ACS Nano November 2024 PMID 39462900

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS-Based Microparticles in a Breast Cancer Model.

Maria Kanelli, Neelkanth M Bardhan, Morteza Sarmadi, Behnaz Eshaghi, Shahad K Alsaiari, William T Rothwell, Apurva Pardeshi, Dhruv Varshney, Dominique C De Fiesta, Howard Mak, Virginia Spanoudaki, Nicole Henning, Ashutosh Kumar, Jooli Han, Angela M Belcher

Mentions

42
Peak: 6 in Oct 2024
across 5 sources since Oct 2024

Extended reach

423,604
potential audience

Total likes

7,898

Video views

238,359

Mentions per month

Oct 2024 – Jun 2025

Where it's discussed

  • News23 articles
  • X / Twitter14 posts
  • YouTube2 videos
  • Blogs2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions consistently praise the article's innovative approach, highlighting phrases like 'game-changing' and 'completely eradicates tumors,' reflecting strong enthusiasm. The tone, supported by technical references and mentions of reduced side effects, underscores a recognition of its potential to revolutionize cancer therapy and influence ongoing research.

AgreementStrong agreement

All discussions express strong support and excitement for the research, frequently calling it 'game-changing' and emphasizing its potential in cancer therapy.

InterestHigh interest

The topics generate high interest, with many posts highlighting innovative aspects like the use of machine learning and near-infrared responsive microparticles.

EngagementHigh engagement

Posts show deep engagement by referencing specific methods, such as pulsatile delivery, thermal ablation, and systemic toxicity reduction, demonstrating thorough understanding and interest.

ImpactHigh impact

The overall tone suggests that users believe this development could significantly influence future cancer treatments and inspire further research, indicating high perceived impact.

Abstract in brief

  • The study developed a light-activated microparticle system made of polycaprolactone containing MoS2 nanosheets and anticancer drugs, enabling localized, pulsatile delivery combined with thermal ablation when exposed to near-infrared laser light.
  • A machine learning algorithm was used to optimize the laser treatment conditions, improving the efficiency of the therapy, which was tested in mice with breast cancer tumors, showing significant tumor eradication and increased survival rates.
  • This approach offers a minimally invasive and precisely targeted treatment option suitable for recurring cycles, reducing side effects and overcoming resistance seen with traditional cancer therapies.]

Top posts

Most liked on X and Bluesky
Koch Institute at MIT
@kochinstitute · X

Cancer treatment, upgraded. Tiny implantable microparticles deliver chemo & heat therapy directly to tumors, reducing side effects. Vote for this #STATMadness entry - Group 2, Matchup 6: https://t.co/cMWdrhlTqO

Mar 4, 2025 · 7 likes · 3 shares · 46,281 followers View post →
Dr Singularity
@Dr_Singularity · X

more here https://t.co/rGNe4F4z02 and here https://t.co/wIO7yznoC7

Dec 24, 2024 · 4 likes · 42,788 followers View post →
Reiner 
@erlesen · X

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment https://t.co/CZa8Joloen Game-Changing Dual Cancer Therapy Completely Eradicates Tumors Without Harsh Side Effects https://t.co/nO3qfgDiJ0 Synergistic effect results in lower systemic toxicity

Dec 21, 2024 · 2 likes · 1 share · 7,860 followers View post →
Machine Learning in Chemistry
@ML_Chem · X

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS2-Based Microparticles in a Breast Cancer Model #machinelearning #compchem https://t.co/OhkaVODpXQ

Nov 4, 2024 · 1 like · 5,265 followers View post →
Free56
@Free5620 · X

https://t.co/ZGfZrDS4U3 https://t.co/SyLFsSFbWu. https://t.co/Jh7aJvL1f0

Oct 29, 2024 · 1 like · 1 share · 197 followers View post →
Tom Varghese Jr. MD, MS, MBA, FACS, MAMSE
@TomVargheseJr · X

RT @ScottSAmyx: A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS…

Oct 30, 2024 · 1 share · 25,773 followers View post →

All mentions

Ivan Vidal (Van-rito Ullij)
@nanoLaniakea · X

RT @kochinstitute: Cancer treatment, upgraded. Tiny implantable microparticles deliver chemo & heat therapy directly to tumors, reducing si…

Mar 4, 2025 · 3 shares · 691 followers View post →
Koch Institute at MIT
@kochinstitute · X

Cancer treatment, upgraded. Tiny implantable microparticles deliver chemo & heat therapy directly to tumors, reducing side effects. Vote for this #STATMadness entry - Group 2, Matchup 6: https://t.co/cMWdrhlTqO

Mar 4, 2025 · 7 likes · 3 shares · 46,281 followers View post →
Reiner 
@erlesen · X

RT @erlesen: A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment https://t.co/CZa8Joloen Game-Changing…

Jan 8, 2025 · 1 share · 7,860 followers View post →
Dr Singularity
@Dr_Singularity · X

more here https://t.co/rGNe4F4z02 and here https://t.co/wIO7yznoC7

Dec 24, 2024 · 4 likes · 42,788 followers View post →
Ariel R Abramovsky
@realAriel_A · X

https://t.co/965Q6cuO4c

Dec 23, 2024 · 94 followers View post →
Reiner
@erlangen.bsky.social · Bluesky

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment pubs.acs.org/doi/10.1021/... Game-Changing Dual Cancer Therapy Completely Eradicates Tumors Without Harsh Side Effects scitechdaily.com/game-changin... This synergistic effect results in lower systemic toxicity

Dec 21, 2024 · 1 share View post →
Reiner 
@erlesen · X

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment https://t.co/CZa8Joloen Game-Changing Dual Cancer Therapy Completely Eradicates Tumors Without Harsh Side Effects https://t.co/nO3qfgDiJ0 Synergistic effect results in lower systemic toxicity

Dec 21, 2024 · 2 likes · 1 share · 7,860 followers View post →
Chidambara .ML.
@chidambara09 · X

https://t.co/d0JKATuprI

Nov 4, 2024 · 11,717 followers View post →
Machine Learning in Chemistry
@ML_Chem · X

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS2-Based Microparticles in a Breast Cancer Model #machinelearning #compchem https://t.co/OhkaVODpXQ

Nov 4, 2024 · 1 like · 5,265 followers View post →
Tom Varghese Jr. MD, MS, MBA, FACS, MAMSE
@TomVargheseJr · X

RT @ScottSAmyx: A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS…

Oct 30, 2024 · 1 share · 25,773 followers View post →
Scott Amyx
@ScottSAmyx · X

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS2-Based Microparticles in a Breast Cancer Model | ACS Nano https://t.co/9NUZZZm0GR

Oct 30, 2024 · 1 share · 24,220 followers View post →
Free56
@Free5620 · X

RT @Free5620: https://t.co/ZGfZrDS4U3 https://t.co/SyLFsSFbWu. https://t.co/Jh7aJvL1f0

Oct 29, 2024 · 1 share · 197 followers View post →
Free56
@Free5620 · X

https://t.co/ZGfZrDS4U3 https://t.co/SyLFsSFbWu. https://t.co/Jh7aJvL1f0

Oct 29, 2024 · 1 like · 1 share · 197 followers View post →
Chidambara .ML.
@chidambara09 · X

https://t.co/s9McPKcpBi

Oct 28, 2024 · 11,717 followers View post →
Epic Plain
@EpicPlain · X

A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic ... https://t.co/HLALMwhBxe #MachineLearning

Oct 28, 2024 · 559 followers View post →