Nat Neurosci December 2024 PMID 39402379

Integrated multimodal cell atlas of Alzheimer's disease.

Mariano I Gabitto, Kyle J Travaglini, Victoria M Rachleff, Eitan S Kaplan, Brian Long, Jeanelle Ariza, Yi Ding, Joseph T Mahoney, Nick Dee, Jeff Goldy, Erica J Melief, Anamika Agrawal, Omar Kana, Xingjian Zhen, Samuel T Barlow

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Many discussions provide insights into the findings, such as noting the two distinct phases of brain damage that the publication discusses. Phrases like 'they did everything!' and 'wow' reflect excitement and acknowledgment of the comprehensive nature of the research, contributing to a tone that communicates both appreciation and eagerness for further exploration of the topic.

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The majority of discussions around the publication indicate general support and understanding of its findings.

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Participants express high curiosity regarding the implications of the research findings on Alzheimer’s disease.

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Several discussions reference the methodologies used and highlight the importance of the research, showing a moderate level of engagement.

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Many participants perceive the publication as having significant implications for understanding Alzheimer’s disease.

Abstract in brief

Alzheimer's disease (AD) is the top cause of dementia in older adults and involves the buildup of harmful proteins, but the specific cell types affected are not well understood.
Researchers analyzed brain cells in the middle temporal gyrus from 84 donors with varying levels of AD and found two phases of disease progression: an early phase with mild pathology and inflammatory responses, and a later phase with more severe changes and loss of key neuron types.
These results were consistent with findings from other significant AD studies, highlighting the importance of understanding cellular changes in different stages of the disease.

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How Alzheimer's Damages the Brain???? by a Two Phase Attack: A New Study Reveals

Science Codons · Nov 13, 2024 137 views

Distinct Phases of Brain Damage in Alzheimer's Disease Revealed

A recent study concludes Alzheimer's disease progresses in two phases: an early stage with mild pathology and inflammation, followed by a later stage characterized by significant neuron loss and more severe changes…

Geneaxis · Nov 7, 2024 93 views

LPJ Lab - Neuroimmunometabolism

@lpjlab.org · Bluesky

Integrated multimodal cell atlas of Alzheimer’s disease www.nature.com/articles/s41...

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HealthyBuilds

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Integrated multimodal cell atlas of Alzheimer’s disease https://t.co/H8E1hdSZ99

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Integrated multimodal cell atlas of Alzheimer’s disease https://t.co/34MkYkQhr2

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Integrated multimodal cell atlas of Alzheimer’s disease www.nature.com/articles/s41...

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Seele Zhao

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RT @LukasValihrach: Integrated multimodal cell atlas of Alzheimer’s disease

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geneaxis

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Estudo revela duas fases distintas de danos cerebrais na doença de #Alzheimer: a fase inicial ocorre lentamente antes do surgimento de sintomas e o Alzheimer afeta apenas alguns tipos de células vulneráveis. Na fase tardia, causa danos mais extensos https://t.co/8jGC9Mwy9y https://t.co/fwZrl46zPB

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John Maki

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Integrated multimodal cell atlas of Alzheimer’s disease | Nature Neuroscience https://t.co/n9NrAcXXee

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Altamiro Bottino

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Dr Imran Sheikh

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Bob and Diane Fund

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RT @NeuroscienceNew: “Integrated multimodal cell atlas of Alzheimer’s disease” by Gabitto, M. I et al. Nature Neuroscience https://t.co/sZ…

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“Integrated multimodal cell atlas of Alzheimer’s disease” by Gabitto, M. I et al. Nature Neuroscience https://t.co/sZLs020x6n

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Shigekazu Ishihara

@shigekzishihara · X

RT @thmonk_pf: Alzheimer病進行に伴う細胞levelの変化を単一細胞/空間genomicsで検証進行は2段階、初期は炎症、後期はsomatostachin陽性/Pvalb陽性・Vip陽性介在神経選択的脱落高度ADでNeuN陽性低下/核外RNAの増加…

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嘯(しゃお,

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thmonk

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Ordo Fraterna Fibonacci

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Integrated multimodal cell atlas of Alzheimer’s disease Nature https://t.co/zqJ60XkYYD

Oct 16, 2024 · 2,568 followers View post →

thmonk

@thmonk_pf · X

Alzheimer病進行に伴う細胞levelの変化を単一細胞/空間genomicsで検証進行は2段階、初期は炎症、後期はsomatostachin陽性/Pvalb陽性・Vip陽性介在神経選択的脱落高度ADでNeuN陽性低下/核外RNAの増加/Chromatin accesible領域減少 OA #Alzheimers #genomics #papers https://t.co/1vVeTYjK03 https://t.co/imUA8PVVXA

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Duy Dương-Trần, PhD

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RT @JunhaoWen: BRAIN Initiative establishes an integrated multimodal cell atlas of Alzheimer’s disease, published in @NatureNeuro https://…

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RT @JunhaoWen: BRAIN Initiative establishes an integrated multimodal cell atlas of Alzheimer’s disease, published in @NatureNeuro https://…

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Junhao (Hao) Wen

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BRAIN Initiative establishes an integrated multimodal cell atlas of Alzheimer’s disease, published in @NatureNeuro https://t.co/CX9Su1EMxg

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Sky Health, LLC

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Integrated multimodal cell atlas of Alzheimer’s disease | Nature Neuroscience #Alzheimers #cognition #brain #BrainHealth #health #imflammation #neuroscience #epigenomics #GeneExpression #research #science https://t.co/Ebf62qYzsq

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Integrated multimodal cell atlas of Alzheimer’s disease Mariano I. Gabitto, Kyle J. Travaglini, Victoria M. Rachleff, Eitan S. Kaplan, Brian Long, Jeanelle Ariza, Yi Ding, Joseph T. Mahoney, Nick Dee, Jeff Goldy, Erica J. Melief, Anamika Agrawal, Omar Kana, Xingjian Zhen, ET AL.

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New: Integrated multimodal #cell #atlas of #Alzheimer’s disease

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{Fighting Stigma} Integrated multimodal cell atlas of Alzheimer's disease | Nature Neuroscience: Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with ... https://t.co/tGUlJPIyTL

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In Seattle at Research Society on Alcoholism. Julia Stevens and I visited the @AllenInstitute; hosted by Ed lein. What a place! Read this #preprint on @researchsquare: Integrated multimodal cell atlas of Alzheimer’s disease https://t.co/VpBBsiKiBZ @CPC_usyd @syd_health

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TW : Integrated multimodal cell atlas of Alzheimer's disease: Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive and stereotyped... https://t.co/1gJwmkaV1s

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Integrated multimodal cell atlas of Alzheimer's disease.

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Where it's discussed

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Abstract in brief

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All mentions

How Alzheimer's Damages the Brain???? by a Two Phase Attack: A New Study Reveals

Distinct Phases of Brain Damage in Alzheimer's Disease Revealed