgerrytan · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 23, 2024 · 10 shares · 310 followers View post →
Tejaswi Kompala
@tkompala · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 450 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 9,551 followers View post →
Viet Le DMSc PA-C FACC FAHA HF-Cert
@VietHeartPA · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 9,793 followers View post →
Leave it to Beaver
@espacetimeNOT · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares View post →
Polar Bear
@chaiwat_non · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 111 followers View post →
Rafael Radaeli
@rfradaeli · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 383 followers View post →
Blad Villavicencio
@bladDV · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 822 followers View post →
Eve Beavers
@espacetimeCO · X

RT @MWeintraubMD: The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 10 shares · 900 followers View post →
Michael Weintraub, MD
@MWeintraubMD · X

The benefits of incretin-memetic drugs (IMD) are clear

Oct 22, 2024 · 27 likes · 10 shares · 4,547 followers View post →
Juan Carlos Obaya
@jcobaya69 · X

RT @sociedadSEEN:

Oct 10, 2024 · 11 shares · 858 followers View post →
Polar Bear
@chaiwat_non · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 111 followers View post →
pity Saint James
@psantiagofernan · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 441 followers View post →
Beatriz González Aguilera
@beatrizgonz86 · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 665 followers View post →
EndoNutri
@endo_nutri · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 365 followers View post →
Nutrióloga Jessica Pérez
@nutriJesssica · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 764 followers View post →
Dr. Suzana Mantovani
@Tweet_Nutrition · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 4,574 followers View post →
EASO
@EASOobesity · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 18,879 followers View post →
ObesitySEEN
@ObesitySeen · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 5,218 followers View post →
ADRIANA ANDRADE
@adryorl68 · X

RT @sociedadSEEN:

Oct 8, 2024 · 11 shares · 806 followers View post →
Sociedad SEEN
@sociedadSEEN · X

Oct 8, 2024 · 32 likes · 11 shares · 17,169 followers View post →
Kirsty Woods
@MetabolicEP · X

https://t.co/ekrNOGCtOz https://t.co/w23Thpu1xZ

Oct 7, 2024 · 2,047 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/wxyKDc2Lsd…

Oct 2, 2024 · 2 shares · 133 followers View post →
Agingdoc
@agingdoc1 · X

Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/wxyKDc2Lsd https://t.co/4BQmfA4aP5

Oct 1, 2024 · 2 likes · 2 shares · 41,719 followers View post →
はも
@senmomo1100 · X

RT @Office_j: 【備忘】 Obes Rev誌に、インクレチン関連薬を用いた肥満治療における筋肉減少抑制を論じたレビュー。同剤による筋肉減少は加齢20年分に相当する可能性にも言及。 https://t.co/rTglujtooH https://t.co/M1IV…

Sep 29, 2024 · 1 share · 37 followers View post →
CMD Wellness
@CmdWellnes4078 · X

Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity Reviews - Wiley Online Library https://t.co/zLSsDH6pPo

Sep 27, 2024 · 24 followers View post →
Cindy Kugler
@Exspec85 · X

RT @PrimaryCarePAC: Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for mi…

Sep 25, 2024 · 7 shares · 235 followers View post →
Mind Your Science!
@MindYourSci · X

RT @PrimaryCarePAC: Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for mi…

Sep 25, 2024 · 7 shares · 133 followers View post →
GDLeahy
@GDLeahy · X

RT @PrimaryCarePAC: Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for mi…

Sep 25, 2024 · 7 shares · 679 followers View post →
Nick Krontiris
@nick_krontiris · X

RT @PrimaryCarePAC: Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for mi…

Sep 24, 2024 · 7 shares · 19,110 followers View post →
Das
@shivadas29 · X

RT @PrimaryCarePAC: Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for mi…

Sep 24, 2024 · 7 shares · 388 followers View post →
Koushik
@koushikphysio · X

RT @PrimaryCarePAC: Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for mi…

Sep 24, 2024 · 7 shares · 518 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

@DrCarlaPrado @imwmhealth @DrZhaopingLi @heymsfield @DrNadolsky Okay, now go read the full study here: https://t.co/fKGEAJpHa1

Sep 24, 2024 · 5 likes · 3,329 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

Hey! What can we do to avoid lean mass loss with weight loss? Check out this recent paper with me: Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://t.co/S81wbAw4E6

Sep 24, 2024 · 42 likes · 7 shares · 3,329 followers View post →
Yu Ning Lin
@YuNingLin1 · X

RT @NeilFlochMD: Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity…

Sep 22, 2024 · 5 shares · 48 followers View post →
Polar Bear
@chaiwat_non · X

RT @NeilFlochMD: Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity…

Sep 21, 2024 · 5 shares · 111 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @NeilFlochMD: Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity…

Sep 21, 2024 · 5 shares · 572 followers View post →
Dr. Hugo Corrales - Endocrinología.
@hugoendocrino · X

RT @NeilFlochMD: Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity…

Sep 21, 2024 · 5 shares · 6,472 followers View post →
Michael Cudworth, MD, FACS, DABS-FPD MBS
@mcudworth_MD · X

RT @NeilFlochMD: Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity…

Sep 21, 2024 · 5 shares · 1,196 followers View post →
Neil Floch MD
@NeilFlochMD · X

Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity - Mechanick - Obesity Reviews - Wiley Online Library https://t.co/I19Yp8d0Ae

Sep 21, 2024 · 4 likes · 5 shares · 130,080 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【備忘】 Obes Rev誌に、インクレチン関連薬を用いた肥満治療における筋肉減少抑制を論じたレビュー。同剤による筋肉減少は加齢20年分に相当する可能性にも言及。 https://t.co/rTglujtooH https://t.co/M1IVxmzMoO

Sep 19, 2024 · 3 likes · 1 share · 4,913 followers View post →